scholarly journals Efficacy, safety, and acceptability of polyethylene glycol 3350 without electrolytes vs magnesium hydroxide in functional constipation in children from six months to eighteen years of age: A controlled clinical trial

2021 ◽  
Author(s):  
L. Worona-Dibner ◽  
R. Vázquez-Frias ◽  
L. Valdez-Chávez ◽  
M. Verdiguel-Oyola
Keyword(s):  
Clinical Trial ◽  
Polyethylene Glycol ◽  
Magnesium Hydroxide ◽  
Functional Constipation ◽  
Controlled Clinical Trial

scholarly journals Comparison of the effect of polyethylene glycol and simultaneous administration of polyethylene glycol with probiotics in the treatment of chronic functional constipation: a clinical trial

2020 ◽  
Vol 22 (3) ◽  
pp. 135-140
Author(s):  
Karamali Kasiri ◽  
Morteza Sedehi ◽  
Sheida Mortazavi
Keyword(s):  
Clinical Trial ◽  
Body Weight ◽  
Polyethylene Glycol ◽  
Lactobacillus Rhamnosus ◽  
Functional Constipation ◽  
Water Soluble ◽  
Fecal Excretion ◽  
Simultaneous Administration ◽  
Double Blind ◽  
Significant Difference

Background and aims: Constipation is one of the most common issues in pediatrics. The aim of this study was to compare the effect of polyethylene glycol and the simultaneous administration of polyethylene glycol along with probiotics in the treatment of chronic functional constipation. Materials and Methods: In this randomized double-blind clinical trial, 150 children with chronic functional constipation referred to Imam Ali Clinic affiliated with Shahrekord University of Medical Sciences from 2017 to 2018 were included. The first group (A) consumed 1 g/ kg of body weight per day of water-soluble polyethylene glycol powder and the second group (B) consumed a probiotic powder and 1 g/kg of body weight of the water-soluble polyethylene glycol powder daily. In weeks 0, 1, and 2, questionnaires were filled out by the parents of the children and the data were analyzed. Results: The results showed that there was no significant difference in any of the variables between groups A and B (P=0.07) including the frequency of fecal excretion in week 1 (77% and 71%) and week 2 (4% and 5.4%) and stool consistency in week 1 (4% and 6.7%) and week 2 (86.7% and 92%). Moreover, there was no significant difference between groups A and B in any of the variables frequency of painful excretion in week 1 (74% and 73%, respectively) and week 2 (5.3% and 4%, respectively), frequency of abdominal pain in week 1 (61.3% and 49.3%, respectively) and week 2 (4% and 5.3%, respectively), and the frequency of fecal incontinence in week 1 (22.77% and 18.7%, respectively) and week 2 (6.7% and 1.3%) (P>0.05, respectively). Conclusion: Our results indicated that the administration of probiotic supplement (Lactobacillus Rhamnosus, Lactobacillus acidophilus, Lactobacillous Bulgaricus) has no effect on the improvement of symptoms in children with chronic constipation.

scholarly journals Single Dose or Divided Dose of Polyethylene Glycol in Treatment of Pediatric Functional Constipation: A Randomized Clinical Trial

2021 ◽  
Author(s):  
Heidar Safarpour ◽  
Mohammad Hadi Imanieh ◽  
naser honar ◽  
sajad hekmati ◽  
Naeimehossadat Asmarian
Keyword(s):  
Clinical Trial ◽  
Single Dose ◽  
Polyethylene Glycol ◽  
Randomized Clinical Trial ◽  
Divided Dose ◽  
Functional Constipation ◽  
Significant Difference ◽  
Group A ◽  
The Mean ◽  
Group B

Abstract BackgroundThis study aimed to compare different regimens of Polyethylene Glycol (PEG, single dose vs. divided dose) in the treatment of functional constipation among children aged 4-15 years.Materials and MethodsThis double-blind randomized clinical trial was conducted on the children (4-15 years old) with functional constipation who were visited in an outpatient pediatric clinic affiliated to Shiraz University of Medical Sciences between February and July 2021. Among the120 eligible patients, 80 ones who met the inclusion criteria were recruited. The patients were divided into two parallel groups; the children who received single-dose PEG (group A) and those who received PEG in divided doses (group B). The study was performed during 12 weeks and follow-up visits were scheduled at 1, 3, 6, and 12 weeks after enrollment. The outcomes were measured using the Bristol Stool Form Scale (BSFS).ResultsThe study was performed on 78 cases including 45 boys (57.7%) and 33 girls (42.3%) with the mean age of 5.52±1.79 years. After 12 weeks, a significant difference was observed between groups A and B regarding the mean of BSFS (4.94±0.52 vs. 4.50±0.88, p=0.008). However, no significant difference was observed between the two groups regarding the number of defecation times during the study. The detected complications included mild abdominal pain in eight children in group A (5.3%), fecal incontinency in six children in group B (3.8%), and painful defecation in six children in group B (3.8%).ConclusionThis study confirmed that the administration of the single dose (0.4 g/kg) of PEG early in the morning was more effective, well tolerated, and accompanied by fewer complications compared to the divided dose.

scholarly journals Effectiveness of Viola Flower Syrup Compared with Polyethylene Glycol in Children with Functional Constipation: A Randomized, Active-Controlled Clinical Trial

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Sara Tavassoli ◽  
Kambiz Eftekhari ◽  
Mehrdad Karimi ◽  
Ali Ghobadi ◽  
Mohsen Shati ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Repeated Measures ◽  
Pediatric Population ◽  
Functional Constipation ◽  
T Test ◽  
Health Concern ◽  
Controlled Clinical Trial ◽  
Repeated Measures Analysis ◽  
Significant Difference ◽  
Rome Iii

Background. Functional constipation (FC) is a health concern that is prevalent in the pediatric population. It lowers the quality of life and increases the probability of comorbidities. As a complementary modality, herbal medicine has been considered useful in a variety of conditions. Persian medicine (PM) resources mention the Viola flower as an effective herb in treating constipation. The purpose of the current trial was to evaluate the efficacy of Viola flower syrup (VFS) compared with polyethylene glycol (PEG) in children with functional constipation. Methods. This randomized, active-controlled, single-center trial was conducted on 140 children aged between 4 and 10 years with confirmed FC according to Rome III criteria. Participants were randomly assigned to receive either VFS or PEG for four weeks. Independent t-test and general linear model (GLM) repeated measures analysis of variance were used to determine the intergroup difference, and paired sample t-test was used to evaluate the intragroup difference. Results. After four weeks of intervention, 133 individuals (66 in VFS and 67 in the PEG group) were analyzed. Results of both groups demonstrated significant improvement in all measured criteria at the end of the study compared to baseline ( P < 0.001 ). No significant difference was observed between the two groups at baseline or at the end of the study ( P > 0.05 ), except for fecal retention at baseline ( P = 0.028 ). Participants in the PEG group experienced more side effects compared to the VFS group. Conclusion. The findings of this investigation indicated that VFS is an effective and relatively safe medication to be used in the treatment of pediatric FC.

scholarly journals Toxicology and safety of the tincture of Operculina alata in patients with functional constipation

2012 ◽  
Vol 48 (3) ◽  
pp. 469-476
Author(s):  
Luciana Kelly Ximenes dos Santos ◽  
Gilmara Holanda da Cunha ◽  
Francisco Vagnaldo Fechine ◽  
Andréa Vieira Pontes ◽  
Jonaina Costa de Oliveira ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Adverse Events ◽  
Functional Constipation ◽  
Clinical Aspects ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Pharmaceutical Form ◽  
Liver And Kidney ◽  
Pre Treatment ◽  
To Receive

The tincture of Operculina alata, popularly known as "tincture of jalapa", is used in Northeast Brazil to treat constipation and encephalic vascular accident, but it has not yet been adequately tested for safety and efficacy. The aim of this study was to evaluate the toxicology and safety of the tincture of O. alata in patients with functional constipation. This was a double-blind, randomized, placebo-controlled clinical trial. The study consisted of three phases: pre-treatment, treatment and post-treatment, each phase with duration of seven days. Arterial pressure, heart rate, body weight, adverse events, hematological, metabolic, liver and kidney functions were monitored. Forty patients were randomized to receive tincture of O. alata and 43 patients to receive placebo. There were statistical differences in the clinical aspects between groups, but these changes were not considered clinically significant. Adverse events were considered not serious and of mild intensity, especially dizziness, headache, abdominal pain and nausea. This clinical trial confirmed the safety of the tincture of O. alata in the pharmaceutical form and dosage tested, allowing the product to be safely used in a larger population for the assessment of its clinical efficacy.

scholarly journals Flixweed vs. Polyethylene Glycol in the Treatment of Childhood Functional Constipation: A Randomized Clinical Trial

2015 ◽  
Vol 25 (3) ◽  
Author(s):  
Majid Nimrouzi ◽  
Omid Sadeghpour ◽  
Mohammad Hadi Imanieh ◽  
Mohammadreza Shams Ardekani ◽  
Alireza Salehi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Polyethylene Glycol ◽  
Randomized Clinical Trial ◽  
Functional Constipation
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