scholarly journals Gadolinium-enhanced brain lesions in multiple sclerosis relapse

Neurología ◽  
2021 ◽  
Author(s):  
L. Martín-Aguilar ◽  
S. Presas-Rodriguez ◽  
À. Rovira ◽  
J. Capellades ◽  
A. Massuet-Vilamajó ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Lesions ◽  
Multiple Sclerosis Relapse

scholarly journals CSF proteome in multiple sclerosis subtypes related to brain lesion transcriptomes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria L. Elkjaer ◽  
Arkadiusz Nawrocki ◽  
Tim Kacprowski ◽  
Pernille Lassen ◽  
Anja Hviid Simonsen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Protein Phosphatase ◽  
Brain Lesion ◽  
Brain Lesions ◽  
Cns Diseases ◽  
Secondary Progressive ◽  
Apolipoprotein A ◽  
Proteomic Approach ◽  
Apolipoprotein C ◽  
Altered Proteins

AbstractTo identify markers in the CSF of multiple sclerosis (MS) subtypes, we used a two-step proteomic approach: (i) Discovery proteomics compared 169 pooled CSF from MS subtypes and inflammatory/degenerative CNS diseases (NMO spectrum and Alzheimer disease) and healthy controls. (ii) Next, 299 proteins selected by comprehensive statistics were quantified in 170 individual CSF samples. (iii) Genes of the identified proteins were also screened among transcripts in 73 MS brain lesions compared to 25 control brains. F-test based feature selection resulted in 8 proteins differentiating the MS subtypes, and secondary progressive (SP)MS was the most different also from controls. Genes of 7 out these 8 proteins were present in MS brain lesions: GOLM was significantly differentially expressed in active, chronic active, inactive and remyelinating lesions, FRZB in active and chronic active lesions, and SELENBP1 in inactive lesions. Volcano maps of normalized proteins in the different disease groups also indicated the highest amount of altered proteins in SPMS. Apolipoprotein C-I, apolipoprotein A-II, augurin, receptor-type tyrosine-protein phosphatase gamma, and trypsin-1 were upregulated in the CSF of MS subtypes compared to controls. This CSF profile and associated brain lesion spectrum highlight non-inflammatory mechanisms in differentiating CNS diseases and MS subtypes and the uniqueness of SPMS.

scholarly journals Elucidating distinct clinico-radiologic signatures in the borderland between neuromyelitis optica and multiple sclerosis

2021 ◽  
Author(s):  
Maciej Juryńczyk ◽  
Elżbieta Klimiec-Moskal ◽  
Yazhuo Kong ◽  
Samuel Hurley ◽  
Silvia Messina ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Neuromyelitis Optica ◽  
Unmet Need ◽  
Transverse Myelitis ◽  
Overlap Syndrome ◽  
Brain Lesions ◽  
Central Vein ◽  
Normal Brain ◽  
Group 4 ◽  
Group 2

Abstract Background Separating antibody-negative neuromyelitis optica spectrum disorders (NMOSD) from multiple sclerosis (MS) in borderline cases is extremely challenging due to lack of biomarkers. Elucidating different pathologies within the likely heterogenous antibody-negative NMOSD/MS overlap syndrome is, therefore, a major unmet need which would help avoid disability from inappropriate treatment. Objective In this study we aimed to identify distinct subgroups within the antibody-negative NMOSD/MS overlap syndrome. Methods Twenty-five relapsing antibody-negative patients with NMOSD features underwent a prospective brain and spinal cord MRI. Subgroups were identified by an unsupervised algorithm based on pre-selected NMOSD/MS discriminators. Results Four subgroups were identified. Patients from Group 1 termed “MS-like” (n = 6) often had central vein sign and cortical lesions (83% and 67%, respectively). All patients from Group 2 (“spinal MS-like”, 8) had short-segment myelitis and no MS-like brain lesions. Group 3 (“classic NMO-like”, 6) had high percentage of bilateral optic neuritis and longitudinally extensive transverse myelitis (LETM, 80% and 60%, respectively) and normal brain appearance (100%). Group 4 (“NMO-like with brain involvement”, 5) typically had a history of NMOSD-like brain lesions and LETM. When compared with other groups, Group 4 had significantly decreased fractional anisotropy in non-lesioned tracts (0.46 vs. 0.49, p = 0.003) and decreased thalamus volume (0.84 vs. 0.98, p = 0.04). Conclusions NMOSD/MS cohort contains distinct subgroups likely corresponding to different pathologies and requiring tailored treatment. We propose that non-conventional MRI might help optimise diagnosis in these challenging patients.

Selection for T-cell receptor Vβ–Dβ–Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis

Nature ◽  
1993 ◽  
Vol 362 (6415) ◽  
pp. 68-70 ◽  
Author(s):  
Jorge R. Oksenberg ◽  
Michael A. Panzara ◽  
Ann B. Begovich ◽  
Dennis Mitchell ◽  
Henry A. Erlich ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Myelin Basic Protein ◽  
T Cell Receptor ◽  
Basic Protein ◽  
Cell Receptor ◽  
Brain Lesions ◽  
Gene Rearrangements ◽  
Selection For ◽  
T Cell Receptor Vβ

scholarly journals Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse

2011 ◽  
Vol 8 (1) ◽  
pp. 2 ◽  
Author(s):  
Ana Longhini ◽  
Felipe von Glehn ◽  
Carlos Brandão ◽  
Rosemeire FO de Paula ◽  
Fernando Pradella ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Dendritic Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Multiple Sclerosis Relapse

Proton MR Spectroscopy and MR Imaging in Acute and Chronic Multiple Sclerosis — Ringlike Appearances in Acute Plaques

1996 ◽  
Vol 37 (1P1) ◽  
pp. 278-287 ◽  
Author(s):  
A.-M. Landtblom ◽  
L. Sjöqvist ◽  
B. Söderfeldt ◽  
H. Nyland ◽  
K.-Å. Thuomas
Keyword(s):  
Multiple Sclerosis ◽  
Relaxation Time ◽  
Mr Imaging ◽  
Brain Lesions ◽  
T2 Relaxation Time ◽  
Healthy Individuals ◽  
T2 Relaxation ◽  
Proton Mrs ◽  
Proton Mr Spectroscopy ◽  
The Core

Purpose: We wanted to compare the metabolite status of brain lesions in different clinical subtypes of multiple sclerosis (MS). Two acute MS lesions with ringlike appearances were also investigated. Material and Methods: Twenty-three clinically stable MS patients, 2 patients with acute relapses, and 15 healthy individuals were examined by MR imaging and localized proton MRS. Results: No metabolite differences were seen in plaques of different subtypes. Decreased NAA/Cr and NAA/choline ratios as well as increased inositol/Cr ratios were observed in the plaques of the clinically stable or chronic active MS patients as compared with controls. The ring plaques had hyperintense cores with surrounding halos, separated from the cores by rings with low signal intensity in T2-weighted images. The core exhibited a prolonged T2 relaxation time. Proton spectra initially contained lactate. Conclusion: No differences between the metabolite status of nonacute plaques in different clinical subtypes could be detected. The ring plaques contained lactate signals indicating oedema, inflammation, and macrophage invasion, and may be transition forms between acute oedematous lesions and chronic demyelinated plaques.

scholarly journals Seasonal variation in multiple sclerosis relapse

2017 ◽  
Vol 264 (6) ◽  
pp. 1059-1067 ◽  
Author(s):  
Katharine Harding ◽  
Kate Tilling ◽  
Claire MacIver ◽  
Mark Willis ◽  
Fady Joseph ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Seasonal Variation ◽  
Multiple Sclerosis Relapse
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