scholarly journals Evaluation of anti-hepatotoxic potential of Cassia javanica (L.) methanol extract against paracetamol-induced liver damage in Wistar albino rats

2018 ◽  
Author(s):  
Esther Lalhmingliani ◽  
Zodinpuii ◽  
R.K. Lalremtluangi ◽  
Lalramdinthara Chenkual ◽  
Lalthansangi
Keyword(s):  
Liver Damage ◽  
Methanol Extract ◽  
Albino Rats ◽  
Wistar Albino Rats

Pharmacological and Pathological Studies on Taiwan Folk Medicine (IX): The Hepatoprotective Effect of the Methanolic Extract from Echinops Grijisii

1993 ◽  
Vol 21 (01) ◽  
pp. 33-44 ◽  
Author(s):  
Chun-Ching Lin ◽  
Cheng-Hung Lin
Keyword(s):  
Liver Biopsy ◽  
Ethyl Acetate ◽  
Liver Damage ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Folk Medicine ◽  
Hepatoprotective Activity ◽  
Albino Rats ◽  
Histopathological Changes ◽  
Wistar Albino Rats

In order to isolate the main hepatoprotective component of Echinops grijisii, the crude drug was extracted with methanol and subjected to continuous extractions using n-hexane chloroform, ethyl acetate and n-butanol. The hepatoprotective studies of each fraction from the methanol extract of E. grijisii was conducted in Wistar albino rats with CC14-induced liver damage. Hepatoprotective activity was evaluated in terms of the modification of serum transaminase values such as SGOT and SGPT, and histopathological changes of liver biopsy. The results indicated that the main hepatoprotective component was concentrated in n-butanol and aqueous fractions.

scholarly journals Investigation on Potential Efficacy of Methanol Extract of Lawsonia inermis L. against Carbon Tetrachloride Induced Hepatotoxicity in Wistar Albino Rats

2021 ◽  
Vol 70 (1) ◽  
Author(s):  
A. Jayavelu ◽  
A. Natarajan ◽  
R. Thangamani ◽  
Senthil Kumar B.
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Defense Mechanism ◽  
Methanol Extract ◽  
Stem Bark ◽  
Cellular Damage ◽  
Bark Extract ◽  
Albino Rats ◽  
Lawsonia Inermis ◽  
Wistar Albino Rats

Carbon tetrachloride (CCl4) a pharmacological tool was used to induce liver damage in Wistar albino rats. Silymarin (100 mg/kg) and methanol extract of Lawsonia inermis Linn. family Lythraceae (known to possess hepatoprotective compounds) was used to reverse the liver damage caused due to CCl4 (induced toxicity). Hydroalcholic extract of stem bark and leaf of Lawsonia inermis Linn. was evaluated, for its restorative efficacy against CCl4 induced hepatotoxicity which was assessed in terms of biochemical and histopathological parameters. CCl4 produce the altitude levels of serum marker enzymes of alanine aminotransferase (ALT), asparate aminotransferase (AST), alanine phosphatase (ALP) and bilirubin in blood serum. Due to the toxicity of CCl4 cause turbine hepatic cell architecture, necrosis, inflammatory cell infiltration, congestion, and sinusoidal dilatation along with reduction of superoxide dismutase (SOD), catalase, Glutathione-S-transferase (GST) and glutathione peroxidase (GPx) appeared in liver tissue. SOD is the primary step in the defense mechanism involved in the antioxidant system against the oxidative stress. It diminishes by converting the superoxide radical in to peroxide and molecular oxygen. CAT or GPx reactions, also exert a similar effect thereby reducing the level of cellular damage. By oral administration of methanol extract of Lawsonia inermis Linn. plant extracts, i.e., stem bark extract (250 mg/kg b.wt.) and leaf extract (250 mg/kg b. wt.) the levels of these parameters was restored to near controlled (untreated) levels. Thus, the present study revealed that the extracts of stem bark and leaf of Lawsonia inermis Linn. offered protection against hepatotoxicity induced by CCl4.

Effect of Methanol Extract of Abrus precatorius Leaves on Male Wistar Albino Rats Induced Liver Damage using Carbon Tetrachloride (CCl4)

2015 ◽  
Vol 15 (3) ◽  
pp. 116-123 ◽  
Author(s):  
Uroko Robert Ikechukwu ◽  
Sangodare Rose Simon Adeyi ◽  
Muhammad Kabir Hadiza ◽  
Asadu Chidimma Lilian
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Methanol Extract ◽  
Albino Rats ◽  
Abrus Precatorius ◽  
Wistar Albino Rats

Ameliorative effect of methanol extract ofRumex vesicariuson CCl4-induced liver damage in Wistar albino rats

2015 ◽  
Vol 53 (8) ◽  
pp. 1163-1167 ◽  
Author(s):  
Majid Ahmad Ganaie ◽  
Tajdar Husain Khan ◽  
Nasir Ali Siddiqui ◽  
Mohd Nazam Ansari
Keyword(s):  
Liver Damage ◽  
Methanol Extract ◽  
Albino Rats ◽  
Ameliorative Effect ◽  
Wistar Albino Rats

The effect of baicalein on endoplasmic reticulum stress and autophagy on liver damage

2021 ◽  
pp. 096032712110036
Author(s):  
MC Üstüner ◽  
C Tanrikut ◽  
D Üstüner ◽  
UK Kolaç ◽  
Z Özdemir Köroğlu ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Transcription Factor ◽  
Er Stress ◽  
Liver Damage ◽  
Albino Rats ◽  
Tem Analysis ◽  
Stress Markers ◽  
Activating Transcription Factor 4 ◽  
Activating Transcription Factor ◽  
Wistar Albino Rats

Carbon tetrachloride (CCl4) is a toxic chemical that causes liver injury. CCl4 triggers endoplasmic reticulum (ER) stress and unfolded protein response (UPR). UPR triggers autophagy to deal with the damage. The aim of this study was to investigate the effect of baicalein, derived from Scutellaria baicalensis, on CCl4-induced liver damage concerning ER stress and autophagy. Two groups of Wistar albino rats (n = 7/groups) were treated with 0.2 ml/kg CCl4 for 10 days with and without baicalein. Histological and transmission electron microscopy (TEM) analysis, autophagy, and ER stress markers measurements were carried out to evaluate the effect of baicalein. Histological examinations showed that baicalein reduced liver damage. TEM analysis indicated that baicalein inhibited ER stress and triggered autophagy. CCl4-induced elevation of C/EBP homologous protein (CHOP), glucose-regulating protein 78 (GRP78), activating transcription factor 4 (ATF4), activating transcription factor 6 (ATF6), inositol requiring enzyme 1 (IRE1), pancreatic ER kinase (PERK), and active/spliced form of X-box-binding protein 1 (XBP1s) ER stress markers were decreased by baicalein. Baicalein also increased the autophagy-related 5 (ATG5), Beclin1, and Microtubule-associated protein 1A/1B-light chain 3-phosphatidylethanolamine-conjugated form (LC3-II) autophagy marker levels. In conclusion, baicalein reduced the CCl4-induced liver damage by inhibiting ER stress and the trigger of autophagy.

Hepatoprotective and Healthy Kidney Promoting Potentials of Methanol Extract of Nauclea latifolia in Alloxan Induced Diabetic Male Wistar Albino Rats

2017 ◽  
Vol 12 (3) ◽  
pp. 71-78 ◽  
Author(s):  
Ogugua Victor Nwadiogbu ◽  
Uroko Robert Ikechukwu ◽  
Egba Simeon Ikechukwu ◽  
Agu Obiora .
Keyword(s):  
Methanol Extract ◽  
Albino Rats ◽  
Wistar Albino Rats ◽  
Nauclea Latifolia

scholarly journals Antioxidant and Hepatoprotective Potentials of Lasimorpha senegalensis Schott Leaf Extract on Carbon Tetrachloride-induced Liver Damage in Rats

2020 ◽  
pp. 70-78
Author(s):  
Chinyere Blessing Chigor ◽  
Felix Ifeanyi Nwafor ◽  
Edith Ugwuja ◽  
Chisimdi S. Obi
Keyword(s):  
Liver Damage ◽  
Leaf Extract ◽  
Liver Enzymes ◽  
Radical Scavenging Activity ◽  
Research Work ◽  
Radical Scavenging ◽  
Albino Rats ◽  
Endogenous Antioxidants ◽  
Wistar Albino Rats

Aims: The present study assessed the antioxidant and hepatoprotective potentials of the methanolic leaf extract of Lasimorpha senegalensis – a medicinal plant used by the indigenous people of Nigeria to treat hepatitis and feverish conditions. Place and Duration of Study: The research work was conducted in the Department of Pharmacognosy and Environmental Medicine and Department of Plant Science and Biotechnology, both in the University of Nigeria, Nsukka, from May to August, 2019. Methodology: Phytochemical analyses and acute toxicity study of the sample followed standard procedures. In vitro antioxidant assay was by DPPH and H2O2 models. A total of 25 male Wistar albino rats (120 – 150 g) were grouped into five, each group with five animals. Hepatotoxicity was induced with carbontetrachloride (1 ml/kg). The treatment groups (3-5) received extract (200 and 400 mg/kg) and Silymarin (100 mg/kg). Endogenous antioxidants (superoxide dismutase, catalase, glutathione peroxidase), plasma malondialdehyde and liver enzymes (aspartate aminotransferase, alanine aminotransferase, alkaline phosphate) were determined after treatment. Results: The results showed the leaf extract had appreciable amounts of bioactive phytochemicals and free radical scavenging activity (IC50 of 0.52 mg/ml and 0.71 mg/ml for DPPH and H2O2 respectively) with no toxicity at 5000 mg/kg. The extract also elevated the endogenous antioxidants and significantly (p ≤ .05) reduced lipid peroxidase and liver enzymes. Conclusion: This report justifies the local use of this plant in the management of various diseases related to oxidative stress and liver damage.

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