Three-dimensional, bioactive, biodegradable, polymer-bioactive glass composite scaffolds with improved mechanical properties support collagen synthesis and mineralization of human osteoblast-like cellsin vitro

2003 ◽  
Vol 64A (3) ◽  
pp. 465-474 ◽  
Author(s):  
Helen H. Lu ◽  
Saadiq F. El-Amin ◽  
Kimberli D. Scott ◽  
Cato T. Laurencin
Keyword(s):  
Mechanical Properties ◽  
Bioactive Glass ◽  
Biodegradable Polymer ◽  
Collagen Synthesis ◽  
Three Dimensional ◽  
Human Osteoblast ◽  
Glass Composite ◽  
Composite Scaffolds

scholarly journals Effect of Melt-Derived Bioactive Glass Particles on the Properties of Chitosan Scaffolds

2019 ◽  
Vol 10 (3) ◽  
pp. 38 ◽  
Author(s):  
Hamasa Faqhiri ◽  
Markus Hannula ◽  
Minna Kellomäki ◽  
Maria Teresa Calejo ◽  
Jonathan Massera
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bioactive Glass ◽  
Pore Size ◽  
Glass Content ◽  
Micro Computed Tomography ◽  
Glass Composite ◽  
Composite Scaffolds ◽  
Bioactive Glasses

This study reports on the processing of three-dimensional (3D) chitosan/bioactive glass composite scaffolds. On the one hand, chitosan, as a natural polymer, has suitable properties for tissue engineering applications but lacks bioactivity. On the other hand, bioactive glasses are known to be bioactive and to promote a higher level of bone formation than any other biomaterial type. However, bioactive glasses are hard, brittle, and cannot be shaped easily. Therefore, in the past years, researchers have focused on the processing of new composites. Difficulties in reaching composite materials made of polymer (synthetic or natural) and bioactive glass include: (i) The high glass density, often resulting in glass segregation, and (ii) the fast bioactive glass reaction when exposed to moisture, leading to changes in the glass reactivity and/or change in the polymeric matrix. Samples were prepared with 5, 15, and 30 wt% of bioactive glass S53P4 (BonAlive ®), as confirmed using thermogravimetric analysis. MicrO–Computed tomography and optical microscopy revealed a flaky structure with porosity over 80%. The pore size decreased when increasing the glass content up to 15 wt%, but increased back when the glass content was 30 wt%. Similarly, the mechanical properties (in compression) of the scaffolds increased for glass content up to 15%, but decreased at higher loading. Ions released from the scaffolds were found to lead to precipitation of a calcium phosphate reactive layer at the scaffold surface. This is a first indication of the potential bioactivity of these materials. Overall, chitosan/bioactive glass composite scaffolds were successfully produced with pore size, machinability, and ability to promote a calcium phosphate layer, showing promise for bone tissue engineering and the mechanical properties can justify their use in non-load bearing applications.

Binary bioactive glass composite scaffolds for bone tissue engineering—Structure and mechanical properties in micro and nano scale. A preliminary study

Micron ◽  
2019 ◽  
Vol 119 ◽  
pp. 64-71 ◽  
Author(s):  
Michał J. Woźniak ◽  
Adrian Chlanda ◽  
Przemysław Oberbek ◽  
Marcin Heljak ◽  
Katarzyna Czarnecka ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Glass Composite ◽  
Composite Scaffolds ◽  
Engineering Structure ◽  
Nano Scale ◽  
Preliminary Study

Biomimetic characterization reveals enhancement of hydroxyapatite formation by fluid flow in gellan gum and bioactive glass composite scaffolds

2019 ◽  
Vol 76 ◽  
pp. 464-472 ◽  
Author(s):  
Jovana Zvicer ◽  
Ana Medic ◽  
Djordje Veljovic ◽  
Sanja Jevtic ◽  
Sasa Novak ◽  
...  
Keyword(s):  
Fluid Flow ◽  
Bioactive Glass ◽  
Gellan Gum ◽  
Glass Composite ◽  
Composite Scaffolds ◽  
Hydroxyapatite Formation

scholarly journals Solution Mediated Effect of Bioactive Glass in Poly (Lactic-Co-Glycolic Acid)- Bioactive Glass Composites on Osteogenesis of Marrow Stromal Cells

2005 ◽  
Vol 284-286 ◽  
pp. 619-622 ◽  
Author(s):  
Jun Yao ◽  
Shula Radin ◽  
Gwendolen Reilly ◽  
Phoebe S. Leboy ◽  
Paul Ducheyne
Keyword(s):  
Bioactive Glass ◽  
Stromal Cells ◽  
Glycolic Acid ◽  
Three Dimensional ◽  
Osteoblastic Differentiation ◽  
Marrow Stromal Cells ◽  
Dimensional Structure ◽  
Composite Scaffolds ◽  
Glass Composites ◽  
Osteogenic Effect

A previous study demonstrated that the incorporation of bioactive glass (BG) into poly (lactic-co-glycolic acid) (PLGA) can promote the osteoblastic differentiation of marrow stromal cells (MSC) on PLGA by forming a calcium phosphate rich layer on its surface. To further understand the mechanisms underlying the osteogenic effect of PLGA-BG composite scaffolds, we tested whether solution-mediated factors derived from composite scaffolds/hybrids can promote osteogenesis of marrow stromal cells. The dissolution product from PLGA-30%BG scaffold stimulated osteogenesis of MSC, as was confirmed by increased mRNA expression of osteoblastic markers such as osteocalcin (OCN), alkaline phosphatase (ALP), and bone sialoprotein (BSP). The three-dimensional structure of the scaffolds may contribute to the production of cell derived factors which promoted distant MSC differentiation. Thus PLGA-BG composites demonstrates significant potential as a bone replacement material.

In vitro and in vivo bone formation potential of surface calcium phosphate-coated polycaprolactone and polycaprolactone/bioactive glass composite scaffolds

2016 ◽  
Vol 30 ◽  
pp. 319-333 ◽  
Author(s):  
Patrina S.P. Poh ◽  
Dietmar W. Hutmacher ◽  
Boris M. Holzapfel ◽  
Anu K. Solanki ◽  
Molly M. Stevens ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Bioactive Glass ◽  
Glass Composite ◽  
Composite Scaffolds ◽  
Formation Potential ◽  
In Vivo Bone Formation

One step solution for fighting bacteria and growing bone

2019 ◽  
Vol 11 (479) ◽  
pp. eaaw5326 ◽  
Author(s):  
Julianne L. Holloway
Keyword(s):  
Blood Vessel ◽  
Bioactive Glass ◽  
Copper Ions ◽  
Glass Composite ◽  
Composite Scaffolds ◽  
Blood Vessel Formation ◽  
Vessel Formation ◽  
Bone Infections ◽  
One Step

The delivery of copper ions from collagen-bioactive glass composite scaffolds offers a promising one-step approach to treating bone infections while also promoting new bone and blood vessel formation.

Shape fidelity, mechanical and biological performance of 3D printed polycaprolactone-bioactive glass composite scaffolds

2021 ◽  
pp. 112540
Author(s):  
Raúl Vallejos Baier ◽  
José I. Contreras Raggio ◽  
Carola Millán Giovanetti ◽  
Humberto Palza ◽  
Iurii Burda ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Glass Composite ◽  
Composite Scaffolds ◽  
3D Printed ◽  
Biological Performance
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