No Effect on Infant Birth Weight and Head Circumference After Exposure to Interferon Beta Prior to Or During Pregnancy: A Register-Based Cohort Study in Finland and Sweden Among Women with Multiple Sclerosis

2020 ◽  
Vol 37 ◽  
pp. 101591
Author(s):  
Pia Vattulainen ◽  
Sarah Burkill ◽  
Yvonne Geissbuehler ◽  
Meritxell Sabidó ◽  
Catrinel Popescu ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cohort Study ◽  
Birth Weight ◽  
Head Circumference ◽  
Interferon Beta ◽  
Infant Birth

scholarly journals Maternal seafood consumption and infant birth weight, length and head circumference in the Norwegian Mother and Child Cohort Study

2011 ◽  
Vol 107 (3) ◽  
pp. 436-444 ◽  
Author(s):  
Anne Lise Brantsæter ◽  
Bryndis Eva Birgisdottir ◽  
Helle Margrete Meltzer ◽  
Helen Engelstad Kvalem ◽  
Jan Alexander ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Head Circumference ◽  
Birth Size ◽  
Seafood Consumption ◽  
Birth Registry ◽  
Negatively Associated ◽  
Lean Fish ◽  
Mother And Child ◽  
Infant Birth

Results from previous studies on associations between maternal fish and seafood intakes and fetal growth are inconclusive. The aim of the present study was to investigate how maternal intakes of seafood, subtypes of seafood and supplementary n-3 fatty acids were associated with infant birth weight, length and head circumference in a prospective study in Norway. The study population included 62 099 participants in the Norwegian Mother and Child Cohort Study. The mothers answered an FFQ in mid pregnancy. The FFQ comprised detailed questions about intake of various seafood items and n-3 supplements. Data on infant birth weight, length and head circumference were obtained from the Medical Birth Registry. We used multivariable regression to examine how total seafood, various seafood subtypes and supplementary n-3 intakes were associated with birth size measures. Total seafood intake was positively associated with birth weight and head circumference. Lean fish was positively associated with all birth size measures; shellfish was positively associated with birth weight, while fatty fish was not associated with any birth size measures. Intake of supplementary n-3 was negatively associated with head circumference. The relative risk of giving birth to a small baby ( < 2500 g) in full-term pregnancies was significantly lower in women who consumed >60 g/d of seafood than in women who consumed ≤ 5 g/d (OR = 0·56 (95 % CI 0·35, 0·88). In conclusion, maternal seafood consumption was positively associated with birth size, driven by lean fish intake, while supplementary n-3 intake was negatively associated with infant head circumference.

scholarly journals Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study

2013 ◽  
Vol 12 (1) ◽  
Author(s):  
Dennis Liang Fei ◽  
Devin C Koestler ◽  
Zhigang Li ◽  
Camilla Giambelli ◽  
Avencia Sanchez-Mejias ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cohort Study ◽  
Birth Weight ◽  
Birth Cohort ◽  
Arsenic Exposure ◽  
In Utero ◽  
Birth Cohort Study ◽  
Infant Birth

scholarly journals An association between maternal weight change in the year before pregnancy and infant birth weight: ELFE, a French national birth cohort study

PLoS Medicine ◽  
2019 ◽  
Vol 16 (8) ◽  
pp. e1002871 ◽  
Author(s):  
Marion Lecorguillé ◽  
Madalina Jacota ◽  
Blandine de Lauzon-Guillain ◽  
Anne Forhan ◽  
Marie Cheminat ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Birth Cohort ◽  
Weight Change ◽  
Birth Cohort Study ◽  
Maternal Weight ◽  
Infant Birth

scholarly journals Interaction Between Pre-pregnancy Body Mass Index and Gestational Weight Gain to Newborn Outcomes: Results From the VDPM Cohort Study in Indonesia

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 770-770
Author(s):  
Dyah Ayu Larasati Kisworo Putri ◽  
Nur Indrawaty Lipoeto ◽  
Arif Sabta Aji
Keyword(s):  
Body Mass Index ◽  
Cohort Study ◽  
Weight Gain ◽  
Birth Weight ◽  
Gestational Weight Gain ◽  
Body Mass ◽  
Head Circumference ◽  
Pregnancy Outcomes ◽  
Gestational Weight ◽  
Newborn Outcomes

Abstract Objectives The aim of this study was to analyze the interaction between pre-pregnancy body mass index (PP BMI), gestational weight gain (GWG), and newborn outcomes among pregnant mothers in West Sumatera, Indonesia. Methods This VDPM cohort study was conducted from September 2017 to March 2018 in West Sumatra, Indonesia. We obtained 195 healthy mother-infant pairs. GWG status created by comparing PP BMI and GWG guidelines based on the World Health Organization (WHO). Newborn birth weight, birth length, and head circumference were taken immediately after delivery as pregnancy outcomes. SPSS version 20.0 was used to analyze bivariate and multivariate analysis to assess the interaction between PP BMI and gestational weight gain in pregnancy outcomes with adjusting potential confounders. A P-value less than 0.05 was considered as a significant association. Results Of the 195 mother-infant pairs (Mean 29.66 years) included in the main sample, Most of the mothers had 46.7% normal PP BMI with most of them had an inadequate GWG status during pregnancy with 53.3%. Adequate and excessive GWG statuses were 34.4% and 12.3%, respectively. There was a significant association between PP BMI and GWG (p &lt; 0.01). This study had no interaction between PP BMI and GWG to the newborn outcomes (p &gt; 0.05). Adverse newborn outcomes were not statistically significant among groups. However, mothers who had inadequate GWG status may have significant lower birth weight and head circumference compared to normal and excessive GWG status (p &lt; 0.05). Conclusions This study had no interaction between PP BMI and GWG status to newborn outcomes. However, the GWG status associated with newborn outcomes in birth weight and head circumference level. Further prospective studies with a larger number are required to confirm this finding. Funding Sources Indonesian Danone Institute Foundation.

Interferon-beta exposure during first trimester is safe in women with multiple sclerosis—A prospective cohort study from the German Multiple Sclerosis and Pregnancy Registry

2016 ◽  
Vol 22 (6) ◽  
pp. 801-809 ◽  
Author(s):  
Sandra Thiel ◽  
Annette Langer-Gould ◽  
Milena Rockhoff ◽  
Aiden Haghikia ◽  
Annette Queisser-Wahrendorf ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Birth Weight ◽  
Preterm Birth ◽  
Pregnancy Outcomes ◽  
Interferon Beta ◽  
First Trimester ◽  
Disease Modifying Therapies ◽  
Disease Modifying ◽  
Multiple Sclerosis Patients ◽  
Pregnancy Registry

Background: Available data suggest that pregnancy exposure to interferon-beta might result in lower mean birth weight and preterm birth. Objective: To determine the effect of interferon-beta exposure during pregnancy on pregnancy outcomes in multiple sclerosis patients. Methods: We compared the pregnancy outcomes of women exposed to interferon-beta with pregnancies unexposed to disease-modifying therapies. Women were enrolled into the German Multiple Sclerosis and Pregnancy Registry. A standardized questionnaire was administered during pregnancy and postpartum. Detailed information on course of multiple sclerosis and pregnancy, concomitant medications, delivery, and outcome of pregnancy was obtained. Results: We collected data on 251 pregnancies exposed to interferon-beta and 194 unexposed to disease-modifying therapies. In all, 246 (98.01%) women discontinued interferon-beta treatment during first trimester. No differences regarding mean birth weight (exposed: 3272.28 ± 563.61 g; unexposed: 3267.46 ± 609.81 g), mean birth length (exposed: 50.73 ± 3.30 cm; unexposed: 50.88 ± 3.45 cm), preterm birth ( p = 0.187), spontaneous abortion ( p = 0.304), and congenital anomalies ( p = 0.197) were observed between the two groups. Conclusions: Interferon-beta exposure during early pregnancy does not influence the mean birth weight, risk of preterm birth, or other adverse pregnancy outcomes. Our study provides further reassurance that interferon-beta treatment can be safely continued up until women become pregnant.

Sign in / Sign up

Export Citation Format

Share Document