VERBAL EPISODIC MEMORY IN FIRST EPISODE AND AT RISK MENTAL STATE FOR PSYCHOSIS PATIENTS COMPARED TO DEPRESSIVE PATIENTS AND HEALTHY CONTROLS

BackgroundStructural brain abnormalities have been described in individuals with an at-risk mental state for psychosis. However, the neuroanatomical underpinnings of the early and late at-risk mental state relative to clinical outcome remain unclear.AimsTo investigate grey matter volume abnormalities in participants in a putatively early or late at-risk mental state relative to their prospective clinical outcome.MethodVoxel-based morphometry of magnetic resonance imaging data from 20 people with a putatively early at-risk mental state (ARMS–E group) and 26 people with a late at-risk mental state (ARMS–L group) as well as from 15 participants with at-risk mental states with subsequent disease transition (ARMS–T group) and 18 participants without subsequent disease transition (ARMS–NT group) were compared with 75 healthy volunteers.ResultsCompared with healthy controls, ARMS–L participants had grey matter volume losses in frontotemporolimbic structures. Participants in the ARMS–E group showed bilateral temporolimbic alterations and subtle prefrontal abnormalities. Participants in the ARMS–T group had prefrontal alterations relative to those in the ARMS–NT group and in the healthy controls that overlapped with the findings in the ARMS–L group.ConclusionsBrain alterations associated with the early at-risk mental state may relate to an elevated susceptibility to psychosis, whereas alterations underlying the late at-risk mental state may indicate a subsequent transition to psychosis.

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Neurocognitive performances in participants of at-risk mental state for schizophrenia and in first-episode patients

Journal of Clinical and Experimental Neuropsychology ◽

10.1080/13803390802206406 ◽

2009 ◽

Vol 31 (4) ◽

pp. 392-401 ◽

Cited By ~ 15

Author(s):

Seza Özgürdal ◽

Ekhart Littmann ◽

Marta Hauser ◽

Heinrich von Reventlow ◽

Yehonala Gudlowski ◽

...

Keyword(s):

At Risk ◽

Mental State ◽

First Episode ◽

At Risk Mental State

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Neural correlates of visuospatial working memory in the ‘at-risk mental state’

Psychological Medicine ◽

10.1017/s0033291710000280 ◽

2010 ◽

Vol 40 (12) ◽

pp. 1987-1999 ◽

Cited By ~ 29

Author(s):

M. R. Broome ◽

P. Fusar-Poli ◽

P. Matthiasson ◽

J. B. Woolley ◽

L. Valmaggia ◽

...

Keyword(s):

At Risk ◽

Working Memory ◽

Frontal Cortex ◽

Parietal Cortex ◽

Mental State ◽

Posterior Parietal Cortex ◽

Group Differences ◽

First Episode ◽

Posterior Parietal ◽

At Risk Mental State

BackgroundImpaired spatial working memory (SWM) is a robust feature of schizophrenia and has been linked to the risk of developing psychosis in people with an at-risk mental state (ARMS). We used functional magnetic resonance imaging (fMRI) to examine the neural substrate of SWM in the ARMS and in patients who had just developed schizophrenia.MethodfMRI was used to study 17 patients with an ARMS, 10 patients with a first episode of psychosis and 15 age-matched healthy comparison subjects. The blood oxygen level-dependent (BOLD) response was measured while subjects performed an object–location paired-associate memory task, with experimental manipulation of mnemonic load.ResultsIn all groups, increasing mnemonic load was associated with activation in the medial frontal and medial posterior parietal cortex. Significant between-group differences in activation were evident in a cluster spanning the medial frontal cortex and right precuneus, with the ARMS groups showing less activation than controls but greater activation than first-episode psychosis (FEP) patients. These group differences were more evident at the most demanding levels of the task than at the easy level. In all groups, task performance improved with repetition of the conditions. However, there was a significant group difference in the response of the right precuneus across repeated trials, with an attenuation of activation in controls but increased activation in FEP and little change in the ARMS.ConclusionsAbnormal neural activity in the medial frontal cortex and posterior parietal cortex during an SWM task may be a neural correlate of increased vulnerability to psychosis.

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Poster #40 LONGITUDINAL HEMODYNAMIC CHANGES AND PREDICTION OF FUNCTIONAL OUTCOME IN AT-RISK MENTAL STATE AND FIRST-EPISODE PSYCHOSIS

Schizophrenia Research ◽

10.1016/s0920-9964(12)70612-6 ◽

2012 ◽

Vol 136 ◽

pp. S199-S200

Author(s):

Shinsuke Koike ◽

Yoshihiro Satomura ◽

Yukika Nishimura ◽

Yosuke Takano ◽

Norichika Iwashiro ◽

...

Keyword(s):

At Risk ◽

Functional Outcome ◽

Mental State ◽

First Episode Psychosis ◽

First Episode ◽

Hemodynamic Changes ◽

Episode Psychosis ◽

At Risk Mental State

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Criticism and Depression among the Caregivers of At-Risk Mental State and First-Episode Psychosis Patients

PLoS ONE ◽

10.1371/journal.pone.0149875 ◽

2016 ◽

Vol 11 (2) ◽

pp. e0149875 ◽

Cited By ~ 8

Author(s):

Yumiko Hamaie ◽

Noriyuki Ohmuro ◽

Masahiro Katsura ◽

Chika Obara ◽

Tatsuo Kikuchi ◽

...

Keyword(s):

At Risk ◽

Mental State ◽

First Episode Psychosis ◽

First Episode ◽

Episode Psychosis ◽

At Risk Mental State

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Structural brain abnormalities in individuals with an at-risk mental state who later develop psychosis

The British Journal of Psychiatry ◽

10.1192/bjp.191.51.s69 ◽

2007 ◽

Vol 191 (S51) ◽

pp. s69-s75 ◽

Cited By ~ 95

Author(s):

Stefan J. Borgwardt ◽

Philip K. McGuire ◽

Jacqueline Aston ◽

Gregor Berger ◽

Paola Dazzan ◽

...

Keyword(s):

At Risk ◽

Healthy Volunteers ◽

Mental State ◽

Grey Matter ◽

First Episode ◽

Grey Matter Volume ◽

Psychotic Illness ◽

Matter Volume ◽

Structural Brain ◽

At Risk Mental State

BackgroundNeuroanatomical abnormalities are a well-established feature of schizophrenia. However, the timing of their emergence and the extent to which they are related to vulnerability to the disorder as opposed to psychotic illness itself is unclearAimsTo assess regional grey matter volume in the at-risk individuals who subsequently developed psychosisMethodMagnetic resonance imaging data from at-risk individuals who developed psychosis (n = 12) within the following 25 months were compared with data from healthy volunteers (n=22) and people with first-episode psychosis (n=25)ResultsCompared with healthy volunteers, individuals who subsequently developed psychosis had smaller grey matter volume in the posterior cingulate gyrus, precuneus, and paracentral lobule bilaterally and in the left superior parietal lobule, and greater grey matter volume in a left parietal/posterior temporal region. Compared with first-episode patients, they had relatively greater grey matter volume in the temporal gyrus bilaterally and smaller grey matter volume in the right lentiform nucleusConclusionsSome of the structural brain abnormalities in individuals with an at-risk mental state may be related to an increased vulnerability to psychosis, while others are associated with the development of a psychotic illness

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Outcomes for first-episode psychosis after entry via an at-risk mental state clinic compared to direct entry to a first episode of psychosis service: A systematic review and meta-analysis

Schizophrenia Research ◽

10.1016/j.schres.2021.12.019 ◽

2022 ◽

Vol 240 ◽

pp. 214-219

Author(s):

Holly Sizer ◽

Ellie Brown ◽

Hellen Geros ◽

Alison Yung ◽

Barnaby Nelson ◽

...

Keyword(s):

Systematic Review ◽

At Risk ◽

Mental State ◽

Meta Analysis ◽

First Episode Psychosis ◽

First Episode ◽

Episode Psychosis ◽

At Risk Mental State

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Gender differences in first self‐perceived signs and symptoms in patients with an at‐risk mental state and first‐episode psychosis

Early Intervention in Psychiatry ◽

10.1111/eip.12528 ◽

2017 ◽

Vol 13 (3) ◽

pp. 582-588 ◽

Cited By ~ 8

Author(s):

Ulrike Heitz ◽

Erich Studerus ◽

Stephanie Menghini‐Müller ◽

Martina Papmeyer ◽

Laura Egloff ◽

...

Keyword(s):

Gender Differences ◽

At Risk ◽

Mental State ◽

Signs And Symptoms ◽

First Episode Psychosis ◽

First Episode ◽

Episode Psychosis ◽

At Risk Mental State

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The Relationship Between Negative Symptoms and Cognitive Functioning in Patients with an at Risk Mental State for Psychosis

European Psychiatry ◽

10.1016/j.eurpsy.2017.02.097 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S270-S271

Author(s):

L. Leanza ◽

L. Egloff ◽

E. Studerus ◽

C. Andreou ◽

U. Heitz ◽

...

Keyword(s):

At Risk ◽

Cognitive Functioning ◽

Mental State ◽

Verbal Fluency ◽

Negative Symptoms ◽

Psychotic Symptoms ◽

First Episode ◽

Clinical Impression ◽

The Relationship ◽

At Risk Mental State

IntroductionNegative symptoms and cognitive impairments are both present in patients with an at risk mental state (ARMS) for psychosis and negatively affect functioning and outcome. According to previous studies in patients with first-episode psychosis, negative symptoms are negatively associated with cognitive functioning while positive symptoms do not seem to be associated. Yet, little is known about the specific relationship of negative symptoms and cognitive functioning in ARMS patients.ObjectiveTo evaluate, the relationship between negative symptoms and cognitive functioning in ARMS patients.MethodsData of 154 ARMS patients were collected within the prospective Basel early detection of psychosis (FePsy) study. Negative symptoms were assessed with the SANS, positive psychotic symptoms with the BPRS, cognitive functioning with an extensive neuropsychological test battery. Multiple regressions were applied and results were controlled for age and gender.ResultsRegression analyses showed a significant, negative association between negative but not positive psychotic symptoms and cognitive functioning, showing the strongest association with verbal fluency (see Fig. 1). However, results mainly did not withstand correction for multiple testing.ConclusionsThe association found between verbal fluency and negative symptoms may be indicative of an overlap between those constructs. Finally, verbal fluency might have a strong influence on the clinical impression of negative symptoms, especially on alogia.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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