Milk fever in dairy cows is preceded by activation of innate immunity and alterations in carbohydrate metabolism prior to disease occurrence

Investigations on the liver function and its prognostic value were performed in dairy cows with hypocalcaemic paralysis. Among the 107 animals affected by milk fever 22 showed signs of liver insufficiency. In spite of the therapy indicated, 7 of these animals were not cured. The remaining 85 sick cows, which had showed a physiologic liver function, were cured after the first therapy was applied.

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Controlling dietary cation-anion differences in forages by chloride fertilisation

Agricultural and Food Science ◽

10.23986/afsci.88781 ◽

2020 ◽

Vol 29 (1) ◽

Author(s):

Lars Nesheim ◽

Olav Martin Synnes ◽

Arvid Steen ◽

Anne Langerud ◽

Anne Kjersti Bakken

Keyword(s):

Dairy Cows ◽

Developmental Stages ◽

Field Trials ◽

Reed Canary Grass ◽

Forage Production ◽

Meadow Fescue ◽

Milk Fever ◽

Western Norway ◽

Canary Grass ◽

The Ideal

Rations with low to negative dietary cation-anion difference (DCAD) given to dairy cows before calving reduce the risk of hypocalcaemia (milk fever). Different strategies for increasing forage DCAD were investigated in field trials in Central and Western Norway. Fertilisation with 70, 140 or 210 kg Cl per hectare as calcium chloride and low supply rates of K reduced DCAD in forage harvested at late developmental stages in spring growth of timothy and meadow fescue. The ideal negative DCAD was only attained on soils very low in plant available K. Timing (spring versus late spring) and source of Cl (CaCl2 versus MgCl2) were of no importance for the result. When pure stands of seven grasses were fertilised in spring either without chloride or with 140 kg chloride per hectare, the lowest values of DCAD after chloride fertilisation were found in perennial ryegrass and reed canary grass. By comparison, cocksfoot had equally high or higher Cl concentrations in its tissues, but accumulated more K, and seemed to be poorly suited for low DCAD forage production. It was concluded that Cl fertilisation is a more efficient means of controlling DCAD than sward species composition.

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Studies of Pathogenesis and Prevention of Milk Fever of Dairy Cows

10.32747/1986.7598184.bard ◽

1986 ◽

Author(s):

Travis Littledike ◽

Arieh Bar ◽

Ronald Horst

Keyword(s):

Dairy Cows ◽

Milk Fever

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1,25-Dihydroxycholecalciferol and the Prevention of Parturient Hypocalcemia and Paresis ("Milk Fever") in Pregnant Dairy Cows

Vitamin D. Basic Research and its Clinical Application ◽

10.1515/9783112330029-115 ◽

1979 ◽

pp. 667-674

Keyword(s):

Dairy Cows ◽

Milk Fever

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Different effects of cortisol on pro-inflammatory gene expressions in LPS-, heat-killed E.coli-, or live E.coli-stimulated bovine endometrial epithelial cells

BMC Veterinary Research ◽

10.1186/s12917-020-2231-z ◽

2020 ◽

Vol 16 (1) ◽

Cited By ~ 1

Author(s):

Luying Cui ◽

Yali Wang ◽

Heng Wang ◽

Junsheng Dong ◽

Zixiang Li ◽

...

Keyword(s):

Innate Immunity ◽

Epithelial Cells ◽

Dairy Cows ◽

Bacterial Infections ◽

Gene Expressions ◽

Tlr4 Mrna ◽

Tnf Α ◽

Peripartum Period ◽

Inflammatory Action ◽

Endometrial Epithelial Cells

Abstract Background Bacterial infections are common in postpartum dairy cows. Cortisol level has been observed to increase in dairy cows during peripartum period, and is associated with the endometrial innate immunity against pathogens like E.coli. However, the mechanism underlying how cortisol regulates E.coli-induced inflammatory response in bovine endometrial epithelial cells (BEEC) remains elusive. Results Cortisol decreased the expressions of IL1β, IL6, TNF-α, IL8, and TLR4 mRNA in BEEC treated with LPS or heat-killed E.coli, but up-regulated these gene expressions in BEEC stimulated by live E.coli. Conclusion Cortisol exerted the anti-inflammatory action on LPS- or heat-killed E.coli-stimulated BEEC, but the pro-inflammatory action on live E.coli-induced BEEC.

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