P-30 The effect of osteocalcin on short-term glucose homeostasis before and after surgery-induced weight loss

2011 ◽  
Vol 7 (3) ◽  
pp. 382
Author(s):  
Raelene E. Maser ◽  
Michael Peters ◽  
Isaias Irgau ◽  
Gail Wynn ◽  
M. James Lenhard
Keyword(s):  
Weight Loss ◽  
Glucose Homeostasis ◽  
Short Term ◽  
Before And After

scholarly journals The Effect of Addition of Antioxidant 1,2-dihydro-2,2,4-trimethyl-quinoline on Characteristics of Crepe Rubber Modified Asphalt in Short Term Aging and Long Term Aging Conditions

2020 ◽  
Vol 10 (20) ◽  
pp. 7236
Author(s):  
Bahruddin Ibrahim ◽  
Arya Wiranata ◽  
Alfian Malik
Keyword(s):  
Weight Loss ◽  
Natural Rubber ◽  
Softening Point ◽  
Total Sample ◽  
Short Term ◽  
Modified Asphalt ◽  
Before And After ◽  
Aging Conditions ◽  
Asphalt Performance

The use of natural rubber to resist bitumen is usually prone to degradation and aging. One method to overcome this problem is the addition of antioxidants. This study aims to determine the effect of the addition of antioxidants 1,2-dihydro-2,2,4-trimethyl-quinoline (TMQ) on natural rubber modified asphalt crepe rubber and its performance in short-term and long-term aging conditions. The modified rubber asphalt mixture’s manufacture begins by melting the crepe rubber at 200 °C before being mixed in asphalt at 165 °C. Addition of antioxidant TMQ during the stirring process of the mixture of asphalt and melted rubber. The crepe rubber content was 8, 10, and 12% w/w, while the TMQ content was 1, 2, and 3% w/w of the total sample weight. The modified asphalt samples’ characterization included penetration, softening point, weight loss after a rolling thin film oven test (RTFOT), penetration after RTFOT, and Marshall test. Review of the performance of asphalt under short-term aging conditions using a dynamic shear rheometer (DSR). Evaluation of asphalt performance under long-term aging conditions using Fourier-transform infrared spectroscopy (FTIR). The results showed that the fact that the best-modified asphalt product was the addition of 10% crepe rubber and 2% TMQ. The best-modified asphalt characteristics have penetration 68.70 dmm, softening point 55.45 °C, weight loss only 0.0579%, penetration after RTFOT 59.60, Marshall stability 1403.96 kg with optimum asphalt content of 5.50%, and rutting factor (G*/Sinδ) 6.91 kPa and 16.1 kPa before and after RTFOT. Overall, the modified crepe rubber asphalt can improve the performance of the asphalt in terms of durability. Simultaneously, the antioxidant TMQ works very well in increasing the resistance of bitumen to aging in the conditions of short-term aging and long-term aging.

Roux-en-y gastric bypass improves in short term the clinical-anthropometric parameters and reduces risk for obesity-related cardiometabolic diseases / Bypass gástrico roux-en-y melhora a curto prazo os parâmetros clínico-antropométricos e reduz o risco de doenças cardiometabólicas relacionadas à obesidade

2021 ◽  
Vol 7 (7) ◽  
pp. 73573-73587
Author(s):  
Thiago da Rosa Lima ◽  
Paula Caroline De Almeida ◽  
Fabrício Azevedo Voltarelli ◽  
Lilian Culturato ◽  
Eudes Thiago Pereira Ávila ◽  
...  
Keyword(s):  
Risk Factors ◽  
Weight Loss ◽  
Gastric Bypass ◽  
Abdominal Circumference ◽  
Short Term ◽  
Anthropometric Parameters ◽  
Significance Level ◽  
Cardiometabolic Diseases ◽  
Abdominal Perimeter ◽  
Before And After

Roux-en-Y gastric bypass surgery (RYGB) is the most applied technique in the treatment of severe obesity worldwide. However, its impact on anthropometric parameters and the risk for cardiometabolic diseases in obese patients is uncertain. To evaluate anthropometric clinical parameters and the evolution of risk factors for obesity-related diseases in individuals of both sexes undergoing RYGB. Sixty-nine adults subjects from both sexes submitted to RYGB surgery treatment were divided into 3 groups: G1(13 months, n=24); G2 (13 and 25 months, n=21), and G3 (25 and 37 months, n=24). Sociodemographic and anthropometric information before and after surgery were collected. The abdominal perimeter was used in the classification of cardiometabolic risk and the BMI was used for the risk of obesity-related diseases. Hypotheses were tested by Student's t-test and ANOVA, and the significance level adopted was 5%. The average age was 36.0±10.0 years, with 69.6% being male and 30.4% female. Anthropometric parameters (weight, BMI, and abdominal circumference) were higher among women, except for weight loss and percentage of weight loss. There was a difference in weight loss between the sexes in the moments before and after RYGB. There was a decrease in the risk of disease due to obesity and cardiovascular diseases after RYGB. Weight loss and %WL were greater years by year in the short term of 3 years after surgery. RYGB proved to be an effective strategy for both sexes in combating obesity, providing in the short term a significant improvement in clinical-anthropometric parameters and reduction of risk factors for obesity-related cardiometabolic diseases.

scholarly journals Short-term weight loss attenuates local tissue inflammation and improves insulin sensitivity without affecting adipose inflammation in obese mice

2013 ◽  
Vol 304 (9) ◽  
pp. E964-E976 ◽  
Author(s):  
Dae Young Jung ◽  
Hwi Jin Ko ◽  
Eben I. Lichtman ◽  
Eunjung Lee ◽  
Elizabeth Lawton ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Weight Loss ◽  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Glucose Metabolism ◽  
Glucose Homeostasis ◽  
Local Inflammation ◽  
Lipid Levels ◽  
Short Term ◽  
Tissue Inflammation

Obesity is a major cause of insulin resistance, and weight loss is shown to improve glucose homeostasis. But the underlying mechanism and the role of inflammation remain unclear. Male C57BL/6 mice were fed a high-fat diet (HFD) for 12 wk. After HFD, weight loss was induced by changing to a low-fat diet (LFD) or exercise with continuous HFD. The weight loss effects on energy balance and insulin sensitivity were determined using metabolic cages and hyperinsulinemic euglycemic clamps in awake mice. Diet and exercise intervention for 3 wk caused a modest weight loss and improved glucose homeostasis. Weight loss dramatically reduced local inflammation in skeletal muscle, liver, and heart but not in adipose tissue. Exercise-mediated weight loss increased muscle glucose metabolism without affecting Akt phosphorylation or lipid levels. LFD-mediated weight loss reduced lipid levels and improved insulin sensitivity selectively in liver. Both weight loss interventions improved cardiac glucose metabolism. These results demonstrate that a short-term weight loss with exercise or diet intervention attenuates obesity-induced local inflammation and selectively improves insulin sensitivity in skeletal muscle and liver. Our findings suggest that local factors, not adipose tissue inflammation, are involved in the beneficial effects of weight loss on glucose homeostasis.

Short-Term Voluntary Exercise Induces Weight Loss and Improved Glucose Homeostasis in Polygenic Obese Female Mice

2015 ◽  
Vol 47 ◽  
pp. 891
Author(s):  
Xiaoya Ma ◽  
Kaitlyn J. Patterson ◽  
Lydia J. Proctor ◽  
Maria R. Ward ◽  
Peter F. Bodary
Keyword(s):  
Weight Loss ◽  
Glucose Homeostasis ◽  
Voluntary Exercise ◽  
Short Term ◽  
Female Mice ◽  
Obese Female

scholarly journals Non-Invasive Characterization of the Pancreas During Bariatric Surgery via Circulating Pancreatic Specific Cell-free Messenger RNA

2021 ◽  
Vol 12 ◽  
Author(s):  
Kong Kiat Whye ◽  
E ShyongTai ◽  
Asim Shabbir ◽  
Chin Meng Khoo ◽  
Winston Koh
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Glucose Homeostasis ◽  
Messenger Rna ◽  
Specific Cell ◽  
Haemoglobin A1c ◽  
Multiple Time ◽  
Short Term ◽  
Non Invasive ◽  
Post Surgery

Bariatric surgery results in sustained weight loss and improvement in glucose homeostasis. However, the lack of accessible non-invasive tools to examine molecular alterations occurring in the pancreas limits our understanding of the causes and recovery of glucose homeostasis. Here, we describe the use of a circulating cell free mRNA (cfmRNA) based multiplex qPCR assay to selectively amplify and quantify circulating pancreatic specific transcripts levels within plasma. We applied this assay to a cohort of 58 plasma samples consisting of 10 patients that tracks multiple time points including pre and post-bariatric surgery. In our targeted multiplex screen of 14 selected pancreatic specific circulating transcripts, we identified 13 pancreatic specific transcripts that can be amplified from plasma. Furthermore, when quantifying the amplicons obtained in the short-term post-surgery (2 weeks–1 month) and long-term (3–12 months), we observed a consistent reduction of circulating GCG transcripts during short term post-surgery. Across the cohort, GCG cfmRNA levels correlated significantly with common metrics of improvement following bariatric surgery such as: haemoglobin A1c levels (R: −0.41, p-value: 0.0039) and percentage of excess weight loss (R: 0.29, p-value: 0.046).

SHORT-TERM WEIGHT LOSS OF THE ENDOSCOPIC SLEEVE GASTROPLASTY FOR PRIMARY OBESITY

2020 ◽  
Author(s):  
AJ del Pozo-Garcia ◽  
DR de la Cruz ◽  
T Valdés-Lacasa ◽  
S Nevado ◽  
R Polanco ◽  
...  
Keyword(s):  
Weight Loss ◽  
Short Term ◽  
Endoscopic Sleeve Gastroplasty ◽  
Sleeve Gastroplasty

Short-term weight loss after hospitalization predicts long-term survival in patients with chronic heart failure

2006 ◽  
Vol 31 (03) ◽  
Author(s):  
M Lainscak ◽  
S von Haehling ◽  
A Sandek ◽  
I Keber ◽  
M Kerbev ◽  
...  
Keyword(s):  
Heart Failure ◽  
Weight Loss ◽  
Chronic Heart Failure ◽  
Short Term ◽  
Term Survival ◽  
Long Term Survival

TO STUDY THE EFFECT OF BMV ON P WAVE DISPERSION AND SHORT TERM PROGNOSTIC IMPACT OF P WAVE DISPERSION IN PREDICTION OF CLINICAL OUTCOME AFTER PERCUTANEOUS BALLOON MITRAL VALVULOPLASTY IN PATIENTS WITH MITRAL STENOSIS AND SINUS RHYTHM

2020 ◽  
Vol 4 (9) ◽  
Author(s):  
Ashish Kumar Agarwal ◽  
Daulat Singh Meena ◽  
Vijay Pathak ◽  
Anoop Jain ◽  
Rakesh Kumar Ola
Keyword(s):  
Clinical Outcome ◽  
Right Ventricular ◽  
Wave Dispersion ◽  
Tissue Doppler ◽  
P Wave ◽  
Short Term ◽  
P Wave Dispersion ◽  
Mitral Valvuloplasty ◽  
Percutaneous Balloon ◽  
Before And After

Background: The aim of the present study was to study the effect of percutaneous balloon mitral  valvuloplasty (PBMV) on P wave dispersion and to test the correlation between P-maximum and  P-dispersion to right ventricular function and pulmonary artery pressure before and after PMBV. Also to study the impact of P-maximum and P-wave dispersion on the short term clinical outcome after successful PBMV in patients with mitral stenosis (MS) and sinus rhythm. Methods: 75 patients undergoing PMBV were enrolled in this study. We evaluated P-maximum, P-minimum and P-wave dispersion before and one month and one year after PBMV . We studied the changes in pulmonary arterial pressure (PAP), left atrial (LA) dimension, mitral diastolic gradient, and mitral valve area, in addition to the changes in right ventricular function utilizing tissue Doppler assessment both before and after PMBV, in addition the role of the P-wave dispersion in prediction of late cardiac events. Results: There were significant decrease in mean diastolic gradient, PAP, and LA size and significant improvement in right ventricular tissue Doppler indices after PMBV. Accompany these hemodynamic changes after PMBV. P-maximum and P-wave dispersion were found to be decreased (P < 0.001). Conclusion: Successful PBMV was associated with a decrease in Pmax and PWD. These simple electrocardiographic indices may predict the success of the procedure immediately after PBMV.  The P-maximum and P-wave dispersion changes were correlated with significant impairment of right dysfunction and the degree of pulmonary artery pressure. Keywords: PBMV.PAP,LA

2016-P: High Dose DACRA Treatment Improves Glucose Homeostasis, without Additional Weight Loss

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2016-P
Author(s):  
NINA SONNE ◽  
ANNA T. LARSEN ◽  
KIM V. ANDREASSEN ◽  
MORTEN ASSER KARSDAL ◽  
KIM HENRIKSEN
Keyword(s):  
Weight Loss ◽  
Glucose Homeostasis ◽  
High Dose ◽  
Additional Weight

Impact of Michigan’s new opioid prescribing laws on spine surgery patients: analysis of the Michigan Spine Surgery Improvement Collaborative

2020 ◽  
pp. 1-6
Author(s):  
Paul Park ◽  
Victor Chang ◽  
Hsueh-Han Yeh ◽  
Jason M. Schwalb ◽  
David R. Nerenz ◽  
...  
Keyword(s):  
Spine Surgery ◽  
Spinal Surgery ◽  
Readmission Rate ◽  
Rating Scale ◽  
Short Term ◽  
Readmission Rates ◽  
Opioid Prescribing ◽  
Number Of Patients ◽  
Before And After ◽  
The Impact

OBJECTIVEIn 2017, Michigan passed new legislation designed to reduce opioid abuse. This study evaluated the impact of these new restrictive laws on preoperative narcotic use, short-term outcomes, and readmission rates after spinal surgery.METHODSPatient data from 1 year before and 1 year after initiation of the new opioid laws (beginning July 1, 2018) were queried from the Michigan Spine Surgery Improvement Collaborative database. Before and after implementation of the major elements of the new laws, 12,325 and 11,988 patients, respectively, were treated.RESULTSPatients before and after passage of the opioid laws had generally similar demographic and surgical characteristics. Notably, after passage of the opioid laws, the number of patients taking daily narcotics preoperatively decreased from 3783 (48.7%) to 2698 (39.7%; p < 0.0001). Three months postoperatively, there were no differences in minimum clinically important difference (56.0% vs 58.0%, p = 0.1068), numeric rating scale (NRS) score of back pain (3.5 vs 3.4, p = 0.1156), NRS score of leg pain (2.7 vs 2.7, p = 0.3595), satisfaction (84.4% vs 84.7%, p = 0.6852), or 90-day readmission rate (5.8% vs 6.2%, p = 0.3202) between groups. Although there was no difference in readmission rates, pain as a reason for readmission was marginally more common (0.86% vs 1.22%, p = 0.0323).CONCLUSIONSThere was a meaningful decrease in preoperative narcotic use, but notably there was no apparent negative impact on postoperative recovery, patient satisfaction, or short-term outcomes after spinal surgery despite more restrictive opioid prescribing. Although the readmission rate did not significantly increase, pain as a reason for readmission was marginally more frequently observed.

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