Intracity occurrence and distribution of airborne PCB congeners in Chicago

Polychlorinated biphenyls (PCBs) are a ubiquitous class of environmental pollutants with toxic and hepatocellular effects, including accumulation of fat, proliferated smooth endoplasmic recticulum (SER), and concentric membrane arrays (CMAs) (1-3). The CMAs appear to be a membrane storage and degeneration organelle composed of a large number of concentric membrane layers usually surrounding one or more lipid droplets often with internalized membrane fragments (3). The present study documents liver alteration after a short term single dose exposure to PCBs with high chlorine content, and correlates them with reported animal weights and central nervous system (CNS) measures. In the brain PCB congeners were concentrated in particular regions (4) while catecholamine concentrations were decreased (4-6). Urinary levels of homovanillic acid a dopamine metabolite were evaluated (7).Wistar rats were gavaged with corn oil (6 controls), or with a 1:1 mixture of Aroclor 1254 and 1260 in corn oil at 500 or 1000 mg total PCB/kg (6 at each level).

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Effect of Sample Storage Conditions on Body Burden Analysis of Organic Contaminants in Unionid Mussels

Water Quality Research Journal ◽

10.2166/wqrj.1992.050 ◽

1992 ◽

Vol 27 (4) ◽

pp. 833-844 ◽

Cited By ~ 1

Author(s):

Micheline Hanna

Keyword(s):

Organic Contaminants ◽

Body Burden ◽

Storage Conditions ◽

The Body ◽

Sample Storage ◽

Pcb Congeners ◽

Unionid Mussels ◽

Group A ◽

The Difference ◽

Group B

Abstract In order to quantitatively assess the effect of sample storage conditions on the body burden analysis of organic contaminants, a comparative analysis was carried out on the unionid mussel Elliptic complanata. The mussels were divided into two groups, each with distinct storage conditions, while Group A was kept in the freezer at −20°C, Group B was kept in the refrigerator for five days at 5°C. All the compounds present in the control were also present in Group B samples. Analysis of the organic contaminants in each of these two groups showed that for total PCB concentrations, the two treatments were not significantly different; however when compared individually 6 of the 13 PCB congeners showed significant differences. The observed differences were relatively small for individual PCB congeners (7.1 to 15.3%), higher for chlorobenzenes (10.5 to 36.4%), and yet higher for HCE (44.1%); the difference for HCE, although large is nevertheless not significant, even if only marginally so.

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Liver Toxicity in Rats Fed A Mixture of Pcb Congeners and 2,3,7,8-Tcdd

Microscopy and Microanalysis ◽

10.1017/s1431927600007145 ◽

1997 ◽

Vol 3 (S2) ◽

pp. 51-52

Author(s):

B.J. Cornell ◽

A. Singh ◽

I. Chu

Keyword(s):

Aromatic Compounds ◽

Liver Toxicity ◽

Corn Oil ◽

Morphological Changes ◽

Test Substance ◽

Sprague Dawley ◽

Morphological Alterations ◽

Pcb Congeners ◽

Transmission Electron ◽

Sprague Dawley Rats

Polyhalogenated aromatic compounds such as polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins (PCDDs) continue to be environmental contaminants because of their bioaccumulation in the food chain and high resistance to biodegradation. The current study was undertaken to determine if a mixture of PCB congeners (WHO-IPCS) were interactive with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in producing morphological changes in the rat liver. Both compounds are known to produce a broad range of biochemical and morphological alterations including enzyme induction.Groups (N=5) of female Sprague-Dawley rats were administered TCDD (0, 2.5, 25, 250, 1000 ng/kg bw/day) or PCB (0, 2, 20 μg/kg bw/day) alone, or in combination with each concentration of both compounds. Incorrect concentrations were published in a previous abstract. The test substance was mixed with corn oil and given by gavage at 2 ml/kg daily for 28 days. At the end of the experiment, the rats were killed and liver samples were prepared for transmission electron microscopy.

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Significant release of unintentionally produced non-Aroclor polychlorinated biphenyl (PCB) congeners PCB 47, PCB 51 and PCB 68 from a silicone rubber production site in North Rhine-Westphalia, Germany

Chemosphere ◽

10.1016/j.chemosphere.2021.131449 ◽

2021 ◽

pp. 131449

Author(s):

Katja Hombrecher ◽

Ulrich Quass ◽

Jörg Leisner ◽

Michael Wichert

Keyword(s):

Silicone Rubber ◽

Polychlorinated Biphenyl ◽

Rubber Production ◽

Pcb Congeners ◽

Production Site ◽

Significant Release

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Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy

Scientific Reports ◽

10.1038/s41598-021-82657-8 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Francesco Donato ◽

Marco Moneda ◽

Nazario Portolani ◽

Angelo Rossini ◽

Sarah Molfino ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Polychlorinated Biphenyls ◽

Serum Levels ◽

Polluted Area ◽

Sufficient Evidence ◽

Pcb Congeners ◽

Non Hodgkin Lymphoma ◽

And Gender ◽

Few Data ◽

Incident Cases

AbstractPolychlorinated biphenyls (PCBs) are human carcinogens, based on sufficient evidence for melanoma and limited evidence for non-Hodgkin lymphoma and breast cancer. Few data are available for liver cancer, although PCBs cause it in rats and determined liver damage in poisoned people. We investigated the association between PCB serum levels and hepatocellular carcinoma (HCC) with a case–control study in a PCB-polluted area in North Italy. We enrolled prospectively 102 HCC incident cases and 102 age and gender-matched hospital controls. Serum concentrations of 33 PCB congeners were determined by a gas chromatograph coupled to mass spectrometry. Of 102 HCC cases, 62 who had lost < 3 kg of body weight in past 3 years were included in the analysis (67.7% males, mean age 68 years). The odds ratio (OR) for HCC for 3rd compared to 1st tertile of PCB distribution was 1.76 (95% confidence interval 0.62–5.03) for total PCB, adjusting for socio-demographic variables and risk factors for HCC by logistic regression. For most PCB congeners, ORs > 1.5 or 2 were found, although the 95% CIs included the null value for almost all of them. This preliminary study suggests that PCBs might play a role in HCC development.

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