Determination of protonation state in molecular salt of minoxidil and 2,4-dihydroxybenzoic acid through a combined experimental and theoretical study: influence of proton transfer on biological activities

2022 ◽  
Vol 1249 ◽  
pp. 131560
Author(s):  
Qi Wang ◽  
Zhixia Sun ◽  
Danping Li ◽  
Kai Ye ◽  
Changjian Xie ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Theoretical Study ◽  
Biological Activities ◽  
Dihydroxybenzoic Acid ◽  
Protonation State ◽  
Molecular Salt

Preparation, spectral properties and biological activities of 5-bromo-6-methyl-2'-deoxyuridine and 5-iodo-6-methyl-2'-deoxyuridine

1980 ◽  
Vol 45 (8) ◽  
pp. 2364-2370 ◽  
Author(s):  
Antonín Holý ◽  
Erik De Clercq
Keyword(s):  
Antiviral Activity ◽  
Spectral Properties ◽  
De Novo ◽  
Biological Activities ◽  
Rabbit Kidney ◽  
Kidney Cells ◽  
Cd Spectra ◽  
Methyl Derivatives ◽  
Primary Rabbit

Reaction of 3',5'-di-O-benzoyl-6-methyl-2'-deoxyuridine (IIa) with elementary bromine or iodine afforded 5-halogeno derivatives IIc and IId which on methanolysis gave 5-bromo-6-methyl-2'-deoxyurine (Ic) and 5-iodo-6-methyl-2'-deoxyurine (Id), respectively. The CD spectra of Ic, Id and 6-methyl-2'-deoxyuridine (Ia) are compared and discussed with regard to determination of the nucleoside conformation. Unlike 5-bromo- and 5-iodo-2'-deoxyuridine, the 6-methyl derivatives Ic and Id exhibit neither antibacterial nor antiviral activity. Nor do they exert any antimetabolic effect on the de novo DNA synthesis in primary rabbit kidney cells.

Regeneration Mechanism Studied by Potential-Time Response to Sinusoidal Current-Time Function

1997 ◽  
Vol 62 (10) ◽  
pp. 1511-1526
Author(s):  
María-Luisa Alcaraz ◽  
Ángela Molina
Keyword(s):  
Kinetic Parameters ◽  
Rate Constant ◽  
Theoretical Study ◽  
Time Function ◽  
Time Response ◽  
Current Time ◽  
Regeneration Mechanism ◽  
Sinusoidal Current ◽  
Regeneration Processes

A theoretical study of the potential-time response to sinusoidal current applied to static and dynamic electrodes for regeneration processes is presented. Methods for determination of the regeneration fraction, rate constant of the chemical reaction and heterogeneous kinetic parameters are proposed.

scholarly journals Antimicrobial Efficiency of Aloe arborescens and Aloe barbadensis Natural and Commercial Products

Plants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 92
Author(s):  
Kaja Kupnik ◽  
Mateja Primožič ◽  
Željko Knez ◽  
Maja Leitgeb
Keyword(s):  
Biological Activities ◽  
Antimicrobial Properties ◽  
Aloe Barbadensis ◽  
Commercial Products ◽  
Qualitative And Quantitative ◽  
Gram Positive Bacteria ◽  
Antimicrobial Efficiency ◽  
Aloe Arborescens ◽  
Pharmaceutical Industries

Nowadays, there are many commercial products from natural resources on the market, but they still have many additives to increase their biological activities. On the other hand, there is particular interest in natural sources that would have antimicrobial properties themselves and would inhibit the growth and the reproduction of opportunistic microorganisms. Therefore, a comparative antimicrobial study of natural samples of aloe and its commercial products was performed. Qualitative and quantitative determination of antimicrobial efficiency of Aloe arborescens and Aloe barbadensis and its commercial products on fungi, Gram-negative, and Gram-positive bacteria was performed. Samples exhibited antimicrobial activity and slowed down the growth of all tested microorganisms. Research has shown that natural juices and gels of A. arborescens and A. barbadensis are at higher added concentrations comparable to commercial aloe products, especially against microbial cultures of Bacillus cereus, Candida albicans, and Pseudomonas aeruginosa, whose growths were completely inhibited at a microbial concentration of 600 μg/mL. Of particular importance are the findings of the good antimicrobial efficacy of fresh juice and gel of A. arborescens on tested microorganisms, which is less known and less researched. These results show great potential of A. arborescens for further use in medicine, cosmetics, food, and pharmaceutical industries.

Determination of copper binding sites in peptides containing basic residues: a combined experimental and theoretical study

2001 ◽  
Vol 204 (1-3) ◽  
pp. 31-46 ◽  
Author(s):  
Brian K. Bluhm ◽  
Sharon J. Shields ◽  
Craig A. Bayse ◽  
Michael B. Hall ◽  
David H. Russell
Keyword(s):  
Binding Sites ◽  
Theoretical Study ◽  
Copper Binding ◽  
Determination Of Copper ◽  
Copper Binding Sites

Theoretical Study and X-ray Structure Determination of Dimethyldihydropyrene

1998 ◽  
Vol 63 (9) ◽  
pp. 3125-3127 ◽  
Author(s):  
Richard Vaughan Williams ◽  
W. Daniel Edwards ◽  
Ashwani Vij ◽  
Robert W. Tolbert ◽  
Reginald H. Mitchell
Keyword(s):  
Structure Determination ◽  
Theoretical Study ◽  
X Ray

scholarly journals Theoretical Study and X-ray Determination of Bianthrones:  Long C−C Bond Length and Preferred Gauche Conformation

2003 ◽  
Vol 68 (6) ◽  
pp. 2528-2528
Author(s):  
Pai-Chi Li ◽  
Tsung-Shing Wang ◽  
Gen-Hsian Lee ◽  
Yi-Hong Liu ◽  
Yu Wang ◽  
...  
Keyword(s):  
Bond Length ◽  
Theoretical Study ◽  
Gauche Conformation ◽  
X Ray

scholarly journals Assessment and determination of lyoprotectant for survival of freeze-dried Lactobacillus rhamnosus

2016 ◽  
Vol 20 (1) ◽  
pp. 105-113
Author(s):  
Zongcheng Miao ◽  
Yang Zhao ◽  
Xiaoping Huo
Keyword(s):  
Amino Acids ◽  
Fractional Factorial Design ◽  
Biological Activities ◽  
Lactobacillus Rhamnosus ◽  
Fractional Factorial ◽  
Practical Application ◽  
Steepest Ascent ◽  
Freeze Dried ◽  
Viable Bacteria

Abstract Currently research of lactic acid bacteria focus primarily on the functional probiotics, which are major beneficial biota in the gastrointestinal tract, have been industrial manufactured. Probiotics confer health benefits on the host need adequate amounts. However, the absence of data makes it difficult to ensure the maintenance biological activities and population of probiotic. In this research, a fractional factorial design and steepest ascent experiment were used to analyze the influence of lyoprotectant as carbohydrates, prebiotics and amino acids on the survival of the probiotic Lactobacillus rhamnosus. The results indicated a maximum survival rate and population of viable bacteria of L. rhamnosus to be 55.84 % and 1.60 ×1011 CFU/g after freeze-dried by using a combination of 10 g/100mL Sucrose, 2.5 g/100mL Isomaltooligosaccharide, 12 g/100mL Hydroxyproline. To a large extent, the survival and viability were dependent on the cryoprotectant used and make probiotics more attractive from a practical application in industrial viewpoint.

Sign in / Sign up

Export Citation Format

Share Document