scholarly journals Development and evaluation of a new method to combine clinical impression survey data with existing laboratory data for veterinary syndromic surveillance with the Canada West Swine Health Intelligence Network (CWSHIN)

Author(s):  
Jette Christensen ◽  
Chris Byra ◽  
Julia Keenliside ◽  
Yanyun Huang ◽  
John C.S. Harding ◽  
...  
2013 ◽  
Vol 109 (3-4) ◽  
pp. 219-227 ◽  
Author(s):  
Fernanda C. Dórea ◽  
Crawford W. Revie ◽  
Beverly J. McEwen ◽  
W. Bruce McNab ◽  
David Kelton ◽  
...  

Geophysics ◽  
2015 ◽  
Vol 80 (2) ◽  
pp. D99-D110 ◽  
Author(s):  
Nishank Saxena ◽  
Gary Mavko

Laboratory measurements of rocks saturated with high-viscosity fluids (such as heavy-oil, bitumen, magma, kerogen, etc.) often exhibit considerable seismic velocity dispersion, which is usually underestimated by the Biot theory. Over the years, grain-scale dispersion mechanisms such as squirt (local-flow) and shear relaxation (nonzero shear stress in the pore fluid) have been more successful in explaining the measured dispersion. We developed a new method to quantify the combined high-frequency effects of squirt and shear dispersion on the effective moduli of rocks saturated with viscous fluids. Viscous fluid at high frequencies was idealized as an elastic solid of finite shear modulus, hydraulically locked in stiff and soft pores. This method entailed performing solid substitution in stiff pores of a dry rock frame, which itself was unrelaxed due to solid-filled soft pores. The unrelaxed frame stiffness solutions required information on the pressure dependency of the rock stiffness and porosity. This method did not have any adjustable parameters, and all required inputs can be directly measured. With various laboratory and numerical examples, we noted that accounting for combined effects of squirt and shear relaxation was necessary to explain laboratory-measured velocities of rocks saturated with fluids of high viscosity. Predictions of the new method were in good agreement with the laboratory data.


PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259601
Author(s):  
Ana Michelle Avina-Galindo ◽  
Zahra A. Fazal ◽  
Shelby Marozoff ◽  
Jessie Kwan ◽  
Na Lu ◽  
...  

Introduction Cases of the novel coronavirus disease (COVID-19) continue to spread around the world even one year after the declaration of a global pandemic. Those with weakened immune systems, due to immunosuppressive medications or disease, may be at higher risk of COVID-19. This includes individuals with autoimmune diseases, cancer, transplants, and dialysis patients. Assessing the risk and outcomes of COVID-19 in this population has been challenging. While administrative databases provide data with minimal selection and recall bias, clinical and behavioral data is lacking. To address this, we are collecting self-reported survey data from a randomly selected subsample with and without COVID-19, which will be linked to administrative health data, to better quantify the risk of COVID-19 infection associated with immunosuppression. Methods and analysis Using administrative and laboratory data from British Columbia (BC), Canada, we established a population-based case-control study of all individuals who tested positive for SARS-CoV-2. Each case was matched to 40 randomly selected individuals from two control groups: individuals who tested negative for SARS-CoV-2 (i.e., negative controls) and untested individuals from the general population (i.e., untested controls). We will contact 1000 individuals from each group to complete a survey co-designed with patient partners. A conditional logistic regression model will adjust for potential confounders and effect modifiers. We will examine the odds of COVID-19 infection according to immunosuppressive medication or disease type. To adjust for relevant confounders and effect modifiers not available in administrative data, the survey will include questions on behavioural variables that influence probability of being tested, acquiring COVID-19, and experiencing severe outcomes. Ethics and dissemination This study has received approval from the University of British Columbia Clinical Research Ethics Board [H20-01914]. Findings will be disseminated through scientific conferences, open access peer-reviewed journals, COVID-19 research repositories and dissemination channels used by our patient partners.


2011 ◽  
Vol 140 (7) ◽  
pp. 1328-1336 ◽  
Author(s):  
E. O. KARA ◽  
A. J. ELLIOT ◽  
H. BAGNALL ◽  
D. G. F. FOORD ◽  
R. PNAISER ◽  
...  

SUMMARYCertain influenza outbreaks, including the 2009 influenza A(H1N1) pandemic, can predominantly affect school-age children. Therefore the use of school absenteeism data has been considered as a potential tool for providing early warning of increasing influenza activity in the community. This study retrospectively evaluates the usefulness of these data by comparing them with existing syndromic surveillance systems and laboratory data. Weekly mean percentages of absenteeism in 373 state schools (children aged 4–18 years) in Birmingham, UK, from September 2006 to September 2009, were compared with established syndromic surveillance systems including a telephone health helpline, a general practitioner sentinel network and laboratory data for influenza. Correlation coefficients were used to examine the relationship between each syndromic system. In June 2009, school absenteeism generally peaked concomitantly with the existing influenza surveillance systems in England. Weekly school absenteeism surveillance would not have detected pandemic influenza A(H1N1) earlier but daily absenteeism data and the development of baselines could improve the timeliness of the system.


2020 ◽  
Author(s):  
Aurelio Sonzogni ◽  
Giulia Previtali ◽  
Michela Seghezzi ◽  
Maria Grazia Alessio ◽  
Andrea Gianatti ◽  
...  

AbstractCOVID-19 breakout in Italy has caused a huge number of severely ill patients with a serious increase in mortality. Although lungs seem to be the main target of the infection very few information are available about liver involvement in COVID-19 infection, that could possibly evocate a systemic disease targeting a lot of organs. Since now there are no reports of large series of histological evaluation of liver morphology in this setting. Knowledge of histological liver findings connected to clinical data is crucial in management of this disease. Post-mortem wedge liver biopsies from 48 patients died for COVID-19 infection were available from two main hospitals located in northern Italy, Lombardy; all sample were obtained during autopsies. No patient has a significant clinical complain of liver disease or signs of liver failure before and during hospitalization; for each of them laboratory data focused on liver were available. All liver samples showed minimal inflammation features; on the other side, many histological pictures compatible with vascular alterations were observed, characterized by portal vein braches number increase associated with lumen massive dilatation, partial or complete recent luminal thrombosis of portal and sinusoidal vessels, fibrosis of portal tract, focally severely enlarged and fibrotic. Our preliminary results concerning histological liver involvement in COVID-19 infection confirm the clinical impression that liver failure is not a main concern and this organ is not the target of significant inflammatory damage; histopatological findings are highly suggestive for marked alteration of intrahepatic blood vessel network secondary to systemic alterations induced by virus that could target, besides lung parenchyma, cardiovascular system, coagulation cascade or endothelial layer of blood vessels.


Author(s):  
Aurelio Sonzogni ◽  
Giulia Previtali ◽  
Michela Seghezzi ◽  
Maria Grazia Alessio ◽  
Andrea Gianatti ◽  
...  

COVID-19 breakout in Italy has caused a huge number of severely ill patients with a serious increase in mortality. Although lungs seem to be the main target of the infection very few information are available about liver involvement in COVID-19 infection, that could possibly evocate a systemic disease targeting a lot of organs. Since now there are no reports of large series of histological evaluation of liver morphology in this setting. Knowledge of histological liver findings connected to clinical data is crucial in management of this disease.Post-mortem wedge liver biopsies from 48 patients died for COVID-19 infection were available from two main hospitals located in northern Italy, Lombardy; all sample were obtained during autopsies. No patient has a significant clinical complain of liver disease or signs of liver failure before and during hospitalization; for each of them laboratory data focused on liver were available. All liver samples showed minimal inflammation features; on the other side, many histological pictures compatible with vascular alterations were observed, characterized by portal vein braches number increase associated with lumen massive dilatation, partial or complete recent luminal thrombosis of portal and sinusoidal vessels, fibrosis of portal tract, focally severely enlarged and fibrotic. Our preliminary results concerning histological liver involvement in COVID-19 infection confirm the clinical impression that liver failure is not a main concern and this organ is not the target of significant inflammatory damage; histopatological findings are highly suggestive for marked alteration of intrahepatic blood vessel network secondary to systemic alterations induced by virus that could target, besides lung parenchyma, cardiovascular system, coagulation cascade or endothelial layer of blood vessels.


2021 ◽  
Author(s):  
Samy A. Helmy ◽  
Judith K. Guy-Caffey ◽  
Leroy J. Detiveaux ◽  
Sabine C. Zeilinger ◽  
Mike D. Barry ◽  
...  

Abstract The completion of wells using solids-laden fluids can impair the reservoir production and also damage the functioning of downhole completion tools, therefore completing wells with clear-brine fluids is the preferred alternative. Clear brines are typically halide or formate salt solutions in water, but they, too, have shortcomings. At lower temperatures or increased pressures, the salts in these fluids can crystallize causing potential well control concerns and/or costly operational disruptions. Completion of high-pressure wells, with densities above approximately 14.3 lb/gal for calcium bromide or 13.1 lb/gal for potassium formate, has historically required the use of brines containing zinc bromide or cesium formate to minimize formation damage, yet, in addition to their merits,both fluids have inherent liabilities. Zinc-based fluids, for example, are restricted and classified as priority pollutants due to their potential harmful effects on the environment, and the low pH(acidity) of zinc-based halides increases the potential for corrosion of metal components and risk to personnel safety. With cesium formate fluids, their limited production may restrict supply and lead to higher cost in high-volume deepwater applications. Moreover, when used as a packer fluid, literature (Javora 2003) suggests that formates may cause hydrogen-induced cracking (HIC), especially in the presence of carbon dioxide (CO2) that could lead to failure of production tubing. An offshore operator required a priority-pollutant-free completion fluid for a subsea development,whose produced fluids (oil and water) are combined and processed with that from several other fields at a shared production facility. Associated produced water separated from the crude is dischargedoverboard and must be free of priority pollutants; detection of any such pollutants would requireextensive processing or, in the worst case, result in shutting down production from all the fields and the facility. This paper describes the development and successful field applications of a novel family of completion fluids, created to address the deficits of conventional high-density clear brines. The new fluids extend the conditions for onset of crystallization to a higher density range and meet environmental concerns, as they are formulated with sustainably sourced materials. The novel high-density,non-zinc, solids-free completion fluid (HDNZ) meets the challenges and requirements of ultra-deepwater environments for fluid densities between 14.4 and 15.3 lb/gal. An overview of the extensive laboratory test data needed to develop the fluid and verify its viability as a completion brine and packer fluid is described. The paper outlines the design criteria and qualification testing performedto ensure that the technical challenges were addressed for this challenging deepwater project. The laboratory data include testing of pressurized crystallization temperatures (PCTs), stress corrosion cracking (SCC), elastomer compatibility, formation regain permeability, long-term stability, and compatibility with multiple fluid types (mud, control line, spacer, frac fluids, sour gases and chemical additives). The discussion on fluid usage will encompass details of the plant trial to validate the performance of the fluid and case history detailing the operational implementation in the first five ultra-deepwater well completions in the GOM. Additionally, engineering these fluids led to the development of a new method to measure brine crystallization temperature at elevated pressures, as there currently is no industry standard for such measurement in downhole conditions. The new method is accurate, repeatable, and executable in rig-site laboratories.


2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Nicholas E. Kman ◽  
Daniel J. Bachmann

Since the terrorist attacks and anthrax release in 2001, almost $32 billion has been allocated to biodefense and biosurveillance in the USA alone. Surveillance in health care refers to the continual systematic collection, analysis, interpretation, and dissemination of data. When attempting to detect agents of bioterrorism, surveillance can occur in several ways. Syndromic surveillance occurs by monitoring clinical manifestations of certain illnesses. Laboratory surveillance occurs by looking for certain markers or laboratory data, and environmental surveillance is the process by which the ambient air or environment is continually sampled for the presence of biological agents. This paper focuses on the ways by which we detect bioterrorism agents and the effectiveness of these systems.


2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Heather Rubino ◽  
David Atrubin ◽  
Janet J. Hamilton

ED chief complaint and discharge diagnosis data accessed through a syndromic surveillance system can be used for effective, timely monitoring of RSV hospitalizations in children < 5 years old and may be a more efficient and complete means of monitoring seasonality of RSV activity by region and statewide compared to hospital-based laboratory data reporting. Additionally, this surveillance technique can efficiently monitor RSV activity as well as estimate hospital admissions due to RSV and may be a useful approach for other states with syndromic surveillance systems.


2010 ◽  
Vol 67 (8) ◽  
pp. 2469-2482 ◽  
Author(s):  
A. J. Heymsfield ◽  
C. D. Westbrook

Abstract Accurate estimates for the fall speed of natural hydrometeors are vital if their evolution in clouds is to be understood quantitatively. In this study, laboratory measurements of the terminal velocity υt for a variety of ice particle models settling in viscous fluids, along with wind-tunnel and field measurements of ice particles settling in air, have been analyzed and compared to common methods of computing υt from the literature. It is observed that while these methods work well for a number of particle types, they fail for particles with open geometries, specifically those particles for which the area ratio Ar is small (Ar is defined as the area of the particle projected normal to the flow divided by the area of a circumscribing disc). In particular, the fall speeds of stellar and dendritic crystals, needles, open bullet rosettes, and low-density aggregates are all overestimated. These particle types are important in many cloud types: aggregates in particular often dominate snow precipitation at the ground and vertically pointing Doppler radar measurements. Based on the laboratory data, a simple modification to previous computational methods is proposed, based on the area ratio. This new method collapses the available drag data onto an approximately universal curve, and the resulting errors in the computed fall speeds relative to the tank data are less than 25% in all cases. Comparison with the (much more scattered) measurements of ice particles falling in air show strong support for this new method, with the area ratio bias apparently eliminated.


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