The relationships between thyroid-stimulating hormone and/or dopamine levels in peripheral blood and IQ in children with different urinary iodine concentrations

2020 ◽  
Vol 729 ◽  
pp. 134981
Author(s):  
Yushan Cui ◽  
Jingwen Yu ◽  
Bin Zhang ◽  
Baihui Guo ◽  
Tongning Gao ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Urinary Iodine ◽  
Thyroid Stimulating Hormone ◽  
Stimulating Hormone

scholarly journals The association between soya consumption and serum thyroid-stimulating hormone concentrations in the Adventist Health Study-2

2015 ◽  
Vol 19 (8) ◽  
pp. 1464-1470 ◽  
Author(s):  
Serena Tonstad ◽  
Karen Jaceldo-Siegl ◽  
Mark Messina ◽  
Ella Haddad ◽  
Gary E Fraser
Keyword(s):  
Urinary Iodine ◽  
Thyroid Stimulating Hormone ◽  
Soya Protein ◽  
High Serum ◽  
Health Study ◽  
Animal Products ◽  
White Ethnicity ◽  
High Consumption ◽  
Stimulating Hormone ◽  
Adventist Health Study

AbstractObjectiveConsumers may choose soya foods as healthful alternatives to animal products, but concern has arisen that eating large amounts of soya may adversely affect thyroid function. The present study aimed to examine the association between soya food consumption and serum thyroid-stimulating hormone (TSH) concentrations in North American churchgoers belonging to the Seventh-day Adventist denomination that encourages vegetarianism.DesignParticipants completed six repeated 24 h dietary recalls within a 6-month period. Soya protein and soya isoflavone intakes were estimated, and their relationships to TSH concentrations measured at the end of 6 months were calculated using logistic regression analyses.SettingCalibration sub-study of the Adventist Health Study-2.SubjectsWomen (n 548) and men (n 295) who were not taking thyroid medications.ResultsIn men, age and urinary iodine concentrations were associated with high serum TSH concentrations (>5 mIU/l), while among women White ethnicity was associated with high TSH. In multivariate models adjusted for age, ethnicity and urinary iodine, soya isoflavone and protein intakes were not associated with high TSH in men. In women higher soya isoflavone consumption was associated with higher TSH, with an adjusted odds ratio (highest v. lowest quintile) of 4·17 (95 % CI 1·73, 10·06). Likewise, women with high consumption of soya protein (midpoint of highest quintile, 11 g/d) v. low consumption (midpoint of lowest quintile, 0 g/d) carried increased odds of high TSH (OR=2·69; 95 % CI 1·34, 5·30).ConclusionsIn women high consumption of soya was associated with elevated TSH concentrations. No associations between soya intake and TSH were found in men.

scholarly journals Thyroid stimulating hormone isn’t a sensitive indicator of iodine nutritional status in schoolchildren

2016 ◽  
Vol 14 (3) ◽  
pp. 350
Author(s):  
Renata De Oliveira Campos ◽  
Joaquim Custódio Silva Júnior ◽  
Elton Estrela Ramos
Keyword(s):  
Public Schools ◽  
Nutritional Status ◽  
Filter Paper ◽  
Urinary Iodine ◽  
Iodine Concentration ◽  
Thyroid Stimulating Hormone ◽  
Urinary Iodine Concentration ◽  
Iodine Nutrition ◽  
Cross Sectional ◽  
Stimulating Hormone

<p><strong><em>Introduction:</em></strong><em> iodine deficiency </em><em>disorders (IDD)</em><em> </em><em>are most common cause of preventable brain damage, mental retardation and stunted growth in children</em><em> worldwide. Several indicators are complementary to urinary iodine concentration (UIC) for assessing iodine nutritional status, as thyroid size, thyroglobulin (Tg) and thyroid stimulating hormone (TSH) concentrations in the blood.</em><strong><em> Objective:</em></strong><em> </em><em>analyze TSH in filter paper blood values and correlate with UIC in schoolchildren from public school at state of Bahia, Brazil</em><em>. <strong>Methodology: </strong></em><em>cross-sectional study was conducted in 880 schoolchildren aged 6-14 years, randomly selected, of public schools in five cities of four micro-regions of Bahia between October 2013 and September 2014. TSH was analyzed in filter-paper blood and UIC were measured by adapted Sandell-Kolthoff reaction. </em><strong><em>Results:</em></strong><em> 880 blood samples on filter-paper were analyzed for TSH. The reference range previously established is 0.72 to 6.0 </em><em>μ</em><em>UI/mL</em><em>. Results of this research TSH dosage ranged from 0.24 </em><em>μ</em><em>IU/L to</em><em> 7.71 </em><em>μ</em><em>IU/L,</em><em> with a mean of 1.01±0.55 </em><em>μ</em><em>UI/L</em><em> and median 0.89 </em><em>μ</em><em>UI/L</em><em>. Only one child presented TSH greater than 6.0 (7.71 </em><em>μ</em><em>IU/L); however, results of urinary iodine were consistent with a more than adequate nutrition iodine (243.70</em><em>μ</em><em>g/L). There’ no correlation between TSH and UIC (r= 0.115; p= 0.002)</em><em>.</em><em> </em><strong><em>Conclusion:</em></strong><em>  in the present study, schoolchildren showed low values of TSH, but the mean UIC was indicative of adequate iodine nutrition</em><em>.</em><em></em></p>

scholarly journals Iodine concentration and prevalence of thyroid disease in older people after salt iodization in Turkey

2021 ◽  
Vol 27 (2) ◽  
pp. 151-158
Author(s):  
Volkan Atmis ◽  
Buket Bülbül ◽  
Remzi Bahşi ◽  
Mesut Gümüşsoy ◽  
Ahmet Yalçin ◽  
...  
Keyword(s):  
Older People ◽  
Thyroid Disease ◽  
Demographic Data ◽  
Urinary Iodine ◽  
Iodine Concentration ◽  
Needle Aspiration ◽  
Thyroid Stimulating Hormone ◽  
Urinary Iodine Concentration ◽  
Salt Iodization ◽  
Stimulating Hormone

Background: Iodine uptake is a main factor affecting thyroid disease. In Turkey, mandatory salt iodization began in 1999–2000. Aims: This study in 2009 determined the prevalence of thyroid diseases in older people in Mamak district, Ankara after iodization to ascertain if salt iodization alone is sufficient to reach adequate iodine levels in the older population. Methods: All Mamak residents ≥ 65 years were eligible for inclusion in the study. Demographic data and medical history were recorded. All participants had a thyroid ultrasound. Blood samples were taken to assess thyroid function and autoantibodies, and urine samples to assess iodine concentration. Participants with low levels of thyroid stimulating hormone underwent scintigraphy to assess thyroid uptake. Fine-needle aspiration biopsy was done of nodules ≥ 1.5 cm where thyroid stimulating hormone was not suppressed. Results: Of 1200 eligible residents, 979 were included. Their mean age was 70.9 (standard deviation (SD) 5.7) years; 49.7% were women. Mean urinary iodine concentration was 98 (SD 81.29) µg/L. Goitre was found in 18.2% (89/487) of women and 6.7% (33/492) of men (P < 0.001) and 43.8% (428/979) had nodules. Subclinical hypothyroidism was found in 5.8% (57/979) of the participants, overt hyperthyroidism in 0.8% (8/979), subclinical hyperthyroidism in 2.2% (22/979) and T3 thyrotoxicosis in 0.3% (3/979). Toxic multinodular goitre and toxic adenoma caused 80% of hyperthyroidism cases. Biopsy detected no malignant pathology. Conclusion: After salt iodization, iodine levels have not yet reached favourable levels in older people. Iodization of salt seems insufficient to achieve these levels in older people; alternative iodine supplementation should be considered.

scholarly journals Thyroid Stimulating Hormone Receptor Transcripts in Correlation with Clinical Parameters in Thyroid Carcinoma Patients

2020 ◽  
Vol 8 (A) ◽  
pp. 866-872
Author(s):  
Tanja Makazlieva ◽  
Olivija Vaskova ◽  
Toni Tripunoski ◽  
Sinisha Stojanoski ◽  
Nevena Manevska ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Hormone Receptor ◽  
Rank Order ◽  
Structural Response ◽  
Significant Negative Correlation ◽  
Absolute Quantification ◽  
Thyroid Stimulating Hormone ◽  
Whole Body ◽  
Serum Thyroglobulin ◽  
Stimulating Hormone

BACKGROUND: Differentiated thyroid carcinomas (DTC) preserve expression of thyroid stimulating hormone receptor (TSHR). AIM: The aim of our study was to evaluate the expression of mRNA-TSHR in peripheral blood of DTC patients, then to correlate the expression with clinical features: Serum thyroglobulin (sTg) value, initial staging and findings from the whole body scan (WBS), neck ultrasound (US), and total received dose of radioiodine therapy. MATERIALS AND METHODS: Forty patients were divided into three groups according to the treatment response: Patients with incomplete structural response (TCs), incomplete biochemical response (TCb), and excellent responders (TCr). Total RNA was isolated from peripheral blood and used for two-step reverse transcriptase-PCR with appropriate primers. Relative quantification using the ΔCt and 2–ΔΔCt and method was applied. sTg levels were evaluated with chemiluminescent assay. The statistical analysis was performed with Spearman Rank Order Correlation. RESULTS: We found that TCs patients expressed mRNA-TSHR by a 5.37-fold higher level than TCr patients, TCb patients expressed TSHR by an 8.88-fold higher level than TCr patients. A significant negative correlation was detected between sTg and ΔCt (CtTSHR - CtGAPDH) value (R = −0.475; p < 0.05), and between WBS/US findings and ΔCt (R= −0.321; p < 0.05). CONCLUSION: Our data revealed higher expression of mRNA-TSHR in peripheral blood of TCs and TCb compared to TCr patients and analysis revealed a significant correlation between mRNA-TSHR and sTg and US/WBS findings. Further studies with larger number of subjects and absolute quantification are needed for understanding the real meaning of mRNA-TSHR as a biomarker in DTC.

scholarly journals Recombinant Human Thyroid-Stimulating Hormone Increases the Percentages of Natural Killer T Cells and B Lymphocytes in Human Peripheral Blood In Vivo

2020 ◽  
Vol 11 ◽  
Author(s):  
Zbigniew Adamczewski ◽  
Mariusz Stasiołek ◽  
Arkadiusz Zygmunt ◽  
Przemysław W. Śliwka ◽  
Katarzyna Wieczorek-Szukała ◽  
...  
Keyword(s):  
T Cells ◽  
Natural Killer ◽  
B Lymphocytes ◽  
Peripheral Blood ◽  
Natural Killer T Cells ◽  
Thyroid Stimulating Hormone ◽  
Killer T Cells ◽  
Natural Killer T ◽  
Stimulating Hormone

Multiple cellular and humoral components of the immune system play a significant role in the physiology and pathophysiology of various organs including the thyroid. On the other hand, both thyroid hormones and thyroid-stimulating hormone (TSH) have been shown to exert immunoregulatory activities, which are difficult to assess independently in vivo. In our study we employed a unique clinical model for the assessment of TSH biological function in humans. The structure of peripheral blood mononuclear cell populations was investigated, using flow cytometry, in athyroid patients (n = 109) after treatment because of the differentiated thyroid carcinoma (DTC) at two time-points: directly before and five days after recombinant human TSH (rhTSH) administration. The analysis revealed significant increase in the percentage of natural killer T cells and B lymphocytes in the peripheral blood of rhTSH treated patients, whereas, we did not observe any effects on investigated subpopulations of dendritic cells and monocytes, T cells and natural killer cells. The findings of the study indicate the immune regulatory role of TSH, directed specifically on selected cell subtypes.

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