Multiple sclerosis and subclinical neuropathology in healthy individuals with familial risk: A scoping review of MRI studies

This scoping review aims to describe occupational therapy interventions carried out with multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) patients in occupational therapy. A peer review of the literature was conducted in different databases: Pubmed, Scopus, Web of Science and Embase, and in some occupational therapy journals. A search of the literature published was carried out before December 2019. The inclusion criteria were as follows: (1) articles evaluating the intervention of occupational therapy in MS or ALS including experimental, randomized, nonrandomized and exploratory studies; (2) written in English or Spanish; (3) adult population (over 18 years old). The initial search identified 836 articles of which we included 32 divided into four areas of intervention: fatigue-targeted interventions, cognitive interventions, physical interventions and others. Only 16 studies were carried out exclusively by occupational therapists. Most occupational therapy interventions are aimed at fatigue and physical rehabilitation. The majority of the studies in our review included MS patients, with little representation from the ALS population. These interventions have shown an improvement in perceived fatigue, manual dexterity, falls prevention and improvement in cognitive aspects such as memory, communication, depression and quality of life in the MS and ALS populations.

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RE: “FAMILIAL RISK OF MULTIPLE SCLEROSIS: A NATIONWIDE COHORT STUDY”

American Journal of Epidemiology ◽

10.1093/aje/kwj130 ◽

2006 ◽

Vol 163 (9) ◽

pp. 873-874 ◽

Cited By ~ 7

Author(s):

Kari Hemminki ◽

Xinjun Li ◽

Sven-Erik Johansson ◽

Kristina Sundquist ◽

Jan Sundquist

Keyword(s):

Multiple Sclerosis ◽

Cohort Study ◽

Familial Risk

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Serum neurofilament light chain levels in healthy individuals: a proposal of cut-off values for use in multiple sclerosis clinical practice

Multiple Sclerosis and Related Disorders ◽

10.1016/j.msard.2021.103090 ◽

2021 ◽

pp. 103090

Author(s):

Paola Valentino ◽

Fabiana Marnetto ◽

Serena Martire ◽

Simona Malucchi ◽

Cecilia Irene Bava ◽

...

Keyword(s):

Multiple Sclerosis ◽

Clinical Practice ◽

Light Chain ◽

Healthy Individuals ◽

Neurofilament Light Chain ◽

Neurofilament Light

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Use of geographical information systems in multiple sclerosis research: A systematic scoping review

10.21203/rs.3.rs-236908/v1 ◽

2021 ◽

Author(s):

Soheil Hashtarkhani ◽

Hossein Tabatabaei-Jafari ◽

Behzad Kiani ◽

MaryAnne Furst ◽

Luis Salvador-Carulla ◽

...

Keyword(s):

Multiple Sclerosis ◽

Scoping Review ◽

Geographical Information Systems ◽

Geographical Information ◽

Complex Nature ◽

Gis Applications ◽

Thematic Mapping ◽

Health Related ◽

Comprehensive Search ◽

Comprehensive Search Strategy

Abstract Introduction: Geographical Information System (GIS) and spatial analysis have an emerging role in the understanding and management of health-related outcomes. However, there is a knowledge gap about the extent to which GIS has supported Multiple Sclerosis (MS) research. Therefore, this review aimed to explore the types of GIS applications and the complexity of their visualisation in MS research. Methods: A systematic scoping review was conducted based on York’s five-stage framework. PubMed, Scopus and Web of Science were searched for relevant studies published between 2000 and 2020 using a comprehensive search strategy based on the main concepts related to GIS and MS. Grounded, inductive analysis was conducted to organize studies into meaningful application areas. Further, we developed a tool to assess the visualisation complexity of the selected papers.Results: Of 3,723 identified unique citations, 42 papers met our inclusion criteria for the final review. One or more of the following types of GIS applications were reported by these studies: (a) thematic mapping (37 papers); (b) spatial cluster detection (16 papers); (c) risk factors detection (16 papers); and (d) health access and planning (two papers). In the majority of studies (88%), the score of visualisation complexity was relatively low: three or less from the range of zero to six. Conclusions: Although the number of studies using GIS techniques has dramatically increased in the last decade, the use of GIS in the areas of MS access and planning is still under-researched. Additionally, the capacity of GIS in visualising complex nature of MS care system is not yet fully investigated.

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Utilizing driving simulators for persons with multiple sclerosis: A scoping review

Transportation Research Part F Traffic Psychology and Behaviour ◽

10.1016/j.trf.2021.12.006 ◽

2022 ◽

Vol 85 ◽

pp. 103-118

Author(s):

Sarah Krasniuk ◽

Melissa Knott ◽

Reem Bagajati ◽

Mahdis Azizderouei ◽

Radhika Sultania ◽

...

Keyword(s):

Multiple Sclerosis ◽

Scoping Review ◽

Driving Simulators

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Supra-Spinal Modulation Of Walking In Healthy Individuals And Persons With Multiple Sclerosis: A fNIRS Mobile Imaging Study

2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) ◽

10.1109/embc.2018.8513052 ◽

2018 ◽

Cited By ~ 1

Author(s):

Soha Saleh ◽

Brian M. Sandroff ◽

Oyindamola Owoeye ◽

Tyler Vitiello ◽

Armand Hoxha ◽

...

Keyword(s):

Multiple Sclerosis ◽

Imaging Study ◽

Healthy Individuals ◽

Mobile Imaging

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A Scoping Review of Modifiable Risk Factors in Pediatric Onset Multiple Sclerosis: Building for the Future

Children ◽

10.3390/children5110146 ◽

2018 ◽

Vol 5 (11) ◽

pp. 146 ◽

Cited By ~ 2

Author(s):

Julie Pétrin ◽

Max Fiander ◽

Prenitha Doss ◽

E. Yeh

Keyword(s):

Physical Activity ◽

Multiple Sclerosis ◽

Vitamin D ◽

Relapse Rate ◽

Scoping Review ◽

Full Text ◽

Lifestyle Factors ◽

Increased Risk ◽

Modifiable Lifestyle Factors ◽

Pediatric Onset

Knowledge of the effect of modifiable lifestyle factors in the pediatric multiple sclerosis (MS) population is limited. We therefore conducted a scoping review, following the framework provided by Arksey and O’Malley. Four databases were searched for pediatric MS and modifiable lifestyle factors using index terms and keywords, from inception to May 2018. All quantitative and qualitative primary articles were included and limited to English and full text. Of the 7202 articles identified and screened, 25 full-text articles were relevant to our objective and were included. These articles focused on diet obesity, physical activity, and sleep. In cross-sectional analyses, these lifestyle factors were associated with increased risk of pediatric onset MS (POMS), and increased disease activity. Diet, particularly vitamin D and vegetable intake, was associated with reduced relapse rate. Obesity was linked to increased risk of POMS, and physical activity was associated with reduced relapse rate and sleep/rest fatigue. Thus, available studies of lifestyle related outcomes in pediatric MS suggest specific lifestyle related factors, including obesity, higher vitamin D levels, and higher physical activity may associate with lower disease burden in POMS. Studies reviewed are limited by their observational designs. Future studies with longitudinal and experimental designs may further clarify the role of modifiable lifestyle factors in this population.

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Olfactory dysfunction in Multiple Sclerosis: A scoping review of the literature

Multiple Sclerosis and Related Disorders ◽

10.1016/j.msard.2015.12.002 ◽

2016 ◽

Vol 6 ◽

pp. 1-9 ◽

Cited By ~ 23

Author(s):

Elisabeth B. Lucassen ◽

Anthony Turel ◽

Amy Knehans ◽

Xuemei Huang ◽

Paul Eslinger

Keyword(s):

Multiple Sclerosis ◽

Scoping Review ◽

Olfactory Dysfunction ◽

Review Of The Literature

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A Novel Haplotype of the Endogenous Retrovirus, HRES-1, in Patients with Multiple Sclerosis and Healthy Individuals

Autoimmunity ◽

10.3109/08916939908995384 ◽

1999 ◽

Vol 29 (2) ◽

pp. 141-145 ◽

Cited By ~ 8

Author(s):

H. B. Rasmussen ◽

J. Clausen

Keyword(s):

Multiple Sclerosis ◽

Endogenous Retrovirus ◽

Healthy Individuals

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Proton MR Spectroscopy and MR Imaging in Acute and Chronic Multiple Sclerosis — Ringlike Appearances in Acute Plaques

Acta Radiologica ◽

10.1177/02841851960371p160 ◽

1996 ◽

Vol 37 (1P1) ◽

pp. 278-287 ◽

Cited By ~ 7

Author(s):

A.-M. Landtblom ◽

L. Sjöqvist ◽

B. Söderfeldt ◽

H. Nyland ◽

K.-Å. Thuomas

Keyword(s):

Multiple Sclerosis ◽

Relaxation Time ◽

Mr Imaging ◽

Brain Lesions ◽

T2 Relaxation Time ◽

Healthy Individuals ◽

T2 Relaxation ◽

Proton Mrs ◽

Proton Mr Spectroscopy ◽

The Core

Purpose: We wanted to compare the metabolite status of brain lesions in different clinical subtypes of multiple sclerosis (MS). Two acute MS lesions with ringlike appearances were also investigated. Material and Methods: Twenty-three clinically stable MS patients, 2 patients with acute relapses, and 15 healthy individuals were examined by MR imaging and localized proton MRS. Results: No metabolite differences were seen in plaques of different subtypes. Decreased NAA/Cr and NAA/choline ratios as well as increased inositol/Cr ratios were observed in the plaques of the clinically stable or chronic active MS patients as compared with controls. The ring plaques had hyperintense cores with surrounding halos, separated from the cores by rings with low signal intensity in T2-weighted images. The core exhibited a prolonged T2 relaxation time. Proton spectra initially contained lactate. Conclusion: No differences between the metabolite status of nonacute plaques in different clinical subtypes could be detected. The ring plaques contained lactate signals indicating oedema, inflammation, and macrophage invasion, and may be transition forms between acute oedematous lesions and chronic demyelinated plaques.

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