scholarly journals High-sensitivity C-reactive protein in obese children: Too complex a marker to use?

2015 ◽  
Vol 34 (10) ◽  
pp. 631
Author(s):  
Ayşe Tuğba Kartal ◽  
Ömer Kartal
Keyword(s):  
High Sensitivity ◽  
Obese Children ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals High-sensitivity C-reactive protein is a good marker of cardiovascular risk in obese children and adolescents.

2008 ◽  
Vol 159 (1) ◽  
pp. R1-R4 ◽  
Author(s):  
Leandro Soriano-Guillén ◽  
Bárbara Hernández-García ◽  
Jimena Pita ◽  
Nieves Domínguez-Garrido ◽  
Genoveva Del Río-Camacho ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Children And Adolescents ◽  
Hdl Cholesterol ◽  
High Sensitivity ◽  
Oral Glucose ◽  
Obese Children ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

ObjectiveWe intend to assess the utility of the high-sensitivity C-reactive protein (hs-CRP) as a marker of cardiovascular risk in obese children and adolescents.MethodsThe study included children and adolescents between 6 and 18 years of age with a body mass index (BMI) higher than 2 SDS. All the patients had their blood pressure taken and hs-CRP, hepatic function, lipid profile and uric acid were determined after 12 h of fasting. Likewise, an oral glucose tolerance test was performed, determining basal glucose and insulin levels, and after stimulus. We considered the presence of metabolic syndrome when the obese children and teenagers showed at least two of the following conditions: decreased high density lipoprotein (HDL)-cholesterol, hypertriglyceridemia, hypertension or alteration in glucose metabolism.ResultsOut of the 115 obese children studied, 24% showed signs of metabolic syndrome. Those with metabolic syndrome presented higher levels of hs-CRP (mean: 3.8 mg/l; 95% CI: 2.8–4.8) in comparison with the obese patients who did not show signs of metabolic syndrome (mean: 2 mg/l; 95% CI: 1.5–2.5). After a multivariate analysis, the variables that appear to influence the changes in hs-CRP were BMI, triglycerides and HDL-cholesterol levels.ConclusionThe hs-CRP is a useful tool for early diagnosis of cardiovascular risk in obese children and teenagers.

scholarly journals Association of high-sensitivity C-reactive protein level with central obesity of the children in a tertiary care hospital of Bangladesh

2021 ◽  
Vol 8 (3) ◽  
pp. 407
Author(s):  
Dhiraj Chandra Biswas ◽  
Moshiur Rahman ◽  
Farzana Sharmin ◽  
Ismat Jahan ◽  
Ananya Roy ◽  
...  
Keyword(s):  
Central Obesity ◽  
Tertiary Care ◽  
High Sensitivity ◽  
Growth Chart ◽  
Care Hospital ◽  
Obese Children ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Control And Prevention ◽  
Hs Crp

Background: Obesity is an exaggeration of normal adiposity. Central obesity in children has increased than general adiposity now a days, which is not routinely measured in clinical practice. Adipose tissue contributes to the secretion of a number of inflammatory cytokines which stimulate the production of high-sensitive C-reactive protein (hs–CRP) by the liver. The study was done to see the association of hs-CRP level with central obesity in Bangladeshi children.Methods: A total of 110 obese children aged between 10 to 18 years with BMI≥95th centile and age and sex matched 55 non-obese children with BMI≥5th to <85th centile according to centers for disease control and prevention (CDC) growth chart were selected. A structured questionnaire was prepared taking into account demographic and clinical parameters. The hs-CRP were estimated in study subjects and then correlated to central obesity by waist height ratio (WHtR).Results: The prevalence central obesity was 45.5% by WHtR and raised hs-CRP levels was 46.4% in obese children. About 62% of obese children had central obesity who had raised hs-CRP level ≥2 mg/l (high risk), which showed significant positive correlation with WHtR and was significantly raised in obese children.Conclusions: A high proportion of central obesity was observed in obese children who had raised hs-CRP level, suggesting that it might be useful to assess future metabolic and cardiovascular complication.

Adiponectin, leptin and high sensitivity C-reactive protein values in obese children – important markers for metabolic syndrome?

2019 ◽  
Vol 32 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Ramona F. Stroescu ◽  
Otilia Mărginean ◽  
Teofana Bizerea ◽  
Mihai Gafencu ◽  
Adrian Voicu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Pediatric Population ◽  
High Sensitivity ◽  
Inflammatory Disorder ◽  
Obese Children ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Chronic Inflammatory Disorder ◽  
Reactive Protein ◽  
Hs Crp

Abstract Background Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C-reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity such as leptin, adiponectin and high sensitivity C-reactive protein (hs-CRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome (MetS) in pediatric population. Methods A cross-sectional study was conducted over a period of 1 year, between July 2013 and June 2014, on 122 cases of obesity in children diagnosed at the Louis Ţurcanu Emergency Hospital for Children Timişoara, in the departments of Diabetes and Nutritional Diseases, Endocrinology and Cardiology. The patients were divided into two groups, according to the presence of MetS. Results MetS was present in 27% of obese children. The groups were homogenous with respect to age, sex and body mass index (BMI). Adiponectin, leptin and hs-CRP were significantly modified in the group with MetS (p=0.04, p=0.04, p=0.01, respectively). Conclusions hs-CRP, leptin and adiponectin can be used as predictors of cardiovascular risk in pediatric population.

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