scholarly journals Biological activities and phytochemical analysis of phenolic extracts from Salsola kali L.. Role of endogenous factors in the selection of the best plant extracts

2019 ◽  
Vol 123 ◽  
pp. 193-199 ◽  
Author(s):  
M. Boulaaba ◽  
F. Medini ◽  
H. Hajlaoui ◽  
K. Mkadmini ◽  
H. Falleh ◽  
...  
Keyword(s):  
Plant Extracts ◽  
Biological Activities ◽  
Phytochemical Analysis ◽  
Endogenous Factors ◽  
Salsola Kali ◽  
Selection Of ◽  
Phenolic Extracts

Quantitative Structure—Activity Relationships (QSARs): An Integrated Multivariate Approach for Risk Assessment Studies

1990 ◽  
Vol 9 (6) ◽  
pp. 629-638 ◽  
Author(s):  
Maria Livia Tosato ◽  
Claudio Chiorboli ◽  
Lennart Eriksson ◽  
Jorgen Jonsson ◽  
Silvia Marchini ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Biological Activities ◽  
Toxic Substances ◽  
Multivariate Approach ◽  
Qsar Study ◽  
Screening Assessment ◽  
Efficient Screening ◽  
Selection Of

The conditions and methods for constructing reliable QSARs are revised in relation to each component of a QSAR study: the selection of a training set out of a QSAR compatible series, the collection of data pertinent to the descriptors matrix (X) and to the effects matrix (Y), the analysis of data to connect X to Y by a regression model, and the validation of the model. In discussing these conditions, attention is given to the constraints that arise from the theoretical foundation of QSARs as analogy models of local validity and to the complexity and limited knowledge about the mechanisms of action. Hence, emphasis is placed on the need and importance to adopt multivariate methods for dealing with (1) the characterization of the structures, (2) the selection of a representative set of training compounds, and (3) analysis of the data. It is finally shown that the same integrated multivariate approach applies to the modeling of biological activities and other properties—chemical and biological—as well as to the modeling of correlations between batteries of data. The role of QSAR in risk assessment is addressed in the second part of the article. The framework of a strategy for an efficient screening assessment of toxic substances through the modeling of their exposure and toxicity-related properties is outlined. Applications of the strategy are reported that deal with two series of compounds. Examples of toxicity and persistency models are illustrated.

scholarly journals IN VITRO BIOLOGICAL STUDY OF SEVEN NEPALESE MEDICINAL PLANTS AND ISOLATION OF CHEMICAL CONSTITUENTS FROM CISSAMPELOS PAREIRA

2020 ◽  
pp. 91-97
Author(s):  
MD AMIT ◽  
KHAGA RAJ SHARMA
Keyword(s):  
Antioxidant Activity ◽  
Medicinal Plants ◽  
Toxic Effect ◽  
Plant Extracts ◽  
Brine Shrimp ◽  
Biological Activities ◽  
Alpha Tocopherol ◽  
Biological Study ◽  
Phytochemical Analysis ◽  
Flavonoid Content

Objective: This study aimed to investigate the phytochemical analysis and biological activities of methanol extracts of seven medicinal plants such as Anisomeles indica, Achyranthes bidentata, Sphenomeris chinensis, Cleistocalyx operculatus, Malvaviscus arboreus, Cissampelos pareira, and Tectaria coadunate collected from Tanahun district of Nepal. Methods: Phytochemical analysis was performed by color differentiation methods adopting the standard protocol. Antioxidant activity of plant extracts was evaluated by 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay. Flavonoid content was estimated by aluminum chloride colorimetric method. Antidiabetic activity was evaluated by α-amylase inhibition assay where acarbose was used as standard. Toxic effect was studied by brine shrimp bioassay. Results: Phytochemical analysis showed the presence of alkaloids, polyphenols, flavonoids glycoside, and terpenoid in most of the extracts. T. coadunate and C. pareira exhibited high antioxidant activity with IC50 41.84 and 52.03 μg/ml, respectively. Whereas, the plant extracts of Malvaviscus arboretum, S. chinensis, and A. bidentata exhibited moderate antioxidant activity with IC50 76.07, 81.05, and 89.93 µg/ml, respectively. The result of flavonoid content showed the values ranged A. indica (1.84 mg quercetin equivalent per gram [mg QE/g]) to A. bidentata (5.93 mg QE/g). C. pareira and S. chinensis exhibited the highest α amylase inhibition activity with IC50 471.68 and 517.59 µg/ml, respectively. Whereas, A. indica and M. arboreus showed moderate activity with IC50 626.12 and 952.39 μg/ml, respectively. C. pareira exhibited against Staphylococcus aureus (ATCC 25923) with a zone of inhibition 12 mm/well, and Escherichia coli (ATCC 25922) 9 mm/well but, T. coadunate showed 14 mm/well against S. aureus. The plant extracts of A. bidentata and C. operculatus showed toxic effect against newly hatched brine shrimp larvae. The chemical compounds isolated from C. pareira indicated by gas chromatography-mass spectrometry analysis were 3-isopropoxy-1,1,1,7,7,7-hexamethyl-3,5,5-tris(trimethylsiloxy) tetrasiloxane, alpha-tocopherol, pentadecanoic acid, and 4,22-stigmastadiene-3-one. The major compound was indicated by percent peak area and base m/z value as alpha-tocopherol. Conclusion: Present study revealed that plant extracts are the potential source of antioxidant, antidiabetic, and antibacterial agents showing different biological activities. The results of this study provide partial scientific support for the traditional application of medicinal plants to cure diabetes and infectious diseases, although further studies are needed to assess the mechanism of action.

Faculty selection of textbooks: Key variables and the role of teaching experience

2010 ◽  
Author(s):  
Aja Taitano ◽  
Bradley Smith ◽  
Cade Hulbert ◽  
Kristin Batten ◽  
Lalania Woodstrom ◽  
...  
Keyword(s):  
Teaching Experience ◽  
Key Variables ◽  
Faculty Selection ◽  
Selection Of

Posttransplant CMV infection and the role of immunosuppression (Sponsor: Novartis Pharma GmbH, Nürnberg)

2016 ◽  
Vol 04 (01) ◽  
pp. 4-10
Keyword(s):  
Lower Incidence ◽  
Paradigm Shift ◽  
Mtor Inhibitor ◽  
De Novo ◽  
Expert Panel ◽  
Risk Of Infection ◽  
Cmv Infection ◽  
Expert Meeting ◽  
Selection Of

AbstractImmunosuppression permits graft survival after transplantation and consequently a longer and better life. On the other hand, it increases the risk of infection, for instance with cytomegalovirus (CMV). However, the various available immunosuppressive therapies differ in this regard. One of the first clinical trials using de novo everolimus after kidney transplantation [1] already revealed a considerably lower incidence of CMV infection in the everolimus arms than in the mycophenolate mofetil (MMF) arm. This result was repeatedly confirmed in later studies [2–4]. Everolimus is now considered a substance with antiviral properties. This article is based on the expert meeting “Posttransplant CMV infection and the role of immunosuppression”. The expert panel called for a paradigm shift: In a CMV prevention strategy the targeted selection of the immunosuppressive therapy is also a key element. For patients with elevated risk of CMV, mTOR inhibitor-based immunosuppression is advantageous as it is associated with a significantly lower incidence of CMV events.

Energy Efficiency Analysis in ERA using NFL-BA Algorithm

2020 ◽  
pp. 340-348
Author(s):  
Palky Mehta ◽  
H. L. Sharma
Keyword(s):  
Cluster Head ◽  
Vital Role ◽  
Wireless Sensor ◽  
Energy Usage ◽  
Cluster Heads ◽  
Comparison Results ◽  
Current Scenario ◽  
Energy Efficiency Analysis ◽  
Selection Of

In the current scenario of Wireless Sensor Network (WSN), power consumption is the major issue associated with nodes in WSN. LEACH technique plays a vital role of clustering in WSN and reduces the energy usage effectively. But LEACH has its own limitation in order to search cluster head nodes which are randomly distributed over the network. In this paper, ERA-NFL- BA algorithm is being proposed for selects the cluster heads in WSN. This algorithm help in selection of cluster heads can freely transform from global search to local search. At the end, a comparison has been done with earlier researcher using protocol ERA-NFL, which clearly shown that proposed Algorithm is best suited and from comparison results that ERA-NFL-BA has given better performance.

Tauchnitz for Translators. The Circulation of English-language Literature in Finland

2019 ◽  
Vol 16 (2-3) ◽  
pp. 161-179
Author(s):  
Outi Paloposki
Keyword(s):  
Foreign Language ◽  
English Language ◽  
Book History ◽  
Language Skills ◽  
Point Of View ◽  
Book Production ◽  
German Publisher ◽  
Language Literature ◽  
Selection Of

The article looks at book production and circulation from the point of view of translators, who, as purchasers and readers of foreign-language books, are an important mediating force in the selection of literature for translation. Taking the German publisher Tauchnitz's series ‘Collection of British Authors’ and its circulation in Finland in the nineteenth and early twentieth century as a case in point, the article argues that the increased availability of English-language books facilitated the acquiring and honing of translators' language skills and gradually diminished the need for indirect translating. Book history and translation studies meet here in an examination of the role of the Collection in Finnish translators' work.

The Adult as Foe or Friend?: Childism in Guus Kuijer's Criticism and Fiction

2013 ◽  
Vol 6 (2) ◽  
pp. 205-217 ◽  
Author(s):  
Vanessa Joosen
Keyword(s):  
Children's Literature ◽  
Children’S Literature ◽  
Age Groups ◽  
Children's Books ◽  
Children’S Books ◽  
Memorial Award ◽  
Adult Reader ◽  
Shed Light ◽  
Selection Of

Compared to the attention that children's literature scholars have paid to the construction of childhood in children's literature and the role of adults as authors, mediators and readers of children's books, few researchers have made a systematic study of adults as characters in children's books. This article analyses the construction of adulthood in a selection of texts by the Dutch author and Astrid Lindgren Memorial Award winner Guus Kuijer and connects them with Elisabeth Young-Bruehl's recent concept of ‘childism’ – a form of prejudice targeted against children. Whereas Kuijer published a severe critique of adulthood in Het geminachte kind [The despised child] (1980), in his literary works he explores a variety of positions that adults can take towards children, with varying degrees of childist features. Such a systematic and comparative analysis of the way grown-ups are characterised in children's texts helps to shed light on a didactic potential that materialises in different adult subject positions. After all, not only literary and artistic aspects of children's literature may be aimed at the adult reader (as well as the child), but also the didactic aspect of children's books can cross over between different age groups.

Sign in / Sign up

Export Citation Format

Share Document