Activation of ERK1/2 and cyclin D1 expression in oral tongue squamous cell carcinomas: Relationship between clinicopathological appearances and cell proliferation

Oral Oncology ◽  
2006 ◽  
Vol 42 (6) ◽  
pp. 625-631 ◽  
Author(s):  
Lihong Wang ◽  
Tingjiao Liu ◽  
Mai Nishioka ◽  
Rodelio L. Aguirre ◽  
Swe Swe Win ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cyclin D1 ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Oral Tongue

scholarly journals Cyclin D1 expression is correlated with cell differentiation and cell proliferation in oral squamous cell carcinomas

2014 ◽  
Vol 7 (4) ◽  
pp. 1123-1127 ◽  
Author(s):  
YUICHI OHNISHI ◽  
MASAHIRO WATANABE ◽  
MASAHIRO WATO ◽  
AKIO TANAKA ◽  
KENJI KAKUDO ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Differentiation ◽  
Cyclin D1 ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas

Cyclin D1 expression in oral squamous cell carcinomas: clinicopathological relevance and correlation with p53 expression

2000 ◽  
Vol 29 (4) ◽  
pp. 167-172 ◽  
Author(s):  
King Y. Lam ◽  
Irene O. L. Ng ◽  
Anthony P. W. Yuen ◽  
Dora L. W. Kwong ◽  
William Wei
Keyword(s):  
Cyclin D1 ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
P53 Expression ◽  
Oral Squamous Cell Carcinomas

scholarly journals Differential mechanisms ofCDKN2A(p16) alteration in oral tongue squamous cell carcinomas and correlation with patient outcome

2014 ◽  
Vol 135 (4) ◽  
pp. 887-895 ◽  
Author(s):  
Annette M. Lim ◽  
Hongdo Do ◽  
Richard J. Young ◽  
Stephen Q. Wong ◽  
Christopher Angel ◽  
...  
Keyword(s):  
Patient Outcome ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Oral Tongue

Loss of p21WAF1/CIP1 expression in invasive fronts of oral tongue squamous cell carcinomas is correlated with tumor progression and poor prognosis

2005 ◽  
Author(s):  
Mitsuo Goto ◽  
Tetsuya Tsukamoto ◽  
Ken-ichi Inada ◽  
Tsutomu Mizoshita ◽  
Tetsuya Ogawa ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Squamous Cell Carcinomas ◽  
Oral Tongue

scholarly journals The Significance of the Dysregulation of Canonical Wnt Signaling in Head and Neck Squamous Cell Carcinomas

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 723 ◽  
Author(s):  
Jarosław Paluszczak
Keyword(s):  
Cell Proliferation ◽  
Head And Neck Cancer ◽  
Wnt Signaling ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
Wnt Signaling Pathway ◽  
Squamous Cell Carcinomas ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

The knowledge about the molecular alterations which are found in head and neck squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are still awaiting the translation of this knowledge to new diagnostic and therapeutic options. Among the many molecular changes that are detected in head and neck cancer, the abnormalities in several signaling pathways, which regulate cell proliferation, cell death and stemness, seem to be especially promising with regard to the development of targeted therapies. Canonical Wnt signaling is a pathway engaged in the formation of head and neck tissues, however it is not active in adult somatic mucosal cells. The aim of this review paper is to bring together significant data related to the current knowledge on the mechanisms and functional significance of the dysregulation of the Wnt/β-catenin pathway in head and neck tumors. Research evidence related to the role of Wnt signaling activation in the stimulation of cell proliferation, migration and inhibition of apoptosis in HNSCC is presented. Moreover, its role in promoting stemness traits in head and neck cancer stem-like cells is described. Evidence corroborating the hypothesis that the Wnt signaling pathway is a very promising target of novel therapeutic interventions in HNSCC is also discussed.

394 Cyclin D1 gene amplification in human laryngeal squamous cell carcinomas: An independent prognostic factor

1995 ◽  
Vol 31 ◽  
pp. S86
Author(s):  
G. Almadori ◽  
A. Bellacosa ◽  
G. Cadoni ◽  
S. Cavallo ◽  
G. Ferrandina ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Cyclin D1 ◽  
Gene Amplification ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Independent Prognostic Factor
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