scholarly journals Effect of methanol extract of Trema orientalis leaf on some biochemical and histopathological indices of wistar albino rats with cadmium-induced - hepatotoxicity

2020 ◽  
Vol 10 ◽  
pp. e00568
Author(s):  
J.E. Olajide ◽  
M. Sanni ◽  
O.J. Achimugu ◽  
M.S. Suleiman ◽  
E.R. Jegede ◽  
...  
Keyword(s):  
Methanol Extract ◽  
Albino Rats ◽  
Trema Orientalis ◽  
Wistar Albino Rats

Hepatoprotective and Healthy Kidney Promoting Potentials of Methanol Extract of Nauclea latifolia in Alloxan Induced Diabetic Male Wistar Albino Rats

2017 ◽  
Vol 12 (3) ◽  
pp. 71-78 ◽  
Author(s):  
Ogugua Victor Nwadiogbu ◽  
Uroko Robert Ikechukwu ◽  
Egba Simeon Ikechukwu ◽  
Agu Obiora .
Keyword(s):  
Methanol Extract ◽  
Albino Rats ◽  
Wistar Albino Rats ◽  
Nauclea Latifolia

Pharmacological and Pathological Studies on Taiwan Folk Medicine (IX): The Hepatoprotective Effect of the Methanolic Extract from Echinops Grijisii

1993 ◽  
Vol 21 (01) ◽  
pp. 33-44 ◽  
Author(s):  
Chun-Ching Lin ◽  
Cheng-Hung Lin
Keyword(s):  
Liver Biopsy ◽  
Ethyl Acetate ◽  
Liver Damage ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Folk Medicine ◽  
Hepatoprotective Activity ◽  
Albino Rats ◽  
Histopathological Changes ◽  
Wistar Albino Rats

In order to isolate the main hepatoprotective component of Echinops grijisii, the crude drug was extracted with methanol and subjected to continuous extractions using n-hexane chloroform, ethyl acetate and n-butanol. The hepatoprotective studies of each fraction from the methanol extract of E. grijisii was conducted in Wistar albino rats with CC14-induced liver damage. Hepatoprotective activity was evaluated in terms of the modification of serum transaminase values such as SGOT and SGPT, and histopathological changes of liver biopsy. The results indicated that the main hepatoprotective component was concentrated in n-butanol and aqueous fractions.

scholarly journals Antidiarrhoeal Studies of Methanol Leaf Extract of Cassia sieberiana Dc in Wistar Albino Rats

2021 ◽  
pp. 43-49
Author(s):  
Jude Nwaogu ◽  
Ibrahim Babangida Abubakar ◽  
Esther Omolade Olaosebikan
Keyword(s):  
Activated Charcoal ◽  
Castor Oil ◽  
Cardiac Glycosides ◽  
Leaf Extract ◽  
Methanol Extract ◽  
Gastrointestinal Transit ◽  
Albino Rats ◽  
Phytochemical Screening ◽  
Standard Methods ◽  
Wistar Albino Rats

Aim: This study was aimed at evaluating the antidiarrhoeal effect methanol leaf extract of Cassia sieberiana. Methodology: The leaf extract of Cassia sieberiana was obtained by extraction using methanol and subjected to phytochemical screening using standard methods. The anti-diarrhoeal effect of methanol leaf extract of Cassia sieberiana DC was investigated in Wistar Albino rats. Results: The result of phytochemical screening revealed the presence of saponins, tannins, phenols, terpenoids, cardiac glycosides, steroids, flavonoids and anthraquinoes. The methanol extract significantly (P<.05) reduced the number of unformed faeces in castor oil induced diarrhoea in the rats. It also significantly (P<.05) reduced the gastrointestinal transit of activated charcoal as well as enteropooling in the rats used for the experiment was significantly reduced (P<.05) in the groups treated with 500 mg/kg and 750 mg/kg. Conclusion: Based on the findings of this research, the methanol leaf extract of Cassia sieberiana possess anti-diarrheal activity and therefore validates its use in traditional medicine for the treatment of diarrhoea.

scholarly journals INVESTIGATION ON IN VIVO ANALGESIC ACTIVITY OF METHANOL EXTRACT OF MARINE BROWN ALGA SPATOGLOSSUM ASPERUM J. AGARTH

2018 ◽  
Vol 11 (11) ◽  
pp. 313
Author(s):  
Pandithurai M ◽  
Murugesan S ◽  
Sivamurugan V
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Analgesic Activity ◽  
Brown Alga ◽  
Methanol Extract ◽  
Albino Rats ◽  
Significant Activity ◽  
Study Evaluation ◽  
Wistar Albino Rats

Objective: In the present study, evaluation of the methanol extract of Spatoglossum asperum, brown marine algae on the analgesic activity using animal model was focussed.Methods: Acetic acid-induced writhing test on Wistar albino rats at a dosage of 10 mg/kg body weight of algal extract have been carried out. It showed significant analgesic activity by reducing the number of acetic acid-induced writhing.Results: The animals at a dosage of 10 mg/kg body weight exhibited, 70.52% of the animals were protected using S. asperum extract, on the other hand, the standard, diclofenac protected 84.21% of the animals. The results are statistically significant at p<0.001, and the investigation revealed dose-dependent significant activity in comparison with standard and control.Conclusion: Hence, it can be concluded that the methanol extracts of the brown alga S. asperum have potent analgesic activity at moderate doses.

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