scholarly journals High-sensitivity C-reactive protein is a good marker of cardiovascular risk in obese children and adolescents.

2008 ◽  
Vol 159 (1) ◽  
pp. R1-R4 ◽  
Author(s):  
Leandro Soriano-Guillén ◽  
Bárbara Hernández-García ◽  
Jimena Pita ◽  
Nieves Domínguez-Garrido ◽  
Genoveva Del Río-Camacho ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Children And Adolescents ◽  
Hdl Cholesterol ◽  
High Sensitivity ◽  
Oral Glucose ◽  
Obese Children ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

ObjectiveWe intend to assess the utility of the high-sensitivity C-reactive protein (hs-CRP) as a marker of cardiovascular risk in obese children and adolescents.MethodsThe study included children and adolescents between 6 and 18 years of age with a body mass index (BMI) higher than 2 SDS. All the patients had their blood pressure taken and hs-CRP, hepatic function, lipid profile and uric acid were determined after 12 h of fasting. Likewise, an oral glucose tolerance test was performed, determining basal glucose and insulin levels, and after stimulus. We considered the presence of metabolic syndrome when the obese children and teenagers showed at least two of the following conditions: decreased high density lipoprotein (HDL)-cholesterol, hypertriglyceridemia, hypertension or alteration in glucose metabolism.ResultsOut of the 115 obese children studied, 24% showed signs of metabolic syndrome. Those with metabolic syndrome presented higher levels of hs-CRP (mean: 3.8 mg/l; 95% CI: 2.8–4.8) in comparison with the obese patients who did not show signs of metabolic syndrome (mean: 2 mg/l; 95% CI: 1.5–2.5). After a multivariate analysis, the variables that appear to influence the changes in hs-CRP were BMI, triglycerides and HDL-cholesterol levels.ConclusionThe hs-CRP is a useful tool for early diagnosis of cardiovascular risk in obese children and teenagers.

Adiponectin, leptin and high sensitivity C-reactive protein values in obese children – important markers for metabolic syndrome?

2019 ◽  
Vol 32 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Ramona F. Stroescu ◽  
Otilia Mărginean ◽  
Teofana Bizerea ◽  
Mihai Gafencu ◽  
Adrian Voicu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Pediatric Population ◽  
High Sensitivity ◽  
Inflammatory Disorder ◽  
Obese Children ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Chronic Inflammatory Disorder ◽  
Reactive Protein ◽  
Hs Crp

Abstract Background Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C-reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity such as leptin, adiponectin and high sensitivity C-reactive protein (hs-CRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome (MetS) in pediatric population. Methods A cross-sectional study was conducted over a period of 1 year, between July 2013 and June 2014, on 122 cases of obesity in children diagnosed at the Louis Ţurcanu Emergency Hospital for Children Timişoara, in the departments of Diabetes and Nutritional Diseases, Endocrinology and Cardiology. The patients were divided into two groups, according to the presence of MetS. Results MetS was present in 27% of obese children. The groups were homogenous with respect to age, sex and body mass index (BMI). Adiponectin, leptin and hs-CRP were significantly modified in the group with MetS (p=0.04, p=0.04, p=0.01, respectively). Conclusions hs-CRP, leptin and adiponectin can be used as predictors of cardiovascular risk in pediatric population.

scholarly journals Association of C-Reactive Protein, Interleukin-1 Receptor Antagonist and Adiponectin with the Metabolic Syndrome

2007 ◽  
Vol 2007 ◽  
pp. 1-8 ◽  
Author(s):  
Juha Saltevo ◽  
Mauno Vanhala ◽  
Hannu Kautiainen ◽  
Esko Kumpusalo ◽  
Markku Laakso
Keyword(s):  
Metabolic Syndrome ◽  
Receptor Antagonist ◽  
Interleukin 1 ◽  
High Sensitivity ◽  
Population Based ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Interleukin 1 Receptor Antagonist ◽  
The Metabolic Syndrome ◽  
Hs Crp

This Finnish population-based study, mean age 46 years, evaluates the association of high-sensitivity C-reactive protein (hs-CRP), interleukin-1 receptor antagonist (IL-1Ra), and adiponectin with the NCEP and IDF definitions of metabolic syndrome (MetS). Adiponectin levels were higher, hs-CRP and IL-1Ra levels lower in subjects without MetS compared to subjects with MetS. If MetS was present according to both IDF and NCEP criteria, BMI, waist, triglycerides, hs-CRP, and IL-1Ra were significantly higher compared to subjects who had MetS according to either only IDF or only NCEP criteria. The hs-CRP, IL-1Ra, and adiponectin linearly correlated with the number of the components of MetS according to both definitions. Decreased levels of adiponectin and increased levels of hs-CRP and IL-1Ra are tightly associated with the components of MetS. Individuals who had MetS according to both criteria had the most adverse changes in cardiovascular risk factors.

scholarly journals MON-099 The Association Between C-Reactive Protein, Metabolic Syndrome, and Pre-Diabetes in Korean Children and Adolescents

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Jihyun Kim ◽  
Jong Bin Lee ◽  
Jung Sub Lim
Keyword(s):  
Metabolic Syndrome ◽  
Children And Adolescents ◽  
Geometric Mean ◽  
High Sensitivity ◽  
Low Grade ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Cross Sectional ◽  
Korean Children ◽  
Reactive Protein

Abstract Objective: Cardiovascular disease (CVD) is a leading cause of death worldwide, including in Korea. In adults, the risk for CVD is increased approximately three-fold in subjects with metabolic syndrome (MetS), and the hazard ratio for subjects with MetS has been reported as 1.37 for mortality from CVD after adjustment for other confounders. Furthermore, MetS in childhood predicts adult MetS and T2DM 25 to 30 years later. Because MetS is a state of chronic low-grade inflammation, measurements of the circulating levels of the inflammatory molecules might provide diagnostic and therapeutic approaches to modulate or alter disease progression. High sensitivity C-reactive protein (hsCRP), a biomarker of inflammation, has emerged as an independent predictor of CVD and T2DM development. The aim of this paper is to evaluate the association between hsCRP and MetS and its components in Korean children and adolescents. Methods: We performed a cross-sectional analysis using data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2016–2017. We analyzed the data of 1,247 subjects (633 males, 14.2 ± 2.7 years) from the KNHANES 2016–2017. MetS were defined by the modified NCEP-ATP III criteria. Results: Among the 1,247 subjects (mean age: 14.2 ± 2.7 years), the prevalence of MetS was 5.8% (7.0% in male subjects and 4.6% in female subjects; p = 0.070). The mean hsCRP level was 0.861 ± 1.567 mg/l (median and interquartile range: 0.370 and 0.430mg/l). Subjects with MetS had higher hsCRP levels than subjects without MetS (geometric mean: 1.08 vs. 0.46 mg/l, p < 0.001). The prevalence of MetS in the lowest, second, third, and highest hsCRP quartiles were 1.8%, 2.4%, 3.5%, and 15.2%, respectively. Compared to the lowest quartile, the odds ratio (OR) for having MetS in the highest quartile was 8.414 (3.272–21.638), adjusting for age and sex. The OR for having abdominal obesity and low HDL-C in the highest quartile were 9.657 (4.818–19.355) and 2.408 (1.286–4.510), adjusting for age, sex, and other components of the MetS. Additionally, the OR for having pre-diabetes (HbA1c ≥ 5.7%) in the highest quartile was 2.061 (1.097–3.870). Conclusion: Serum hsCRP level is positively associated with MetS and pre-diabetes in Korean children and adolescents.

scholarly journals Association of Clinical Characteristics with the Proportion of the HDL-Cholesterol Subclasses HDL-2b and HDL-3 Among Patients Undergoing Hemodialysis

2020 ◽  
Author(s):  
Jin-Bor Chen ◽  
Wen-Chin Lee ◽  
Sin-Hua Moi ◽  
Cheng-Hong Yang
Keyword(s):  
Clinical Characteristics ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Sensitivity ◽  
Healthy Individuals ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Diabetic Status ◽  
The Mean ◽  
Hs Crp

Abstract Background: Altered high-density lipoprotein cholesterol (HDL-C) composition in patients with chronic kidney disease is common. However, reports on the distribution of HDL-C subclasses in patients undergoing hemodialysis (HD) are limited. Objective: We aimed to compare the two main HDL-C subclasses, HDL-2b and HDL-3, in two cohorts of HD patients and healthy individuals and examine their associations with clinical characteristics. Methods: A total of 164 prevalent HD patients and 71 healthy individuals in one hospital-facilitated outpatient clinic were enrolled from May 2019 to July 2019. The HDL-2b and HDL-3 proportions were measured and statistical analysis was performed. Results: The mean ages of HD patients and healthy individuals were 63 and 49.9 years, respectively. HD patients showed lower HDL-2b and HDL-3 proportions compared with those of healthy individuals (23.6% vs. 31.2%, P < 0.001; 31.7% vs. 33.6%, P = 0.137, respectively). The HDL-2b proportion was significantly higher with a high-sensitivity C-reactive protein (hs-CRP) levels of <3 mg/L compared with hs-CRP ≥3mg/L in the HD cohort (P = 0.005). HDL-3 proportion was lower with a hs-CRP level of <3 mg/L compared with hs-CRP ≥3mg/L in the HD cohort (P = 0.022). Sex and diabetes did not influence the HDL-2b and HDL-3 proportions in the HD cohort.Conclusions: HD patients had lower HDL-2b and HDL-3 proportions than those of healthy individuals. The distribution of the HDL-2b and HDL-3 subclasses in HD patients is influenced by proinflammatory status, not by sex and diabetic status.

Changes in High-sensitivity C-reactive Protein Levels after Laparoscopic Gastric Stapling Procedures versus Laparoscopic Gastric Banding

2014 ◽  
Vol 80 (10) ◽  
pp. 1044-1048
Author(s):  
Alana Gebhart ◽  
Monica Young ◽  
James Villamere ◽  
Anderson Shih ◽  
Ninh T. Nguyen
Keyword(s):  
Cardiovascular Risk ◽  
Gastric Banding ◽  
Laparoscopic Gastric Banding ◽  
High Sensitivity ◽  
Risk Category ◽  
Morbidly Obese ◽  
C Reactive Protein ◽  
Preoperative Body Mass Index ◽  
Reactive Protein ◽  
Hs Crp

Obesity, hypertension, diabetes, and hyperlipidemia are risk factors for the development of coronary artery disease. High-sensitivity C-reactive protein (hs-CRP) is an inflammatory biomarker that has been shown to be an independent predictor for cardiovascular risk. The aim of the current study was to examine the changes in cardiovascular risk profile in morbidly obese patients who underwent laparoscopic gastric stapling procedures (bypass and sleeve) compared with laparoscopic gastric banding. Levels of hs-CRP were measured preoperatively and at 12 to 24 months post-operatively. Based on hs-CRP levels, cardiovascular risk was categorized as low (less than 1 mg/L), moderate (1 to 3 mg/L), or high (greater than 3 mg/L). A total of 52 patients underwent gastric stapling procedures and 49 underwent gastric banding and both had preoperative and postoperative hs-CRP levels measured. There were no significant differences in age, gender, or preoperative body mass index (BMI) between groups. At baseline, 48.0 per cent of patients undergoing gastric stapling and 38.8 per cent of patients undergoing gastric banding had moderate or high cardiovascular risk. BMI at 24 months was significantly lower in the gastric stapling compared with the gastric banding group (30.4 ± 5.4 vs 36.1 ± 5.5 kg/m2, respectively, P < 0.01). Of the patients with elevated cardiovascular risk, 64.0 per cent of gastric stapling versus 57.8 per cent of gastric banding patients had a reduction in risk category at 12 to 24 months follow-up, whereas 1.9 per cent of patients undergoing gastric stapling versus 4.1 per cent of patients undergoing gastric banding had an increase in risk category. The mean reduction in hs-CRP level for patients with elevated cardiovascular risk was greater for gastric stapling compared with gastric banding procedures (-1.10 ± 0.94 mg/L vs -0.67 ± 0.82 mg/L, respectively, P < 0.05). Cardiovascular risk improved in the majority of patients after bariatric surgery, but a more pronounced improvement occurred in patients who underwent gastric stapling procedures.

scholarly journals Prevalence of Metabolic Syndrome among Obese Children and Adolescents

2012 ◽  
Vol 1 (1) ◽  
pp. 21-25 ◽  
Author(s):  
F Mohsin ◽  
A Baki ◽  
J Nahar ◽  
S Akhtar ◽  
T Begum ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Glucose Tolerance ◽  
Children And Adolescents ◽  
Blood Pressure Measurement ◽  
Hdl Cholesterol ◽  
Oral Glucose ◽  
Obese Children ◽  
Female Ratio ◽  
Age And Sex

Objectives: The Prevalence and magnitude of childhood obesity are increasing dramatically. The study was undertaken to see the prevalence of metabolic syndrome among children and adolescents with obesity, attending the Paediatric Endocrine OPD, BIRDEM. Methods: A cross sectional study was conducted from January 2006 to December 2008 among obese children and adolescents (6-18 years) attending Paediatric endocrine out patient department of BIRDEM. Children with any other endocrine disorder, dysmorphism/syndrome were excluded. Obesity was defined as BMIe”95th percentile for age and sex using CDC growth chart. Children underwent two-hour oral glucose tolerance test, anthropometric and blood pressure measurement. Fasting serum insulin and lipid profile were measured. Impaired glucose tolerance (IGT) was defined as fasting plasma glucose (FPG) <7 mmol/L and 2 hr post glucose load e”7.8 mmol/L to<11.1 mmol/L. Metabolic syndrome was identified if 3 or more of following criteria were met: BMI > 97th percentile for age and sex, high triglyceride (TGe”150 mg/dl), low high-density lipoprotein cholesterol (HDL cholesterol<40mg/dl), Systolic or diastolic blood pressure>95th percentile for age and sex, IGT. Results: A total of 161 children presented with obesity. Male to female ratio was 1.3:1. Mean age was 10.3±2.5 years. Metabolic syndrome was identified in 36.6% subjects (59 out of 161, twenty five male and 34 female). Higher BMI and hip circumference, systolic and diastolic hypertension, high TG, low HDL cholesterol and IGT were significantly associated with metabolic syndrome. Conclusions: The prevalence of metabolic syndrome is high among obese children and adolescents. Factors contributing towards obesity needs to be identified and strategies should be planned for prevention and management of this health problem. DOI: http://dx.doi.org/10.3329/birdem.v1i1.12382 Birdem Med J 2011; 1(1): 21-25

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