Studies on the stability and kinetics of drug release of dexamethasone phosphate intercalated layered double hydroxides nanohybrids

Dendritic-polysaccharide PIC micelles represent promising delivery systems where dendritic rigidity and polysaccharide stiffness synchronize to determine the stability of the micelles, their kinetics of intracellular drug release, and cytotoxicity.

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Layered double hydroxide and sulindac coiled and scrolled nanoassemblies for storage and drug release

RSC Advances ◽

10.1039/c5ra25814f ◽

2016 ◽

Vol 6 (20) ◽

pp. 16419-16436 ◽

Cited By ~ 30

Author(s):

Michele A. Rocha ◽

Philippe A. D. Petersen ◽

Erico Teixeira-Neto ◽

Helena M. Petrilli ◽

Fabrice Leroux ◽

...

Keyword(s):

Drug Release ◽

Layered Double Hydroxide ◽

Layered Double Hydroxides ◽

P Systems ◽

Synthetic Method ◽

One Pot ◽

High Crystallinity ◽

Anti Inflammatory ◽

Double Hydroxide ◽

Double Hydroxides

Systems comprising anti-inflammatory sulindac intercalated into biocompatible layered double hydroxides nanovehicles were isolated through one pot synthetic method and showed high crystallinity and curled or scrolled particles.

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Thermal Analysis On The Kinetics Of Magnesium-Aluminum Layered Double Hydroxides In Different Heating Rates

Archives of Metallurgy and Materials ◽

10.1515/amm-2015-0130 ◽

2015 ◽

Vol 60 (2) ◽

pp. 1357-1359 ◽

Cited By ~ 5

Author(s):

Y. Hongbo ◽

C. Meiling ◽

W. Xu ◽

G. Hong

Keyword(s):

Activation Energy ◽

Thermal Analysis ◽

Layered Double Hydroxides ◽

Heating Rates ◽

Scanning Calorimetry ◽

Exponential Factor ◽

Thermal Kinetic Parameters ◽

Double Hydroxides ◽

Kinetics Of ◽

Dsc Curves

Abstract The thermal decomposition of magnesium-aluminum layered double hydroxides (LDHs) was investigated by thermogravimetry analysis and differential scanning calorimetry (DSC) methods in argon environment. The influence of heating rates (including 2.5, 5, 10, 15 and 20K/min) on the thermal behavior of LDHs was revealed. By the methods of Kissinger and Flynn-Wall-Ozawa, the thermal kinetic parameters of activation energy and pre-exponential factor for the exothermic processes under non-isothermal conditions were calculated using the analysis of corresponding DSC curves.

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Monovalent Ion Exchange Kinetics of Hydrated Calcium-Alumino Layered Double Hydroxides

Industrial & Engineering Chemistry Research ◽

10.1021/acs.iecr.6b03474 ◽

2016 ◽

Vol 56 (1) ◽

pp. 63-74 ◽

Cited By ~ 10

Author(s):

Guillermo Puerta-Falla ◽

Magdalena Balonis ◽

Gabriel Falzone ◽

Mathieu Bauchy ◽

Narayanan Neithalath ◽

...

Keyword(s):

Ion Exchange ◽

Layered Double Hydroxides ◽

Ion Exchange Kinetics ◽

Monovalent Ion ◽

Exchange Kinetics ◽

Double Hydroxides ◽

Kinetics Of ◽

Hydrated Calcium

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Effect of Divalent Metal Ions on the Stability of Cu-Containing Layered Double Hydroxides

Acta Physico-Chimica Sinica ◽

10.3866/pku.whxb201204191 ◽

2012 ◽

Vol 28 (07) ◽

pp. 1714-1720 ◽

Cited By ~ 3

Author(s):

NI Zhe-Ming ◽

◽

LIU Jiao ◽

XUE Ji-Long ◽

LI Yuan ◽

...

Keyword(s):

Metal Ions ◽

Layered Double Hydroxides ◽

Divalent Metal ◽

Divalent Metal Ions ◽

The Stability ◽

Double Hydroxides

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Synthesis and release behavior of layered double hydroxides–carbamazepine composites

Scientific Reports ◽

10.1038/s41598-021-00117-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Ma. F. Peralta ◽

S. N. Mendieta ◽

I. R. Scolari ◽

G. E. Granero ◽

M. E. Crivello

Keyword(s):

Layered Double Hydroxides ◽

Release Kinetics ◽

Sodium Cholate ◽

Basal Spacing ◽

Reconstruction Method ◽

Formal Charge ◽

Axis Parallel ◽

Double Hydroxides ◽

Ray Patterns ◽

Kinetics Of

AbstractCarbamazepine (CBZ) was incorporated into layered double hydroxides (LDH) to be used as a controlled drug system in solid tumors. CBZ has a formal charge of zero, so its incorporation in the anionic clay implies a challenge. Aiming to overcome this problem, CBZ was loaded into LDH with sodium cholate (SC), a surfactant with negative charge and, for comparison, without SC by the reconstruction method. Surprisingly, it was found that both resultant nanocomposites had similar CBZ encapsulation efficiency, around 75%, and the LDH-CBZ system without SC showed a better performance in relation to the release kinetics of CBZ in simulated body fluid (pH 7.4) and acetate buffer simulating the cellular cytoplasm (pH 4.8) than the system with SC. The CBZ dimensions were measured with Chem3D and, according to the basal spacing obtained from X-ray patterns, it can be arranged in the LDH-CBZ system as a monolayer with the long axis parallel to the LDH layers. Fourier transform infrared spectroscopy and solid state NMR measurements confirmed the presence of the drug, and thermogravimetric analyses showed an enhanced thermal stability for CBZ. These results have interesting implications since they increase the spectrum of LDH application as a controlled drug system to a large number of nonionic drugs, without the addition of other components.

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A Comparison among Synthetic Layered Double Hydroxides (LDHs) as Effective Adsorbents of Inorganic Arsenic from Contaminated Soil–Water Systems

Soil Systems ◽

10.3390/soilsystems4020037 ◽

2020 ◽

Vol 4 (2) ◽

pp. 37

Author(s):

Massimo Pigna ◽

Antonio Violante ◽

Antonio Giandonato Caporale

Keyword(s):

Layered Double Hydroxides ◽

Large Scale ◽

Inorganic Arsenic ◽

Cost Effective ◽

Efficient Removal ◽

Removal Capacity ◽

Adsorption Capacities ◽

Competing Anions ◽

Double Hydroxides ◽

Kinetics Of

The need for cost-effective adsorbents of inorganic arsenic (As(III) and As(V)) stimulates the academia to synthesize and test novel materials that can be profitably applied at large-scale in most affected areas worldwide. In this study, four different layered double hydroxides (Cu-Al-, Mg-Al-, Mg-Fe- and Zn-Al-LDH), previously synthesized and studied for As(III) removal capacity, were evaluated as potential adsorbents of As(V) from contaminated systems, in absence or presence of common inorganic anions (Cl−, F−, SO42−, HCO3− and H2PO4−). The As(V) desorption by H2PO4− was also assessed. Lastly, the As(V) adsorption capacities of the four layered double hydroxides (LDHs) were compared with those observed with As(III) in a complementary paper. All the LDHs adsorbed higher amounts of As(V) than As(III). Fe-Mg-LDH and Cu-Al-LDH showed higher adsorption capacities in comparison to Mg-Al-LDH and Zn-Al-LDH. The presence of competing anions inhibited the adsorption of two toxic anions according to the sequence: Cl− < F− < SO42− < HCO3− < < H2PO4−, in particular on Mg-Al-LDH and Zn-Al-LDH. The kinetics of As(V) desorption by H2PO4− indicated a higher occurrence of more easily desorbable As(V) on Zn-Al-LDH vs. Cu-Al-LDH. In conclusion, synthetic Cu- and Fe-based LDHs can be good candidates for an efficient removal of inorganic As, however, further studies are necessary to prove their real feasibility and safety.

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