Damage to the right superior longitudinal fasciculus in the inferior parietal lobe plays a role in spatial neglect

We examined priming of visual search by repeated target location or color in two patients with left visual neglect and extinction, following strokes centered on the right inferior parietal lobe. Both patients, like the healthy controls we tested, showed intact priming, with performance speeded when either the location or color of a singleton target was repeated over successive trials in a standard search condition (Experiment 1). This was observed both from and to targets on the contralesional (left) side. Moreover, priming of search was still observed even when a return of fixation back to display-center was required between successive trials (Experiment 2). When briefer displays were used (Experiment 3), the patients often failed to detect left targets. This situation revealed an important dissociation: Whereas location priming only arose from preceding left targets that had been consciously detected, color priming (possibly arising within the intact ventral stream) did not depend on awareness of the preceding target. There was considerable color priming from missed targets. These findings demonstrate relatively intact priming of visual search by color and location in patients with right parietal damage, and also reveal that location priming may differ from color priming in requiring awareness.

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Damage to the Upper Portion of Area 19 and the Deep White Matter in the Left Inferior Parietal Lobe, Including the Superior Longitudinal Fasciculus, Results in Alexia with Agraphia

European Neurology ◽

10.1159/000318175 ◽

2010 ◽

Vol 64 (4) ◽

pp. 224-229 ◽

Cited By ~ 5

Author(s):

Nobusada Shinoura ◽

Toshiyuki Onodera ◽

Kotoyo Kurokawa ◽

Masanobu Tsukada ◽

Ryozi Yamada ◽

...

Keyword(s):

White Matter ◽

Parietal Lobe ◽

Superior Longitudinal Fasciculus ◽

Deep White Matter ◽

Inferior Parietal Lobe ◽

Area 19

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Relationship between Visual Perception and Microstructural Change of the Superior Longitudinal Fasciculus in Patients with Brain Injury in the Right Hemisphere: A Preliminary Diffusion Tensor Tractography Study

Diagnostics ◽

10.3390/diagnostics10090641 ◽

2020 ◽

Vol 10 (9) ◽

pp. 641

Author(s):

Su-Hong Kim ◽

Hyeong-Eun Jeon ◽

Chan-Hyuk Park

Keyword(s):

Visual Perception ◽

Right Hemisphere ◽

Diffusion Tensor ◽

Microstructural Change ◽

Spatial Neglect ◽

Superior Longitudinal Fasciculus ◽

Microstructural Changes ◽

Control Subjects ◽

Significant Difference ◽

The Right

Right hemisphere brain damage often results in visual-spatial deficits. Because various microstructural changes of the superior longitudinal fasciculus (SLF) after a stroke in the right hemisphere affect visual perception, including neglect, the present study investigates the relationship between both microstructural change and lateralization of SLF and visual perception, using diffusion tensor imaging (DTI) in patients with lesions in the right hemisphere. Eight patients with strokes (five patients with intracranial hemorrhage, and three patients with infarction; mean age of 52.5 years) and 16 mean-age-matched healthy control subjects were involved in this study. The visual perception of all eight patients was assessed with the motor-free visual perception test (MVPT), and their SLFs were reconstructed using DTI. The results showed that there was a significant difference between the DTI parameters of the patients and the control subjects. Moreover, patients with microstructural damage to the right SLF showed impairment of visual perception. In patients with damage to both the dorsal and ventral pathways of the right SLF, spatial neglect was present. However, although a leftward SLF asymmetry was revealed in our patients, this lateralization did not show a relationship with visual perception. In conclusion, the microstructural changes of the right SLF play an important role in visual perception, and both pathways contribute to spatial neglect, but leftward lateralization of the right SFL activity after a stroke does not contribute to general visual perception.

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Increased Anxiety After Stimulation of the Right Inferior Parietal Lobe and the Left Orbitofrontal Cortex

Frontiers in Psychiatry ◽

10.3389/fpsyt.2020.00375 ◽

2020 ◽

Vol 11 ◽

Cited By ~ 1

Author(s):

Matthias Grieder ◽

Philipp Homan ◽

Andrea Federspiel ◽

Claus Kiefer ◽

Gregor Hasler

Keyword(s):

Orbitofrontal Cortex ◽

Parietal Lobe ◽

Inferior Parietal Lobe ◽

The Right ◽

Stimulation Of

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How Would You Feel versus How Do You Think She Would Feel? A Neuroimaging Study of Perspective-Taking with Social Emotions

Journal of Cognitive Neuroscience ◽

10.1162/0898929041502661 ◽

2004 ◽

Vol 16 (6) ◽

pp. 988-999 ◽

Cited By ~ 380

Author(s):

Perrine Ruby ◽

Jean Decety

Keyword(s):

Perspective Taking ◽

Parietal Lobe ◽

Social Emotions ◽

Inferior Parietal Lobe ◽

Person Perspective ◽

Temporal Pole ◽

Postcentral Gyrus ◽

Third Person ◽

First Person Perspective ◽

The Right

Perspective-taking is a complex cognitive process involved in social cognition. This positron emission tomography (PET) study investigated by means of a factorial design the interaction between the emotional and the perspective factors. Participants were asked to adopt either their own (first person) perspective or the (third person) perspective of their mothers in response to situations involving social emotions or to neutral situations. The main effect of third-person versus first-person perspective resulted in hemodynamic increase in the medial part of the superior frontal gyrus, the left superior temporal sulcus, the left temporal pole, the posterior cingulate gyrus, and the right inferior parietal lobe. A cluster in the postcentral gyrus was detected in the reverse comparison. The amygdala was selectively activated when subjects were processing social emotions, both related to self and other. Interaction effects were identified in the left temporal pole and in the right postcentral gyrus. These results support our prediction that the frontopolar, the somatosensory cortex, and the right inferior parietal lobe are crucial in the process of self/ other distinction. In addition, this study provides important building blocks in our understanding of social emotion processing and human empathy.

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Electrostimulation Mapping of Spatial Neglect

Neurosurgery ◽

10.1227/neu.0b013e31822aefd2 ◽

2011 ◽

Vol 69 (6) ◽

pp. 1218-1231 ◽

Cited By ~ 35

Author(s):

Franck-Emmanuel Roux ◽

Olivier Dufor ◽

Valérie Lauwers-Cances ◽

Leila Boukhatem ◽

David Brauge ◽

...

Keyword(s):

Right Hemisphere ◽

Parietal Lobe ◽

Group Analysis ◽

Posterior Part ◽

Line Bisection ◽

Spatial Neglect ◽

Control Group ◽

Cortical Areas ◽

Specificity And Sensitivity ◽

The Right

Abstract BACKGROUND Cortical and subcortical electrostimulation mapping during awake brain surgery for tumor removal is usually used to minimize deficits. OBJECTIVE To use electrostimulation to study neuronal substrates involved in spatial awareness in humans. METHODS Spatial neglect was studied using a line bisection task in combination with electrostimulation mapping of the right hemisphere in 50 cases. Stimulation sites were identified with Talairach coordinates. The behavioral effects induced by stimulation, especially eye movements and deviations from the median, were quantified and compared with preoperative data and a control group. RESULTS Composite and highly individualized spatial neglect maps were generated. Both rightward and leftward deviations were induced, sometimes in the same patient but for different stimulation sites. Group analysis showed that specific and reproducible line deviations were induced by stimulation of discrete cortical areas located in the posterior part of the right superior and middle temporal gyri, inferior parietal lobe, and inferior postcentral and inferior frontal gyri (P > .05). Fiber tracking identified stimulated subcortical areas important to spare as sections of fronto-occipital and superior longitudinal II fascicles. According to preoperative and postoperative neglect battery tests, the specificity and sensitivity of intraoperative line bisection tests were 94% and 83%, respectively. CONCLUSION In humans, discrete cortical areas that are variable in location between individuals but mainly located within the right posterior Sylvian fissure sustain visuospatial attention specifically toward the contralateral or ipsilateral space direction. Line bisection mapping was found to be a reliable method for minimizing spatial neglect caused by brain tumor surgery.

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Left egocentric neglect in early subacute right-stroke patients is related to damage of the superior longitudinal fasciculus

Brain Imaging and Behavior ◽

10.1007/s11682-021-00493-w ◽

2021 ◽

Author(s):

Barbara Spanò ◽

Davide Nardo ◽

Giovanni Giulietti ◽

Alessandro Matano ◽

Ilenia Salsano ◽

...

Keyword(s):

White Matter ◽

Right Hemisphere ◽

Neural Substrates ◽

Spatial Neglect ◽

Stroke Patients ◽

Superior Longitudinal Fasciculus ◽

Unilateral Spatial Neglect ◽

Object Based ◽

The Right ◽

The Relationship

AbstractA typical consequence of stroke in the right hemisphere is unilateral spatial neglect. Distinct forms of neglect have been described, such as space-based (egocentric) and object-based (allocentric) neglect. However, the relationship between these two forms of neglect is still far from being understood, as well as their neural substrates. Here, we further explore this issue by using voxel lesion symptoms mapping (VLSM) analyses on a large sample of early subacute right-stroke patients assessed with the Apples Cancellation Test. This is a sensitive test that simultaneously measures both egocentric and allocentric neglect. Behaviourally, we found no correlation between egocentric and allocentric performance, indicating independent mechanisms supporting the two forms of neglect. This was confirmed by the VLSM analysis that pointed out a link between a damage in the superior longitudinal fasciculus and left egocentric neglect. By contrast, no association was found between brain damage and left allocentric neglect. These results indicate a higher probability to observe egocentric neglect as a consequence of white matter damages in the superior longitudinal fasciculus, while allocentric neglect appears more “globally” related to the whole lesion map. Overall, these findings on early subacute right-stroke patients highlight the role played by white matter integrity in sustaining attention-related operations within an egocentric frame of reference.

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Mapping visuospatial and self-motion perception functions in the left parietal lobe

Neurosurgical FOCUS ◽

10.3171/2018.10.focusvid.18286 ◽

2018 ◽

Vol 45 (VideoSuppl2) ◽

pp. V8 ◽

Cited By ~ 1

Author(s):

Carlos Velásquez ◽

Elsa Goméz ◽

Juan Martino

Keyword(s):

Motion Perception ◽

Parietal Lobe ◽

Spatial Neglect ◽

Low Grade ◽

Language Mapping ◽

Subcortical Stimulation ◽

The Right ◽

Glioma Resection ◽

Self Motion ◽

Stimulation Of

Parietal lobe functions include somesthesia, language, calculation, self-motion perception, and visuospatial awareness. In this video, the authors show the intraoperative mapping of a left parietal lobe for a low-grade glioma resection. Standard sensory and language mapping were performed. Interestingly, by using the “Line Bisection” task, subcortical stimulation of the gyrus angularis was repeatedly associated with ipsilateral spatial neglect, often described in the right parietal lobe. In a similar way, subcortical stimulation in a more posterior point elicited episodes of vertigo, probably due to stimulation of the superior longitudinal fasciculus. Both findings were useful to define the functional limit of the resection.The video can be found here: https://youtu.be/qgGDRW_6u0A.

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Information content best characterises the hemispheric selectivity of the inferior parietal lobe: a meta-analysis

Scientific Reports ◽

10.1038/s41598-020-72228-8 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Oliver Gray ◽

Lewis Fry ◽

Daniela Montaldi

Keyword(s):

Episodic Memory ◽

Left Hemisphere ◽

Memory Retrieval ◽

Right Hemisphere ◽

Parietal Lobe ◽

Meta Analysis ◽

Compelling Evidence ◽

Inferior Parietal Lobe ◽

Hemispheric Specialisation ◽

The Right

Abstract Our understanding of the inferior parietal lobe (IPL) remains challenged by inconsistencies between neuroimaging and neuropsychological perspectives. To date, others assume that hemispheric specialisation of the IPL is linked with the type of processing; attention processing in the right hemisphere; memory retrieval and semantic judgement in the left hemisphere. Here, we provide compelling evidence associating the type of information being processed with the recruitment of each hemisphere’s IPL. In a meta-analysis, we classify 121 previous fMRI reports of IPL activity arising from episodic memory retrieval, according to the type of information that characterises each fMRI contrast. We demonstrate that the left IPL is more consistently associated with retrieval of the semantic (95% of eligible contrasts) than perceptual aspects of memory (83%). In contrast, the right IPL is more consistently associated with the retrieval of perceptual (97%), than semantic aspects of memory (43%). This work revises assumptions of how the IPL contributes to healthy cognition and has major implications for IPL-related neuropsychological deficits.

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The Left Superior Longitudinal Fasciculus within the Primary Sensory Area of Inferior Parietal Lobe Plays a Role in Dysgraphia of Kana Omission within Sentences

Behavioural Neurology ◽

10.1155/2012/561427 ◽

2012 ◽

Vol 25 (4) ◽

pp. 363-368 ◽

Cited By ~ 3

Author(s):

Nobusada Shinoura ◽

Akira Midorikawa ◽

Toshiyuki Onodera ◽

Ryozi Yamada ◽

Yusuke Tabei ◽

...

Keyword(s):

Brain Tumor ◽

Parietal Lobe ◽

Diffusion Tensor ◽

Superior Longitudinal Fasciculus ◽

Inferior Parietal Lobe ◽

Sensory Area ◽

Anatomical Localization ◽

Dti Tractography ◽

The Brain ◽

Diffusion Tensor Imaging Dti

Functional neurological changes after surgery combined with diffusion tensor imaging (DTI) tractography can directly provide evidence of anatomical localization of brain function. Using these techniques, a patient with dysgraphia before surgery was analyzed at our hospital in 2011. The patient showed omission of kana within sentences before surgery, which improved after surgery. The brain tumor was relatively small and was located within the primary sensory area (S1) of the inferior parietal lobe (IPL). DTI tractography before surgery revealed compression of the branch of the superior longitudinal fasciculus (SLF) by the brain tumor. These results suggest that the left SLF within the S1 of IPL plays a role in the development of dysgraphia of kana omission within sentences.

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