The Book of Kells: A non-invasive MOLAB investigation by complementary spectroscopic techniques

2013 ◽  
Vol 115 ◽  
pp. 330-336 ◽  
Author(s):  
B. Doherty ◽  
A. Daveri ◽  
C. Clementi ◽  
A. Romani ◽  
S. Bioletti ◽  
...  
Keyword(s):  
Spectroscopic Techniques ◽  
Non Invasive ◽  
Book Of Kells

scholarly journals NMR microsystem for label-free characterization of 3D nanoliter microtissues

2020 ◽  
Author(s):  
Marco Grisi ◽  
Gaurasundar M. Conley ◽  
Kyle J. Rodriguez ◽  
Erika Riva ◽  
Lukas Egli ◽  
...  
Keyword(s):  
Early Stage ◽  
Cmos Technology ◽  
Time Frame ◽  
Ease Of Use ◽  
Chemical Information ◽  
Spectroscopic Techniques ◽  
Label Free ◽  
Alcoholic Fatty Liver ◽  
Non Invasive

AbstractPerforming chemical analysis at the nanoliter (nL) scale is of paramount importance for medicine, drug development, toxicology, and research. Despite the numerous methodologies available, a tool for obtaining chemical information non-invasively is still missing at this scale. Observer effects, sample destruction and complex preparatory procedures remain a necessary compromise1. Among non-invasive spectroscopic techniques, one able to provide holistic and highly resolved chemical information in-vivo is nuclear magnetic resonance (NMR)2,3. For its renowned informative power and ability to foster discoveries and life-saving applications4,5, efficient NMR at microscopic scales is highly sought after6–10, but so far technical limitations could not match the stringent necessities of microbiology, such as biocompatible handling, ease of use, and high throughput. Here we introduce a novel microsystem, which combines CMOS technology with 3D microfabrication, enabling nL NMR as a platform tool for non-invasive spectroscopy of organoids, 3D cell cultures, and early stage embryos. In this study we show its application to microlivers models simulating non-alcoholic fatty liver disease (NAFLD), demonstrating detection of lipid metabolism dynamics in a time frame of 14 days based on 117 measurements of single 3D human liver microtissues.

scholarly journals Portable XRF: A Tool for the Study of Corundum Gems

2017 ◽  
Vol 3 (1) ◽  
Author(s):  
Germana Barone ◽  
Paolo Mazzoleni ◽  
Danilo Bersani ◽  
Simona Raneri
Keyword(s):  
Spectroscopic Techniques ◽  
Portable Xrf ◽  
Correct Evaluation ◽  
Non Invasive ◽  
Heritage Studies ◽  
Origin Determination ◽  
Non Destructive ◽  
Xrf Spectroscopy ◽  
Destructive Methods

AbstractOrigin of gemstones is a key aspect not only in gemological field but also in Cultural Heritage studies, for the correct evaluation of precious artifacts. The studies on gems require the application of non-invasive and non-destructive methods; among them, portable spectroscopic techniques has been demonstrated as powerful tools, providing a fingerprint of gems for origin and provenance determination. In this study, portable XRF spectroscopy has been applied to test the potential of the technique for the origin determination of corundum gems. The obtained results allowed distinguishing natural and synthetic rubies and sapphires.

scholarly journals NMR microsystem for label-free characterization of 3D nanoliter microtissues

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Marco Grisi ◽  
Gaurasundar M. Conley ◽  
Kyle J. Rodriguez ◽  
Erika Riva ◽  
Lukas Egli ◽  
...  
Keyword(s):  
Early Stage ◽  
Cmos Technology ◽  
Time Frame ◽  
Ease Of Use ◽  
Chemical Information ◽  
Spectroscopic Techniques ◽  
Label Free ◽  
Alcoholic Fatty Liver ◽  
Non Invasive

AbstractPerforming chemical analysis at the nanoliter (nL) scale is of paramount importance for medicine, drug development, toxicology, and research. Despite the numerous methodologies available, a tool for obtaining chemical information non-invasively is still missing at this scale. Observer effects, sample destruction and complex preparatory procedures remain a necessary compromise. Among non-invasive spectroscopic techniques, one able to provide holistic and highly resolved chemical information in-vivo is nuclear magnetic resonance (NMR). For its renowned informative power and ability to foster discoveries and life-saving applications, efficient NMR at microscopic scales is highly sought after, but so far technical limitations could not match the stringent necessities of microbiology, such as biocompatible handling, ease of use, and high throughput. Here we introduce a novel microsystem, which combines CMOS technology with 3D microfabrication, enabling nL NMR as a platform tool for non-invasive spectroscopy of organoids, 3D cell cultures, and early stage embryos. In this study we show its application to microlivers models simulating non-alcoholic fatty liver disease, demonstrating detection of lipid metabolism dynamics in a time frame of 14 days based on 117 measurements of single 3D human liver microtissues.

scholarly journals Non-invasive spectroscopic techniques in the diagnosis of non-melanoma skin cancer

2017 ◽  
Vol 931 ◽  
pp. 012036 ◽  
Author(s):  
E Drakaki ◽  
IA Sianoudis ◽  
EN Zois ◽  
M Makropoulou ◽  
AA Serafetinides ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Spectroscopic Techniques ◽  
Non Invasive ◽  
Non Melanoma Skin Cancer ◽  
Melanoma Skin

scholarly journals Sicilian Byzantine Icons through the Use of Non-Invasive Imaging Techniques and Optical Spectroscopy: The Case of the Madonna dell’Elemosina

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7595
Author(s):  
Francesco Armetta ◽  
Gabriella Chirco ◽  
Fabrizio Lo Celso ◽  
Veronica Ciaramitaro ◽  
Eugenio Caponetti ◽  
...  
Keyword(s):  
Imaging Techniques ◽  
Spectroscopic Techniques ◽  
Eastern European ◽  
X Ray ◽  
Non Invasive ◽  
Byzantine Art ◽  
Byzantine Icons ◽  
Foreign Materials ◽  
Infrared Reflectography ◽  
First Time

The iconographic heritage is one of the treasures of Byzantine art that have enriched the south of Italy, and Sicily in particular, since the early 16th century. In this work, the investigations of a Sicilian Icon of Greek-Byzantine origin, the Madonna dell’Elemosina, is reported for the first time. The study was carried out using mainly non-invasive imaging techniques (photography in reflectance and grazing visible light, UV fluorescence, infrared reflectography, radiography, and computed tomography) and spectroscopic techniques (X-ray fluorescence and infrared spectroscopy). The identification of the constituent materials provides a decisive contribution to the correct historical and artistic placement of the Icon, a treasure of the Eastern European historical community in Sicily. Some hidden details have also been highlighted. Most importantly, the information obtained enables us to define its conservation state, the presence of foreign materials, and to direct its protection and restoration.

Regulation of Industrial Process For Non-Invasive Scanning Instrumentation—A Novel Approach

GIS Business ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. 875-884
Author(s):  
Naeem Z Azeemi ◽  
Riktesh Srivastava ◽  
Meraj Naem ◽  
Ghassan Al Utaibi ◽  
Omar al Basheer ◽  
...  
Keyword(s):  
Point Of Care ◽  
Industrial Process ◽  
Ultra Violet ◽  
Scientific Data ◽  
Spectroscopic Techniques ◽  
Precise Control ◽  
Non Invasive ◽  
Novel Approach ◽  
Infra Red ◽  
Pharmaceutical Industries

Despite the diversity in application of spectroscopic techniques ranging from pharmaceutical industries, food and beverage or petrochemical industries; scientific data produced by these instrument is still limited in accuracy and errors associated with the luminescence. Unlike Chemical Force Microscopy (CFM), non-invasive instrumentation provides reliable and precise control in Industrial Process Regulation (IPR), where a chemical compound is always a point-of-care. Additionally, growing trends in analytical instrumentation towards Lab-On-a-Chip (LOC) has shift the manufacturer’s emphasis on sensitivity as well as robustness.  Though expensive, but imaging spectrometer characterize a process or an object over a large range of luminescence  such as Visual, Ultra-Violet (UV), Near Infra-Red (NIR), Infra-Red (IR), and Raman, to name a few.

Non-Invasive and Spectroscopic Techniques for the Study of Alonso Cano's Visitation from the Golden Age of Spain

2020 ◽  
pp. 1-15
Author(s):  
Eloisa Manzano ◽  
Louis Rodrigo Rodríguez-Simón ◽  
Natalia Navas ◽  
Luis Fermin Capitán-Vallvey
Keyword(s):  
Golden Age ◽  
Spectroscopic Techniques ◽  
Non Invasive

scholarly journals THE TOMB OF SETI I (KV17) IN THE FLORENCE EGYPTIAN MUSEUM. INTEGRATED NON-INVASIVE METHODS FOR DOCUMENTATION, MATERIAL HISTORY AND DIAGNOSTICS

2017 ◽  
Vol XLII-5/W1 ◽  
pp. 127-135
Author(s):  
M. Coppola ◽  
S. Bracci ◽  
E. Cantisani ◽  
D. Magrini
Keyword(s):  
Spectroscopic Techniques ◽  
Conservation Assessment ◽  
Non Invasive ◽  
Funerary Architecture ◽  
History Of ◽  
Material History ◽  
Digital Documentation ◽  
Seti I ◽  
University Of Florence ◽  
The University

The tomb of Seti I (KV17) is a magnificent example of New Kingdom funerary architecture, among the longest tombs in the Valley of the Kings. As part of a collaboration between the Egyptian Museum in Florence, the University of Florence and CNR, a survey project was launched, with non-invasive methods, on the fragments from the Seti I tomb, in Florence, coming from a gate jamb connecting the chamber F to the corridor G, taken by the franco-tuscan expedition in 1829. The primary goal is to achieve the best level of documentation, knowledge of the material history and conservation assessment. Preliminary results allowed to focus some steps of the history of this fragment, from its realization to the present. The digital documentation created an excellent support for the mapping and management of the collected information. Even if still on a preliminary phase, this study shows how the combination of imaging and spectroscopic techniques allowed the characterization of many materials and the mapping of their distribution on the surface. Several original pigments have been identified as well as many anomalies due to subsequent interventions.

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