Degradability and in vivo biocompatibility of micro-alloyed Mg-Ca-La alloys as orthopedic implants

2021 ◽  
pp. 131510
Author(s):  
Wufei Ge ◽  
Kai Chen ◽  
Hongyan Tang ◽  
Xahriyar Arken ◽  
Xianzuo Zhang ◽  
...  
Keyword(s):  
Orthopedic Implants

scholarly journals Rationale for Processing of a Mg-Zn-Ca Alloy by Equal-Channel Angular Pressing for Use in Biodegradable Implants for Osteoreconstruction

Crystals ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1381
Author(s):  
Natalia S. Martynenko ◽  
Natalia Yu. Anisimova ◽  
Olga V. Rybalchenko ◽  
Mikhail V. Kiselevskiy ◽  
Georgy Rybalchenko ◽  
...  
Keyword(s):  
Equal Channel Angular Pressing ◽  
Stromal Cells ◽  
Orthopedic Implants ◽  
Biodegradable Implants ◽  
Promising Candidate ◽  
Human Mesenchymal Stromal Cells ◽  
Angular Pressing ◽  
Cell Adhesion And Proliferation ◽  
Stimulation Of

Widespread use of Mg-Zn-Ca alloys in clinical orthopedic practice requires improvement of their mechanical properties—in particular, ductility—and enhancement of their bioactivity for accelerated osteoreconstruction. The alloy was studied in two structural states: after homogenization and after equal-channel angular pressing. Immersion and potentiodynamic polarization tests showed that the corrosion rate of the alloy was not increased by deformation. The mass loss in vivo was also statistically insignificant. Furthermore, it was found that deformation did not compromise the biocompatibility of the alloy and did not have any significant effect on cell adhesion and proliferation. However, an extract of the alloy promoted the alkaline phosphatase activity of human mesenchymal stromal cells, which indicates osteogenic stimulation of cells. The osteoinduction of the deformed alloy significantly exceeded that of the homogenized one. Based on the results of this work, it can be concluded that the alloy Mg-1%Zn-0.3%Ca modified by equal-channel angular pressing is a promising candidate for the manufacture of biodegradable orthopedic implants since it stimulates osteogenic differentiation and has greater ductility, which provides it with a competitive advantage in comparison with the homogenized state.

scholarly journals Fluoride Treatment and In Vitro Corrosion Behavior of Mg-Nd-Y-Zn-Zr Alloys Type

Materials ◽  
2022 ◽  
Vol 15 (2) ◽  
pp. 566
Author(s):  
Pham Hong Quan ◽  
Iulian Antoniac ◽  
Florin Miculescu ◽  
Aurora Antoniac ◽  
Veronica Manescu (Păltânea) ◽  
...  
Keyword(s):  
Corrosion Behavior ◽  
Orthopedic Implants ◽  
Immersion Test ◽  
Nacl Solution ◽  
Fluoride Ions ◽  
Fluoride Treatment ◽  
Cardiovascular Stents ◽  
Before And After

Fluoride conversion coatings on Mg present many advantages, among which one can find the reduction of the corrosion rate under “in vivo” or “in vitro” conditions and the promotion of the calcium phosphate deposition. Moreover, the fluoride ions released from MgF2 do not present cytotoxic effects and inhibit the biofilm formation, and thus these treated alloys are very suitable for cardiovascular stents and biodegradable orthopedic implants. In this paper, the biodegradation behavior of four new magnesium biodegradable alloys that have been developed in the laboratory conditions, before and after surface modifications by fluoride conversion (and sandblasting) coatings, are analyzed. We performed structural and surface analysis (XRD, SEM, contact angle) before and after applying different surface treatments. Furthermore, we studied the electrochemical behavior and biodegradation of all experimental samples after immersion test performed in NaCl solution. For a better evaluation, we also used LM and SEM for evaluation of the corroded samples after immersion test. The results showed an improved corrosion resistance for HF treated alloy in the NaCl solution. The chemical composition, uniformity, thickness and stability of the layers generated on the surface of the alloys significantly influence their corrosion behavior. Our study reveals that HF treatment is a beneficial way to improve the biofunctional properties required for the studied magnesium alloys to be used as biomaterials for manufacturing the orthopedic implants.

scholarly journals Osseointegration of Antimicrobial Acrylic Bone Cements Modified with Graphene Oxide and Chitosan

2020 ◽  
Vol 10 (18) ◽  
pp. 6528 ◽  
Author(s):  
Mayra Eliana Valencia Zapata ◽  
José Herminsul Mina Hernandez ◽  
Carlos David Grande Tovar ◽  
Carlos Humberto Valencia Llano ◽  
Blanca Vázquez-Lasa ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Bone Cement ◽  
Orthopedic Surgery ◽  
Bending Strength ◽  
Orthopedic Implants ◽  
Parietal Bone ◽  
Maximum Temperature ◽  
Cement Interface

Acrylic bone cement (ABC) is one of the most used materials in orthopedic surgery, mainly for the fixation of orthopedic implants to the bone. However, ABCs usually present lack of biological activity and osseointegration capacity that leads to loosening of the prosthesis. This work reports the effect of introducing graphene oxide (GO) and chitosan (CS), separately or together, in the ABC formulation on setting performance, mechanical behavior, and biological properties. Introduction of both CS and GO to the ABC decreased the maximum temperature by 21% and increased the antibacterial activity against Escherichia coli by 87%, while introduction of only CS decreased bending strength by 32%. The results of cell viability and cell adhesion tests showed in vitro biocompatibility. The in vivo response was investigated using both subdermal and bone parietal implantations in Wistar rats. Modified ABCs showed absence of immune response, as confirmed by a normal inflammatory response in Wistar rat subdermal implantation. The results of the parietal bone implantation showed that the addition of CS and GO together allowed a near total healing bone–cement interface, as observed in the micrographic analysis. The overall results support the great potential of the modified ABCs for application in orthopedic surgery mainly in those cases where osseointegration is required.

scholarly journals In VivoMicroCT Monitoring of Osteomyelitis in a Rat Model

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Vincent A. Stadelmann ◽  
Inga Potapova ◽  
Karin Camenisch ◽  
Dirk Nehrbass ◽  
R. Geoff Richards ◽  
...  
Keyword(s):  
Morphological Changes ◽  
Orthopedic Implants ◽  
Surgical Removal ◽  
Element Analysis ◽  
Bone Implant ◽  
Bone Implant Contact ◽  
Bone Changes ◽  
Bone Fraction ◽  
Microct Imaging

Infection associated with orthopedic implants often results in bone loss and requires surgical removal of the implant. The aim of this study was to evaluate morphological changes of bone adjacent to a bacteria-colonized implant, with the aim of identifying temporal patterns that are characteristic of infection. In anin vivostudy with rats, bone changes were assessed usingin vivomicroCT at 7 time points during a one-month postoperative period. The rats received either a sterile orStaphylococcus aureus-colonized polyetheretherketone screw in the tibia. Bone-implant contact, bone fraction, and bone changes (quiescent, resorbed, and new bone) were calculated from consecutive scans and validated against histomorphometry. The screw pullout strength was estimated from FE models and the results were validated against mechanical testing. In the sterile group, bone-implant contact, bone fraction, and mechanical fixation increased steadily until day 14 and then plateaued. In the infected group, they decreased rapidly. Bone formation was reduced while resorption was increased, with maximum effects observed within 6 days. In summary, the model presented is capable of evaluating the patterns of bone changes due to implant-related infections. The combined use of longitudinalin vivomicroCT imaging and image-based finite element analysis provides characteristic signs of infection within 6 days.

Implantable 9-Channel Telemetry System for In Vivo Load Measurements With Orthopedic Implants

2007 ◽  
Vol 54 (2) ◽  
pp. 253-261 ◽  
Author(s):  
Friedmar Graichen ◽  
Rdiger Arnold ◽  
Antonius Rohlmann ◽  
Georg Bergmann
Keyword(s):  
Orthopedic Implants ◽  
Telemetry System

scholarly journals Antimicrobial Susceptibility of Bacteria Isolated from Orthopedic Implants following Revision Hip Surgery

1998 ◽  
Vol 42 (11) ◽  
pp. 3002-3005 ◽  
Author(s):  
Michael M. Tunney ◽  
Gordon Ramage ◽  
Sheila Patrick ◽  
James R. Nixon ◽  
Philip G. Murphy ◽  
...  
Keyword(s):  
Bone Cement ◽  
Antimicrobial Susceptibility ◽  
Antimicrobial Agents ◽  
Orthopedic Implants ◽  
Hip Surgery ◽  
Broth Microdilution ◽  
Microdilution Method ◽  
Broth Microdilution Method ◽  
Revision Hip Surgery

The susceptibilities of 49 isolates recovered from orthopedic implants to seven antimicrobial agents were evaluated by the broth microdilution method. Ciprofloxacin and vancomycin were more active than gentamicin, representing aminoglycosides which are routinely incorporated into bone cement, and also more active than the peroperative antimicrobial agents cefamandole and erythromycin. The use of ciprofloxacin and vancomycin in vivo, therefore, warrants further evaluation.

Electrosurgery Induced Damage to Ti-6Al-4V and CoCrMo Alloy Surfaces in Orthopedic Implants In Vivo and In Vitro

2017 ◽  
Vol 32 (11) ◽  
pp. 3533-3538 ◽  
Author(s):  
Gregory W. Kubacki ◽  
Shiril Sivan ◽  
Jeremy L. Gilbert
Keyword(s):  
Orthopedic Implants ◽  
Cocrmo Alloy

scholarly journals Local and Systemic In Vivo Responses to Osseointegrative Titanium Nanotube Surfaces

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 583
Author(s):  
Erin A. Baker ◽  
Mackenzie M. Fleischer ◽  
Alexander D. Vara ◽  
Meagan R. Salisbury ◽  
Kevin C. Baker ◽  
...  
Keyword(s):  
Inductively Coupled Plasma ◽  
Metal Ion ◽  
Complete Blood Count ◽  
Cell Attachment ◽  
Marrow Cell ◽  
Orthopedic Implants ◽  
Distal Region ◽  
Multinucleated Cells

Orthopedic implants requiring osseointegration are often surface modified; however, implants may shed these coatings and generate wear debris leading to complications. Titanium nanotubes (TiNT), a new surface treatment, may promote osseointegration. In this study, in vitro (rat marrow-derived bone marrow cell attachment and morphology) and in vivo (rat model of intramedullary fixation) experiments characterized local and systemic responses of two TiNT surface morphologies, aligned and trabecular, via animal and remote organ weight, metal ion, hematologic, and nondecalcified histologic analyses. In vitro experiments showed total adherent cells on trabecular and aligned TiNT surfaces were greater than control at 30 min and 4 h, and cells were smaller in diameter and more eccentric. Control animals gained more weight, on average; however, no animals met the institutional trigger for weight loss. No hematologic parameters (complete blood count with differential) were significantly different for TiNT groups vs. control. Inductively coupled plasma mass spectrometry (ICP-MS) showed greater aluminum levels in the lungs of the trabecular TiNT group than in those of the controls. Histologic analysis demonstrated no inflammatory infiltrate, cytotoxic, or necrotic conditions in proximity of K-wires. There were significantly fewer eosinophils/basophils and neutrophils in the distal region of trabecular TiNT-implanted femora; and, in the midshaft of aligned TiNT-implanted femora, there were significantly fewer foreign body giant/multinucleated cells and neutrophils, indicating a decreased immune response in aligned TiNT-implanted femora compared to controls.

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