Alterations in innate immunity reactants and carbohydrate and lipid metabolism precede occurrence of metritis in transition dairy cows

2016 ◽  
Vol 104 ◽  
pp. 30-39 ◽  
Author(s):  
Elda Dervishi ◽  
Guanshi Zhang ◽  
Dagnachew Hailemariam ◽  
Seyed Ali Goldansaz ◽  
Qilan Deng ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Lipid Metabolism ◽  
Dairy Cows ◽  
Carbohydrate And Lipid Metabolism ◽  
Transition Dairy Cows

scholarly journals Milk yield, milk composition, and hepatic lipid metabolism in transition dairy cows fed flaxseed or linola

2016 ◽  
Vol 99 (11) ◽  
pp. 8831-8846 ◽  
Author(s):  
R.M. do Prado ◽  
M.F. Palin ◽  
I.N. do Prado ◽  
G.T. dos Santos ◽  
C. Benchaar ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Dairy Cows ◽  
Milk Yield ◽  
Milk Composition ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Transition Dairy Cows

Dietary trans octadecenoic acids upregulate the liver gene encoding Peroxisome Proliferator-Activated Receptor-α in transition dairy cows

2005 ◽  
Vol 72 (1) ◽  
pp. 107-114 ◽  
Author(s):  
Kurt T Selberg ◽  
Charles R Staples ◽  
N Dan Luchini ◽  
Lokenga Badinga
Keyword(s):  
Lipid Metabolism ◽  
Dairy Cows ◽  
Post Partum ◽  
Basal Diet ◽  
Peroxisome Proliferator ◽  
Calcium Salts ◽  
Peroxisome Proliferator Activated Receptor ◽  
Transition Dairy Cows ◽  
Mrna Content ◽  
Octadecenoic Acids

Effects of feeding calcium salts of conjugated linoleic acid (CLA) or trans octadecenoic acids (trans 18[ratio ]1) on lipid metabolism and hepatic contents of mRNA encoding carnitine palmitoyltransferase 1 (CPT1), microsomal triglyceride transfer protein (MTP) and peroxisome proliferator-activated receptor alpha (PPARα) were examined in 15 early post-partum Holstein cows. Dietary treatments were initiated at approximately 4 weeks prior to expected calving dates and continued for 7 weeks post partum. Treatments prepartum consisted of 1) a basal diet (Control), 2) basal diet+150 g/d of CLA mix (CLA), or 3) basal diet+150 g/d of trans 18[ratio ]1 mix (TRANS). Intakes of calcium salts of CLA and trans 18[ratio ]1 mixes were adjusted to 225 g/d during the 7-week post-partum treatment period. Blood samples were collected at weeks 1, 2 and 4 post partum and plasma was harvested immediately for subsequent hormone and metabolite assays. Concentrations of insulin, insulin-like growth factor-I (IGF-I), and leptin in blood did not vary among cows fed the three diets. Plasma nonesterified fatty acid (NEFA) concentrations decreased between weeks 1 and 4 of lactation and were lower in cows fed the diet supplemented with trans 18[ratio ]1 than in those fed a control diet at week 2 post partum. Periparturient fat supplementation had no detectable effects on CPT1 mRNA content in the liver. Steady-state concentration of MTP mRNA in the liver was greater in the TRANS treatment group than in the control group at week 1 post partum. Feeding trans 18[ratio ]1 supplements to transition dairy cows upregulated hepatic PPARα mRNA content during the first month of lactation. Under the present experimental conditions, dietary CLA had minimal effects on plasma and hepatic lipid metabolite concentrations in early lactation Holstein cows. Results indicate that dietary trans fatty acids may affect liver lipid metabolism in post-partum dairy cows through alterations in PPARα gene expression.

scholarly journals Alterations of Innate Immunity Reactants in Transition Dairy Cows before Clinical Signs of Lameness

Animals ◽  
2015 ◽  
Vol 5 (3) ◽  
pp. 717-747 ◽  
Author(s):  
Guanshi Zhang ◽  
Dagnachew Hailemariam ◽  
Elda Dervishi ◽  
Qilan Deng ◽  
Seyed Goldansaz ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Dairy Cows ◽  
Clinical Signs ◽  
Transition Dairy Cows

scholarly journals Hepatic Lipid Metabolism in Transition Dairy Cows Fed Flaxseed

2007 ◽  
Vol 90 (10) ◽  
pp. 4780-4792 ◽  
Author(s):  
H.V. Petit ◽  
M.F. Palin ◽  
L. Doepel
Keyword(s):  
Lipid Metabolism ◽  
Dairy Cows ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Transition Dairy Cows

scholarly journals Effect of rumen-protected niacin on lipid metabolism, oxidative stress, and performance of transition dairy cows

2012 ◽  
Vol 95 (5) ◽  
pp. 2673-2679 ◽  
Author(s):  
K. Yuan ◽  
R.D. Shaver ◽  
S.J. Bertics ◽  
M. Espineira ◽  
R.R. Grummer
Keyword(s):  
Oxidative Stress ◽  
Lipid Metabolism ◽  
Dairy Cows ◽  
Transition Dairy Cows ◽  
And Performance

DYSLIPIDEMIA IN THYROID DISORDERS

2020 ◽  
Vol 4 (7) ◽  
Author(s):  
Kashish Narula ◽  
Narendra Kumar Dara ◽  
Shyam Lal Meena
Keyword(s):  
Lipid Metabolism ◽  
Thyroid Dysfunction ◽  
Cross Sectional Study ◽  
Control Group ◽  
Thyroid Disorders ◽  
Cross Sectional ◽  
Carbohydrate And Lipid Metabolism ◽  
History Of ◽  
Thyroid Profile ◽  
Basal Energy Expenditure

Background: Thyroid hormones influence nearly all major metabolic pathways. Their most obvious and well-known action is the increase in basal energy expenditure obtained by acting on protein, carbohydrate and lipid metabolism. The lipid metabolism is more influenced by the thyroid hormone. Methods: A cross-sectional study was conducted on 100 patients with suspicion of thyroid disorders were taken as cases. One hundred patients with normal thyroid profile and no history of other chronic diseases were taken as control group. Results: The serum TC, TG and LDL levels in hypothyroid individuals (both overt and subclinical) were significantly higher than euthyroid subjects but the levels were comparable between hyperthyroid and euthyroid group. Conclusion: Dyslipidemias are associated with thyroid disorders, so biochemical screening for thyroid dysfunction in all dyslipidemic patients. Therefore, patients presenting with dyslipidemia are recommended for investigation to explore thyroid dysfunction. Keywords: Thyroid profile, Total cholesterol, Triglycerides and LDL

scholarly journals Dysregulated liver lipid metabolism and innate immunity associated with hepatic steatosis in neonatal BBdp rats and NOD mice

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
D. Serrano ◽  
J. A. Crookshank ◽  
B. S. Morgan ◽  
R. W. Mueller ◽  
M.-F. Paré ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Lipid Metabolism ◽  
Hepatic Steatosis ◽  
Liver Lipid ◽  
Nod Mice ◽  
Gene Signature ◽  
Enhanced Expression ◽  
Liver Lipid Metabolism ◽  
Hepatic Innate Immunity ◽  
Lipid Metabolism Genes

Abstract In a previous study we reported that prediabetic rats have a unique gene signature that was apparent even in neonates. Several of the changes we observed, including enhanced expression of pro-inflammatory genes and dysregulated UPR and metabolism genes were first observed in the liver followed by the pancreas. In the present study we investigated further early changes in hepatic innate immunity and metabolism in two models of type 1 diabetes (T1D), the BBdp rat and NOD mouse. There was a striking increase in lipid deposits in liver, particularly in neonatal BBdp rats, with a less striking but significant increase in neonatal NOD mice in association with dysregulated expression of lipid metabolism genes. This was associated with a decreased number of extramedullary hematopoietic clusters as well as CD68+ macrophages in the liver of both models. In addition, PPARɣ and phosphorylated AMPKα protein were decreased in neonatal BBdp rats. BBdp rats displayed decreased expression of antimicrobial genes in neonates and decreased M2 genes at 30 days. This suggests hepatic steatosis could be a common early feature in development of T1D that impacts metabolic homeostasis and tolerogenic phenotype in the prediabetic liver.

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