Body-first Parkinson’s disease and variant Creutzfeldt–Jakob disease – similar or different?

This chapter covers the palliative care aspects of non-malignant neurological diseases, including multiple sclerosis, Parkinson’s disease, motor neurone disease, multiple system atrophy, progressive supranuclear palsy, and Creutzfeldt–Jakob disease. MS is a disease characterized by inflammation and demyelination affecting the central nervous system and ultimately injury and gliosis. Parkinson’s disease (PD) is the commonest neurodegenerative disease after Alzheimer’s disease, with an estimated incidence of 2/1000. It affects just under 1% of people over the age of 65 years. PD is probably not one disease but several with common clinical features. Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by Parkinsonian features, plus autonomic dysfunction in the form of orthostatic hypotension, and/or urogenital dysfunction in the form of incontinence and incomplete bladder emptying. At times it can also include cerebellar symptoms. It is not hereditary, and affects adults usually in the fourth or fifth decade. Post-mortem studies of patients diagnosed with PD indicate that 10–25% had multiple system atrophy.

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CSF Concentrations of cAMP and cGMP Are Lower in Patients with Creutzfeldt-Jakob Disease but Not Parkinson's Disease and Amyotrophic Lateral Sclerosis

PLoS ONE ◽

10.1371/journal.pone.0032664 ◽

2012 ◽

Vol 7 (3) ◽

pp. e32664 ◽

Cited By ~ 15

Author(s):

Patrick Oeckl ◽

Petra Steinacker ◽

Stefan Lehnert ◽

Sarah Jesse ◽

Hans A. Kretzschmar ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Amyotrophic Lateral Sclerosis ◽

Jakob Disease ◽

Camp And Cgmp ◽

Lateral Sclerosis

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Coexistence of Idiopathic Parkinson’s Disease and Creutzfeldt-Jakob Disease

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100047156 ◽

1985 ◽

Vol 12 (3) ◽

pp. 272-273 ◽

Cited By ~ 12

Author(s):

C. Ezrin-Waters ◽

L. Resch ◽

A.E. Lang

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Differential Diagnosis ◽

Clinical Findings ◽

Idiopathic Parkinson’S Disease ◽

Psychiatric Disturbances ◽

Idiopathic Parkinson's Disease ◽

Jakob Disease

ABSTRACT:The association of idiopathic Parkinson’s disease and Creutzfeldt-Jakob disease has not been reported previously. We describe the clinical findings in a patient with both disorders, confirmed at autopsy. The differential diagnosis of parkinsonism with cognitive and psychiatric disturbances is reviewed with emphasis on conditions which may complicate the course of idiopathic Parkinson’s disease. The etiological implications of this combination are considered.

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The Nucleus Basalis of Meynert

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100035721 ◽

1986 ◽

Vol 13 (1) ◽

pp. 8-14 ◽

Cited By ~ 41

Author(s):

Cheryl Ezrin-Waters ◽

L. Resch

Keyword(s):

Alzheimer’S Disease ◽

Parkinson’S Disease ◽

Alzheimer's Disease ◽

Parkinson's Disease ◽

Recent Literature ◽

Neuronal Loss ◽

Nucleus Basalis ◽

Nucleus Basalis Of Meynert ◽

Jakob Disease

ABSTRACT:The nucleus basalis of Meynert has been studied extensively in the recent literature. Interest in this nucleus has resulted from the discovery that it is a major source of cortical cholinergic input and that there is neuronal loss in the nucleus basalis in some dementing illnesses. Consistent and severe involvement of the nucleus basalis of Meynert has been found in Alzheimer's disease and in the dementia accompanying Parkinson's disease. Occasional involvement is present in other dementing illnesses, such as progressive supranuclear palsy, Parkinsonism-Dementia complex of Guam, dementia pugilistica, Pick's disease, Korsakoff's syndrome, Down's Syndrome and Creutzfeldt- Jakob disease. Huntington's disease spares this nucleus. However, the role of the nucleus in cognitive function is as yet undetermined. Even its alteration with normal aging remains controversial. This review details the pathological studies of this region to date, with particular emphasis on the dementias. Its role in the dementias of Alzheimer's disease and Parkinson's disease is specifically addressed.

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V180I genetic Creutzfeldt-Jakob disease with cardiac sympathetic nerve denervation masquerading as Parkinson's disease

Medicine ◽

10.1097/md.0000000000024294 ◽

2021 ◽

Vol 100 (2) ◽

pp. e24294 ◽

Cited By ~ 1

Author(s):

Hiroaki Fujita ◽

Keitaro Ogaki ◽

Tomohiko Shiina ◽

Hiroki Onuma ◽

Hirotaka Sakuramoto ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Sympathetic Nerve ◽

Cardiac Sympathetic Nerve ◽

Jakob Disease

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Treatments for Dementia

A Guide to Treatments that Work ◽

10.1093/med:psych/9780195304145.003.0004 ◽

2007 ◽

pp. 105-144

Author(s):

Larry Tune

Keyword(s):

Alzheimer’S Disease ◽

Parkinson’S Disease ◽

Alzheimer's Disease ◽

Parkinson's Disease ◽

Executive Functioning ◽

Vascular Dementia ◽

Therapeutic Interventions ◽

Design Criteria ◽

Hiv Dementia ◽

Jakob Disease

Dementia refers to a large number of disorders characterized by global cognitive deficits, including impairments of recent memory, and one or more of the following: aphasia, apraxia, agnosia, and disturbance of executive functioning. The most common dementias are Alzheimer’s disease (AD), vascular dementia, dementia due to general medical conditions (including HIV dementia), head trauma, Parkinson’s disease (PD), Huntington’s disease, Pick’s disease, Creutzfeldt-Jakob disease, substance-induced persisting dementia, and multiple etiologies. Alzheimer’s disease, alone or in combination with other conditions (e.g., stroke), is easily the most common. With the exception of dementia associated with Parkinson’s disease, the remaining syndromes are either so rare or heterogeneous that it is difficult to find well-controlled studies that would meet diagnostic and clinical design criteria for standards defined for this book. The focus of this chapter is on therapeutic interventions for Alzheimer’s disease. Innumerable articles investigating patient populations defined as “geropsychiatric” or “gerontopsychiatric” have been excluded. Following this discussion, there is a brief review of therapeutic interventions for Parkinson’s disease.

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Parkinson’s disease with a typical clinical course of 17 years overlapped by Creutzfeldt–Jakob disease: an autopsy case report

BMC Neurology ◽

10.1186/s12883-021-02504-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Shin-ichiro Kubo ◽

Tomoyasu Matsubara ◽

Takeshi Taguchi ◽

Renpei Sengoku ◽

Atsuko Takeuchi ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Late Stage ◽

Clinical Course ◽

Neuropsychiatric Symptoms ◽

Depression And Anxiety ◽

Autopsy Case ◽

Case Presentation ◽

Jakob Disease

Abstract Background Late-stage Parkinson’s disease (PD) often presents with neuropsychiatric symptoms such as dementia, psychosis, excessive daytime sleepiness, apathy, depression, and anxiety. However, neuropsychiatric symptoms are the cardinal features of Creutzfeldt–Jakob disease (CJD), raising the possibility that CJD may be an overlooked condition when it accompanies late-stage PD. Case presentation We describe a female autopsy case of PD with a typical clinical course of 17 years, in which CJD overlapped with PD during the final year of the patient’s life. The patient died aged 85 years. Neuropathological features included widespread Lewy body-related α-synucleinopathy predominantly in the brainstem and limbic system, as well as the typical pathology of methionine/methionine type 1 CJD in the brain. Conclusions Our case demonstrates the clinicopathological co-occurrence of PD and CJD in a sporadic patient. The possibility of mixed pathology, including prion pathology, should be taken into account when neuropsychiatric symptoms are noted during the disease course of PD.

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