First case of Covid-19 presented with cerebral venous thrombosis: A rare and dreaded case

Cerebral Venous Thrombosis (CVT) is a rare form of Stroke characterized by thrombus formation in the cerebral veins. CVT is a result of various reasons among which the hyperthyroidism is not so frequently encountered. This is probably the first case report published from Nepal. The aim of this case report is to give the message that persistent severe headache in patient with hyperthyroidism can be the red flag and needs to be investigated further. We present a case of a 35 years old female who presented with complaints of severe headache and persistent in nature associated with vomiting since 5 days. She was a diagnosed subacute thryroiditis and under medicine from 1 month before presenting to us. Her Magnetic Resonance Venography (MRV) brain showed venous thrombosis within superior saggital sinus, left transverse sinus and sigmoid sinus. Her thyroid function test showed pretreatment T3 of 2.98 ng/ml T4 of 1.02 mg/ ml and TSH of 0.12 μIU/L. She was kept on anticoagulants and other supportive measures. The patient showed improving status with the conservative management.Nepal Journal of Neuroscience 15:29-31, 2018

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Uterine rhabdomyosarcoma complicated by cerebral venous thrombosis and uterine inversion in a young woman: case report and literature review

BMC Women s Health ◽

10.1186/s12905-021-01459-2 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Hongfa Peng ◽

Jingjing Jiang ◽

Xianghua Huang

Keyword(s):

Venous Thrombosis ◽

Adolescent Girls ◽

Cerebral Venous Thrombosis ◽

Actinomycin D ◽

Surgical Intervention ◽

Abnormal Uterine Bleeding ◽

Uterine Neoplasms ◽

Case Presentation ◽

Uterine Inversion ◽

First Case

Abstract Background Uterine rhabdomyosarcoma is an extremely rare malignant tumor that usually affects young women and has a poor prognosis. Case presentation A 19-year-old nulliparous woman presented to the emergency department under sedation due to seizures. Imaging examination revealed cerebral venous thrombosis. During thrombolytic therapy, she developed vaginal bleeding followed by uterine inversion secondary to uterine rhabdomyosarcoma. The inverted uterus was mistaken for a cervical tumour and was removed vaginally. The patient’s disease progressed despite chemotherapy with vincristine, actinomycin D and cyclophosphamide and she died within 6 months. To our knowledge, this is the first case of uterine rhabdomyosarcoma complicated with cerebral venous thrombosis. Conclusions Malignancy is an important diagnostic in patients with cerebral venous thrombosis with no obvious cause. This case demonstrates the importance of considering uterine neoplasms in the differential diagnosis of adolescent girls with abnormal uterine bleeding. Further, careful anatomical evaluation of vaginal masses should be performed prior to surgical intervention.

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Cerebral venous thrombosis secondary to an occult maxillary sinusitis in a young male from sub-Saharan Africa

10.36811/ojor.2019.110002 ◽

2019 ◽

pp. 08-12

Author(s):

Mazou N Temgoua ◽

Mickael Essouma ◽

Larry N Tangie ◽

Cedric Tsinda ◽

Drusille Feze Foko ◽

...

Keyword(s):

Venous Thrombosis ◽

Acute Stroke ◽

Cerebral Venous Thrombosis ◽

Fungal Infections ◽

Sinus Thrombosis ◽

Maxillary Sinusitis ◽

Case Reports ◽

Sub Saharan Africa ◽

First Case ◽

Increased Risk

Cerebral venous thrombosis (CVT) also termed cerebral venous sinus thrombosis (CVST), is a special type of cerebrovascular disease characterized by cerebral venous infarction [1]. As from 1825 when the first case was described by Ribes[2], epidemiological descriptions are still restricted to case reports and small retrospective cross-sectional studies yielding low butincreasing incidence: <10 cases per million per year in 1995 to about 13.2 cases per million per year in 2012.CVT mainly occurs in women of child bearing age, probably owing to the use of oral contraceptive pills, and mostly has an acute or subacute course [1]. It can be categorized as primary/idiopathicand secondary. Secondary CVT can further be classified into infective (mainly due to bacterial or fungal infections) and non-infective CVT; the latterbeing due tocoagulation disorders, neoplasms, procoagulant hemodynamic states, vascularitis,homocystinuria, or head trauma [3].With the advent of antibiotics, the epidemiology of CVT has shifted from predominant infective CVT to predominant non-infective CVT, leading to increased risk of misdiagnosis and delayed treatment [3]. We report occult purulent maxillary sinusitis-related CVT in a male Cameroonian patient who presented with headaches, seizures and acute stroke syndrome. The aim of this paper is to reiterate CVT as the main cause of acute stroke syndrome in young adults irrespective of ethnic origin and sex, and suggest systematic screening of infections in those patients, especially in regions with high rates of infections likesub-Saharan Africa.We describe this case with regard to CARE guidelines.

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Coccidioidomycosis Meningitis With Massive Dural and Cerebral Venous Thrombosis and Tissue Arthroconidia

Archives of Pathology & Laboratory Medicine ◽

10.5858/2000-124-0310-cmwmda ◽

2000 ◽

Vol 124 (2) ◽

pp. 310-314 ◽

Cited By ~ 2

Author(s):

B. K. Kleinschmidt-DeMasters ◽

Michael Mazowiecki ◽

Lian A. Bonds ◽

David L. Cohn ◽

Michael L. Wilson

Keyword(s):

Venous Thrombosis ◽

Cerebral Venous Thrombosis ◽

Coccidioides Immitis ◽

Pathogenic Organism ◽

The Past ◽

First Case ◽

Coagulation Defects ◽

Acquired Immunodeficiency ◽

Immunodeficiency Syndrome ◽

Thrombotic Tendency

Abstract To our knowledge we report the first case of meningitis from Coccidioides immitis associated with massive dural and cerebral venous thrombosis and with mycelial forms of the organism in brain tissue. The patient was a 43-year-old man with late-stage acquired immunodeficiency syndrome (AIDS) whose premortem and postmortem cultures confirmed C immitis as the only central nervous system pathogenic organism. Death was attributable to multiple hemorrhagic venous infarctions with cerebral edema and herniation. Although phlebitis has been noted parenthetically to occur in C immitis meningitis in the past, it has been overshadowed by the arteritic complications of the disease. This patient's severe C immitis ventriculitis with adjacent venulitis appeared to be the cause of the widespread venous thrombosis. AIDS-related coagulation defects may have contributed to his thrombotic tendency.

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Cerebral Venous Thrombosis and COVID-19 Infection in a Patient With Sickle Cell Disease: A Case Report

Case Reports in Clinical Practice ◽

10.18502/crcp.v5is1.6239 ◽

2021 ◽

Author(s):

Athena Sharifi Razavi ◽

Narges Karimi

Keyword(s):

Case Report ◽

Sickle Cell Disease ◽

Venous Thrombosis ◽

Sickle Cell ◽

Cerebral Venous Thrombosis ◽

Antiviral Agents ◽

Common Symptom ◽

Cell Disease ◽

First Case ◽

Novel Coronavirus

Background: The most common symptom of the novel Coronavirus Disease 2019 (COVID-19) infection is fever and dyspnea that leads to hypoxia in severe cases. Some COVID-19 patients experience neurological symptoms, including ischemic stroke and intracerebral hemorrhage. Sickle Cell Disease (SCD) is a hypercoagulable state, however, it has not been approved as a significant cause of Cerebral Venous Thrombosis (CVT). Case presentation: In this case report, we described CVT in an SCD patient who had COVID-19, as well. We reported a 32-year-old man with a history of sickle cell anemia presented with left hemiparesis, headache, and seizure. After evaluation of the patient, CVT accompanied by COVID-19 infection was diagnosed. He was treated with intravenous unsaturated heparin, antiepileptic drugs, and antiviral agents with a favorable outcome. Based on our knowledge, this is the first case study to describe an association between CVT and COVID-19 infection in a patient with SCD. Conclusion: During the recent pandemic, vaso-occlusive attacks in SCD patients can be evaluated for COVID-19 as an etiological factor.

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Charles bonnet syndrome due to cerebral venous thrombosis

Headache Medicine ◽

10.48208/headachemed.2020.supplement.8 ◽

2020 ◽

pp. 8

Author(s):

Rafaela Ianisky ◽

Thaise Wrubleski ◽

Jean Tafarel ◽

Maria Figueroa Magalhães ◽

Vitor Dias

Keyword(s):

Venous Thrombosis ◽

Cerebral Venous Thrombosis ◽

Vision Loss ◽

Cortical Lesion ◽

Psychotic Symptoms ◽

Magnetic Resonance Imaging Scan ◽

Visual Hallucinations ◽

Charles Bonnet Syndrome ◽

First Case ◽

The Right

IntroductionCharles Bonnet Syndrome (CBS) is characterized by visual hallucinations, preserved awareness of unreal visions and absence of psychotic symptoms. There are limited cases reported on CBS after ischemic stroke and just one describing CBS due to cerebral venous thrombosis (CVT). Our aim is to describe the clinical course of the first case of CBS after CVT without optic nerve atrophy or vision loss in a patient admitted with intense headache and acute onset of visual hallucinations. The patient has signed the consent form and were only used the medical records for the case.Case ReportA fifty-nine years old healthy man was admitted with complaints of recurrent episodes of headache in the last month and subsequent visual hallucinations, specifically prosopometamorphopsia - he reported seeing distorted images of faces and objects -. It was not associated with any sensory or motor complaints. General medical and neurological examination on admission was intact. He had no meningismus. Blood work revealed an alteration in C-reactive protein and cerebrospinal revealed lymphocytic pleocytosis. Brain computed tomography scan showed an ill-defined hypodense cortical lesion in the right temporal and occipital region. Magnetic resonance imaging scan confirmed the presence of a cerebral venous thrombosis in the right sigmoid and transverse sinuses. He was treated with heparin followed by warfarin, but the visual hallucinations remained. It was opted to start corticosteroid. The patient had excellent recovery a few weeks after admission and was regularly followed up. Later, he was found to be positive for the mutation in the prothrombin gene.ConclusionsCerebral venous thrombosis can be presented with different neurological symptoms but does not typically present with hallucinations. For this reason, illusions should be added to the already broad spectrum of presenting features of CVT. This diagnosis may be, still, considered in patients presenting with new auditory hallucinations and illusions, particularly in the context of accompanying headache and conventional risk factors for venous thrombosis.

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Cerebral venous thrombosis, neutropenia and iron-deficiency anemia in Huntington disease

Neurodegenerative Disease Management ◽

10.2217/nmt-2020-0045 ◽

2021 ◽

Vol 11 (2) ◽

pp. 137-142

Author(s):

Farinaz Tabibian ◽

Iman Adibi ◽

Parisa Emami Ardestani ◽

Elnaz Tabibian ◽

Sahar Akbaripour ◽

...

Keyword(s):

Risk Factors ◽

Iron Deficiency ◽

Venous Thrombosis ◽

Iron Deficiency Anemia ◽

Huntington Disease ◽

Cerebral Venous Thrombosis ◽

Neurodegenerative Disorder ◽

Deficiency Anemia ◽

First Case ◽

Chronic Risk

Neurologic and nonneurologic manifestations have been shown for Huntington disease (HD) as a genetic neurodegenerative disorder. However, cerebral venous thrombosis (CVT), iron-deficiency anemia and neutropenia have not been reported as its presentations to date. We introduce the first case of a HD patient with CVT, iron-deficiency anemia and neutropenia. All transient and chronic risk factors for development of these manifestations were ruled out. According to the experimental evidences reviewed in this article, we suggest that HD itself could promote formation of CVT, iron-deficiency anemia and neutropenia through vascular and blood cell abnormalities.

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Cerebral venous thrombosis and demyelinating diseases: report of a case in a clinically isolated syndrome suggestive of multiple sclerosis onset and review of the literature

Multiple Sclerosis Journal ◽

10.1191/1352458505ms1125cr ◽

2005 ◽

Vol 11 (2) ◽

pp. 242-244 ◽

Cited By ~ 14

Author(s):

Maurizia Maurelli ◽

Roberto Bergamaschi ◽

Elisa Candeloro ◽

Alessandra Todeschini ◽

Giuseppe Micieli

Keyword(s):

Multiple Sclerosis ◽

Venous Thrombosis ◽

Lumbar Puncture ◽

Cerebral Venous Thrombosis ◽

Corticosteroid Treatment ◽

Clinically Isolated Syndrome ◽

Demyelinating Diseases ◽

High Dose ◽

First Case ◽

Definite Multiple Sclerosis

Cerebral venous thrombosis (CVT) has been described in several cases of clinically definite multiple sclerosis (MS). In the majority of these, lumbar puncture followed by intravenous corticosteroid treatment was suspected as the cause. We report what is, to our knowledge, the first case of a patient with a multifocal clinically isolated syndrome suggestive of MS onset, who developed multiple CVT after lumbar puncture and during high-dose i.v. corticosteroid treatment. We conclude that the sequence ‘lumbar puncture followed by corticosteroid treatment’ may be a contributory risk factor for the development of CVT when associated with other risk factors.

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