Capsid-like supramolecular dendritic systems as pH-responsive nanocarriers for drug penetration and site-specific delivery

2016 ◽  
Vol 12 (2) ◽  
pp. 355-364 ◽  
Author(s):  
Yachao Li ◽  
Yusi Lai ◽  
Xianghui Xu ◽  
Xiao Zhang ◽  
Yahui Wu ◽  
...  
Keyword(s):  
Drug Penetration ◽  
Ph Responsive ◽  
Site Specific

pH-responsive size-shrinkable mesoporous silica-based nanocarrier for improved tumor penetration and therapeutic efficacy

Nanoscale ◽  
2022 ◽  
Author(s):  
Yongju He ◽  
Xingyu Fan ◽  
Xiaozan Wu ◽  
Taishun Hu ◽  
Fangfang Zhou ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Mesoporous Silica ◽  
Therapeutic Efficacy ◽  
Anticancer Therapy ◽  
Major Obstacle ◽  
Drug Penetration ◽  
Ph Responsive ◽  
Tumor Penetration ◽  
Promising Strategy

Poor tumor penetration is a major obstacle to nanomedicine for achieving effective anticancer therapy. Tumor microenvironment-induced nanomedicine size shrinkage is a promising strategy to overcome the drug penetration barrier across...

pH responsive doxorubucin loaded zein nanoparticle crosslinked pectin hydrogel as effective site-specific anticancer substrates

2020 ◽  
Vol 152 ◽  
pp. 1027-1037 ◽  
Author(s):  
Priyanka Kaushik ◽  
Eepsita Priyadarshini ◽  
Kamla Rawat ◽  
Paulraj Rajamani ◽  
H.B. Bohidar
Keyword(s):  
Ph Responsive ◽  
Site Specific ◽  
Effective Site

pH responsive delivery of lumefantrine with calcium phosphate nanoparticles loaded lipidic cubosomes for the site specific treatment of lung cancer

2019 ◽  
Vol 224 ◽  
pp. 104763 ◽  
Author(s):  
Vaidevi Sethuraman ◽  
Kumar Janakiraman ◽  
Venkateshwaran Krishnaswami ◽  
Subramanian Natesan ◽  
Ruckmani Kandasamy
Keyword(s):  
Lung Cancer ◽  
Calcium Phosphate ◽  
Specific Treatment ◽  
Ph Responsive ◽  
Site Specific ◽  
Calcium Phosphate Nanoparticles

Improving the protein activity and stability under acidic conditions via site-specific conjugation of a pH-responsive polyelectrolyte

2015 ◽  
Vol 3 (3) ◽  
pp. 498-504 ◽  
Author(s):  
Lei Wang ◽  
Xin Li ◽  
Lin Yuan ◽  
Hongwei Wang ◽  
Hong Chen ◽  
...  
Keyword(s):  
Ph Responsive ◽  
Protein Surface ◽  
Protein Activity ◽  
Site Specific ◽  
Acidic Conditions

Site-specific conjugation of pDMAEMA to the protein surface led to a significant increase in protein activity and stability under acidic conditions.

A pH-responsive MOF for site-specific delivery of fungicide to control citrus disease of Botrytis Cinerea

2021 ◽  
pp. 133351
Author(s):  
Xuqian Zhang ◽  
Xinyi Tang ◽  
Chenchen Zhao ◽  
Zitong Yuan ◽  
Di Zhang ◽  
...  
Keyword(s):  
Botrytis Cinerea ◽  
Ph Responsive ◽  
Site Specific ◽  
Citrus Disease

scholarly journals Graphene Oxide Functional Nanohybrids with Magnetic Nanoparticles for Improved Vectorization of Doxorubicin to Neuroblastoma Cells

Pharmaceutics ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 3 ◽  
Author(s):  
Luigi Lerra ◽  
Annafranca Farfalla ◽  
Beatriz Sanz ◽  
Giuseppe Cirillo ◽  
Orazio Vittorio ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Neuroblastoma Cells ◽  
Ph Responsive ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Functional Coating ◽  
Site Specific ◽  
Cell Internalization ◽  
Core Elements ◽  
Responsive Behavior ◽  
A Site

With the aim to obtain a site-specific doxorubicin (DOX) delivery in neuroblastoma SH-SY5Y cells, we designed an hybrid nanocarrier combining graphene oxide (GO) and magnetic iron oxide nanoparticles (MNPs), acting as core elements, and a curcumin–human serum albumin conjugate as functional coating. The nanohybrid, synthesized by redox reaction between the MNPs@GO system and albumin bioconjugate, consisted of MNPs@GO nanosheets homogeneously coated by the bioconjugate as verified by SEM investigations. Drug release experiments showed a pH-responsive behavior with higher release amounts in acidic (45% at pH 5.0) vs. neutral (28% at pH 7.4) environments. Cell internalization studies proved the presence of nanohybrid inside SH-SY5Y cytoplasm. The improved efficacy obtained in viability assays is given by the synergy of functional coating and MNPs constituting the nanohybrids: while curcumin moieties were able to keep low DOX cytotoxicity levels (at concentrations of 0.44–0.88 µM), the presence of MNPs allowed remote actuation on the nanohybrid by a magnetic field, increasing the dose delivered at the target site.

Orthogonally functionalizable polyacetals: a versatile platform for the design of acid sensitive amphiphilic copolymers

2019 ◽  
Vol 10 (38) ◽  
pp. 5215-5227 ◽  
Author(s):  
Adrian Moreno ◽  
Gerard Lligadas ◽  
Juan Carlos Ronda ◽  
Marina Galià ◽  
Virginia Cádiz
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Rational Approach ◽  
Specific Drug ◽  
Amphiphilic Copolymers ◽  
Ph Responsive ◽  
Site Specific

Dually functionalized amphiphilic copolyacetals as rational approach to the development of pH-responsive site-specific drug delivery systems.

scholarly journals Encapsulation of Liposomes within pH Responsive Microspheres for Oral Colonic Drug Delivery

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
M. J. Barea ◽  
M. J. Jenkins ◽  
Y. S. Lee ◽  
P. Johnson ◽  
R. H. Bridson
Keyword(s):  
Drug Delivery ◽  
Small Intestine ◽  
Drug Release ◽  
Ph Responsive ◽  
Site Specific ◽  
Colonic Drug Delivery ◽  
Eudragit S100 ◽  
Release Studies ◽  
Model Drug

A novel liposome-in-microsphere (LIM) formulation has been created comprising drug-loaded liposomes within pH responsive Eudragit S100 microspheres. The liposomes contained the model drug 5-ASA and were coated with chitosan in order to protect them during encapsulation within the microspheres and to improve site-specific release characteristics.In vitrodrug release studies showed that LIMs prevented drug release within simulated stomach and small intestine conditions with subsequent drug release occurring in large intestine conditions. The formulation therefore has potential for oral colonic drug delivery.

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