Congenital anomalies, labor/delivery complications, maternal risk factors and their relationship with perfluorooctanoic acid (PFOA)-contaminated public drinking water

Abstract: Nowadays, problems of the quality of the child life is the main priority in national health program, inter alia congenital anomaly which is defined as structural or functional anomaly (example metabolic disorders) that occurs during intrauterine life and can be identified before birth, at birth, or after birth. This study was aimed to find out the risk factors that related to the occurrence of congenital anomalies in the neonati at Prof . Dr. R. D. Kandou Hospital Manado. This was a descriptive retrospective study. Total samples were 66 neonates that fulfilled the inclusion criteria as follows: neonates who were born and taken cared at Prof. Dr. R. D. Kandou Hospital Manado. The results showed that maternal risk factors had a major role to the occurrence of congenital anomalies. Conclusion: Maternal infection during pregnancy was the most common risk factor, however, several congenital anomalies had unknown risk factor.Keywords: neonates, congenital anomalies, maternal risk factor Abstrak: Pada zaman sekarang ini masalah kualitas hidup anak merupakan prioritas utama bagi program kesehatan nasional. Salah satu faktor yang memengaruhi kualitas hidup anak ialah adanya kelainan bawaan yaitu anomali struktural atau fungsional (misalnya gangguan metabolisme) yang terjadi selama hidup intrauterin dan dapat diidentifikasi sebelum lahir, saat lahir, atau di kemudian hari. Penelitian ini bertujuan untuk mengetahui faktor risiko yang berhubungan dengan kejadian kelainan bawaan pada neonatus di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif retrospektif. Sampel sebanyak 66 neonati dengan kriteria inklusi neonatus yang lahir dan dirawat di RSUP Prof Dr. R. D. Kandou Manado. Hasil penelitian memperlihatkan bahwa faktor risiko ibu berperan penting terhadap kejadian kelainan bawaan. Simpulan: Infeksi ibu selama kehamilan merupakan faktor risiko ibu yang paling sering ditemukan pada kelainan bawaan. Walalupun demikian, terdapat juga faktor-faktor yang tidak diketahui yang memengaruhi kejadian kelainan bawaan. Kata kunci: neonatus, kelainan bawaan, faktor risiko ibu

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Response to Comment on “Occurrence and Potential Significance of Perfluorooctanoic Acid (PFOA) Detected in New Jersey Public Drinking Water Systems”

Environmental Science & Technology ◽

10.1021/es9027524 ◽

2009 ◽

Vol 43 (22) ◽

pp. 8699-8700 ◽

Cited By ~ 3

Author(s):

Gloria B. Post ◽

Keith R. Cooper ◽

Judith B. Louis ◽

R. Lee Lippincott

Keyword(s):

Drinking Water ◽

New Jersey ◽

Perfluorooctanoic Acid ◽

Water Systems ◽

Potential Significance ◽

Public Drinking Water ◽

Public Drinking ◽

Drinking Water Systems

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Comment on “Occurrence and Potential Significance of Perfluorooctanoic Acid (PFOA) Detected in New Jersey Public Drinking Water Systems”

Environmental Science & Technology ◽

10.1021/es902326f ◽

2009 ◽

Vol 43 (22) ◽

pp. 8701-8701 ◽

Cited By ~ 1

Author(s):

Robert G. Tardiff

Keyword(s):

Drinking Water ◽

New Jersey ◽

Perfluorooctanoic Acid ◽

Water Systems ◽

Potential Significance ◽

Public Drinking Water ◽

Public Drinking ◽

Drinking Water Systems

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Congenital anomalies: the spectrum of distribution and associated maternal risk factors in a tertiary teaching hospital

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20171427 ◽

2017 ◽

Vol 6 (4) ◽

pp. 1555

Author(s):

Vinitha Wills ◽

Jacob Abraham ◽

N. S. Sreedevi

Keyword(s):

Risk Factors ◽

Cardiovascular System ◽

Congenital Anomalies ◽

Public Awareness ◽

Maternal Diabetes ◽

Tertiary Hospital ◽

Urinary System ◽

Maternal Risk Factors ◽

Maternal Risk ◽

Tertiary Teaching

Background: To study the system-wise occurrence of congenital anomalies in newborns admitted in a tertiary hospital and to study the associated maternal factors.Methods: This is a retrospective study of all the mothers and their newborn babies with congenital anomalies who were delivered or referred to the Obstetrical Department / Neonatology unit during a two-year study period. The maternal risk factors and associated Obstetric complications were studied.Results: Among the babies born with congenital anomalies, the systems most involved were Genito-urinary System (28.5%) and Cardiovascular System (20.5%). Among the maternal risk factors, Diabetes (14.01%), previous abortions (12.7%) and hypothyroidism (8.7%) were the most significant associated factors. Intrauterine growth restriction (17.4%) was noted to be more common in these babies.Conclusions: The incidence of anomalies was most involving the Genito-urinary System and Cardiovascular System. The major risk factor identified was maternal Diabetes. Prevention by public awareness during adolescence, pre-conceptional counseling and antenatal screening is stressed. Availability of Pediatric surgery and Rehabilitative facilities to improve the quality of life would be warranted.

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Addition to “Response to Comment on ‘Occurrence and Potential Significance of Perfluorooctanoic Acid (PFOA) Detected in New Jersey Public Drinking Water Systems’”

Environmental Science & Technology ◽

10.1021/es903038p ◽

2009 ◽

Vol 43 (22) ◽

pp. 8702-8702

Author(s):

Gloria B. Post ◽

Keith R. Cooper ◽

Judith B. Louis ◽

R. Lee Lippincott

Keyword(s):

Drinking Water ◽

New Jersey ◽

Perfluorooctanoic Acid ◽

Water Systems ◽

Potential Significance ◽

Public Drinking Water ◽

Public Drinking ◽

Drinking Water Systems

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Spectrum of congenital malformations at birth among neonates in a private medical college in South Rajasthan

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20193723 ◽

2019 ◽

Vol 6 (5) ◽

pp. 2053

Author(s):

Ravi Bhatia ◽

Gunjan Bhatia

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Congenital Anomalies ◽

Congenital Malformations ◽

Significant Risk ◽

Management Problem ◽

Maternal Risk Factors ◽

Patient Counseling ◽

Maternal Risk ◽

Medical College

Background: Congenital anomalies contribute to about 12% neonatal deaths annually .Neonates with multiple congenital malformations pose a very difficult management problem for the treating physician. This study was done to know the incidence, pattern of congenital anomalies and to study various maternal risk factors leading to congenital anomalies which may help us in devising strategies for better patient counseling and management.Methods: Prospective cross sectional study carried out from 1st Jan 2014 to 31st December 2018 in a private medical college in India. Neonates (both live and still born) delivered in our hospital during this period formed the part of study group. All congenital anomalies present were documented and classified according to system involoved.Results: Total number of neonates with congenital anomalies were 90, out of which 73 were live births and 17 were still births. The overall incidence of congenital anomalies was 2.375%. The commonest system affected was musculoskeletal system (27.7%) followed by CNS (24.4%). Among the maternal risk factors studied, increased maternal age, consanguineous marriage, maternal gestational diabetes mellitus were all significant risk factors associated with congenital anomalies.Conclusion: Congenital anomalies are a global health problem. In our study we have documented that multiparity, consanguinity, diabetes mellitus, Pregnancy induced Hypertension (PIH), maternal anemia, maternal malnutrition to be major contributing factors for congenital anomalies. Present study highlighted that musculoskeletal and CNS systems to be the most commonly affected by congenital malformations. Antenatal scans remain an important diagnostic tool in screening for congenital anomalies. A good clinical examination at birth could help in early detection of life threatening congenital malformation thereby improving chances of his or her survival.

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