Shape fidelity, mechanical and biological performance of 3D printed polycaprolactone-bioactive glass composite scaffolds

2021 ◽  
pp. 112540
Author(s):  
Raúl Vallejos Baier ◽  
José I. Contreras Raggio ◽  
Carola Millán Giovanetti ◽  
Humberto Palza ◽  
Iurii Burda ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Glass Composite ◽  
Composite Scaffolds ◽  
3D Printed ◽  
Biological Performance

Biomimetic characterization reveals enhancement of hydroxyapatite formation by fluid flow in gellan gum and bioactive glass composite scaffolds

2019 ◽  
Vol 76 ◽  
pp. 464-472 ◽  
Author(s):  
Jovana Zvicer ◽  
Ana Medic ◽  
Djordje Veljovic ◽  
Sanja Jevtic ◽  
Sasa Novak ◽  
...  
Keyword(s):  
Fluid Flow ◽  
Bioactive Glass ◽  
Gellan Gum ◽  
Glass Composite ◽  
Composite Scaffolds ◽  
Hydroxyapatite Formation

scholarly journals Effect of Melt-Derived Bioactive Glass Particles on the Properties of Chitosan Scaffolds

2019 ◽  
Vol 10 (3) ◽  
pp. 38 ◽  
Author(s):  
Hamasa Faqhiri ◽  
Markus Hannula ◽  
Minna Kellomäki ◽  
Maria Teresa Calejo ◽  
Jonathan Massera
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bioactive Glass ◽  
Pore Size ◽  
Glass Content ◽  
Micro Computed Tomography ◽  
Glass Composite ◽  
Composite Scaffolds ◽  
Bioactive Glasses

This study reports on the processing of three-dimensional (3D) chitosan/bioactive glass composite scaffolds. On the one hand, chitosan, as a natural polymer, has suitable properties for tissue engineering applications but lacks bioactivity. On the other hand, bioactive glasses are known to be bioactive and to promote a higher level of bone formation than any other biomaterial type. However, bioactive glasses are hard, brittle, and cannot be shaped easily. Therefore, in the past years, researchers have focused on the processing of new composites. Difficulties in reaching composite materials made of polymer (synthetic or natural) and bioactive glass include: (i) The high glass density, often resulting in glass segregation, and (ii) the fast bioactive glass reaction when exposed to moisture, leading to changes in the glass reactivity and/or change in the polymeric matrix. Samples were prepared with 5, 15, and 30 wt% of bioactive glass S53P4 (BonAlive ®), as confirmed using thermogravimetric analysis. MicrO–Computed tomography and optical microscopy revealed a flaky structure with porosity over 80%. The pore size decreased when increasing the glass content up to 15 wt%, but increased back when the glass content was 30 wt%. Similarly, the mechanical properties (in compression) of the scaffolds increased for glass content up to 15%, but decreased at higher loading. Ions released from the scaffolds were found to lead to precipitation of a calcium phosphate reactive layer at the scaffold surface. This is a first indication of the potential bioactivity of these materials. Overall, chitosan/bioactive glass composite scaffolds were successfully produced with pore size, machinability, and ability to promote a calcium phosphate layer, showing promise for bone tissue engineering and the mechanical properties can justify their use in non-load bearing applications.

In vitro and in vivo bone formation potential of surface calcium phosphate-coated polycaprolactone and polycaprolactone/bioactive glass composite scaffolds

2016 ◽  
Vol 30 ◽  
pp. 319-333 ◽  
Author(s):  
Patrina S.P. Poh ◽  
Dietmar W. Hutmacher ◽  
Boris M. Holzapfel ◽  
Anu K. Solanki ◽  
Molly M. Stevens ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Bioactive Glass ◽  
Glass Composite ◽  
Composite Scaffolds ◽  
Formation Potential ◽  
In Vivo Bone Formation

scholarly journals Characterisation of bone regeneration in 3D printed ductile PCL/PEG/hydroxyapatite scaffolds with high ceramic microparticle concentrations

2021 ◽  
Author(s):  
Jing Yang ◽  
Chuanliang Cao ◽  
Pengren Huang ◽  
Aruna Prasopthum ◽  
Andy James Parsons ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Particle Concentration ◽  
Composite Scaffolds ◽  
Reinforced Composite ◽  
3D Printed ◽  
Particle Reinforced Composite ◽  
Very High

3D printed bioactive glass or bioceramic particle reinforced composite scaffolds for bone tissue engineering currently suffer from low particle concentration (<50 wt%) hence low osteoconductivity. Meanwhile, composites with very high...

One step solution for fighting bacteria and growing bone

2019 ◽  
Vol 11 (479) ◽  
pp. eaaw5326 ◽  
Author(s):  
Julianne L. Holloway
Keyword(s):  
Blood Vessel ◽  
Bioactive Glass ◽  
Copper Ions ◽  
Glass Composite ◽  
Composite Scaffolds ◽  
Blood Vessel Formation ◽  
Vessel Formation ◽  
Bone Infections ◽  
One Step

The delivery of copper ions from collagen-bioactive glass composite scaffolds offers a promising one-step approach to treating bone infections while also promoting new bone and blood vessel formation.

Binary bioactive glass composite scaffolds for bone tissue engineering—Structure and mechanical properties in micro and nano scale. A preliminary study

Micron ◽  
2019 ◽  
Vol 119 ◽  
pp. 64-71 ◽  
Author(s):  
Michał J. Woźniak ◽  
Adrian Chlanda ◽  
Przemysław Oberbek ◽  
Marcin Heljak ◽  
Katarzyna Czarnecka ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Glass Composite ◽  
Composite Scaffolds ◽  
Engineering Structure ◽  
Nano Scale ◽  
Preliminary Study

scholarly journals Manufacturing and Characterization of Highly Porous Bioactive Glass Composite Scaffolds Using Unidirectional Freeze Casting

2017 ◽  
Vol 19 (10) ◽  
pp. 1700129 ◽  
Author(s):  
Laura M. Henning ◽  
Sara Zavareh ◽  
Paul H. Kamm ◽  
Miriam Höner ◽  
Horst Fischer ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Freeze Casting ◽  
Glass Composite ◽  
Composite Scaffolds ◽  
Highly Porous
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