How high-fat diet and high-intensity interval training affect lipid metabolism in the liver and visceral adipose tissue of rats

2018 ◽  
Vol 14 (1) ◽  
pp. 55-62 ◽  
Author(s):  
M. Ebrahimi ◽  
R. Fathi ◽  
Z. Ansari Pirsaraei ◽  
E. Talebi Garakani ◽  
M. Najafi
Keyword(s):  
Weight Gain ◽  
Lipid Profile ◽  
High Intensity ◽  
High Fat Diet ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
High Fat ◽  
Insulin Effect ◽  
Significant Difference ◽  
High Intensity Interval

Lipogenic and lipolytic pathways are tightly regulated by nuclear receptors and binding proteins, such as farnesoid x receptor (FXR) and sterol regulatory element binding protein 1c (SREBP-1c). We designed this research to study the effects of high-intensity interval training (HIIT) and high-fat diet (HFD) on hepatic and adipose FXR and SREBP-1c gene expression beside the plasma levels of lipid profile and insulin. 24 male Wistar rats were randomly divided into normal (~12% fat) and HFD (~56% fat) groups with or without participating in the 8 weeks HIIT protocol. Results from two-way ANOVA and Pearson tests (P<0.05) showed that the HFD rats experienced a larger weight gain correlated with dyslipidemia and hyperinsulinemia, higher hepatic and adipose SREBP-1c expression and lower hepatic FXR expression compared with normal diet fed rats. Although HIIT rats showed higher hepatic FXR and lower hepatic and adipose SREBP-1c expression and lower weight gain compared with untrained rats, plasma lipid profile levels had not any significant difference between trained and untrained rats. Interestingly, hepatic FXR expression was negatively correlated with weight gain and SREBP-1c expression in both tissues while only the hepatic SREBP-1c was positively correlated to insulin levels. In conclusion, HFD-induced dyslipidemia could occur via the activation of the hepatic SREBP-1c pathway under the insulin effect. Although HIIT rats showed lower SREBP-1c correlated to hepatic FXR activation it seems diet is more effective on lipid profile than HIIT. Also, in presence of HFD, HIIT only affects adipose lipolysis.

Effect of High-Intensity Interval Training with Eryngium Campestre on Lipid Profile and Glycemic Indices in High-Fat Diet-Induced Obese Rats

2020 ◽  
Vol 24 (2) ◽  
Author(s):  
Behnoush Ghadery ◽  
Farshad Ghazalian ◽  
Seyed Ali Hosseini ◽  
Hossein Abed Natanzy ◽  
Alireza Shamsoddini
Keyword(s):  
Lipid Profile ◽  
High Intensity ◽  
High Fat Diet ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
High Fat ◽  
Glucose Levels ◽  
Obese Rats ◽  
Glycemic Indices ◽  
High Intensity Interval

Background: Obesity is a multi-factorial physical disorder that results in high serum lipid levels and glycemic disorders. On the other hand, regular exercise and administration of Eryngium Campestre (EC) have glucose and lipid-lowering effects. Objectives: The present study aimed to review the effect of high-intensity interval training (HIIT) with EC on lipid profile and glycemic indices in high-fat diet (HFD)-induced obese rats. Methods: Twenty-four obese rats were divided into four groups, including: (1) control, (2) HIIT, (3) EC, and (4) HIIT+EC. To investigate the effect of obesity on research variables, six rats were assigned to a healthy control group. During six weeks, groups 2 and 4 received HIIT three days per week, and groups 3 and 4 received 30 mg/kg EC by gavage. Data were analyzed using the Shapiro-Wilk test and one-way ANOVA with Tukey’s post hoc test (P ≤ 0.05). Results: Obesity significantly increased cholesterol (Cho), triglyceride (TG), insulin, and glucose levels (P ≤ 0.05). However, HIIT significantly decreased Cho, TG, insulin, and glucose levels (P ≤ 0.05), and EC significantly decreased Cho, TG, low-density lipoprotein (LDL), insulin, and glucose levels (P ≤ 0.05). Besides, HIIT+EC significantly decreased LDL and insulin (P ≤ 0.05). HIIT+EC could decrease LDL more than did HIIT (P ≤ 0.05). Conclusions: Although HIIT and EC alone improved the lipid profile and glycemic indices in obese rats, HIIT combined with EC had greater effects on the decrease of LDL compared to HIIT.

Acute effect of high-intensity interval training exercise on redox status in the ovaries of rats fed a high-fat diet

2021 ◽  
Vol 33 (12) ◽  
pp. 713
Author(s):  
Rodrigo L. Furtado ◽  
Jonathan Elias R. Martins ◽  
Maria Alice F. Oliveira ◽  
Denise D. Guerreiro ◽  
Naiza A. R. de Sá ◽  
...  
Keyword(s):  
High Intensity ◽  
High Fat Diet ◽  
Interval Training ◽  
Redox Status ◽  
Female Rats ◽  
Standard Diet ◽  
High Intensity Interval Training ◽  
High Fat ◽  
Antral Follicles ◽  
High Intensity Interval

This study demonstrates the effect of a single high-intensity interval training (HIIT) session on the redox status of rat ovaries with excess adiposity. Forty Wistar female rats (mean (±s.e.m.) weight 94.40 ± 13.40 g) were divided into two groups and fed either a standard diet (SD) or a high-fat diet (HFD) for 62 days. At the end of this period, the rats were subjected to a single HIIT session and were killed 24 h after exercise. Both groups subjected to exercise (SDex and HFDex) generated a significantly higher antioxidant environment by presenting a higher thiol content, which represents a lower oxidation rate of GSH than their respective controls (SD and HFD). The percentage of morphologically normal primary follicles decreased, whereas that of antral follicles increased, in the SDex group. In addition, the HFD group had a higher percentage of degenerated antral follicles than the SD and SDex groups. Cells immunoreactive for α-smooth muscle actin were seen in the cortical stroma and thecal layer enclosing late secondary and tertiary follicles in all groups. Moreover, heme oxygenase and cytochrome P450 family 19 subfamily A member 1 (Cyp19A1) labelling was seen in all antral follicles. Progesterone concentrations were significantly higher in the HFDex than SDex group. In conclusion, this study indicates that a single session of HIIT may result in an improvement in ovary redox status because of metabolic muscle activity by inducing physiological adaptation after exercise in a paracrine manner.

scholarly journals The TOTUM-63 Supplement and High-Intensity Interval Training Combination Limits Weight Gain, Improves Glycemic Control, and Influences the Composition of Gut Mucosa-Associated Bacteria in Rats on a High Fat Diet

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1569
Author(s):  
Marine Dupuit ◽  
Vivien Chavanelle ◽  
Benoit Chassaing ◽  
Fanny Perriere ◽  
Monique Etienne ◽  
...  
Keyword(s):  
Glycemic Control ◽  
High Intensity ◽  
High Fat Diet ◽  
Interval Training ◽  
Standard Diet ◽  
High Intensity Interval Training ◽  
High Fat ◽  
Beneficial Effects ◽  
Α Diversity ◽  
High Intensity Interval

Obesity and prediabetes are the two strongest risk factors of type 2 diabetes. It has been reported that TOTUM-63, a polyphenol-rich plant extract, has beneficial effects on body weight (BW) and insulin resistance in mice fed a high fat diet (HFD). The study aim was to determine whether high-intensity interval training (HIIT) and/or TOTUM-63 supplementation improved body composition and glycemic control and gut microbiota composition in a Western diet-induced obesity rat model. Wistar rats received a standard diet (CTRL; control; n = 12) or HFD (HFD; n = 48) for 16 weeks. Then, HFD rats were divided in four groups: HFD, HFD + TOTUM-63 (T63), HFD + HIIT (HIIT), and HFD + HIIT +T63 (HIIT + T63). Training was performed 4 days/week for 12 weeks. TOTUM-63 was included in diet composition (2%). The HIIT + T63 combination significantly limited BW gain, without any energy intake modulation, and improved glycemic control. BW variation was correlated with increased α-diversity of the colon mucosa microbiota in the HIIT + T63 group. Moreover, the relative abundance of Anaeroplasma, Christensenellaceae and Oscillospira was higher in the HIIT + T63 group. Altogether, these results suggest that the HIIT and TOTUM-63 combination could be proposed for the management of obesity and prediabetes.

scholarly journals Role or Synergistic Interaction of Adenosine and Vitamin D3 Alongside High-Intensity Interval Training and Isocaloric Moderate Intensity Training on Metabolic Parameters: Protocol for an Experimental Study (Preprint)

2018 ◽  
Author(s):  
Seyed Javad Mirghani ◽  
Maghsoud Peeri ◽  
Omid Yaghoobpour Yekani ◽  
Masoud Zamani ◽  
Foad Feizolahi ◽  
...  
Keyword(s):  
Experimental Study ◽  
Vitamin D3 ◽  
High Intensity ◽  
High Fat Diet ◽  
Interval Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
High Fat ◽  
High Intensity Interval ◽  
Intensity Training

BACKGROUND Obesity is known as one of the major causes of epidemiologic diseases worldwide; therefore, the introduction of treatment strategies by medical professionals, such as the use of various medicines and exercise programs to reduce fat or prevent obesity, is on the rise. Recently, researchers have shown special interest in assessing the effect of lipolytic adenosine and vitamin D deficiency, as well as the effect of exercise, on decreasing body fat percentage. OBJECTIVE This study has been designed to examine the effect of adenosine and vitamin D3 injections, in conjunction with high-intensity interval training and isocaloric moderate-intensity training, on the metabolic parameters of obesity induced by a high-fat diet. METHODS This is an experimental study using 92 Wistar rats. At 6 weeks of age, the rats' weights will be recorded, after which they will have 1 week to adapt to their new environment before being divided into 12 groups. The rats will participate in a 2-stage experimental intervention, including a 13-week fattening diet phase followed by a 12-week exercise training phase consisting of an exercise program and the injection of adenosine and vitamin D3. Groups 1 and 2 will have a normal diet, and the other groups will have a diet of 40% fat, with free access to food and water up to the second half of the second stage of the study (end of the sixth week of training). After termination of the interventions, tissue collection and molecular assessments (blood for biochemical, tissues for gene expression analyses, and anthropometrical indexes) will be performed. RESULTS The project was initiated in April 2017 and completed in December 2017. Data analysis is under way, and the first results are expected to be submitted for publication in November 2018. CONCLUSIONS We hypothesize that weight loss–induced molecular changes and upregulation will be observed in line with an increase in lipolysis and beta oxidation in muscle and fat tissue as a result of performing isocaloric training in drug-receiving rats and groups on a high-fat diet. INTERNATIONAL REGISTERED REPOR RR1-10.2196/10753

scholarly journals Effects of high intensity interval training on neuro-cardiovascular dynamic changes and mitochondrial dysfunction induced by high-fat diet in rats

PLoS ONE ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. e0240060
Author(s):  
Silvio R. Marques Neto ◽  
Raquel C. Castiglione ◽  
Teresa C. B. da Silva ◽  
Lorena da S. Paes ◽  
Aiza Pontes ◽  
...  
Keyword(s):  
Mitochondrial Dysfunction ◽  
High Intensity ◽  
High Fat Diet ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
High Fat ◽  
Dynamic Changes ◽  
Cardiovascular Dynamic ◽  
High Intensity Interval

scholarly journals Probiotic Supplementation and High-Intensity Interval Training Modify Anxiety-Like Behaviors and Corticosterone in High-Fat Diet-Induced Obesity Mice

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1762
Author(s):  
Parisa Foroozan ◽  
Maryam Koushkie Koushkie Jahromi ◽  
Javad Nemati ◽  
Hosein Sepehri ◽  
Mohammad Amin Safari ◽  
...  
Keyword(s):  
Exercise Training ◽  
High Intensity ◽  
High Fat Diet ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
High Fat ◽  
Probiotic Supplementation ◽  
Male Adult ◽  
Serum Corticosterone ◽  
High Intensity Interval

Evidence supports the role of exercise training and probiotics on reducing obesity. Considering the relationship between obesity and high-fat diet with anxiety indices, the aim of this study was to assess the effect of probiotic supplementation and high-intensity interval training (HIIT) on anxiety-like behaviors, corticosterone and obesity indices in high-fat diet (HFD)-induced obesity mice. Thirty male adult C57BL/6 mice were randomly divided into five groups: (1) Control with normal diet (CON), (2) High-fat diet (HFD), (3) HFD + exercise training (HT), (4) HFD + probiotics supplement (HP) and (5) HFD + exercise training +probiotics (HTP). Exercise training consisted of 8 weeks of high-intensity interval training (HIIT) programs. Probiotics supplement included 0.2 mL Lactobacillus rhamnosus GG. Anxiety-like behaviors were measured by open field (OF) and Elevated plus maze (EPM). OF and EPM tests, visceral fat mass (VFM) measurement, and blood sampling for corticosterone were performed after the intervention. Bodyweight was measured at different stages during the intervention. HFD regime in C57BL/6 mice increased bodyweight, VFM, and serum corticosterone levels and anxiety-like behaviors (p < 0.05). HIIT, probiotic and their combination, decreased bodyweight, VFM, and serum corticosterone levels and improved anxiety-like behavior in the HFD mice (p < 0.05). The effect of a combination of HIIT and probiotic on most of the anxiety indices was more than each one separately (p < 0.5). HIIT and probiotic supplements separately or above all in combination, may have beneficial effects in reducing obesity and anxiety indices.

scholarly journals A Meta-Analytical Comparison of the Effects of Small-Sided Games vs. Running-Based High-Intensity Interval Training on Soccer Players’ Repeated-Sprint Ability

2021 ◽  
Vol 18 (5) ◽  
pp. 2781
Author(s):  
Filipe Manuel Clemente ◽  
Rodrigo Ramirez-Campillo ◽  
José Afonso ◽  
Hugo Sarmento ◽  
Thomas Rosemann ◽  
...  
Keyword(s):  
High Intensity ◽  
Interval Training ◽  
Soccer Players ◽  
High Intensity Interval Training ◽  
Training Interventions ◽  
Repeated Sprint Ability ◽  
Repeated Sprint ◽  
Significant Difference ◽  
High Intensity Interval ◽  
Sprint Ability

This systematic review with a meta-analysis was conducted to compare the effects of small-sided games (SSGs)-based interventions with the effects of running-based high-intensity interval training (HIIT) interventions on soccer players’ repeated sprint ability (RSA). The data sources utilized were Web of Science, Scopus, SPORTDiscus, and PubMed. The study eligibility criteria were: (i) parallel studies (SSG-based programs vs. running-based HIIT) conducted in soccer players with no restrictions on age, sex, or competitive level; (ii) isolated intervention programs (i.e., only SSG vs. only running-based HIIT as individual forms) with no restrictions on duration; (iii) a pre–post outcome for RSA; (iv) original, full-text, peer-reviewed articles written in English. An electronic search yielded 513 articles, four of which were included in the present study. There was no significant difference between the effects of SSG-based and HIIT-based training interventions on RSA (effect size (ES) = 0.30; p = 0.181). The within-group analysis revealed no significant effect of SSG-based training interventions (ES = −0.23; p = 0.697) or HIIT-based training interventions (ES = 0.08; p = 0.899) on RSA. The meta-comparison revealed that neither SSGs nor HIIT-based interventions were effective in improving RSA in soccer players, and no differences were found between the two types of training. This suggests that complementary training may be performed to improve the effects of SSGs and HIIT. It also suggests that different forms of HIIT can be used because of the range of opportunities that such training affords.

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