Potential role of blood microRNAs as non-invasive biomarkers for early detection of asymptomatic coronary atherosclerosis in obese children with metabolic syndrome

Background: Metabolic Syndrome (MetS) has a high prevalence in children, and its presence increases in those with a high BMI. This fact confirms the need for early detection to avoid the development of other comorbidities. Non-invasive variables are presented as a cost-effective and easy to apply alternative in any clinical setting. Aim: To propose a non-invasive method for the early diagnosis of MetS in overweight and obese Chilean children. Methods: We conducted a cross-sectional study on 221 children aged 6 to 11 years. We carried out multivariate logistic regressions, receiver operating characteristic curves, and discriminant analysis to determine the predictive capacity of non-invasive variables. The proposed new method for early detection of MetS is based on clinical decision trees. Results: The prevalence of MetS was 26.7%. The area under the curve for the BMI and waist circumference was 0.827 and 0.808, respectively. Two decision trees were calculated: the first included blood pressure (≥104.5/69 mmHg), BMI (≥23.5 Kg/m2) and WHtR (≥0.55); the second used BMI (≥23.5 Kg/m2) and WHtR (≥0.55), with validity index of 74.7% and 80.5%, respectively. Conclusions: Early detection of MetS is possible through non-invasive methods in overweight and obese children. Two models (Clinical decision trees) based on anthropometric (non-invasive) variables with acceptable validity indexes have been presented. Clinical decision trees can be applied in different clinical and non-clinical settings, adapting to the tools available, being an economical and easy to measurement option. These methods reduce the use of blood tests to those patients who require confirmation.

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Potential Role of Cytokines in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis

Acta Chirurgica Latviensis ◽

10.2478/v10163-012-0025-5 ◽

2011 ◽

Vol 11 (1) ◽

pp. 130-133

Author(s):

Astra Zviedre ◽

Arnis Engelis ◽

Mohit Kakar ◽

Aigars Pētersons

Keyword(s):

Early Detection ◽

Acute Appendicitis ◽

Inflammatory Mediators ◽

Potential Role ◽

Clinical Symptoms ◽

Future Research ◽

Mesenteric Lymphadenitis ◽

Proper Diagnosis ◽

Near Future

Potential Role of Cytokines in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis Although, AAP and AML have different etiological factors, clinical symptoms are very much similar but treatment tactics in both the disease differ a lot. In case of AML, treatment is more conservative and does not require hospitalization while in case of AAP immediate hospitalization and maybe further surgery can be mandatory. With the identification of group of cytokines serum inflammatory mediators IL-8, IL-10, IL-12[p70], IL-17, TNF-a and MCP-1, it is believed early and proper diagnosis of AAP in the near future. Research of cytokines-serum inflammatory mediators has opened new opportunities for an early detection and differentiation of these two diseases in children.

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The Potential Role of Antioxidants in Metabolic Syndrome

Current Pharmaceutical Design ◽

10.2174/1381612822666151209152352 ◽

2016 ◽

Vol 22 (7) ◽

pp. 859-869 ◽

Cited By ~ 34

Author(s):

Bianca Martins Gregório ◽

Diogo Benchimol De Souza ◽

Fernanda Amorim de Morais Nascimento ◽

Leonardo Matta ◽

Caroline Fernandes-Santos

Keyword(s):

Metabolic Syndrome ◽

Potential Role

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Plasma from obese children increases monocyte-endothelial adhesion and affects intracellular insulin signaling in cultured endothelial cells: potential role of mTORC1-S6K1

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ◽

10.1016/j.bbadis.2021.166076 ◽

2021 ◽

pp. 166076

Author(s):

Nadia Di Pietrantonio ◽

Carola Palmerini ◽

Caterina Pipino ◽

Maria Pompea Antonia Baldassarre ◽

Giuseppina Bologna ◽

...

Keyword(s):

Endothelial Cells ◽

Insulin Signaling ◽

Potential Role ◽

Obese Children ◽

Cultured Endothelial Cells

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Identification of non-invasive biomarkers for early detection of breast cancer: A Review

Clinical Oncology Research and Reports ◽

10.31579/2693-4787/017 ◽

2021 ◽

Vol 2 (1) ◽

pp. 01-05

Author(s):

Asima Tayyab

Keyword(s):

Breast Cancer ◽

Early Breast Cancer ◽

Potential Role ◽

Small Volume ◽

Breast Cancer Diagnosis ◽

Diagnostic Purpose ◽

Diagnose Breast Cancer ◽

Non Invasive ◽

Early Stages

Despite decades of research, diagnostic tests with specificity and accuracy for early breast cancer are yet unavailable. Major problems associated with poor diagnosis are either due to incompetency of reported biomarkers or small volume of patients under study. Moreover, heterogeneity of the disease further complicates the struggle of identifying effective biomarkers. Therefore, to improve the survival rate, look for new, sensitive and specific biomarkers for early breast cancer diagnosis is need of hour. In this study, we have reviewed recently reported serum biomarkers and categorized them based on their biomolecular nature such as protein, ctDNA, epigenetics regulation and miRNA. Potential role of these available biomarkers in early diagnosis of breast cancer has also been discussed. Based on the facts obtained from literature review, it is revealed that using any individual biomolecule as a biomarker is not sufficient to diagnose breast cancer at early stages rather it is suggested that a panel of proteins or miRNAs would offer better sensitivity and specificity. Whereas, unavailability of a potential ctDNA and epigenetics regulation candidate for diagnostic purpose is and suggest the use of more sophisticated techniques to unwound these regulations in serum especially at early stages of breast cancer.

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Potential role of circulating microRNAs (486-5p, 497, 509-5p and 605) in metabolic syndrome Egyptian male patients

Diabetes Metabolic Syndrome and Obesity Targets and Therapy ◽

10.2147/dmso.s187422 ◽

2019 ◽

Vol Volume 12 ◽

pp. 601-611 ◽

Cited By ~ 2

Author(s):

Mohamed Bakr Zaki ◽

Ahmed Ibrahim Abulsoud ◽

Ahmed Mohamed Elsisi ◽

Ahmed Soliman Doghish ◽

Ossama Abd Elmotaal Mansour ◽

...

Keyword(s):

Metabolic Syndrome ◽

Potential Role ◽

Circulating Micrornas ◽

Male Patients

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1173Anti-heart and anti-intercalated disk autoantibodies: possible novel biomarkers of cardiac sarcoidosis

European Heart Journal ◽

10.1093/eurheartj/ehz748.0015 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

A Caforio ◽

S Gianstefani ◽

A Baritussio ◽

R Marcolongo ◽

M Seguso ◽

...

Keyword(s):

Potential Role ◽

Cardiac Involvement ◽

Cardiac Sarcoidosis ◽

Cross Sectional Study ◽

Cross Sectional ◽

Non Invasive ◽

Immune Mediated ◽

Novel Biomarkers ◽

Intercalated Disk

Abstract Background Sarcoidosis is an immune-mediated disease; cardiac involvement, a granulomatous form of myocarditis, is under-recognised and prognostically relevant, as it can present with significant morbidity and mortality. Anti-heart autoantibodies (AHA) and anti-intercalated disk autoantibodies (AIDA) are reliable autoimmune markers in non-sarcoidosis myocarditis forms. Purpose The aim of this study was to assess the potential role of serum AHA and AIDA in cardiac sarcoidosis. Methods This is a cross-sectional study on a series of 29 patients with biopsy proven extra-cardiac sarcoidosis and with biopsy-proven or clinically suspected cardiac involvement, who were tested for AHA and AIDA. Patients were recruited in two recruiting tertiary centres, in USA and Italy. AHA and AIDA were detected by indirect immunofluorescence on human myocardium and skeletal muscle. Controls included sera from patients with non-inflammatory cardiac disease (NICD) (n=160), with ischemic heart failure (IHF) (n=141) and normal blood donors (NBD) (n=270). Results The frequencies of AHA and of AIDA were higher in sarcoidosis (86%; 62%) than in NICD (8%; 4%), IHF (7%; 2%), NBD (9%; 0%) (p=0.0001; p=0.0001 respectively). Sensitivity and specificity were: 86% and 92% for positive AHA and 62% and 98% for positive AIDA, respectively (see figure). Figure 1 Conclusions The detection of serum AHA and AIDA in biopsy-proven or clinically suspected cardiac sarcoidosis supports the involvement of heart-specific autoimmunity in the majority of our cases and may provide a novel non invasive diagnostic marker.

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