scholarly journals Association between glutathione S-transferase P1 Ile (105) Val gene polymorphism and chronic obstructive pulmonary disease: A meta-analysis based on seventeen case–control studies

Meta Gene ◽  
2015 ◽  
Vol 6 ◽  
pp. 59-64 ◽  
Author(s):  
Lingjing Yang ◽  
Xixia Li ◽  
Xiang Tong ◽  
Hong Fan
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Gene Polymorphism ◽  
Pulmonary Disease ◽  
Meta Analysis ◽  
Case Control ◽  
Chronic Obstructive ◽  
Glutathione S Transferase ◽  
Case Control Studies ◽  
Obstructive Pulmonary Disease

scholarly journals Chronic obstructive pulmonary disease associated with biomass fuel use in women: a systematic review and meta-analysis

2018 ◽  
Vol 5 (1) ◽  
pp. e000246 ◽  
Author(s):  
Adama Sana ◽  
Serge M A Somda ◽  
Nicolas Meda ◽  
Catherine Bouland
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Meta Analysis ◽  
Case Control ◽  
Chronic Obstructive ◽  
Case Control Studies ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Biomass Smoke ◽  
Cross Sectional Studies

IntroductionChronic obstructive pulmonary disease (COPD) is a major and growing cause of morbidity and mortality worldwide. The global prevalence of COPD is growing faster in women than in men. Women are often exposed to indoor pollutants produced by biomass fuels burning during household activities.MethodsWe conducted a meta-analysis to establish the association between COPD and exposure to biomass smoke in women.Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we searched MEDLINE and Scopus databases in 31December 2016, with the terms: “wood”, “charcoal”, “biomass”, “solid fuels”, “organic fuel”, “biofuel”, “female”, “women”, “COPD”, “chronic bronchitis”, “emphysema”, “chronic obstructive pulmonary disease”. Studies were eligible if they were case–control or cross-sectional studies involving exposure to indoor biomass smoke, conducted at any time and in any geographic location. Fixed-effects or random-effects meta-analysis was used to generate pooled OR.Results24 studies were included: 5 case–control studies and 19 cross-sectional studies. Biomass-exposed individuals were 1.38 times more likely to be diagnosed with COPD than non-exposed (OR 1.38, 95% CI 1.28 to 1.57).Spirometry-diagnosed COPD studies failed to show a significant association (OR 1.20, 95% CI 0.99 to 1.40). Nevertheless, the summary estimate of OR for chronic bronchitis (CB) was significant (OR 2.11, 95% CI 1.70 to 2.52). The pooled OR for cross-sectional studies and case–control studies were respectively 1.82 (95% CI 1.54 to 2.10) and 1.05 (95% CI 0.81 to 1.30). Significant association was found between COPD and biomass smoke exposure for women living as well in rural as in urban areas.ConclusionsThis study showed that biomass smoke exposure is associated with COPD in rural and urban women.In many developing countries, modern fuels are more and more used alongside traditional ones, mainly in urban area. Data are needed to further explore the benefit of the use of mixed fuels for cooking on respiratory health, particularly on COPD reduction.

scholarly journals Association between the TGF-β1 polymorphisms and chronic obstructive pulmonary disease: a meta-analysis

2017 ◽  
Vol 37 (4) ◽  
Author(s):  
Ning Liao ◽  
Hua Zhao ◽  
Min-Li Chen ◽  
Zheng-Fu Xie
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Transforming Growth Factor ◽  
Meta Analysis ◽  
Transforming Growth Factor Β1 ◽  
Chronic Obstructive ◽  
Case Control Studies ◽  
China National Knowledge Infrastructure ◽  
Obstructive Pulmonary Disease ◽  
Tgf Β1

It has been hypothesized that polymorphisms in the transforming growth factor-β1 (TGF-β1) gene on chromosome 19 modify the risk for chronic obstructive pulmonary disease (COPD). However, results from previous studies are contradictory. We therefore conducted a meta-analysis of published case–control studies on the association between five common TGF-β1 polymorphisms (rs1982073, rs1800469, rs2241712, rs6957, and rs2241718) and COPD risk. Data sources were Pubmed, Scopus, ISI Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang databases. Twelve studies including 6749 participants were reviewed and analyzed. For the TGF-β1 polymorphism rs1982073, the results indicted that the C allele was associated with decreased risk of COPD in Caucasians (odds ratio (OR) =0.79, 95% confidence interval (CI): 0.64–0.99, P=0.038) but not in Asians (OR =0.95, 95% CI: 0.71–1.28, P=0.741). No associations with COPD were identified for other polymorphisms evaluated in the present study including rs1800469 (T allele compared with C allele, OR =0.89, 95% CI: 0.77–1.02, P=0.099), rs2241712 (A allele compared with G allele, OR =1.03, 95% CI: 0.89–1.20, P=0.666), rs6957 (A allele compared with G allele, OR =1.14, 95% CI: 0.95–1.36, P=0.160), and rs2241718 (C allele compared with T allele, OR =0.95, 95% CI: 0.79–1.14, P=0.571). In conclusion, this meta-analysis showed that the C allele of rs1982073 was protective against COPD in Caucasians but not in Asians, whereas there was no association of rs1800469, rs2241712, rs6957, and rs2241718 with COPD.

scholarly journals Impact ofCYP1A1Polymorphisms on Susceptibility to Chronic Obstructive Pulmonary Disease: A Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Cheng-Di Wang ◽  
Nan Chen ◽  
Lin Huang ◽  
Jia-Rong Wang ◽  
Zhi-Yuan Chen ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Meta Analysis ◽  
Asian Population ◽  
Chronic Obstructive ◽  
Case Control Studies ◽  
China National Knowledge Infrastructure ◽  
Obstructive Pulmonary Disease ◽  
Mspi Polymorphism ◽  
Online Databases

Objective.Several studies have evaluated the association betweenCYP1A1polymorphisms and the susceptibility of chronic obstructive pulmonary disease (COPD) with inconclusive results. We performed the first comprehensive meta-analysis to summarize the association betweenCYP1A1polymorphisms and COPD risk.Method.A systematic literature search was conducted (up to April 2015) in five online databases: PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), WeiPu, and WanFang databases. The strength of association was calculated by odds ratio (OR) and corresponding 95% confidence interval (CI).Results.Seven case-control studies with 1050 cases and 1202 controls were included. Our study suggested a significant association between the MspI polymorphism and COPD risk (CC versus TC + TT: OR = 1.57, CI: 1.09–2.26,P=0.02; CC versus TT: OR = 1.73, CI: 1.18–2.55,P=0.005). For the Ile/Val polymorphism, a significant association with COPD risk was observed (GG versus AG + AA: OR = 2.75, CI: 1.29–5.84,P= 0.009; GG versus AA: OR = 3.23, CI: 1.50–6.93,P=0.003; AG versus AA: OR = 1.39, CI: 1.01–1.90,P=0.04). Subgroup analysis indicated a significant association between the MspI variation and COPD risk among Asians (CC versus TC + TT: OR = 1.70, CI: 1.06–2.71,P=0.03; CC versus TT: OR = 1.84, CI: 1.11–3.06,P=0.02).Conclusion.The MspI and Ile/Val polymorphisms might alter the susceptibility of COPD, and MspI polymorphism might play a role in COPD risk among Asian population.

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