Periventricular white matter damage in the hypoxic neonatal brain: Role of microglial cells

2009 ◽  
Vol 87 (4) ◽  
pp. 264-280 ◽  
Author(s):  
C. Kaur ◽  
E.A. Ling
Keyword(s):  
White Matter ◽  
Microglial Cells ◽  
Periventricular White Matter ◽  
Neonatal Brain ◽  
White Matter Damage

scholarly journals Acute and Chronic Cerebral White Matter Damage in Neonatal Hydrocephalus

1994 ◽  
Vol 21 (4) ◽  
pp. 299-305 ◽  
Author(s):  
Marc R. Del Bigio ◽  
Marcia C. da Silva ◽  
James M. Drake ◽  
Ursula I. Tuor
Keyword(s):  
White Matter ◽  
Periventricular Leukomalacia ◽  
Cerebral White Matter ◽  
Periventricular White Matter ◽  
Histopathological Changes ◽  
Neonatal Brain ◽  
White Matter Damage ◽  
White Matter Changes ◽  
Deep Layers ◽  
Cat Model

Abstract:The neonatal cat model of kaolin-induced hydrocephalus is associated with progressive and severe ventriculomegaly. In this experiment we studied the evolution of the histopathological changes in hydrocephalic (n = 23) cats from 5–168 days after the induction of hydrocephalus along with age-matched controls (n = 10). In the periventricular white matter, extracellular edema and axonal damage were present within days of the onset of hydrocephalus. This was followed by reactive gliosis, white matter atrophy, and in some animals gross cavitation of the white matter. Even in the chronic, apparently compensated state there was ongoing glial cell death. Six cats were shunted an average of 23.6 ± 6.5 days after the induction of hydrocephalus because they were no longer able to feed independently. In spite of clinical improvement the white matter changes persisted. Overt cortical changes were minimal except where areas of white matter destruction encroached upon the deep layers. The white matter changes are very similar to those seen in periventricular leukomalacia and suggest that ischemia plays a role in neonatal brain injury caused by hydrocephalus.

scholarly journals Circular RNA expression alteration in whole blood of premature infants with periventricular white matter damage

Genomics ◽  
2020 ◽  
Vol 112 (4) ◽  
pp. 2875-2885
Author(s):  
Lixing Qiao ◽  
Sisi Mo ◽  
Yan Zhou ◽  
Yi Zhang ◽  
Bangbang Li ◽  
...  
Keyword(s):  
White Matter ◽  
Premature Infants ◽  
Whole Blood ◽  
Circular Rna ◽  
Periventricular White Matter ◽  
Rna Expression ◽  
White Matter Damage

The role of white matter damage in late onset bipolar disorder

Maturitas ◽  
2011 ◽  
Vol 70 (2) ◽  
pp. 160-163 ◽  
Author(s):  
Ariadna Besga ◽  
Monica Martinez-Cengotitabengoa ◽  
Itxaso González-Ortega ◽  
Miguel Gutierrez ◽  
Sara Barbeito ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
Late Onset ◽  
White Matter Damage

scholarly journals Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Lucia M. Marseglia ◽  
Antonio Nicotera ◽  
Vincenzo Salpietro ◽  
Elisa Giaimo ◽  
Giovanna Cardile ◽  
...  
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
Full Term ◽  
Late Preterm ◽  
Periventricular White Matter ◽  
Cranial Ultrasound ◽  
Mthfr Polymorphisms ◽  
White Matter Abnormalities ◽  
Term Newborns

Higher total homocysteine (tHcy) levels, and C677T and A1298C methylenetetrahydrofolate (MTHFR) polymorphisms, have been reported in preterm or full term newborns with neonatal encephalopathy following perinatal hypoxic-ischemic insult. This study investigated the causal role of tHcy and MTHFR polymorphisms together with other acquired risk factors on the occurrence of brain white matter abnormalities (WMA) detected by cranial ultrasound scans (cUS) in a population of late preterm and full term infants. A total of 171 newborns (81 M, 47.4%), 45 (26.3%) born <37 wks, and 126 (73.7%) born ≥37 wks were recruited in the study. cUS detected predominant WMA pattern in 36/171 newborns (21.1%) mainly characterized by abnormal periventricular white matter signal and mild-to-moderate periventricular white matter volume loss with ventricular dilatation (6/36, 16.6%). WMA resulted in being depending on tHcy levels(P<0.014), lower GA(P<0.000), lower Apgar score at 1 minutes(P<0.000)and 5 minutes(P<0.000), and 1298AC and 677CT/1298AC genotypes (P<0.000andP<0.000). In conclusion, both acquired and genetic predisposing antenatal factors were significantly associated with adverse neonatal outcome and WMA. The role of A1298C polymorphism may be taken into account for prenatal assessment and treatment counseling.

Impact of Xenon on CLIC4 and Bcl-2 Expression in Lipopolysaccharide and Hypoxia-Ischemia-Induced Periventricular White Matter Damage

Neonatology ◽  
2018 ◽  
Vol 113 (4) ◽  
pp. 339-346 ◽  
Author(s):  
Xiangyun Yin ◽  
Jixiu Zhao ◽  
Hong Jiang ◽  
Liangliang Li ◽  
Jian Jiang ◽  
...  
Keyword(s):  
White Matter ◽  
Periventricular White Matter ◽  
White Matter Damage ◽  
Hypoxia Ischemia

scholarly journals Defective motion processing in children with cerebral visual impairment due to periventricular white matter damage

2011 ◽  
Vol 54 (7) ◽  
pp. e1-e8 ◽  
Author(s):  
JOEL M WEINSTEIN ◽  
RICK O GILMORE ◽  
SUMERA M SHAIKH ◽  
ALLEN R KUNSELMAN ◽  
WILLIAM V TRESCHER ◽  
...  
Keyword(s):  
White Matter ◽  
Visual Impairment ◽  
Motion Processing ◽  
Periventricular White Matter ◽  
White Matter Damage ◽  
Cerebral Visual Impairment

scholarly journals Characterization of Cerebral White Matter Damage in Preterm Infants Using 1H and 31P Magnetic Resonance Spectroscopy

2000 ◽  
Vol 20 (10) ◽  
pp. 1446-1456 ◽  
Author(s):  
Nicola J. Robertson ◽  
Jacob Kuint ◽  
Serena J. Counsell ◽  
Mary A. Rutherford ◽  
Glyn A. Coutts ◽  
...  
Keyword(s):  
White Matter ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Preterm Infants ◽  
Term Infant ◽  
Cerebral White Matter ◽  
Resonance Spectroscopy ◽  
Periventricular White Matter ◽  
White Matter Damage ◽  
Term Infants

The biochemical characteristics of white matter damage (WMD) in preterm infants were assessed using magnetic resonance spectroscopy (MRS). The authors hypothesized that preterm infants with WMD at term had a persisting cerebral lactic alkalosis and reduced N-acetyl aspartate (NAA)/creatine plus phosphocreatine (Cr), similar to that previously documented in term infants weeks after perinatal hypoxia–ischemia (HI). Thirty infants (gestational age 27.9 ± 3.1 weeks, birth weight 1122 ± 445 g) were studied at postnatal age of 9.8 ± 4.1 weeks (corrected age 40.3 ± 3.9 weeks). Infants were grouped according to the presence or absence of WMD on magnetic resonance (MR) images. The peak area ratios of lactate/Cr, NAA/Cr, myo-inositol/Cr, and choline (Cho)/Cr were measured from an 8-cm3 voxel in the posterior periventricular white matter (WM) using proton MRS. Intracellular pH (pHi) was calculated using phosphorus MRS. Eighteen infants had normal WM on MR imaging; 12 had WMD. For infants with WMD, lactate/Cr and myo-inositol/Cr were related ( P < 0.01); lactate/Cr and pHi were not ( P = 0.8). In the WMD group, mean lactate/Cr and myo-inositol/Cr were higher ( P < 0.001, P < 0.05, respectively) than the normal WM group. There was no difference in the NAA/Cr, Cho/Cr, or pHi between the two groups, although pHi was not measured in all infants. These findings suggest that WMD in the preterm infant at term has a different biochemical profile compared with the term infant after perinatal HI.

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