scholarly journals 100 Years of insulin: Lifesaver, immune target, and potential remedy for prevention

Med ◽  
2021 ◽  
Vol 2 (10) ◽  
pp. 1120-1137
Author(s):  
Anette-Gabriele Ziegler ◽  
Thomas Danne ◽  
Carolin Daniel ◽  
Ezio Bonifacio
Keyword(s):  
Potential Remedy ◽  
Immune Target

scholarly journals The potential remedy of melatonin on osteoarthritis

2021 ◽  
Author(s):  
Ko‐Hsiu Lu ◽  
Peace Wun‐Ang Lu ◽  
Eric Wun‐Hao Lu ◽  
Chih‐Hsin Tang ◽  
Shih‐Chi Su ◽  
...  
Keyword(s):  
Potential Remedy

Potential remedy against Echinococcus multilocularis in wild red foxes using baits with anthelmintic distributed around fox breeding dens in Hokkaido, Japan

Parasitology ◽  
2002 ◽  
Vol 125 (2) ◽  
pp. 119-129 ◽  
Author(s):  
H. TSUKADA ◽  
K. HAMAZAKI ◽  
S. GANZORIG ◽  
T. IWAKI ◽  
K. KONNO ◽  
...  
Keyword(s):  
Echinococcus Multilocularis ◽  
Red Fox ◽  
Red Foxes ◽  
Clethrionomys Rufocanus ◽  
Efficient Control ◽  
Positive Rate ◽  
Potential Remedy ◽  
Patent Infection

The effect of bait-delivered anthelmintic to reduce the prevalence of Echinococcus multilocularis in wild red foxes was evaluated in Koshimizu, in the eastern part of Hokkaido, Japan. The study area (200 km2) was divided into baited and non-baited sections. The anthelmintic baits were distributed around fox den sites in the baited section every month for 13 months. After 1 year of the anthelmintic bait distribution, the prevalence of E. multilocularis in foxes, evaluated either by the parasite egg examination (from 27.1 to 5.6%) or coproantigen ELISA (from 59.6 to 29.7%), decreased in the baited section contrasting to that in the non-baited section (parasite egg: from 18.8 to 24.2%; ELISA: from 41.9 to 45.8%). The prevalence of E. multilocularis in grey red-backed vole Clethrionomys rufocanus, caught around fox dens, born after bait distribution also decreased and was significantly lower than that in non-baited section. However, within the study periods, the coproantigen-positive rate in fox faeces sporadically increased, while egg-positive rate constantly decreased. Since coproantigen ELISA can detect pre-patent infection, this observation indicates that reinfection pressure in the baited section was still high even after the 13 months of anthelmintic bait distribution. Therefore, the bait distribution longer than our study period is required for the efficient control of E. multilocularis in wild red fox population.

scholarly journals Moringa oleifera Extract Extenuates Echis ocellatus Venom-Induced Toxicities, Histopathological Impairments and Inflammation via Enhancement of Nrf2 Expression in Rats

2021 ◽  
Vol 28 (1) ◽  
pp. 98-115
Author(s):  
Akindele O. Adeyi ◽  
Sodiq O. Adeyemi ◽  
Enoh-Obong P. Effiong ◽  
Babafemi S. Ajisebiola ◽  
Olubisi E. Adeyi ◽  
...  
Keyword(s):  
Moringa Oleifera ◽  
Ethanol Extract ◽  
Male Rats ◽  
Blood Electrolytes ◽  
Tnf Α ◽  
Group 3 ◽  
Group 2 ◽  
Haematological Indices ◽  
Nrf2 Expression ◽  
Potential Remedy

Echis ocellatus snakebite causes more fatalities than all other African snake species combined. Moringa oleifera reportedly possesses an antivenom property. Therefore, we evaluated the effectiveness of M. oleifera ethanol extract (MOE) against E. ocellatus venom (EOV) toxicities. Thirty male rats were grouped as follows (n = 5): Group 1 (normal control received saline), groups 2 to 6 were administered intraperitoneally, 0.22 mg/kg (LD50) of EOV. Group 2 was left untreated while group 3 to 6 were treated post-envenoming with 0.2 mL of polyvalent antivenom, 200, 400, and 600 mg/kg of MOE respectively. MOE significantly (p<0.05) normalized the altered haematological indices and blood electrolytes profiles. MOE attenuated venom-induced cellular dysfunctions, characterized by a significant increase in NRF2, and concomitant downregulation of increased antioxidant enzymes (SOD and CAT) activities in the serum and heart of the treated rats. MOE normalized the elevated TNF-α and IL-1β in serum and heart tissues. Furthermore, the IgG titre value was significantly (p<0.5) higher in the envenomed untreated group compared to the MOE-treated groups. Hemorrhagic, hemolytic and coagulant activities of the venom were strongly inhibited by the MOE dose, dependently. Lesions noticed on tissues of vital organs of untreated rats were abolished by MOE. Our findings substantiate the effectiveness of MOE as a potential remedy against EOV toxicities.

scholarly journals A survey on network contraflow evacuation planningproblems

2015 ◽  
Vol 3 ◽  
pp. 44-53
Author(s):  
Phanindra Prasad Bhandari ◽  
Shree Ram Khadka
Keyword(s):  
Network Flow ◽  
Dynamic Network ◽  
Route Planning ◽  
Evacuation Planning ◽  
Solution Strategies ◽  
General Network ◽  
Evacuation Route Planning ◽  
Network Flow Optimization ◽  
Evacuation Route ◽  
Potential Remedy

Evacuation planning is becoming crucial due to an increasing number of natural and human-created disasters over last few decades. One of the efficient ways to model the evacuation situation is a network flow optimization model. This model captures most of the necessities of the evacuation planning. Moreover, dynamic network contraflow modeling is considered a potential remedy to decrease the congestion due to its direction reversal property and it addresses the challenges of evacuation route planning. However, there do not exist satisfactory analytical results to this model for general network. In this paper, it is tried to provide an annotated overview on dynamic network contraflow problems related to evacuation planning and to incorporate models and solution strategies to them developed in this field to date.

scholarly journals Jump or kink: on super-efficiency in segmented linear regression breakpoint estimation

Biometrika ◽  
2020 ◽  
Author(s):  
Yining Chen
Keyword(s):  
Structural Change ◽  
Linear Regression ◽  
Convergence Rate ◽  
Pointwise Convergence ◽  
Mean Absolute Error ◽  
Absolute Error ◽  
The Other ◽  
Fixed Parameter ◽  
The Mean ◽  
Potential Remedy

Summary We consider the problem of segmented linear regression with a single breakpoint, with the focus on estimating the location of the breakpoint. If $n$ is the sample size, we show that the global minimax convergence rate for this problem in terms of the mean absolute error is $O(n^{-1/3})$. On the other hand, we demonstrate the construction of a super-efficient estimator that achieves the pointwise convergence rate of either $O(n^{-1})$ or $O(n^{-1/2})$ for every fixed parameter value, depending on whether the structural change is a jump or a kink. The implications of this example and a potential remedy are discussed.

Passive Mechanical Analysis of Engineered Myotube Fibers

2009 ◽  
Author(s):  
Ryan A. Koppes ◽  
Nathan R. Schiele ◽  
Douglas M. Swank ◽  
Douglas B. Chrisey ◽  
David T. Corr
Keyword(s):  
Mechanical Properties ◽  
Genetic Disease ◽  
Traumatic Injury ◽  
Mechanical Analysis ◽  
Muscular Tissue ◽  
Surgical Excisions ◽  
Potential Remedy ◽  
Cell Versus

The loss of functional muscle as a product of genetic disease, traumatic injury, or surgical excisions results in a physiological deficiency that still remains without an effective clinical treatment [1]. Engineering of functional tissue in vitro for replacement in vivo might pose as a potential remedy for this clinical demand. By approaching tissue engineering from the bottom-up, geometrically directing myoblast growth provides a means for constructing tissue replacements cell-by-cell versus the traditional decellularized construct that remains limited by its size and ability to deliver cellular nutrients. Furthermore, geometrically controlling the growth of myoblasts allows for direct manipulation of the structural and mechanical properties inherent to muscular tissue.

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