Vestibular drop attack: A potential origin from perilymphatic fistula?

2020 ◽  
Vol 140 ◽  
pp. 109668
Author(s):  
A. Pace ◽  
G. Iannella ◽  
V. Rossetti ◽  
A. Colizza ◽  
G. Magliulo
Keyword(s):  
Perilymphatic Fistula ◽  
Drop Attack ◽  
Potential Origin

scholarly journals Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X)

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Rong Zhang ◽  
Ning Dong ◽  
Zhangqi Shen ◽  
Yu Zeng ◽  
Jiauyue Lu ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Resistance Gene ◽  
Gc Content ◽  
Zhejiang Province ◽  
Bacterial Strains ◽  
Gram Negative ◽  
E Coli ◽  
Transmission Mechanisms ◽  
Low Prevalence ◽  
Potential Origin

Abstract Emergence of tigecycline-resistance tet(X) gene orthologues rendered tigecycline ineffective as last-resort antibiotic. To understand the potential origin and transmission mechanisms of these genes, we survey the prevalence of tet(X) and its orthologues in 2997 clinical E. coli and K. pneumoniae isolates collected nationwide in China with results showing very low prevalence on these two types of strains, 0.32% and 0%, respectively. Further surveillance of tet(X) orthologues in 3692 different clinical Gram-negative bacterial strains collected during 1994–2019 in hospitals in Zhejiang province, China reveals 106 (2.7%) tet(X)-bearing strains with Flavobacteriaceae being the dominant (97/376, 25.8%) bacteria. In addition, tet(X)s are found to be predominantly located on the chromosomes of Flavobacteriaceae and share similar GC-content as Flavobacteriaceae. It also further evolves into different orthologues and transmits among different species. Data from this work suggest that Flavobacteriaceae could be the potential ancestral source of the tigecycline resistance gene tet(X).

scholarly journals Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant of Imperata cylindrica (L.) Raeusch (Gramineae)

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4717
Author(s):  
Romeo Nago ◽  
Paul Nayim ◽  
Armelle Mbaveng ◽  
James Mpetga ◽  
Gabin Bitchagno ◽  
...  
Keyword(s):  
Silica Gel ◽  
Methanol Extract ◽  
Antibacterial Properties ◽  
Imperata Cylindrica ◽  
Drug Resistant ◽  
Bacterial Strains ◽  
Prenylated Flavonoids ◽  
Whole Plant ◽  
Crude Methanol Extract ◽  
Potential Origin

The local botanical Imperata cylindrica in Cameroon was investigated for its antibacterial potency. The methanol extract afforded a total of seven compounds, including five hitherto unreported compounds comprising three flavonoids (1–3) and two C-15 isoprenoid analogues (4 and 5) together with known derivatives (6 and 7). The novelty of the flavonoids was related to the presence of both methyl and prenyl groups. The potential origin of the methyl in the flavonoids is discussed, as well as the chemophenetic significance of our findings. Isolation was performed over repeated silica gel and Sephadex LH-20 column chromatography and the structures were elucidated by (NMR and MS). The crude methanol extract and isolated compounds showed considerable antibacterial potency against a panel of multi-drug resistant (MDR) bacterial strains. The best MIC values were obtained with compound (2) against S. aureus ATCC 25923 (32 µg/mL) and MRSA1 (16 µg/mL).

scholarly journals Vestibular syncope: A disorder associated with drop attack in Ménière’s disease

2018 ◽  
Vol 45 (2) ◽  
pp. 234-241 ◽  
Author(s):  
Ilmari Pyykkö ◽  
Vinaya Manchaiah ◽  
Jing Zou ◽  
Hilla Levo ◽  
Erna Kentala
Keyword(s):  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Drop Attack ◽  
Ménière's Disease

Ataxia and Hearing Loss Secondary to Perilymphatic Fistula

PEDIATRICS ◽  
1978 ◽  
Vol 61 (2) ◽  
pp. 238-241
Author(s):  
Gerald B. Healy ◽  
Jules M. Friedman ◽  
Joseph DiTroia
Keyword(s):  
Hearing Loss ◽  
Soft Tissue ◽  
Head Trauma ◽  
Middle Ear ◽  
Vestibular System ◽  
Perilymphatic Fistula ◽  
Labyrinthine Fistula ◽  
First Case ◽  
The Absolute ◽  
Physical Findings

Ataxia is rarely attributed to lesions of the peripheral vestibular system. In 1973, the first case of ataxia and hearing loss secondary to a labyrinthine fistula was reported. Until now, this syndrome has not been reported in patients under the age of 10 years. A case is presented of a 5-year-old boy with symptoms of ataxia and hearing loss as well as vertigo and tinnitus after head trauma. Three physical findings appear to be most characterisitic of patients with perilymphatic fistulas: a positive fistula response, positive positional testing with the involved ear down, and evidence of vestibular ataxia when testing station and gait. The absolute diagnosis of perilymphatic fistula can only be established by exploration of the middle ear space. If a fistula is found, it may be sealed with soft tissue and, if this fails, actual stapedectomy may be required.

Cataloging recent advances in epigenetic alterations in major mental disorders and autism

Epigenomics ◽  
2021 ◽  
Author(s):  
Hamid Mostafavi Abdolmaleky ◽  
Jin-Rong Zhou ◽  
Sam Thiagalingam
Keyword(s):  
Dna Methylation ◽  
Mental Disorders ◽  
Psychiatric Disorders ◽  
Drug Effects ◽  
Tissue Cell ◽  
Epigenetic Alterations ◽  
Cell Specificity ◽  
Aberrant Dna Methylation ◽  
Potential Origin

During the last two decades, diverse epigenetic modifications including DNA methylation, histone modifications, RNA editing and miRNA dysregulation have been associated with psychiatric disorders. A few years ago, in a review we outlined the most common epigenetic alterations in major psychiatric disorders (e.g., aberrant DNA methylation of DTNBP1, HTR2A, RELN, MB-COMT and PPP3CC, and increased expression of miR-34a and miR-181b). Recent follow-up studies have uncovered other DNA methylation aberrations affecting several genes in mental disorders, in addition to dysregulation of many miRNAs. Here, we provide an update on new epigenetic findings and highlight potential origin of the diversity and inconsistencies, focusing on drug effects, tissue/cell specificity of epigenetic landscape and discuss shortcomings of the current diagnostic criteria in mental disorders.

scholarly journals Perilymphatic Fistula.

1994 ◽  
Vol 87 (11) ◽  
pp. 1608-1609
Author(s):  
TSUTOMU NAKAJIMA
Keyword(s):  
Perilymphatic Fistula

scholarly journals Design and Efficient Network Investigation of Passive Periodic Drop Attack

2021 ◽  
Vol 13 (0203) ◽  
pp. 110-116
Author(s):  
Sunil Kumar ◽  
Maninder Singh
Keyword(s):  
Network Performance ◽  
Ad Hoc ◽  
Mobile Ad Hoc Network ◽  
Denial Of Service ◽  
High Mobility ◽  
Network Simulator ◽  
Denial Of Service Attack ◽  
Drop Attack ◽  
Service Attack ◽  
The Impact

A Mobile Ad Hoc Network (MANET) is much more vulnerable to various security attacks due to its high mobility, multi-hop communication and the absence of centralized administration. In this paper, we investigate the impact of Jellyfish periodic dropping attack on MANETs under different routing protocols. This investigate is under the class of denial-of-service attack and targets closed loop flows which results in delay and data loss. In this paper, the simulation results are gathered using OPNET network simulator and its effect on network performance is studied by analysing re-transmission attempts, network load and throughput. The results have shown that the impact of Jellyfish periodic dropping attack which reduces the network performance. Performance shows OLSR performs better than AODV under periodic drop attack.

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