Congenital anomalies: the spectrum of distribution and associated maternal risk factors in a tertiary teaching hospital

Background: To study the system-wise occurrence of congenital anomalies in newborns admitted in a tertiary hospital and to study the associated maternal factors.Methods: This is a retrospective study of all the mothers and their newborn babies with congenital anomalies who were delivered or referred to the Obstetrical Department / Neonatology unit during a two-year study period. The maternal risk factors and associated Obstetric complications were studied.Results: Among the babies born with congenital anomalies, the systems most involved were Genito-urinary System (28.5%) and Cardiovascular System (20.5%). Among the maternal risk factors, Diabetes (14.01%), previous abortions (12.7%) and hypothyroidism (8.7%) were the most significant associated factors. Intrauterine growth restriction (17.4%) was noted to be more common in these babies.Conclusions: The incidence of anomalies was most involving the Genito-urinary System and Cardiovascular System. The major risk factor identified was maternal Diabetes. Prevention by public awareness during adolescence, pre-conceptional counseling and antenatal screening is stressed. Availability of Pediatric surgery and Rehabilitative facilities to improve the quality of life would be warranted.

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Study of congenital malformations in newborns: a hospital based prospective study

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20172676 ◽

2017 ◽

Vol 4 (4) ◽

pp. 1409

Author(s):

Kinjal G. Patel ◽

Chintu Chaudhary

Keyword(s):

Risk Factors ◽

Cardiovascular System ◽

Congenital Malformations ◽

Tertiary Care ◽

Maternal Diabetes ◽

Fetal Life ◽

Care Hospital ◽

Maternal Risk Factors ◽

Maternal Risk ◽

Antenatal Ultrasonography

Background: Congenital malformations represent a defect in the morphogenesis during fetal life. Since the introduction of primary health care and immunization programme, congenital malformations have emerged as one of the commonest cause of perinatal mortality. The objective was to study the incidence, systemic distribution, various maternal risk factors and immediate outcome of congenital malformations in hospital delivered neonates.Methods: This study was conducted at a tertiary care hospital for a period of 2 years. All the hospital delivered live neonates and stillbirth babies with congenital malformations are included in this study. Detailed history, examinations and investigations are carried out to identify etiological factors. Their outcome in form of morbidity and mortality are taken up to their hospital stay.Results: Out of 9600 babies with malformations 171(1.88%) having single malformation and 23(0.25%) having multiple malformations. Incidence of malformations was higher in stillbirths (24.25/1000 livebirths) against than in live births (19.96/1000 livebirths). The cardiovascular system was involved in 23.4% of babies, followed by musculoskeletal system (22.3%) then gastrointestinal (15.9%) and genitourinary system (15.4%). Multiple malformations were seen in 11.8% cases. Maternal risk factors associated with malformations were oligohydramnios in 4.12%, previous abortion in 2.5%, eclampsia in 2.5%, polyhydramnios in 1.54%, maternal diabetes in 1.54% and consanguinity in 1.03%. Maximum mortality occurred in babies with gastrointestinal system malformations (56.5%) followed by cardiovascular system malformations (21.7%). Majority of babies with malformations discharged (78.9%) only 11.8% of babies expired and 2.6% of babies left against medical advice (LAMA).Conclusions: Congenital malformations represent one of the causes of neonatal mortality. Stillborn babies have higher incidence of malformations. Antenatal ultrasonography and maternal risk factors has important role to identify malformations. Early detection and timely management required to decrease the mortality.

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Pattern of congenital anomalies and associated maternal risk factors : A study from Mysore, South India

Indian Journal of Obstetrics and Gynecology Research ◽

10.18231/j.ijogr.2019.097 ◽

2019 ◽

Vol 6 (4) ◽

pp. 444-447

Author(s):

Swathi Hassan Kumarachar ◽

Mamatha Shivanagappa ◽

Mahesh Mahadevaiah ◽

Madhumitha Mahesh

Keyword(s):

Risk Factors ◽

Congenital Anomalies ◽

South India ◽

Maternal Risk Factors ◽

Maternal Risk

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Assessment of maternal risk factors associated with low birth weight neonates at a tertiary hospital, Nanded, Maharashtra

Nigerian Medical Journal ◽

10.4103/0300-1652.180564 ◽

2016 ◽

Vol 57 (1) ◽

pp. 37 ◽

Cited By ~ 5

Author(s):

VijayKishanrao Domple ◽

MohanK Doibale ◽

Abhilasha Nair ◽

PinkeshS Rajput

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Low Birth Weight ◽

Tertiary Hospital ◽

Maternal Risk Factors ◽

Maternal Risk ◽

Factors Associated

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Faktor risiko yang berhubungan dengan kejadian kelainan bawaan pada neonatus di RSUP Prof Dr. R. D. Kandou Manado

e-CliniC ◽

10.35790/ecl.4.2.2016.14466 ◽

2016 ◽

Vol 4 (2) ◽

Author(s):

Evan G. Polii ◽

Rocky Wilar ◽

Adrian Umboh

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Congenital Anomalies ◽

Health Program ◽

Child Life ◽

Maternal Risk Factors ◽

Common Risk Factor ◽

Maternal Risk ◽

Unknown Risk

Abstract: Nowadays, problems of the quality of the child life is the main priority in national health program, inter alia congenital anomaly which is defined as structural or functional anomaly (example metabolic disorders) that occurs during intrauterine life and can be identified before birth, at birth, or after birth. This study was aimed to find out the risk factors that related to the occurrence of congenital anomalies in the neonati at Prof . Dr. R. D. Kandou Hospital Manado. This was a descriptive retrospective study. Total samples were 66 neonates that fulfilled the inclusion criteria as follows: neonates who were born and taken cared at Prof. Dr. R. D. Kandou Hospital Manado. The results showed that maternal risk factors had a major role to the occurrence of congenital anomalies. Conclusion: Maternal infection during pregnancy was the most common risk factor, however, several congenital anomalies had unknown risk factor.Keywords: neonates, congenital anomalies, maternal risk factor Abstrak: Pada zaman sekarang ini masalah kualitas hidup anak merupakan prioritas utama bagi program kesehatan nasional. Salah satu faktor yang memengaruhi kualitas hidup anak ialah adanya kelainan bawaan yaitu anomali struktural atau fungsional (misalnya gangguan metabolisme) yang terjadi selama hidup intrauterin dan dapat diidentifikasi sebelum lahir, saat lahir, atau di kemudian hari. Penelitian ini bertujuan untuk mengetahui faktor risiko yang berhubungan dengan kejadian kelainan bawaan pada neonatus di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif retrospektif. Sampel sebanyak 66 neonati dengan kriteria inklusi neonatus yang lahir dan dirawat di RSUP Prof Dr. R. D. Kandou Manado. Hasil penelitian memperlihatkan bahwa faktor risiko ibu berperan penting terhadap kejadian kelainan bawaan. Simpulan: Infeksi ibu selama kehamilan merupakan faktor risiko ibu yang paling sering ditemukan pada kelainan bawaan. Walalupun demikian, terdapat juga faktor-faktor yang tidak diketahui yang memengaruhi kejadian kelainan bawaan. Kata kunci: neonatus, kelainan bawaan, faktor risiko ibu

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Congenital anomalies, labor/delivery complications, maternal risk factors and their relationship with perfluorooctanoic acid (PFOA)-contaminated public drinking water

Reproductive Toxicology ◽

10.1016/j.reprotox.2009.10.012 ◽

2010 ◽

Vol 29 (2) ◽

pp. 147-155 ◽

Cited By ~ 23

Author(s):

Lynda A. Nolan ◽

John M. Nolan ◽

Frances S. Shofer ◽

Nancy V. Rodway ◽

Edward A. Emmett

Keyword(s):

Risk Factors ◽

Drinking Water ◽

Congenital Anomalies ◽

Perfluorooctanoic Acid ◽

Maternal Risk Factors ◽

Delivery Complications ◽

Maternal Risk ◽

Public Drinking Water ◽

Public Drinking

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Maternal diabetes and assisted reproductive techniques as maternal risk factors for the VACTERL association using data of EUROCAT registries and the distribution of VACTERL anomalies among VACTERL patients of EUROCAT

European Journal of Medical Genetics ◽

10.1016/j.ejmg.2018.06.054 ◽

2018 ◽

Vol 61 (9) ◽

pp. 566-567

Author(s):

Romy van de Putte ◽

Iris A.L.M. van Rooij ◽

Nel Roeleveld ◽

Maria Loane ◽

Ingeborg Barisic ◽

...

Keyword(s):

Risk Factors ◽

Maternal Diabetes ◽

Assisted Reproductive Techniques ◽

Vacterl Association ◽

Maternal Risk Factors ◽

Maternal Risk ◽

Reproductive Techniques ◽

Using Data

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Neonatal Thrombocytopenia: Its associated risk factors and outcome in NICU in a tertiary hospital in Nepal

Journal of College of Medical Sciences-Nepal ◽

10.3126/jcmsn.v14i2.19322 ◽

2018 ◽

Vol 14 (2) ◽

pp. 65-68

Author(s):

Bishow Bandhu Bagale ◽

Anita Bhandari

Keyword(s):

Risk Factors ◽

Neonatal Intensive Care ◽

Platelet Transfusion ◽

Late Onset ◽

Tertiary Hospital ◽

Severe Thrombocytopenia ◽

Maternal Risk Factors ◽

Maternal Risk ◽

Neonatal Thrombocytopenia ◽

Neonatal Risk Factors

ABSTRACTBackground: Thrombocytopenia is a frequently encountered hematological abnormality in Neonatal Intensive Care Unit (NICU). There are various maternal and neonatal risk factors associated and the incidence varies greatly depending upon the population studies. This study was performed on neonates admitted in Bharatpur Hospital NICU.Materials & Methods: In this retrospective study, 412 neonates who were admitted in NICU from November 2016 to October 2017 were included in the study. Frequency of thrombocytopenia was determined along with associated maternal and neonatal risk factors. Maternal risk factors like Pregnancy induced hypertension (PIH), Diabetes, Eclampsia, drug use and neonatal risk factors like sepsis, asphyxia, intrauterine growth retardation (IUGR), prematurity were analyzed. Requirement of platelet transfusion and the outcome were also evaluated. Results: Of the 412 neonates included, 74 had thrombocytopenia which comprised approximately 18% neonates admitted in NICU. Early onset thrombocytopenia occurring within 72 hrs comprised 91.8% while late onset thrombocytopenia occurring after 72 hrs comprised 8.2% of total thrombocytopenia. 58.1% (43) were mild , 29.7% (22) moderate and 12.2% (9) severe thrombocytopenia. The major neonatal risk factors were sepsis, asphyxia, IUGR and prematurity while gestational diabetes and PIH were maternal risk factors contributing to neonatal thrombocytopenia. Only 4.05% received platelet transfusion. 77.03% of the neonates recovered and were discharged while 12.16% neonates were referred to other centres and 5.40% neonates died.Conclusion: Neonatal thrombocytopenia accounted for 18% of neonates which were admitted in the NICU. Significant neonatal risk factors were asphyxia and sepsis and maternal risk factors were PIH and diabetes. Majority did not require platelet transfusion and outcome was also good.

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Spectrum of congenital malformations at birth among neonates in a private medical college in South Rajasthan

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20193723 ◽

2019 ◽

Vol 6 (5) ◽

pp. 2053

Author(s):

Ravi Bhatia ◽

Gunjan Bhatia

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Congenital Anomalies ◽

Congenital Malformations ◽

Significant Risk ◽

Management Problem ◽

Maternal Risk Factors ◽

Patient Counseling ◽

Maternal Risk ◽

Medical College

Background: Congenital anomalies contribute to about 12% neonatal deaths annually .Neonates with multiple congenital malformations pose a very difficult management problem for the treating physician. This study was done to know the incidence, pattern of congenital anomalies and to study various maternal risk factors leading to congenital anomalies which may help us in devising strategies for better patient counseling and management.Methods: Prospective cross sectional study carried out from 1st Jan 2014 to 31st December 2018 in a private medical college in India. Neonates (both live and still born) delivered in our hospital during this period formed the part of study group. All congenital anomalies present were documented and classified according to system involoved.Results: Total number of neonates with congenital anomalies were 90, out of which 73 were live births and 17 were still births. The overall incidence of congenital anomalies was 2.375%. The commonest system affected was musculoskeletal system (27.7%) followed by CNS (24.4%). Among the maternal risk factors studied, increased maternal age, consanguineous marriage, maternal gestational diabetes mellitus were all significant risk factors associated with congenital anomalies.Conclusion: Congenital anomalies are a global health problem. In our study we have documented that multiparity, consanguinity, diabetes mellitus, Pregnancy induced Hypertension (PIH), maternal anemia, maternal malnutrition to be major contributing factors for congenital anomalies. Present study highlighted that musculoskeletal and CNS systems to be the most commonly affected by congenital malformations. Antenatal scans remain an important diagnostic tool in screening for congenital anomalies. A good clinical examination at birth could help in early detection of life threatening congenital malformation thereby improving chances of his or her survival.

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