Brief cognitive assessment instruments in schizophrenia and bipolar patients, and healthy control subjects: A comparison study between the Brief Cognitive Assessment Tool for Schizophrenia (B-CATS) and the Screen for Cognitive Impairment in Psychiatry (SCIP)

Background: Cognitive impairment is a common and troubling feature of pediatric-onset multiple sclerosis (POMS). Brief cognitive assessment in the outpatient setting can identify and longitudinally monitor cognitive involvement so that early intervention is possible. Objectives: The goal of this study was to measure the sensitivity of two cognitive assessment approaches that are brief, repeatable, and suitable for clinical practice and for multicenter investigation. Methods: Participants with POMS ( n = 69) were consecutively evaluated as part of outpatient neurologic visits and compared to healthy control participants (HC, n = 66) using the Brief International Cognitive Assessment for MS (BICAMS) approach and timed information processing measures from Cogstate, a computer-based assessment. Results: There was strong agreement in the detection rate of impairment between both assessments, with 26% for the BICAMS and 27% for Cogstate. Two of the Cogstate tasks were the most sensitive individual measures. Conclusion: Both the BICAMS and Cogstate timed processing measures offer practical, sensitive, and standardized approaches for cognitive screening assessment in POMS.

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The brief cognitive assessment tool (BCAT): cross-validation in a community dwelling older adult sample

International Psychogeriatrics ◽

10.1017/s1041610214001458 ◽

2014 ◽

Vol 27 (2) ◽

pp. 243-250 ◽

Cited By ~ 7

Author(s):

Elizabeth E. MacDougall ◽

William E. Mansbach ◽

Kristen Clark ◽

Ryan A. Mace

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Roc Curve ◽

Cognitive Assessment ◽

Assessment Tool ◽

Executive Dysfunction ◽

Community Dwelling ◽

Cut Score ◽

Brief Cognitive Assessment ◽

Community Dwelling Older Adults

ABSTRACTBackground:Cognitive impairment is underrecognized and misdiagnosed among community-dwelling older adults. At present, there is no consensus about which cognitive screening tool represents the “gold standard.” However, one tool that shows promise is the Brief Cognitive Assessment Tool (BCAT), which was originally validated in an assisted living sample and contains a multi-level memory component (e.g. word lists and story recall items) and complex executive functions features (e.g. judgment, set-shifting, and problem-solving).Methods:The present study cross-validated the BCAT in a sample of 75 community-dwelling older adults. Participants completed a short battery of several individually administered cognitive tests, including the BCAT and the Montreal Cognitive Assessment (MoCA). Using a very conservative MoCA cut score of <26, the base rate of cognitive impairment in this sample was 35%.Results:Adequate internal consistency and strong evidence of construct validity were found. A receiver operating characteristic (ROC) curve was calculated from sensitivity and 1-specificity values for the classification of cognitively impaired versus cognitively unimpaired. The area under the ROC curve (AUC) for the BCAT was .90,p< 0.001, 95% CI [0.83, 0.97]. A BCAT cut-score of 45 (scores below 45 suggesting cognitive impairment) resulted in the best balance between sensitivity (0.81) and specificity (0.80).Conclusions:A BCAT cut-score can be used for identifying persons to be referred to appropriate healthcare professionals for more comprehensive cognitive assessment. In addition, guidelines are provided for clinicians to interpret separate BCAT memory and executive dysfunction component scores.

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Prevalence and correlates of parkinsonism in patients with primary depression

Neurology ◽

10.1212/wnl.57.3.553 ◽

2001 ◽

Vol 57 (3) ◽

pp. 553-555 ◽

Cited By ~ 10

Author(s):

Sergio E. Starkstein ◽

Gustavo Petracca ◽

Eran Chemerinski ◽

Marcelo Merello

Keyword(s):

Cognitive Impairment ◽

Mood Disorder ◽

Severe Depression ◽

Older Age ◽

Longitudinal Changes ◽

Clinical Correlates ◽

Severe Cognitive Impairment ◽

Control Subjects ◽

Depressed Patients ◽

Healthy Control

The authors examined the prevalence, clinical correlates, and longitudinal changes of parkinsonism in 94 patients with primary depression and 20 healthy control subjects. Parkinsonism was present in 20% of patients with primary depression. This syndrome was significantly associated with older age, more severe depression, and more severe cognitive impairment. In a subgroup of depressed patients, parkinsonism was reversible upon recovery from the mood disorder.

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Validity of Brief Cognitive Assessment Tool modifications for older adults with visual and motor limitations

Journal of Clinical and Experimental Neuropsychology ◽

10.1080/13803395.2017.1423041 ◽

2018 ◽

Vol 40 (7) ◽

pp. 715-721 ◽

Cited By ~ 2

Author(s):

Ryan A. Mace ◽

William E. Mansbach

Keyword(s):

Older Adults ◽

Cognitive Assessment ◽

Assessment Tool ◽

Brief Cognitive Assessment

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Patterns of Cognitive Dysfunction in Progressive MS

Behavioural Neurology ◽

10.1155/2013/743878 ◽

2013 ◽

Vol 27 (3) ◽

pp. 259-265 ◽

Cited By ~ 13

Author(s):

Peter Connick ◽

Siddharthan Chandran ◽

Thomas H. Bak

Keyword(s):

Cognitive Impairment ◽

Cognitive Dysfunction ◽

High Frequency ◽

Cognitive Assessment ◽

Assessment Tool ◽

Visuospatial Deficits ◽

Relative Contribution ◽

Visuospatial Functions ◽

Global Influence ◽

Addenbrooke’S Cognitive Examination

Background:Progressive MS is associated with a high frequency of cognitive impairment. However, it is not clear to what extent this reflects global dysfunction, or independent deficits in specific functions.Objective:To characterise patterns of cognitive impairment in progressive MS on a multi-dimensional cognitive assessment tool well established in neurodegenerative diseases.Methods:Patients with secondary (SPMS;n= 60) and primary progressive MS (PPMS;n= 28) were assessed using the Addenbrooke’s Cognitive Examination-Revised (ACE-R) multi-dimensional cognitive assessment scale. Independent dimensions of impairment and their relative contribution to the overall burden of cognitive dysfunction were then determined by factor analysis.Results:Two independent dimensions of impairment were seen: frontal-executive (attention, verbal fluency, recall) on one hand, and language and visuospatial functions on the other. These accounted for 55% and 45% respectively of the variance not explained by a global influence (14.2% and 11.6% respectively of total variance). Isolated language and visuospatial dysfunction was seen in both groups, whereas isolated impairment in frontal-executive functions was underrepresented in SPMS (p= 0.001) and not seen in PPMS patients (p= 0.040).Conclusions:In addition to a prominent global influence on cognitive performance, patients with progressive MS commonly exhibit language and visuospatial deficits. Evaluation of these abilities should therefore be included in clinical assessment of cognition in progressive MS.

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Dynamic functional connectivity changes associated with dementia in Parkinson’s disease

Brain ◽

10.1093/brain/awz192 ◽

2019 ◽

Vol 142 (9) ◽

pp. 2860-2872 ◽

Cited By ~ 19

Author(s):

Eleonora Fiorenzato ◽

Antonio P Strafella ◽

Jinhee Kim ◽

Roberta Schifano ◽

Luca Weis ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Functional Connectivity ◽

Parkinson’S Disease Dementia ◽

Dynamic Functional Connectivity ◽

Control Subjects ◽

Healthy Control ◽

Normal Cognition

AbstractDynamic functional connectivity captures temporal variations of functional connectivity during MRI acquisition and it may be a suitable method to detect cognitive changes in Parkinson’s disease. In this study, we evaluated 118 patients with Parkinson’s disease matched for age, sex and education with 35 healthy control subjects. Patients with Parkinson’s disease were classified with normal cognition (n = 52), mild cognitive impairment (n = 46), and dementia (n = 20) based on an extensive neuropsychological evaluation. Resting state functional MRI and a sliding-window approach were used to study the dynamic functional connectivity. Dynamic analysis suggested two distinct connectivity ‘States’ across the entire group: a more frequent, segregated brain state characterized by the predominance of within-network connections, State I, and a less frequent, integrated state with strongly connected functional internetwork components, State II. In Parkinson’s disease, State I occurred 13.89% more often than in healthy control subjects, paralleled by a proportional reduction of State II. Parkinson’s disease subgroups analyses showed the segregated state occurred more frequently in Parkinson’s disease dementia than in mild cognitive impairment and normal cognition groups. Further, patients with Parkinson’s disease dementia dwelled significantly longer in the segregated State I, and showed a significant lower number of transitions to the strongly interconnected State II compared to the other subgroups. Our study indicates that dementia in Parkinson’s disease is characterized by altered temporal properties in dynamic connectivity. In addition, our results show that increased dwell time in the segregated state and reduced number of transitions between states are associated with presence of dementia in Parkinson’s disease. Further studies on dynamic functional connectivity changes could help to better understand the progressive dysfunction of networks between Parkinson’s disease cognitive states.

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