The endoplasmic reticulum stress sensor, ATF6α, protects against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced dopaminergic neuronal death in a p38 Mitogen-Activated Protein Kinase dependent manner

2010 ◽  
Vol 68 ◽  
pp. e193
Author(s):  
Naohiro Egawa ◽  
Keisuke Yamamoto ◽  
Haruhisa Inoue ◽  
Katsunori Nishi ◽  
Kazutoshi Mori
Keyword(s):  
Endoplasmic Reticulum ◽  
Protein Kinase ◽  
Endoplasmic Reticulum Stress ◽  
Neuronal Death ◽  
Mitogen Activated Protein Kinase ◽  
Dependent Manner ◽  
Stress Sensor ◽  
Mitogen Activated Protein

scholarly journals Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Mayumi Soga ◽  
Atsushi Matsuzawa ◽  
Hidenori Ichijo
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Protein Kinase ◽  
Endoplasmic Reticulum Stress ◽  
Signaling Pathway ◽  
Mitogen Activated Protein Kinase ◽  
Regulatory Mechanisms ◽  
Cellular Functions ◽  
Mapk Kinase ◽  
Mitogen Activated Protein

Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK) kinase kinase that activates the downstream MAPKs, c-Jun N-terminal kinase (JNK) and p38. ASK1 is activated by various types of stress, such as oxidative stress, endoplasmic reticulum stress, and infection, and regulates various cellular functions. Recently, it has been reported that ASK1 is associated with various diseases induced by oxidative stress. In this review, we introduce recent findings of the regulatory mechanisms of ASK1 and the oxidative stress-induced diseases mediated by the ASK1 signaling pathway.

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