Antioxidant vitamin supplementation prevents oxidative stress but does not enhance performance in young football athletes

Nutrition ◽  
2019 ◽  
Vol 63-64 ◽  
pp. 29-35 ◽  
Author(s):  
Donizete C.X. de Oliveira ◽  
Flavia Troncon Rosa ◽  
Lívia Simões-Ambrósio ◽  
Alceu Afonso Jordao ◽  
Rafael Deminice
Keyword(s):  
Oxidative Stress ◽  
Vitamin Supplementation ◽  
Antioxidant Vitamin

Antioxidant vitamins induce angiogenesis in the normal pig kidney

2007 ◽  
Vol 293 (1) ◽  
pp. F371-F381 ◽  
Author(s):  
Elena Daghini ◽  
Xiang-Yang Zhu ◽  
Daniele Versari ◽  
Michael D. Bentley ◽  
Claudio Napoli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vascular Function ◽  
Ex Vivo ◽  
Antioxidant Vitamins ◽  
Vitamin Supplementation ◽  
Spatial Density ◽  
Antioxidant Vitamin ◽  
High Dose ◽  
Vascular Endothelial ◽  
Microvascular Proliferation

The effects of chronic supplementation with antioxidant vitamins on angiogenesis are controversial. The aim of the present study was to evaluate in kidneys of normal pigs the effect of chronic supplementation with vitamins E and C, at doses that are effective in reducing oxidative stress and attenuating angiogenesis under pathological conditions. Domestic pigs were randomized to receive a 12-wk normal diet without ( n = 6) or with antioxidant vitamins supplementation (1g/day vitamin C, 100 IU·kg−1·day−1 vitamin E; n = 6). Electron beam computed tomography (CT) was used to evaluate renal cortical vascular function in vivo, and micro-CT was to assess the spatial density and average diameter of cortical microvessels (diameter <500 μm) ex vivo. Oxidative stress and expressions of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF)-1α were evaluated in renal tissue. The effects of increasing concentrations of the same vitamins on redox status and angiogenesis were also evaluated in human umbilical vascular endothelial cells (HUVEC). Compared with normal pigs, the density of cortical transmural microvessels was significantly greater in vitamin-supplemented pigs (149.0 ± 11.7 vs. 333.8 ± 48.1 vessel/cm2, P < 0.05), whereas the cortical perfusion response to ACh was impaired. This was accompanied by a significant increase in tissue oxidative stress and levels of VEGF and HIF-1α. A low dose of antioxidant decreased, whereas a high dose increased, HUVEC oxidative stress and angiogenesis, which was partly mediated by hydrogen peroxide. Antioxidant vitamin supplementation can increase tissue oxidative redox and microvascular proliferation in the normal kidney, probably due to a biphasic effect that depends on basal redox balance.

Antioxidant vitamin supplementation in Crohn's disease decreases oxidative stress: a randomized controlled trial

2003 ◽  
Vol 98 (2) ◽  
pp. 348-353 ◽  
Author(s):  
Elaheh Aghdassi ◽  
Barbara E. Wendland ◽  
A.Hillary Steinhart ◽  
Stephen L. Wolman ◽  
Khursheed Jeejeebhoy ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Randomized Controlled Trial ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Controlled Trial ◽  
Vitamin Supplementation ◽  
Antioxidant Vitamin ◽  
Randomized Controlled

A Soccer Match’s Ability to Enhance Lymphocyte Capability to Produce ROS and Induce Oxidative Damage

2009 ◽  
Vol 19 (3) ◽  
pp. 243-258 ◽  
Author(s):  
Miguel David Ferrer ◽  
Pedro Tauler ◽  
Antoni Sureda ◽  
Pedro Pujol ◽  
Franchec Drobnic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Coenzyme Q ◽  
Training Period ◽  
Antioxidant Vitamin ◽  
Antioxidant Enzyme Activities ◽  
Double Blind ◽  
Soccer Match ◽  
Before And After ◽  
Soccer Training

Soccer-associated oxidative stress has barely been studied. The aims of this study were to establish the effect of a soccer training match and the effect of a diet supplementation with a multivitamin complex and coenzyme Q during 3 months of soccer training on the pro-oxidant and antioxidant status of lymphocytes. In a randomized, double-blind trial, 19 male preprofessional soccer players were treated with either an antioxidant nutrient cocktail or placebo for 90 days. After this period the athletes played a soccer match lasting 60 min. All determinations were made under basal conditions before and after the training period and after the match. Basal lymphocyte hydrogen peroxide (H2O2) production did not change after the 3 months of training. Catalase activity decreased (about 50%) after the 3 months, whereas glutathione reductase increased its activity (150–200%) both with placebo and in the supplemented group. Basal ascorbate levels were maintained during the training period, whereas α-tocopherol and MDA decreased (about 40%) in both groups. The match increased H2O2 production (180%) in both groups when the lymphocytes were stimulated with phorbol myristate acetate, and it also increased MDA levels (150%). Antioxidant enzyme activities and antioxidant vitamin levels were maintained before and after the match. Regular soccer training modifies the lymphocyte strategy to eliminate ROS and increases protection against oxidative damage. A friendly soccer match raises lymphocyte capacity to produce ROS and oxidative damage, but it is not enough to induce a defensive response, thus leading to a situation of postexercise oxidative stress. Supplementation with low doses of antioxidant vitamins and coenzyme Q does not modify the endogenous antioxidant response to training.

scholarly journals Has Oxidative Stress any Role on Mechanisms of Aminophylline – Induced Seizures? An Animal Study

2015 ◽  
Vol 12 (4) ◽  
pp. 269-274 ◽  
Author(s):  
UK Roy ◽  
M Pal ◽  
S Datta ◽  
S Harlalka
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Free Radical ◽  
Molecular Mechanisms ◽  
Clinical History ◽  
Antioxidant Vitamin ◽  
Dependent Manner ◽  
Free Radical Generation ◽  
Radical Generation ◽  
Pre Treatment

Background Aminophylline can trigger seizures in patients without known underlying epilepsy or added risk factor for seizure exacerbation in epilepsy. Most of these seizures are difficult to control and are underappreciated compared to other drug toxicities. Despite a long clinical history of aminophylline-induced seizures, relatively little is known about the underlying molecular mechanisms that contribute to methylxanthine-induced seizure generation.Objective The present study evaluated the possible involvement of free radicals in aminophylline induced seizures in rat.Method The rats were divided into two groups. The first group graded single doses of aminophylline from 100 to 300 mg/kg were administered intraperitoneally. On the basis of the results Aminophylline, a dose (300 mg/kg) producing tonic-clonic seizures and mortality in 100% animals was selected as control in the study. The second group were subjected to single antioxidant (Vitamin E or Vitamin C) or in combination for 45 days then single doses of aminophylline 300 mg/kg administered intraperitoneally to rats.Result Aminophylline induced convulsions in rats in a dose-dependent manner, and both incidence of seizure and mortality were maximum at 300 mg/kg and there was significant increase of free radical generation. But though pre-treatment with antioxidants showed differential attenuating effects on aminophylline induced free radical generation as we all known but they were very much ineffective in antagonizing aminophylline induced seizures and post-seizure mortality by any appreciable extent.Conclusion Though Aminophylline induces oxidative stress the results are suggestive that at least free radicals is not only cause of convulsiogenic effects and post-seizure mortality of aminophylline.Kathmandu University Medical Journal Vol.12(4) 2014; 269-274

scholarly journals The Effects of a 6-Month Omega Fatty Acid and Antioxidant Vitamin Supplementation on Functional Capacity and Cognitive Function in Older Adults with Cognitive Impairment

Proceedings ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 36
Author(s):  
Stavrinou ◽  
Andreou ◽  
Aphamis ◽  
Ioannou ◽  
Pantzaris ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Fatty Acid ◽  
Cognitive Function ◽  
Functional Capacity ◽  
Vitamin Supplementation ◽  
Antioxidant Vitamin ◽  
High Dose ◽  
Omega 3 ◽  
Omega Fatty Acid

Aim: Aging is associated with declines in functional capacity and cognitive function. The aim of the present study was to examine, for the first time, the effects of a high-dose omega-3 and omega-6 fatty acid supplementation, in combination with antioxidant vitamins, on functional capacity and cognitive function in older adults with cognitive impairment, over a 6-month period in a randomized, double-blind, placebo-controlled design. Material & Method: Thirty-six older adults with cognitive impairment (aged 79.3 ± 7.6 yrs, 22 females) were randomized to receive either a formula containing a mixture of omega-3 and omega-6 fatty acids with antioxidant vitamins or placebo for six months. Participants completed assessments of functional capacity, cognitive function, and various aspects of quality of life at baseline and following three and six months of supplementation. Functional capacity was evaluated using two sit-to-stand tests (STS-5, STS-60), the timed-up-and-go test (TUG), the 6-min walk test (6MWT), and the handgrip strength test. Cognitive function was evaluated through the Addenbrooke’s Cognitive Examination Revised (ACE-R) and the Mini Mental State Examination (MMSE), whilst health-related quality of life, sleep quality, daily sleepiness, and fatigue were assessed by specific questionnaires. A linear mixed model with a random effect for participant was used to evaluate differences in the dependent variables between the supplementation and placebo groups throughout time, whilst it was adjusted for age and education of the participants. Results: A significant interaction between supplementation and time was found on functional capacity (6MWT and STS-60; p = 0.028 and p = 0.032, respectively), cognitive function (ACER and MMSE; p < 0.001 and p = 0.011, respectively), fatigue (p < 0.001), physical health component (p = 0.007), and daily sleepiness (p = 0.007), showing a favorable improvement for the participants receiving the nutritional supplement. Conclusions: The results of the present study showed that high-dose omega fatty acid and antioxidant vitamin supplementation improves functional capacity and cognitive function in older adults with cognitive impairment. Thus, this novel approach appears promising for reducing cognitive decline and frailty in the elderly.

scholarly journals Effects of Redox Modulation on Cell Proliferation, Viability, and Migration in Cultured Rat and Human Tendon Progenitor Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Yuk Wa Lee ◽  
Sai Chuen Fu ◽  
Man Yi Yeung ◽  
Chun Man Lawrence Lau ◽  
Kai Ming Chan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Proliferation ◽  
Vitamin C ◽  
Tendon Healing ◽  
In Vitro Study ◽  
Tendon Injury ◽  
Antioxidant Vitamin ◽  
Redox Modulation ◽  
And Migration

Tendon healing is slow and usually results in inferior fibrotic tissue formation. Recently, application of tendon derived stem cells (TDSCs) improved tendon healing in animal studies. In a chicken model, local injection of antioxidants reduced tendon adhesion after tendon injury. An in vitro study demonstrated that supplementation of H2O2reduced tenogenic marker expression in TDSCs. These findings suggested that the possibility of TDSCs is involved in tendon healing and the cellular activities of TDSCs might be affected by oxidative stress of the local environment. After tendon injury, oxidative stress is increased. Redox modulation might affect healing outcomes via affecting cellular activities in TDSCs. To study the effect of oxidative stress on TDSCs, the cellular activities of rat/human TDSCs were measured under different dosages of vitamin C or H2O2in this study. Lower dose of vitamin C increased cell proliferation, viability and migration; H2O2affected colony formation and suppressed cell migration, cell viability, apoptosis, and proliferation. Consistent with previous studies, oxidative stresses (H2O2) affect both recruitment and survival of TDSCs, while the antioxidant vitamin C may exert beneficial effects at low doses. In conclusion, redox modulation affected cellular activities of TDSCs and might be a potential strategy for tendon healing treatment.

Sign in / Sign up

Export Citation Format

Share Document