Long-term electrical stability of next generation LV Trench IGBT at Hitachi ABB Power Grids

2021 ◽  
pp. 114300
Author(s):  
Nick Schneider ◽  
Elizabeth Buitrago ◽  
Wolfgang Vitale ◽  
Luca De-Michielis
Keyword(s):  
Power Grids ◽  
Next Generation ◽  
Electrical Stability

scholarly journals Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primates

2021 ◽  
Author(s):  
Jewell N Walters ◽  
Blake Schouest ◽  
Ami Patel ◽  
Emma L Reuschel ◽  
Katherine Schultheis ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Nonhuman Primates ◽  
First Generation ◽  
Rhesus Macaques ◽  
Natural Infection ◽  
Next Generation ◽  
Synthetic Dna ◽  
One Year ◽  
Global Population

The enhanced transmissibility and immune evasion associated with emerging SARS-CoV-2 variants demands the development of next-generation vaccines capable of inducing superior protection amid a shifting pandemic landscape. Since a portion of the global population harbors some level of immunity from vaccines based on the original Wuhan-Hu-1 SARS-CoV-2 sequence or natural infection, an important question going forward is whether this immunity can be boosted by next-generation vaccines that target emerging variants while simultaneously maintaining long-term protection against existing strains. Here, we evaluated the immunogenicity of INO-4800, our synthetic DNA vaccine candidate for COVID-19 currently in clinical evaluation, and INO-4802, a next-generation DNA vaccine designed to broadly target emerging SARS-CoV-2 variants, as booster vaccines in nonhuman primates. Rhesus macaques primed over one year prior with the first-generation INO-4800 vaccine were boosted with either INO-4800 or INO-4802 in homologous or heterologous prime-boost regimens. Both boosting schedules led to an expansion of antibody responses which were characterized by improved neutralizing and ACE2 blocking activity across wild-type SARS-CoV-2 as well as multiple variants of concern. These data illustrate the durability of immunity following vaccination with INO-4800 and additionally support the use of either INO-4800 or INO-4802 in prime-boost regimens.

scholarly journals Evaluation method of clean power grid development mode

2021 ◽  
Vol 236 ◽  
pp. 02002
Author(s):  
Bingqi Jiao ◽  
Zhicheng Xu ◽  
Kuan Zheng ◽  
Xiaoqing Yan ◽  
Junshu Feng
Keyword(s):  
Evaluation Method ◽  
Power Grid ◽  
Clean Energy ◽  
Power Grids ◽  
Analysis Method ◽  
Development Mode ◽  
Grid Construction ◽  
Development Evaluation ◽  
Relative Change

In response to the climate change, it has been becoming the consensus of most countries in the world to accelerate the development of a high proportion of clean energy. The power grid is the core to support the development of a high proportion of clean energy, and the key is to accelerate the construction of clean power grids. This paper focuses on the main characteristics of clean power grid construction, and proposes a set of clean power grid development evaluation indicators including 5 first-level indicators and 19 second-level indicators and an analysis method based on radar charts. Taking China Power Grid as an example, this paper analyzes in detail the characteristics of the medium and long-term development mode of clean power grids and the relative change trends of specific indicators, and discusses the key links and potential problems that need attention in the development of clean power grids.

The Temporal-Spatial Evolution of the Southern Corridor of West-to-East Power Transmission Project in China

2014 ◽  
Vol 521 ◽  
pp. 485-489
Author(s):  
Hong Hao Fu ◽  
Guo Tian Cai ◽  
Dai Qing Zhao
Keyword(s):  
Power Supply ◽  
Power Plants ◽  
Power Transmission ◽  
Market Mechanism ◽  
Power Grids ◽  
Total Power ◽  
Spatial Process ◽  
Market Situation ◽  
Increasing Demand

This paper analyzes temporal and spatial process, and problems based on data between 1986 and 2010. Conclusions are as follows. Power supply of Guangdong relied more on distant outer-province power grids over time, not inner-province ones, close ones or independent power plants. This accelerating enlargement of power supply range could well satisfy its increasing power consumption. However, power production of western provinces couldnt simultaneously meet their own increasing demand and demand by Guangdong. Furthermore, total power transmission and electricity tariff were fixed by long-term framework agreements signed among governments, in which the transmission amount was too much while the tariff was too low, forcing the western provinces limiting their domestic demand without proper compensation. So the current enlarging trend of power supply range of Guangdong is unsustainable and its necessary to introduce power market mechanism through adjusting short-term total power transmission and power tariff according to the market situation.

scholarly journals Next Generation Sequencing Discoveries of the Nitrate-Responsive Oral Microbiome and Its Effect on Vascular Responses

2019 ◽  
Vol 8 (8) ◽  
pp. 1110 ◽  
Author(s):  
Melissa M. Grant ◽  
Daniel Jönsson
Keyword(s):  
Nitric Oxide ◽  
Next Generation Sequencing ◽  
Human Condition ◽  
Oral Microbiome ◽  
Oral Microbiota ◽  
Next Generation ◽  
Contributing Factors ◽  
Future Directions ◽  
Generation Sequencing

Cardiovascular disease is a worldwide human condition which has multiple underlying contributing factors: one of these is long-term increased blood pressure—hypertension. Nitric oxide (NO) is a small nitrogenous radical species that has a number of physiological functions including vasodilation. It can be produced enzymatically through host nitric oxide synthases and by an alternative nitrate–nitrite–NO pathway from ingested inorganic nitrate. It was discovered that this route relies on the ability of the oral microbiota to reduce nitrate to nitrite and NO. Next generation sequencing has been used over the past two decades to gain deeper insight into the microbes involved, their location and the effect of their removal from the oral cavity. This review article presents this research and comments briefly on future directions.

Carbon coated porous silicon flakes with high initial coulombic efficiency and long-term cycling stability for lithium ion batteries

2019 ◽  
Vol 3 (9) ◽  
pp. 2361-2365 ◽  
Author(s):  
Xiaoyong Dou ◽  
Ming Chen ◽  
Jiantao Zai ◽  
Zhen De ◽  
Boxu Dong ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Lithium Ion Batteries ◽  
Anode Material ◽  
Coulombic Efficiency ◽  
Lithium Ion ◽  
Cycling Stability ◽  
Next Generation ◽  
Carbon Coated ◽  
Initial Coulombic Efficiency

Silicon (Si) has been regarded as a promising next-generation anode material to replace carbon-based materials for lithium ion batteries (LIBs).

scholarly journals Correlation of Long-term Results of Imatinib in Advanced Gastrointestinal Stromal Tumors With Next-Generation Sequencing Results

JAMA Oncology ◽  
2017 ◽  
Vol 3 (7) ◽  
pp. 944 ◽  
Author(s):  
Michael C. Heinrich ◽  
Cathryn Rankin ◽  
Charles D. Blanke ◽  
George D. Demetri ◽  
Ernest C. Borden ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Gastrointestinal Stromal Tumors ◽  
Long Term Results ◽  
Next Generation ◽  
Stromal Tumors ◽  
Generation Sequencing

Consideration of Relationship Between Decommissioning With Digital-Twin and Knowledge Management

2020 ◽  
Author(s):  
Yasuyoshi Taruta ◽  
Satoshi Yanagihara ◽  
Takashi Hashimoto ◽  
Shigeto Kobayashi ◽  
Yukihiro Iguchi ◽  
...  
Keyword(s):  
Knowledge Management ◽  
Power Plant ◽  
Nuclear Power Plant ◽  
Digital Technology ◽  
Nuclear Power ◽  
Next Generation ◽  
Digital Twin ◽  
Advanced Technologies ◽  
The World

Abstract Decommissioning of Nuclear Power Plant is a long-term project during which generations are expected to change. Therefore, it is necessary to appropriately transfer knowledge, technology and skills to the next generation. In recent years, in the world of decommissioning, attempts have been made to apply advanced technologies such as utilization of knowledge management and digital technology. This study describes adaptation in decommissioning from viewpoint of utilizing IT technology called digital twin and aspect of knowledge management.

NEXT GENERATION FISSION EXPERIMENTS AT GSI: SHORT AND LONG TERM PERSPECTIVES

2010 ◽  
Author(s):  
A. BAIL ◽  
J. TAIEB ◽  
A. CHATILLON ◽  
B. LAURENT ◽  
G. BELIER ◽  
...  
Keyword(s):  
Next Generation ◽  
Short And Long Term

scholarly journals Human hematopoietic stem cell maintenance and myeloid cell development in next-generation humanized mouse models

2019 ◽  
Vol 3 (3) ◽  
pp. 268-274 ◽  
Author(s):  
Trisha R. Sippel ◽  
Stefan Radtke ◽  
Tayla M. Olsen ◽  
Hans-Peter Kiem ◽  
Anthony Rongvaux
Keyword(s):  
Myeloid Cell ◽  
Humanized Mice ◽  
Next Generation ◽  
Humanized Mouse ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Key Points ◽  
Humanized Mouse Models ◽  
Cell Maintenance

Key Points Next-generation humanized mice differentially support human HSPC maintenance and myelopoiesis. MISTRG mice support long-term human HSPC maintenance demonstrated by quaternary transplantation and development of human tissue macrophages.

scholarly journals Advances in endovascular aneurysm management: coiling and adjunctive devices

2020 ◽  
Vol 5 (1) ◽  
pp. 14-21
Author(s):  
Jessica K Campos ◽  
Brian V Lien ◽  
Alice S Wang ◽  
Li-Mei Lin
Keyword(s):  
Cerebral Aneurysms ◽  
Next Generation ◽  
Coil Embolisation ◽  
Interventional Techniques ◽  
Technological Advances ◽  
Aneurysm Occlusion ◽  
Unruptured Cerebral Aneurysms ◽  
Endovascular Coils

Endovascular coil embolisation continues to evolve and remains a valid modality in managing ruptured and unruptured cerebral aneurysms. Technological advances in coil properties, adjunctive devices and interventional techniques continue to improve long-term aneurysm occlusion rates. This review elaborates on the latest advances in next-generation endovascular coils and adjunctive coiling techniques for treating cerebral aneurysms.

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