scholarly journals Spectrum of congenital malformations at birth among neonates in a private medical college in South Rajasthan

2019 ◽  
Vol 6 (5) ◽  
pp. 2053
Author(s):  
Ravi Bhatia ◽  
Gunjan Bhatia
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Congenital Anomalies ◽  
Congenital Malformations ◽  
Significant Risk ◽  
Management Problem ◽  
Maternal Risk Factors ◽  
Patient Counseling ◽  
Maternal Risk ◽  
Medical College

Background: Congenital anomalies contribute to about 12% neonatal deaths annually .Neonates with multiple congenital malformations pose a very difficult management problem for the treating physician. This study was done to know the incidence, pattern of congenital anomalies and to study various maternal risk factors leading to congenital anomalies which may help us in devising strategies for better patient counseling and management.Methods: Prospective cross sectional study carried out from 1st Jan 2014 to 31st December 2018 in a private medical college in India. Neonates (both live and still born) delivered in our hospital during this period formed the part of study group. All congenital anomalies present were documented and classified according to system involoved.Results: Total number of neonates with congenital anomalies were 90, out of which 73 were live births and 17 were still births. The overall incidence of congenital anomalies was 2.375%. The commonest system affected was musculoskeletal system (27.7%) followed by CNS (24.4%). Among the maternal risk factors studied, increased maternal age, consanguineous marriage, maternal gestational diabetes mellitus were all significant risk factors associated with congenital anomalies.Conclusion: Congenital anomalies are a global health problem. In our study we have documented that multiparity, consanguinity, diabetes mellitus, Pregnancy induced Hypertension (PIH), maternal anemia, maternal malnutrition to be major contributing factors for congenital anomalies. Present study highlighted that musculoskeletal and CNS systems to be the most commonly affected by congenital malformations. Antenatal scans remain an important diagnostic tool in screening for congenital anomalies. A good clinical examination at birth could help in early detection of life threatening congenital malformation thereby improving chances of his or her survival.

scholarly journals A Case-Control Study for Assessing Risk Factors for Congenital Anomalies among Children in Sulaimani City

2018 ◽  
pp. 90-95 ◽  
Author(s):  
Niaz Mustafa Kamal ◽  
Nasih Othman
Keyword(s):  
Risk Factors ◽  
Congenital Anomalies ◽  
Maternal Obesity ◽  
Case Control Study ◽  
Significant Risk ◽  
Case Control ◽  
P Value ◽  
Maternal Risk ◽  
Wide Range ◽  
Control Study

Congenital anomalies comprise a wide range of abnormalities in body structure or function that are present at birth and are of prenatal origin. These are defined as structural changes that have significant medical, social or cosmetic consequences for the affected individual, and typically require medical intervention. According to our Knowledge, research is scarce on these conditions in Sulaimaniyah city. Therefore, the current study was conducted to investigate potential risk factors for congenital anomalies. A case-control study was carried out from March to August 2017 involving 400 children (200 cases and 200 controls) aged 0-5 years. Required data were obtained on the risk factors through face to face interviews with mothers of cases and controls. The data were using descriptive statistical methods, Chi-square and Logistic Regression using STATA 11, calculating odds ratios and condensing P value less than 0.05 as statistically significant. The mean age of the children was 1.9 years and age of their mothers at the time of pregnancy was 28 years. Congenital heart anomalies were the commonest type accounting for 27.5%. Significant risk factors for congenital anomalies were family history (OR=2.24, P= 0.007), maternal obesity (OR= 2.26, P= 0.001), mothers age over 30 (OR=2.78, P= 0.002) and mothers not using folic acid during pregnancy (OR=2.12, P= 0.0007). In general, in order to control and prevent the cases of CM, it is important to provide health education and policies to reduce environmental and maternal risk factors. Further, studies with larger sample size are needed to investigate incidence and risk factors of congenital anomalies.

Pattern of congenital anomalies and associated maternal risk factors : A study from Mysore, South India

2019 ◽  
Vol 6 (4) ◽  
pp. 444-447
Author(s):  
Swathi Hassan Kumarachar ◽  
Mamatha Shivanagappa ◽  
Mahesh Mahadevaiah ◽  
Madhumitha Mahesh
Keyword(s):  
Risk Factors ◽  
Congenital Anomalies ◽  
South India ◽  
Maternal Risk Factors ◽  
Maternal Risk

scholarly journals Amniotic fluid disorders and the effects on prenatal outcome: a retrospective cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
H. Bakhsh ◽  
H. Alenizy ◽  
S. Alenazi ◽  
S. Alnasser ◽  
N. Alanazi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Cohort Study ◽  
Amniotic Fluid ◽  
Retrospective Cohort ◽  
Fetal Outcome ◽  
Maternal Risk Factors ◽  
Amniotic Fluid Index ◽  
Maternal Risk ◽  
Vaginal Deliveries

Abstract Background The amniotic fluid is a protective liquid present in the amniotic sac. Two types of amniotic fluid disorders have been identified. First refers to polyhydramnios, which is an immoderate volume of amniotic fluid with an Amniotic Fluid Index (AFI) greater than 24 cm. Second includes oligohydramnios, which refers to decreased AFI i.e., less than 5 cm. This study aims to; a) identify the maternal risk factors associated with amniotic fluid disorders, b) assess the effect of amniotic fluid disorders on maternal and fetal outcome c) examine the mode of delivery in pregnancy complicated with amniotic fluid disorders. Methods A comparative retrospective cohort study design is followed. Sample of 497 pregnant women who received care at King Abdullah bin Abdul-Aziz University Hospital (KAAUH) between January 2017 to October 2019 was included. Data were collected from electronic medical reports, and was analyzed using descriptive statistics. Association of qualitative variables was conducted by Chi-square test, where p-value < 0.05 was considered statistically significant. Results Among the collected data, 2.8% of the cases had polyhydramnios and 11.7% patients had oligohydramnios. One case of still born was identified. A statically significant association was found between polyhydramnios and late term deliveries (P = 0.005) and cesarean section (CS) rates (P = 0.008). The rate of term deliveries was equal in normal AFI and oligohydramnios group (P = 0.005). Oligohydramnios was mostly associated with vaginal deliveries (P = 0.008). Oligohydramnios and polyhydramnios were found to be associated with diabetes mellitus patients (P = 0.005), and polyhydramnios with gestational diabetes patients (P = 0.052). Other maternal chronic diseases showed no effect on amniotic fluid index, although it might cause other risks on the fetus. Conclusion Diabetes mellitus and gestational diabetes are the most important maternal risk factors that can cause amniotic fluid disorders. Maternal and fetal outcome data showed that oligohydramnios associated with gestational age at term and low neonatal birth weight with high rates of vaginal deliveries, while polyhydramnios associated with gestational age at late term and high birth weight with higher rates of CS.

scholarly journals Risk of hearing loss in small for gestational age neonates

2011 ◽  
Vol 51 (1) ◽  
pp. 52 ◽  
Author(s):  
Melani Rakhmi Mantu ◽  
Lelani Reniarti ◽  
Sjarif Hidajat Effendi
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Hearing Loss ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Later Life ◽  
Cross Sectional Study ◽  
Maternal Risk Factors ◽  
Cross Sectional ◽  
Maternal Risk

Background Small for gestational age (SGA) neonates often have intrauterine growth restriction due to placental insufficiency and chronic hypoxia. These conditions may cause developmental impairment, psychosocial disabilities, or metabolic dysfunction in later life. Previous studies have shown greater incidence of speech and language disabilities, learning impairment, and neuromotor dysfunction in term SGA infants compared to term appropriate for gestational age (AGA) infants.Objective To compare hearing loss in SGA and AGA neonates using otoocoustic emission (OAE) tests and to study correlations between maternal risk factors and hearing loss in SGA neonates.Methods A cross-sectional study was performed in St. Borromeus Hospital, Limijati Hospital, and Melinda Hospital in Bandung from February to May 2010. Study subjects consisted of full-term neonates born in these three hospitals. A retrospective medical record review was performed for this study. Statistical analysis was done by multivariable logistic-regression.Results There was a total of 4279 subjects in our study, including 100 SGA neonates and 4179 AGA neonates. We observed a greater percentage of OAE 'refer' (indicating abnormal OAE) results in the SGA group compared to the AGA group (P<0.001, Z=13.247). For suhjects with OAE 'refer' results, we also analyzed the correlation to the following maternal risk factors: smoking, hypertension, diabetes mellitus and asthma. We also found significant differences between  those with and without each of the four maternal risk factors studied (P< 0.001). By using multivariant analysis to compare SGA and AGA neonates, we found the odds ratio (OR) to he 4.34 (95% CI 2.52 to 7.49, P=0.001), meaning the SGA group had a 4.34 times higher risk of hearing loss than the AGA group.Conclusion SGA neonates had a higher risk of hearing loss than AGA neonates. In addition, maternal smoking, hypertension, diabetes mellitus and asthma significantly correlated to hearing loss in all newborns. [

scholarly journals Faktor risiko yang berhubungan dengan kejadian kelainan bawaan pada neonatus di RSUP Prof Dr. R. D. Kandou Manado

e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Evan G. Polii ◽  
Rocky Wilar ◽  
Adrian Umboh
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Congenital Anomalies ◽  
Health Program ◽  
Child Life ◽  
Maternal Risk Factors ◽  
Common Risk Factor ◽  
Maternal Risk ◽  
Unknown Risk

Abstract: Nowadays, problems of the quality of the child life is the main priority in national health program, inter alia congenital anomaly which is defined as structural or functional anomaly (example metabolic disorders) that occurs during intrauterine life and can be identified before birth, at birth, or after birth. This study was aimed to find out the risk factors that related to the occurrence of congenital anomalies in the neonati at Prof . Dr. R. D. Kandou Hospital Manado. This was a descriptive retrospective study. Total samples were 66 neonates that fulfilled the inclusion criteria as follows: neonates who were born and taken cared at Prof. Dr. R. D. Kandou Hospital Manado. The results showed that maternal risk factors had a major role to the occurrence of congenital anomalies. Conclusion: Maternal infection during pregnancy was the most common risk factor, however, several congenital anomalies had unknown risk factor.Keywords: neonates, congenital anomalies, maternal risk factor Abstrak: Pada zaman sekarang ini masalah kualitas hidup anak merupakan prioritas utama bagi program kesehatan nasional. Salah satu faktor yang memengaruhi kualitas hidup anak ialah adanya kelainan bawaan yaitu anomali struktural atau fungsional (misalnya gangguan metabolisme) yang terjadi selama hidup intrauterin dan dapat diidentifikasi sebelum lahir, saat lahir, atau di kemudian hari. Penelitian ini bertujuan untuk mengetahui faktor risiko yang berhubungan dengan kejadian kelainan bawaan pada neonatus di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif retrospektif. Sampel sebanyak 66 neonati dengan kriteria inklusi neonatus yang lahir dan dirawat di RSUP Prof Dr. R. D. Kandou Manado. Hasil penelitian memperlihatkan bahwa faktor risiko ibu berperan penting terhadap kejadian kelainan bawaan. Simpulan: Infeksi ibu selama kehamilan merupakan faktor risiko ibu yang paling sering ditemukan pada kelainan bawaan. Walalupun demikian, terdapat juga faktor-faktor yang tidak diketahui yang memengaruhi kejadian kelainan bawaan. Kata kunci: neonatus, kelainan bawaan, faktor risiko ibu

scholarly journals Assessment of epidemiological profile of neonatal seizure cases admitted to a tertiary health center of Odisha, India: a cross-sectional study

2018 ◽  
Vol 6 (1) ◽  
pp. 181
Author(s):  
Geetanjali Sethy ◽  
Dhaneswari Jena ◽  
Pullakranjan Mallik ◽  
Sithun Kumar Patro ◽  
Biswakalyan Mishra
Keyword(s):  
Risk Factors ◽  
Newborn Care ◽  
Cross Sectional Study ◽  
Neonatal Seizures ◽  
Sectional Study ◽  
Maternal Risk Factors ◽  
Cross Sectional ◽  
Maternal Risk ◽  
Medical College ◽  
Epidemiological Profile

Background: Neonatal seizures are common manifestations of neurologic dysfunction in newborns. The incidence of  seizures in neonatal period is higher than any other period of life. It is one of the common causes of admission to special newborn care unit. Therefore, it has been decided to assess the epidemiological profile of neonatal seizure.Methods: A cross-sectional study was conducted from January2017 to June 2018, in the SNCU of MKCG Medical College and Hospital, Berhampur. A total of 300 neonates admitted to SNCU with clinically apparent seizure were the study population and convenient sampling method was used for selecting them. The approval was taken from IEC MKCG Medical College to carry out the study. The data was collected by using a pretested proforma from parents and hospital records. Verbal informed consent was taken from parents. The data so collected was analysed in the department of Pediatrics.Results: Out of the total 300 babies, 66% were males, 61.34% were early neonates,77% babies were of primi  mothers,76% of babies were outborn . 62.12% of babies were born by vaginal route. HIE was most common (88%) cause of seizure. Out of the all seizure types, subtle seizure was most common (87.67%), followed by clonic seizure (35.67%). Various maternal risk factors were present in 81.81 % of cases. Most common risk factor was anemia (50.57%).18.93% of cases were born with  history of obstructed labor/prolonged labor. Overall mortality was 8%.Conclusions: Neonatal seizures are important causes of morbidity and mortality in newborns. Prevention of HIE and maternal risk factors along with early use of an effective drug with minimum side effects are the ways to overcome this problem.

scholarly journals Maternal Factors for Low Birth Weight and Preterm Birth At Tertiary Care Hospital

2015 ◽  
Vol 53 (200) ◽  
pp. 250-255 ◽  
Author(s):  
Neebha Ojha
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
Significant Risk ◽  
Maternal Risk Factors ◽  
Maternal Risk ◽  
Medical Disorders ◽  
History Of ◽  
The Mean

Introduction: Low birth weight and preterm birth are the major community health problems in developing countries. They are the major determinants of perinatal survival and infant morbidity and mortality.  The aim of this study was to determine the proportion and the maternal risk factors for low birth weight and preterm birth among hospital deliveries in Tribhuvan University Teaching Hospital. Methods: A cross sectional retrospective study was carried out in the Department of Obstetrics and Gynecology of TUTH. Maternal risk factors like age, parity, ethnicity, history of previous abortion, history of previous cesarean section, antepartum hemorrhage and medical disorders were studied. Information on all births that occurred was extracted from maternity case notes and delivery registers. Results: During the study period, there were 685 singleton live births.  Among these 78(11.4%) were low birth weight and 47(6.9%) were preterm birth. The mean birth weight was 2950 ± 488 gm. The mean weight of female was statistically less compared to male babies (p=0.032). The significant risk factors for LBW were primiparity (OR 2.12; 95%CI 1.25-3.58), Indo-Aryan ethnicity (OR 1.97; 95%CI 1.12-3.45) and history of medical disorder (OR 3.08; 95%CI 1.17-8.12). As for PTB antepartum hemorrhage (OR 8.63; 95%CI 1.99-37.30) and history of medical disorder (OR 3.20; 95%CI 1.04-9.89) were significant risk factors. Conclusions: Parity, ethnicity, and medical disorders were the main risk factors for low birth weight. Antepartum hemorrhage and medical disorders were significant risk factors for preterm birth. Keywords: low birth weight; preterm birth; risk factors.

scholarly journals Congenital anomalies: the spectrum of distribution and associated maternal risk factors in a tertiary teaching hospital

2017 ◽  
Vol 6 (4) ◽  
pp. 1555
Author(s):  
Vinitha Wills ◽  
Jacob Abraham ◽  
N. S. Sreedevi
Keyword(s):  
Risk Factors ◽  
Cardiovascular System ◽  
Congenital Anomalies ◽  
Public Awareness ◽  
Maternal Diabetes ◽  
Tertiary Hospital ◽  
Urinary System ◽  
Maternal Risk Factors ◽  
Maternal Risk ◽  
Tertiary Teaching

Background: To study the system-wise occurrence of congenital anomalies in newborns admitted in a tertiary hospital and to study the associated maternal factors.Methods: This is a retrospective study of all the mothers and their newborn babies with congenital anomalies who were delivered or referred to the Obstetrical Department / Neonatology unit during a two-year study period. The maternal risk factors and associated Obstetric complications were studied.Results: Among the babies born with congenital anomalies, the systems most involved were Genito-urinary System (28.5%) and Cardiovascular System (20.5%). Among the maternal risk factors, Diabetes (14.01%), previous abortions (12.7%) and hypothyroidism (8.7%) were the most significant associated factors. Intrauterine growth restriction (17.4%) was noted to be more common in these babies.Conclusions: The incidence of anomalies was most involving the Genito-urinary System and Cardiovascular System. The major risk factor identified was maternal Diabetes. Prevention by public awareness during adolescence, pre-conceptional counseling and antenatal screening is stressed. Availability of Pediatric surgery and Rehabilitative facilities to improve the quality of life would be warranted.

PREDICTORS OF PREECLAMPSIA IN PREGNANT WOMEN WITH DIABETES MELLITUS

Vestnik ◽  
2021 ◽  
pp. 1-6
Author(s):  
С.Ш. Исенова ◽  
Г.Ж. Бодыков ◽  
Н.В. Ким ◽  
А.Б. Асемов
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Lipid Metabolism ◽  
Early Diagnosis ◽  
Biochemical Markers ◽  
First Trimester ◽  
Maternal Risk Factors ◽  
Maternal Risk ◽  
Potential Value ◽  
First Trimester Of Pregnancy

В данном обзоре на основании литературных данных изучен ряд биомаркеров и определена их связь с развитием преэклампсии у женщин с прегестационным сахарным диабетом в I триместре беременности. В связи с тем, что в основе этих состояний лежат схожие механизмы, ранняя диагностика преэклампсии у данной категории пациенток значительно затруднена. Выполнена оценка материнских факторов риска, биофизических и биохимических маркеров, показана их роль в предикции преэклампсии. Установлено, что при наличии сахарного диабета исследование некоторых гормонов, маркеров воспалительной реакции, метаболизма липидов может иметь потенциальную ценность для прогнозирования развития преэклампсии. Таким образом, для активного внедрения биомаркеров в практическую деятельность требуются дальнейшее, более детальное изучение этого направления и оптимизация дизайна исследований. In this review, based on the literature data, a number of biomarkers have been studied and their relationship with the development of preeclampsia in women with pregestational diabetes mellitus in the first trimester of pregnancy has been determined. Due to the fact that these conditions are based on similar mechanisms, early diagnosis of preeclampsia in this category of patients is significantly difficult. The assessment of maternal risk factors, biophysical and biochemical markers was carried out, their role in the prediction of preeclampsia was shown. It has been established that in the presence of diabetes mellitus, the study of certain hormones, markers of the inflammatory response, lipid metabolism may be of potential value for predicting the development of preeclampsia. Thus, for the active introduction of biomarkers into practice, further, more detailed study of this area and optimization of research design are required.

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