Priming the brain to learn: The future of therapy?

2012 ◽  
Vol 17 (2) ◽  
pp. 184-186 ◽  
Author(s):  
Siobhan M. Schabrun ◽  
Lucinda S. Chipchase
Keyword(s):  

We have new answers to how the brain works and tools which can now monitor and manipulate brain function. Rapid advances in neuroscience raise critical questions with which society must grapple. What new balances must be struck between diagnosis and prediction, and invasive and noninvasive interventions? Are new criteria needed for the clinical definition of death in cases where individuals are eligible for organ donation? How will new mobile and wearable technologies affect the future of growing children and aging adults? To what extent is society responsible for protecting populations at risk from environmental neurotoxins? As data from emerging technologies converge and are made available on public databases, what frameworks and policies will maximize benefits while ensuring privacy of health information? And how can people and communities with different values and perspectives be maximally engaged in these important questions? Neuroethics: Anticipating the Future is written by scholars from diverse disciplines—neurology and neuroscience, ethics and law, public health, sociology, and philosophy. With its forward-looking insights and considerations for the future, the book examines the most pressing current ethical issues.


KronoScope ◽  
2013 ◽  
Vol 13 (2) ◽  
pp. 228-239
Author(s):  
Rémy Lestienne

Abstract J.T. Fraser used to emphasize the uniqueness of the human brain in its capacity for apprehending the various dimensions of “nootemporality” (Fraser 1982 and 1987). Indeed, our brain allows us to sense the flow of time, to measure delays, to remember past events or to predict future outcomes. In these achievements, the human brain reveals itself far superior to its animal counterpart. Women and men are the only beings, I believe, who are able to think about what they will do the next day. This is because such a thought implies three intellectual abilities that are proper to mankind: the capacity to take their own thoughts as objects of their thinking, the ability of mental time travels—to the past thanks to their episodic memory or to the future—and the possibility to project very far into the future, as a consequence of their enlarged and complexified forebrain. But there are severe limits to our timing abilities of which we are often unaware. Our sensibility to the passing time, like other of our intellectual abilities, is often competing with other brain functions, because they use at least in part the same neural networks. This is particularly the case regarding attention. The deeper the level of attention required, the looser is our perception of the flow of time. When we pay attention to something, when we fix our attention, then our inner sense of the flux of time freezes. This limitation should not sound too unfamiliar to the reader of J.T. Fraser who wrote in his book Time, Conflict, and Human Values (1999) about “time as a nested hierarchy of unresolvable conflicts.”


eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Qing Yu ◽  
Bradley R Postle
Keyword(s):  

The brain stores information that is needed immediately and information that will be needed in the future in different ways.


Author(s):  
Stephen J. Morse

This chapter considers whether the new sciences of the brain/mind, especially neuroscience and behavioural genetics, are likely to transform the law’s traditional concepts of the person, agency, and responsibility. The chapter begins with a brief speculation about why so many people think these sciences will transform the law. It reviews the law’s concepts of the person, agency and responsibility, misguided challenges to these concepts, and the achievements of the new sciences. It then confronts the claim that the brain/mind sciences prove that we are not agents who can guide our conduct by reason and thus cannot be responsible. It argues that this claim cannot be supported empirically or conceptually, and that no revolution in legal thinking is foreseeable. The chapter concludes by suggesting that the new sciences have little to offer the law at present, but in the future, they may contribute modestly to reforming doctrine, policy, and practice.


Author(s):  
Richard McCarty

Several exciting lines of research have emerged from the study of animal models of mental disorders. This chapter presents seven opportunities for enhancing the diagnosis and treatment of mental disorders. They include improvements to the system for diagnosis of mental disorders, use of induced pluripotent stem cells from patients to generate neuronal cultures for in vitro determination of effective drug therapies for those individuals, use of data-mining techniques for understanding patient variability, a commitment to a greater focus on the prevention of mental disorders, innovative uses of smartphones to track patients and individuals at high risk of developing a mental disorder, and developing next-generation therapies and delivery systems that target a specific area of the brain rather than the entire brain. A common theme in these seven thoughts for the future is a commitment to bringing precision medicine tools to the treatment of patients with mental disorders.


Author(s):  
J.A. Kaltenbach ◽  
D.A. Godfrey

Tinnitus most commonly begins with alterations of input from the ear resulting from cochlear trauma or overstimulation of the ear. Because the cochlear nucleus is the first processing center in the brain receiving cochlear input, it is the first brainstem station to adjust to this modified input from the cochlea. Research published over the last 30 years demonstrates changes in neural circuitry and activity in the cochlear nucleus that are associated with and may be the origin of the signals that give rise to tinnitus percepts at the cortical level. This chapter summarizes what is known about these disturbances and their relationships to tinnitus. It also summarizes the mechanisms that trigger tinnitus-related disturbances and the anatomical, chemical, neurophysiological, and biophysical defects that underlie them. It concludes by highlighting some major controversies that research findings have generated and discussing the clinical implications the findings have for the future treatment of tinnitus.


2018 ◽  
Vol 100 (4) ◽  
pp. 64-65
Author(s):  
Maria Ferguson

The growth of online content has raised questions about how digital reading affects the brain and what kinds of reading instruction students need to be prepared for the future. Some researchers have noted that the need to process large amounts of information may be causing readers’ brains to become more suited to skimming than to deep reading. Maria Ferguson observes that this raises a dilemma for educators who prize the critical thinking and analytical skills that come from deep reading while recognizing that the ability to sift large amounts of material is a valued skill in today’s workplaces.


2020 ◽  
Vol 21 (8) ◽  
pp. 2744 ◽  
Author(s):  
Adriana Kubis-Kubiak ◽  
Aleksandra Dyba ◽  
Agnieszka Piwowar

The brain is an organ in which energy metabolism occurs most intensively and glucose is an essential and dominant energy substrate. There have been many studies in recent years suggesting a close relationship between type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD) as they have many pathophysiological features in common. The condition of hyperglycemia exposes brain cells to the detrimental effects of glucose, increasing protein glycation and is the cause of different non-psychiatric complications. Numerous observational studies show that not only hyperglycemia but also blood glucose levels near lower fasting limits (72 to 99 mg/dL) increase the incidence of AD, regardless of whether T2DM will develop in the future. As the comorbidity of these diseases and earlier development of AD in T2DM sufferers exist, new AD biomarkers are being sought for etiopathogenetic changes associated with early neurodegenerative processes as a result of carbohydrate disorders. The S100B protein seem to be interesting in this respect as it may be a potential candidate, especially important in early diagnostics of these diseases, given that it plays a role in both carbohydrate metabolism disorders and neurodegenerative processes. It is therefore necessary to clarify the relationship between the concentration of the S100B protein and glucose and insulin levels. This paper draws attention to a valuable research objective that may in the future contribute to a better diagnosis of early neurodegenerative changes, in particular in subjects with T2DM and may be a good basis for planning experiments related to this issue as well as a more detailed explanation of the relationship between the neuropathological disturbances and changes of glucose and insulin concentrations in the brain.


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