Affective forecasting in individuals with social anhedonia: The role of social components in anticipated emotion, prospection and neural activation

2020 ◽  
Vol 215 ◽  
pp. 322-329 ◽  
Author(s):  
Rui-ting Zhang ◽  
Zhuo-ya Yang ◽  
Yong-ming Wang ◽  
Yi Wang ◽  
Tian-Xiao Yang ◽  
...  
Keyword(s):  
Affective Forecasting ◽  
Neural Activation ◽  
Social Anhedonia ◽  
Social Components

scholarly journals cAMP-dependent recruitment of acidic organelles for Ca2+ signaling in the salivary gland

2016 ◽  
Vol 311 (5) ◽  
pp. C697-C709 ◽  
Author(s):  
John F. Imbery ◽  
Sumit Bhattacharya ◽  
Sura Khuder ◽  
Amanda Weiss ◽  
Priyodarshan Goswamee ◽  
...  
Keyword(s):  
Secretory Activity ◽  
Neural Activation ◽  
Potential Therapeutic Target ◽  
Parotid Acinar Cells ◽  
Saliva Secretion ◽  
Intracellular Ca ◽  
Low Levels ◽  
Protein Components ◽  
Acidic Organelles

Autonomic neural activation of intracellular Ca2+ release in parotid acinar cells induces the secretion of the fluid and protein components of primary saliva critical for maintaining overall oral homeostasis. In the current study, we profiled the role of acidic organelles in shaping the Ca2+ signals of parotid acini using a variety of imaging and pharmacological approaches. Results demonstrate that zymogen granules predominate as an apically polarized population of acidic organelles that contributes to the initial Ca2+ release. Moreover, we provide evidence that indicates a role for the intracellular messenger NAADP in the release of Ca2+ from acidic organelles following elevation of cAMP. Our data are consistent with the “trigger” hypothesis where localized release of Ca2+ sensitizes canonical intracellular Ca2+ channels to enhance signals from the endoplasmic reticulum. Release from acidic stores may be important for initiating saliva secretion at low levels of stimulation and a potential therapeutic target to augment secretory activity in hypofunctioning salivary glands.

scholarly journals Seizures start as silent microseizures by neuronal ensembles

2018 ◽  
Author(s):  
Michael Wenzel ◽  
Jordan P. Hamm ◽  
Darcy S. Peterka ◽  
Rafael MD Yuste
Keyword(s):  
Calcium Imaging ◽  
Travelling Wave ◽  
Inhibitory Neurons ◽  
Neural Activation ◽  
Calcium Dynamics ◽  
Neuronal Ensembles ◽  
Two Photon ◽  
Step Model

AbstractUnderstanding seizure formation and spread remains a critical goal of epilepsy research. While many studies have documented seizure spread, it remains mysterious how they start. We used fast in-vivo two-photon calcium imaging to reconstruct, at cellular resolution, the dynamics of focal cortical seizures as they emerge in epileptic foci (intrafocal), and subsequently propagate (extrafocal). We find that seizures start as intrafocal coactivation of small numbers of neurons (ensembles), which are electrographically silent. These silent “microseizures” expand saltatorily until they break into neighboring cortex, where they progress smoothly and first become detectable by LFP. Surprisingly, we find spatially heterogeneous calcium dynamics of local PV interneuron sub-populations, which rules out a simple role of inhibitory neurons during seizures. We propose a two-step model for the circuit mechanisms of focal seizures, where neuronal ensembles first generate a silent microseizure, followed by widespread neural activation in a travelling wave, which is then detected electrophysiologically.

scholarly journals Evaluating and Planning Green Infrastructure: A Strategic Perspective for Sustainability and Resilience

2019 ◽  
Vol 11 (10) ◽  
pp. 2726 ◽  
Author(s):  
Angioletta Voghera ◽  
Benedetta Giudice
Keyword(s):  
Case Studies ◽  
Green Infrastructure ◽  
Evaluation Process ◽  
Ecological Indicators ◽  
Social Ecological ◽  
The Social ◽  
The One ◽  
Strategic Perspective ◽  
Social Components

In the light of the current changing global scenarios, green infrastructure is obtaining increasing relevance in planning policies, especially due to its ecological, environmental and social components which contribute to pursuing sustainable and resilient planning and designing of cities and territories. The issue of green infrastructure is framed within the conceptual contexts of sustainability and resilience, which are described through the analysis of their common aspects and differences with a particular focus on planning elements. In particular, the paper uses two distinct case studies of green infrastructure as representative: the green infrastructure of the Region Languedoc-Roussillon in France and the one of the Province of Turin in Italy. The analysis of two case studies focuses on the evaluation process carried on about the social-ecological system and describes the methodologies and the social-ecological indicators used to define the green infrastructure network. We related these indicators to their possible contribution to the measurement of sustainability and resilience. The analysis of this relationship led us to outline some conclusive considerations on the complex role of the design of green infrastructure with reference to sustainability and resilience.

scholarly journals Sex Differences in Demand for Highly Palatable Foods: Role of the Orexin System

2020 ◽  
Author(s):  
Linnea R Freeman ◽  
Brandon S Bentzley ◽  
Morgan H James ◽  
Gary Aston-Jones
Keyword(s):  
Sex Differences ◽  
Demand Curve ◽  
Female Rats ◽  
Demand Elasticity ◽  
Male Rats ◽  
Neural Activation ◽  
Palatable Food ◽  
Behavioral Economic ◽  
Male And Female Rats

Abstract Background The prevalence of eating disorders, including binge eating disorder, is significantly higher in women. These findings are mirrored by preclinical studies, which indicate that female rats have a higher preference for palatable food and show greater binge-like eating compared with male rats. Methods Here, we describe a novel within-session behavioral-economic paradigm that allows for the simultaneous measurement of the intake at null cost (Q0) and normalized demand elasticity (α) of 3 types of palatable food (low fat, high fat, and chocolate sucrose pellets) via demand curve analysis. In light of evidence that the orexin (hypocretin) system is critically involved in reward and feeding behaviors, we also examined the role of orexin function in sex differences of economic demand for palatable foods. Results The novel within-session behavioral-economic approach revealed that female rats have higher intake (demand) than males for all palatable foods at low cost (normalized to body weight) but no difference in intake at higher prices, indicating sex-dependent differences in the hedonic, but not motivational, aspects of palatable food. Immediately following behavioral-economic testing, we observed more orexin-expressing neurons and Fos expression (measure of recent neural activation) in these neurons in female rats compared with male rats. Moreover, the orexin-1 receptor antagonist SB334867 reduced both low- and high-cost intake for palatable food in both male and female rats. Conclusions These findings provide evidence of higher demand at low prices for palatable food in females and indicate that these behavioral differences may be associated with sexual dimorphism in orexin system function.

scholarly journals Investigating the Role of Time in Affective Forecasting: Temporal Influences on Forecasting Accuracy

2007 ◽  
Vol 33 (8) ◽  
pp. 1152-1166 ◽  
Author(s):  
Catrin Finkenauer ◽  
Marcello Gallucci ◽  
Wilco W. van Dijk ◽  
Monique Pollmann
Keyword(s):  
Affective Forecasting ◽  
Forecasting Accuracy

The Role of Work Group in Individual Sickness Absence Behavior

2008 ◽  
Vol 49 (4) ◽  
pp. 452-467 ◽  
Author(s):  
Ari Väänänen ◽  
Nuria Tordera ◽  
Mika Kivimäki ◽  
Anne Kouvonen ◽  
Jaana Pentti ◽  
...  
Keyword(s):  
Sickness Absence ◽  
Work Group ◽  
Individual Level ◽  
Municipal Employees ◽  
The Social ◽  
Liberal Attitude ◽  
Study Population ◽  
The Individual ◽  
Social Components

The purpose of our two-year follow-up study was to examine the effect of the social components of the work group, such as group absence norms and cohesion, on sickness absence behavior among individuals with varying attitudes toward work attendance. The social components were measured using a questionnaire survey, and data on sickness absence behavior were collected from the employers' records. The study population consisted of 19,306 Finnish municipal employees working in 1,847 groups (78% women). Multilevel Poisson regression modeling was applied. The direct effects of work group characteristics on sickness absence were mostly insignificant. In contrast, both of the social components of a work group had an indirect impact: The more tolerant the group absence norms (at both individual- and cross-level) and the lower the group cohesion (at the individual level), the more the absence behavior of an individual was influenced by his or her attitude toward work attendance. We conclude that work group moderates the extent to which individuals with a liberal attitude toward work attendance actually engage in sickness absence behavior.

scholarly journals The role of the gustatory cortex in incidental experience-evoked enhancement of later taste learning

2018 ◽  
Author(s):  
Veronica L. Flores ◽  
Tamar Parmet ◽  
Narendra Mukherjee ◽  
Sacha Nelson ◽  
Donald B. Katz ◽  
...  
Keyword(s):  
Early Gene ◽  
Neural Activation ◽  
Site Specific ◽  
Gustatory Cortex ◽  
Multiple Factors ◽  
Incidental Exposure ◽  
Fos Expression ◽  
A Site ◽  
Full Day

ABSTRACTThe strength of learned associations between pairs of stimuli is affected by multiple factors, the most extensively studied of which is prior experience with the stimuli themselves. In contrast, little data is available regarding how experience with incidental stimuli (independent of any conditioning situation) impacts later learning. This lack of research is striking given the importance of incidental experience to survival. We have recently begun to fill this void using conditioned taste aversion (CTA), wherein an animal learns to avoid a taste that has been associated with malaise. We previously demonstrated that incidental exposure to salty and sour tastes (taste pre-exposure—TPE) enhances aversions learned later to sucrose. Here, we investigate the neurobiology underlying this phenomenon. First, we use immediate early gene (c-Fos) expression to identify gustatory cortex (GC) as a site at which TPE specifically increases the neural activation caused by taste-malaise pairing (i.e., TPE did not change c-Fos induced by either stimulus in isolation). Next, we use site-specific infection with the optical silencer Archaerhodopsin-T to show that GC inactivation during TPE inhibits the expected enhancements of both learning and CTA-related c-Fos expression, a full day later. Thus, we conclude that GC is almost certainly a vital part of the circuit that integrates incidental experience into later associative learning.

scholarly journals Neural correlates of effort-based valuation with prospective choices

2018 ◽  
Author(s):  
Nadav Aridan ◽  
Nicholas J. Malecek ◽  
Russell A. Poldrack ◽  
Tom Schonberg
Keyword(s):  
Anterior Cingulate ◽  
Neural Activation ◽  
Neural Basis ◽  
Physical Effort ◽  
Actual Performance ◽  
Future Performance ◽  
Primary Sensory Cortex ◽  
Subjective Value ◽  
Risk Choice

AbstractHow is effort integrated in value-based decision-making? Animal models and human neuroimaging studies, primarily linked the anterior cingulate cortex (ACC) and ventral striatum (VS) to the integration of effort in valuation. Other studies demonstrated the role of these regions in invigoration to effort demands, thus it is hard to separate the neural activity linked to anticipation and subjective valuation from actual performance. Here, we studied the neural basis of effort valuation separated from performance. We scanned forty participants with fMRI and they were asked to accept or reject monetary gambles that could be resolved with future performance of a familiar grip force effort challenge or a fixed risk prospect. Participants’ willingness to accept prospective gambles reflected discounting of values by physical effort and risk. Choice-locked neural activation in contralateral primary sensory cortex and ventromedial prefrontal cortex (vmPFC) tracked the magnitude of prospective effort the participants faced, independent of choice time and monetary stakes. Estimates of subjective value discounted by effort were found to be tracked by the activation of a network of regions common to valuation under risk and delay, including vmPFC, VS and sensorimotor cortex. Together, our findings show separate neural mechanisms underlying prospective effort and actual effort performance.

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