Glimepiride (GMP) is poorly water soluble drug, so solubility is the main constraint for its oral bioavailability. Because, poor aqueous solubility and slow dissolution rate of the glimepiride lead to irreproducible clinical response or therapeutic failure in some cases due to sub therapeutic plasma drug levels. In this study, binary and ternary solid dispersion of glimepiride were prepared with polyethylene glycol 6000 (PEG 6000) and polyethylene glycol 4000 (PEG 4000) at different weight ratios using the solvent evaporation and melting method. It was found the drug was released 0.46% after 5 minutes and only 15.83% within 60 minutes from active glimepiride on the other hand the release pattern of glimepiride from the binary formulation containing PEG 4000 in 1:5 (Formulation coding: G5) showed the best result. It was found that the ternary different SD formulation containing(PEG4000:Glimepiride:Povidone) In ratio 1:1:0.25 (Formulation coding were : G13) showed the best result. The drug was changed to amorphous form after solid dispersion. Itwas also evident that solid dispersions improve solubility of drug particles thus enhancing dissolution characteristics of drugs they increase the oral bioavailability.
Peer Review History:
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Received file
Average Peer review marks at initial stage: 4.5/10
Average Peer review marks at publication stage: 7.5/10
Reviewer(s) detail:
Name: Dr. Mohammed Abdel-Wahab Sayed Abourehab
Affiliation: Umm Al-Qura University; Makkah Al-Mukarramah, Saudi Arabia
E-mail: [email protected]
Name: Dr. Evren Alğin Yapar
Affiliation: Turkish Medicines and Medical Devices Agency, Turkiye
E-mail: [email protected]
Comments of reviewer(s):
Enhanced Oral Bioavailability of Celecoxib Nanocrystalline Solid Dispersion based on Wet Media Milling Technique: Formulation, Optimization and In Vitro/In Vivo Evaluation