Pulmonary function tests (maximum inspiratory pressure, maximum expiratory pressure, vital capacity, forced vital capacity) predict ventilator use in late-onset Pompe disease

<p> Due to regular exercises, athletes tend to have an increase in pulmonary functions when compared to non exercising individuals, especially when the exercise is strenuous. Intensity and severity of sports engaged in by the athletes determines the extent of strengthening of the inspiratory muscles with a resultant increase in the lung volumes and capacities. Pulmonary parameters like tidal volume and forced vital capacity are significantly higher in athletes than in non athletes. A cross sectional comparative study was carried out in national sports council, Tribhuvan army club and institute of medicine, Kathmandu, Nepal. The athletes were footballers from Tribhuvan army club and sprinters from national sports council. The non-athletes were medical students from the institute of medicine, Kathmandu. Data were collected after performing spirometry and mean values were compared between athletes and non-athletes. Pulmonary functions were assessed based on forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1) and peak expiratory flow rate (PEFR) expressed as percent predicted for the age, sex, height, weight and race. Spirometry was performed in 169 subjects, out of which 84 were athletes and 85 were non-athletes. Athletes had a significantly superior FVC (P =0.00) compared to non-athletes. FEV1 was also recorded significantly higher in athletes than in non-athletes (P=0.023). Athletes have better pulmonary function tests than non-athletes because exercise in athletes strengthens the muscles of respiration. </p>

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Modeling of changes in forced vital capacity and late-onset Pompe disease related outcomes

Molecular Genetics and Metabolism ◽

10.1016/j.ymgme.2016.11.141 ◽

2017 ◽

Vol 120 (1-2) ◽

pp. S62

Author(s):

Alaa Hamed ◽

Steve Kanters ◽

Andrew Stewart ◽

Milki Tilimo ◽

Anna Bolzani ◽

...

Keyword(s):

Forced Vital Capacity ◽

Pompe Disease ◽

Vital Capacity ◽

Late Onset

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Incidence of Exercise-Induced Asthma in Children

PEDIATRICS ◽

10.1542/peds.56.5s.847 ◽

1975 ◽

Vol 56 (5s) ◽

pp. 847-850

Author(s):

C. Warren Bierman ◽

Isamu Kawabori ◽

William E. Pierson

Keyword(s):

Pulmonary Function ◽

Forced Vital Capacity ◽

Vital Capacity ◽

Pulmonary Function Tests ◽

Forced Expiratory Volume ◽

Running Exercise ◽

Airway Function ◽

Free Running ◽

Asthma In Children ◽

Exercise Induced

The incidence of exercise-induced asthma (EIA) was studied in 134 asthmatic, 102 nonasthmatic atopic, and 56 nonatopic children. Pulmonary function tests measuring forced vital capacity (FVC) and one-second forced expiratory volume (FEV1) were performed on each child prior to and serially for 20 minutes following free running exercise. The incidence of EIA among the asthmatic and atopic nonasthmatic children was 63% and 41% respectively, and 7% among control subjects. Airway function was studied prior to and after a standardized free running exercise test. Forty-one percent of the nonasthmatic and 63% of the asthmatic atopic children had a significant decrease in airway function as compared to 5% of the nonallergic subjects.

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Effects of exercise on pulmonary function tests: A comparative study between athletes and non-athletes in Nepalese settings

Journal of Chitwan Medical College ◽

10.3126/jcmc.v6i1.16575 ◽

2017 ◽

Vol 6 (1) ◽

pp. 21-23

Author(s):

N B Mahotra ◽

T M Amatya ◽

B SJB Rana ◽

D Banstola

Keyword(s):

Comparative Study ◽

Pulmonary Function ◽

Forced Vital Capacity ◽

Vital Capacity ◽

Pulmonary Function Tests ◽

Institute Of Medicine ◽

Cross Sectional ◽

Pulmonary Functions ◽

Inspiratory Muscles ◽

Function Tests

Due to regular exercises, athletes tend to have an increase in pulmonary functions when compared to non exercising individuals, especially when the exercise is strenuous. Intensity and severity of sports engaged in by the athletes determines the extent of strengthening of the inspiratory muscles with a resultant increase in the lung volumes and capacities. Pulmonary parameters like tidal volume and forced vital capacity are significantly higher in athletes than in non athletes. A cross sectional comparative study was carried out in national sports council, Tribhuvan army club and institute of medicine, Kathmandu, Nepal. The athletes were footballers from Tribhuvan army club and sprinters from national sports council. The non-athletes were medical students from the institute of medicine, Kathmandu. Data were collected after performing spirometry and mean values were compared between athletes and non-athletes. Pulmonary functions were assessed based on forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1) and peak expiratory flow rate (PEFR) expressed as percent predicted for the age, sex, height, weight and race. Spirometry was performed in 169 subjects, out of which 84 were athletes and 85 were non-athletes. Athletes had a significantly superior FVC (P =0.00) compared to non-athletes. FEV1 was also recorded significantly higher in athletes than in non-athletes (P=0.023). Athletes have better pulmonary function tests than non-athletes because exercise in athletes strengthens the muscles of respiration.

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Effects of Breast Reduction on Pulmonary Function

International Surgery ◽

10.9738/intsurg-d-13-00060.1 ◽

2014 ◽

Vol 99 (4) ◽

pp. 300-304 ◽

Cited By ~ 2

Author(s):

Yavuz Kececi ◽

Seyhan Dagistan

Keyword(s):

Pulmonary Function ◽

Chest Wall ◽

Forced Vital Capacity ◽

Vital Capacity ◽

Breast Reduction ◽

Pulmonary Function Tests ◽

T Test ◽

Chest Wall Compliance ◽

Wall Compliance ◽

Paired T Test

Abstract Macromastia causes several health problems, and reduction surgery alleviates them successfully. The purpose of this study was to investigate whether reduction mammaplasty improves possible impairments on pulmonary functions related to macromastia. Thirty-one patients participated in the study. Pulmonary function tests were performed before and 3 months after surgery with a spirometry. Preoperative and postoperative pulmonary function values were compared using a paired t test. Two patients were found to have mild restriction in preoperative spirometric analysis, and they went to normal range in postoperative analysis. All other patients were assessed as having normal values in both preoperative and postoperative analyses. Preoperative and postoperative forced vital capacity values were 2.72 ± 0.06 and 2.79 ± 0.05 L, respectively. The difference was statistically significant (paired t test, P = 0.014). The other parameter in which breast reduction had statistically significant improvement was forced vital capacity performed/predicted ratio (paired t test, P = 0.041). Additionally, the weight of resected breast tissue correlated significantly with the change of forced vital capacity (Pearson correlation coefficient = 0.379, P = 0.036). Breast reduction surgery improves the pulmonary function parameters that are mainly influenced by restrictive states. This result led us to consider that macromastia causes a relative restriction in chest wall compliance, and reduction of breast weight may enhance chest wall compliance and improve pulmonary function.

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The impact of interrupting enzyme replacement therapy in late-onset Pompe disease

Journal of Neurology ◽

10.1007/s00415-021-10475-z ◽

2021 ◽

Author(s):

Stephan Wenninger ◽

Kristina Gutschmidt ◽

Corinna Wirner ◽

Krisztina Einvag ◽

Federica Montagnese ◽

...

Keyword(s):

Clinical Outcome ◽

Adverse Events ◽

Enzyme Replacement Therapy ◽

Pulmonary Function ◽

Replacement Therapy ◽

Pompe Disease ◽

Late Onset ◽

Pulmonary Function Tests ◽

Enzyme Replacement ◽

The Impact

Abstract Background Late-onset Pompe disease (LOPD) is a rare autosomal recessive disorder caused by mutations in the GAA gene, leading to progressive weakness of locomotor and respiratory muscles. Enzyme replacement therapy (ERT), administered every second week, has been proven to slow down disease progression and stabilize pulmonary function. Due to the COVID-19 pandemic in Germany, ERT was interrupted at our centre for 29 days. As reports on ERT discontinuation in LOPD are rare, our study aimed to analyse the impact of ERT interruption on the change in clinical outcome. Methods We performed a prospective cohort study in 12 LOPD patients. Clinical assessments were performed after ERT interruption and after the next three consecutive infusions. We assessed motor function by muscle strength testing, a 6-minute-walk-test, pulmonary function tests, and adverse events. For statistical analysis, an estimated baseline was calculated based on the individual yearly decline. Results The mean time of ERT interruption was 49.42 days (SD ± 12.54). During ERT interruption, seven patients reported 14 adverse events and two of them were severe. Frequent symptoms were reduced muscle endurance/increased muscle fatigability and shortness of breath/worsening of breathing impairment. After ERT interruption, significant deterioration was found for MIP%pred (p = 0.026) and MRC%pred, as well as a trend to clinical deterioration in FVC%pred and the 6MWT%pred. Conclusion Interruption of ERT was associated with a deterioration in the core clinical outcome measures. Therefore, an interruption of ERT should be kept as short as possible.

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Pulmonary functions in car air conditioner users and non-air conditioner users in tertiary care centre, South Tamilnadu, India

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20193938 ◽

2019 ◽

Vol 7 (9) ◽

pp. 3510

Author(s):

Hoshea Jeba Ruth S. ◽

Lisha Vincent

Keyword(s):

Pulmonary Function ◽

Forced Vital Capacity ◽

Vital Capacity ◽

Pulmonary Function Tests ◽

Forced Expiratory Volume ◽

Control Group ◽

Air Conditioner ◽

Air Conditioners ◽

Function Tests ◽

Expiratory Flow

Background: Air conditioners are used extensively these days of the modern lifestyle. Inhalation of cold dry air while using Air conditioners causes bronchoconstriction due to which alteration may occur in pulmonary function. This study was aimed to compare the Pulmonary Function tests of Car AC users and non AC users. Methods: The Study included 52 employees not exposed to car air conditioner as a control (group I) and 52 employees exposed to car air conditioner with minimum exposure of 1 hour per day for 6 months as a subject (group II). Pulmonary function tests were performed using computerised spirometer. Statistical analysis was done by unpaired t test.Results: Age, Height and weight are not statistically significant between study group and control group. Forced vital capacity, forced expiratory volume in 1 second, Ratio of Forced vital capacity and Forced expiratory volume in 1 second, Inspiratory reserve volume, Expiratory reserve volume, Maximum voluntary ventilation are decreased in car air conditioner users compared to non-users, but was not significant. Forced expiratory flow (FEF), Peak expiratory flow rate (PEFR) values shows statistically significant decreased in car air conditioner users.Conclusions: The present study shows hyper-responsive airways on exposure to cold air which leads to bronchoconstriction. The significant decrease in PEFR, FEF suggest that upper airways as well as smaller airways are affected on exposure to car AC. So, Exposure to car Air Conditioner leads to risk of developing respiratory dysfunction.

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A study of pulmonary function abnormalities in obese individuals

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20200520 ◽

2020 ◽

Vol 8 (3) ◽

pp. 811

Author(s):

Bhumika T. Vaishnav ◽

Tushar V. Tonde

Keyword(s):

Pulmonary Function ◽

Forced Vital Capacity ◽

Vital Capacity ◽

Pulmonary Function Tests ◽

Forced Expiratory Volume ◽

The Body ◽

Serum Samples ◽

Skin Fold Thickness ◽

Skin Fold ◽

Triceps Skin Fold

Background: Previous studies suggest that obese individuals are prone to pulmonary function abnormalities. The aim of this study was to evaluate pulmonary function tests in obese individuals and to relate pulmonary abnormalities if any found to lipid abnormalities and to the extent and duration of obesity.Methods: This prospective study was done on 40 obese patients attending to Dr. D. Y. Patil Hospital, Mumbai with complaints of pulmonary functions during the period from January to December 2012. Pulmonary function test was done with the help of Jaegers pneumoscreen. The percentage of body fat was determined by using triceps skin fold thickness technique by using Vernier callipers. Fasting serum samples was collected to analyses cholesterol and triglycerides.Results: Female preponderance was seen in the study (57.5%). Forced expiratory volume, forced vital capacity, maximum mid expiratory flow rate was significantly reduced and the ratio of forced expiratory volume in one second to forced vital capacity was significantly increased in individuals who had abnormal pulmonary function. Decrease in pulmonary function was noted with increased levels of cholesterol and triglyceride but the correlation was not significant.Conclusions: Obese individuals although asymptomatic have significant lung function abnormality in the form of restrictive as well as obstructive pattern. Hence, reduction in the body weight may help in reversal of the pulmonary function indices.

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