P-41: Low resting metabolic rate is associated with low cardiorespiratory fitness, low vitamin D and hyperuricemia in bariatric surgery patients

We investigated the effect of daily intake of yogurt drink fortified with either vitamin D alone or with added calcium on resting metabolic rate (RMR), thyroid hormones and homeostatic model assessment for insulin resistance (HOMA-IR) in subjects with type 2 diabetes (T2D). A total of 75 adult subjects with T2D were randomly assigned to one of the three groups to receive either D-fortified yogurt drink (DY; 1000 IU vitamin D/d), Ca-D-fortified yogurt drink (CDY; 1000 IU vitamin D plus 500 mg calcium), or plain yogurt drink (PY) for 12 weeks. All assessments were done at the baseline and after the intervention. The concentrations of anti-thyroid peroxidase antibody (anti-TPO-Ab), intact parathyroid hormone (iPTH) and thyroid stimulating hormone (TSH) had significant decline compared with baseline values only in CDY group. The mean RMR increased in both DY and CDY groups (p<0.001 for both). Also, changes of serum concentrations of 25(OH)D (B= 2.96, 95%CI= 1.3- 4.6, p=0.001) and iPTH (B= -2.41, 95%CI= -4.5- -0.31, p=0.025) remained significant predictors of RMR changes even after adjustment for changes of serum concentrations of TSH (B= -18.2, 95%CI= -61.7- 25.2, p=0.406). Daily intake of vitamin D together with calcium at physiological doses has attenuating effect on anti-TPO-Ab and TSH. Also, vitamin D with or without added calcium causes a significant thyroid-independent increase in RMR in euthyroid subjects with T2D. Registered at clinicaltrials.gov as NCT01229891. Novelty: Daily intake of vitamin D with calcium at physiological doses has attenuating effect on anti-TPO-Ab and TSH. Vitamin D with or without added calcium causes a thyroid-independent increase in RMR in euthyroid subjects with T2D.

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Comparison of Resting Metabolic Rate of Patients Submitted to Bariatric Surgery and an Equivalent Non-Operated Group with and without Cardiometabolic Alterations

Canadian Journal of Diabetes ◽

10.1016/j.jcjd.2015.01.218 ◽

2015 ◽

Vol 39 ◽

pp. S58

Author(s):

Rafaela P. Dada ◽

Danilo F. Da Silva ◽

Ronano P. Oliveria ◽

Josiane A. Bianchini ◽

Veridiana M. Moreira ◽

...

Keyword(s):

Bariatric Surgery ◽

Metabolic Rate ◽

Resting Metabolic Rate

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Lower Than Predicted Resting Metabolic Rate Is Associated With Severely Impaired Cardiorespiratory Fitness in Obese Individuals

Obesity ◽

10.1038/oby.2011.262 ◽

2012 ◽

Vol 20 (3) ◽

pp. 505-511 ◽

Cited By ~ 16

Author(s):

Wendy M. Miller ◽

Thomas J. Spring ◽

Kerstyn C. Zalesin ◽

Kaylee R. Kaeding ◽

Katherine E. Nori Janosz ◽

...

Keyword(s):

Metabolic Rate ◽

Cardiorespiratory Fitness ◽

Resting Metabolic Rate

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Lack of a relationship between vitamin D status and resting metabolic rate in Iranian adults

American Journal of Human Biology ◽

10.1002/ajhb.23543 ◽

2020 ◽

Author(s):

Mojdeh Ebaditabar ◽

Nadia Babaei ◽

Samira Davarzani ◽

Hossein Imani ◽

Mario J. Soares ◽

...

Keyword(s):

Vitamin D ◽

Metabolic Rate ◽

Resting Metabolic Rate ◽

Vitamin D Status

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Vitamin D Status and Resting Metabolic Rate May Modify through Expression of Vitamin D Receptor and Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene in Overweight and Obese Adults

Annals of Nutrition and Metabolism ◽

10.1159/000485662 ◽

2017 ◽

Vol 72 (1) ◽

pp. 43-49 ◽

Cited By ~ 3

Author(s):

Seyedeh Forough Sajjadi ◽

Khadijeh Mirzaei ◽

Leila Khorrami-Nezhad ◽

Zhila Maghbooli ◽

Seyed Ali Keshavarz

Keyword(s):

Vitamin D ◽

Body Weight ◽

Metabolic Rate ◽

Resting Metabolic Rate ◽

Fat Free Mass ◽

Peroxisome Proliferator ◽

Vitamin D Status ◽

Obese Adults ◽

Peroxisome Proliferator Activated Receptor ◽

The Relationship

Background: Resting metabolic rate (RMR) used to prognosticate and measure the amount of energy required. Vitamin D is known as a new predictor of RMR. The aim of this study is to investigate the relationship between vitamin D effects on RMR in connection with the vitamin D receptor (VDR) and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) gene expression. Methods: We enrolled 298 overweight and obese adults in this cross-sectional study. Body mass index (BMI), fat mass, fat-free mass, insulin level, visceral fat, and vitamin D status were assessed. RMR was measured by means of indirect calorimetry. The real-time polymerase chain reaction using specific primer pairs for VDR and PGC-1α was performed. Results: There were significant differences in terms of fat free mass, fat percentage, insulin levels, RMR/kg body weight, and RMR/BMI, VDR, and PGC-1α among participants were categorized based on the vitamin D status. But after using general linear model for adjusting, all significant results missed their effectiveness except RMR/kg body weight and VDR. Linear regression analysis used to show the mediatory role of VDR and PGC-1α on the RMR/kg body weight and vitamin D status relationship. Our results showed that VDR had a mediatory effect on the relationship between RMR/kg body weight and vitamin D status (β = 0.38, 95% CI –0.48 to 1.60; β = –1.24, 95% CI –5.36 to 1.70). However, PGC-1α did not affect the relationship between RMR/kg body weight and vitamin D status (β = 0.50, 95% CI = –0.02 to 3.42; β = 0.59, 95% CI 0.14–3.90). Conclusion: Our study showed the mediatory effect of VDR gene expression in the association of 25(OH)2D plasma levels and resting metabolic rate among obese individuals.

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Resting metabolic rate and weight loss after bariatric surgery

Surgery for Obesity and Related Diseases ◽

10.1016/j.soard.2018.02.026 ◽

2018 ◽

Vol 14 (6) ◽

pp. 803-807 ◽

Cited By ~ 11

Author(s):

Roberto de Cleva ◽

Filippe Camarotto Mota ◽

Alexandre Vieira Gadducci ◽

Lilian Cardia ◽

Julia Maria D’Andréa Greve ◽

...

Keyword(s):

Bariatric Surgery ◽

Weight Loss ◽

Metabolic Rate ◽

Resting Metabolic Rate

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Vitamin D Supplementation Does Not Impact Resting Metabolic Rate, Body Composition and Strength in Vitamin D Sufficient Physically Active Adults

Nutrients ◽

10.3390/nu12103111 ◽

2020 ◽

Vol 12 (10) ◽

pp. 3111

Author(s):

Karina Romeu Montenegro ◽

Vinicius Cruzat ◽

Hilton Melder ◽

Angela Jacques ◽

Philip Newsholme ◽

...

Keyword(s):

Vitamin D ◽

Young Adults ◽

Body Composition ◽

Placebo Group ◽

Metabolic Rate ◽

Resting Metabolic Rate ◽

Vitamin D Supplementation ◽

Total Serum ◽

Physically Active ◽

Active Adults

Supplementation with the most efficient form of Vitamin D (VitD3) results in improvements in energy metabolism, muscle mass and strength in VitD deficient individuals. Whether similar outcomes occur in VitD sufficient individuals’ remains to be elucidated. The aim of this study is to determine the effect of VitD3 supplementation on resting metabolic rate (RMR), body composition and strength in VitD sufficient physically active young adults. Participants completed pre-supplementation testing before being matched for sunlight exposure and randomly allocated in a counterbalanced manner to the VitD3 or placebo group. Following 12 weeks of 50 IU/kg body-mass VitD3 supplementation, participants repeated the pre-supplementation testing. Thirty-one adults completed the study (19 females and 12 males; mean ± standard deviation (SD); age = 26.6 ± 4.9 years; BMI = 24.2 ± 4.1 kg·m2). The VitD group increased serum total 25(OH)D by 30 nmol/L while the placebo group decreased total serum concentration by 21 nmol/L, reaching 123 (51) and 53 (42.2) nmol/L, respectively. There were no significant changes in muscle strength or power, resting metabolic rate and body composition over the 12-week period. Physically active young adults that are VitD sufficient have demonstrated that no additional physiological effects of achieving supraphysiological serum total 25(OH)D concentrations after VitD3 supplementation.

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0139 Associations of Actigraphic Sleep Parameters with Maximal Oxygen Consumption and Resting Metabolism in Well-Functioning Older Adults

SLEEP ◽

10.1093/sleep/zsaa056.137 ◽

2020 ◽

Vol 43 (Supplement_1) ◽

pp. A54-A55

Author(s):

A J Alfini ◽

A A Wanigatunga ◽

J A Schrack ◽

S Wanigatunga ◽

J Li ◽

...

Keyword(s):

Older Adults ◽

Oxygen Consumption ◽

Metabolic Rate ◽

Cardiorespiratory Fitness ◽

Resting Metabolic Rate ◽

Maximal Oxygen Consumption ◽

Sleep Onset ◽

Community Dwelling ◽

Wrist Actigraphy ◽

Resting Metabolism

Abstract Introduction Both poor sleep and poor cardiorespiratory fitness are common in older age and associated with negative health outcomes. Additionally, among older adults, higher resting metabolic rate (RMR) has been associated with increased morbidity and mortality risk. To evaluate whether, and in what ways, sleep may affect these relationships, we investigated the association of actigraphic sleep indices with cardiorespiratory fitness and RMR in older adults. Methods We studied 393 community-dwelling participants in the Baltimore Longitudinal Study of Aging (mean age 73.5±10.3 years, 52% women) who completed 6.7±0.9 nights of wrist actigraphy, RMR testing, and a maximal graded exercise test. Primary predictors included mean actigraphic total sleep time (TST, minutes), sleep efficiency (SE, %), wake after sleep onset (WASO, minutes), and average wake bout length (WBL, minutes). Cardiorespiratory fitness, as measured by maximal oxygen consumption (V O2MAX; ml/kg/min), and RMR (kcal/day) were the primary outcomes. Results After adjustment for age, sex, race, body mass index, comorbidity index, and depressive symptoms, longer WBL was associated with lower V O2MAX (β=-0.12, 95% confidence interval (CI)=-0.20, -0.04), greater WASO was associated with lower V O2MAX (β=-0.09, 95% CI=-0.17, -0.01), and greater SE was associated with higher V O2MAX (β=0.12, 95% CI=0.03, 0.20). In addition, longer TST was associated with lower RMR (β=-0.10, 95% CI=-0.19, -0.01) and longer WBL was linked to higher RMR (β=0.12, 95% CI=0.04, 0.21). Conclusion In well-functioning older adults, indices of greater wakefulness after sleep onset are linked with poorer cardiorespiratory fitness and higher resting metabolism, while longer and more efficient sleep are associated with better fitness and lower resting metabolic rate. Our findings suggest that sleep disturbance may be linked to disrupted energy homeostasis, evidenced by excessive energy expenditure at rest and inefficient energy utilization in response to maximal demands. Prospective analyses are necessary to determine the nature of these associations. Support This study was supported in part by National Institute on Aging (NIA) grants R01AG050507 and T32-AG027668, the NIA Intramural Research Program (IRP), and Research and Development Contract HHSN-260-2004-00012C.

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