Retroperitoneal white adipose tissue mitochondrial function and adiponectin expression in response to ovariectomy and 17β-estradiol replacement

Steroids ◽  
2012 ◽  
Vol 77 (6) ◽  
pp. 659-665 ◽  
Author(s):  
Emilia Amengual-Cladera ◽  
Isabel Lladó ◽  
Magdalena Gianotti ◽  
Ana M. Proenza
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Mitochondrial Function ◽  
Retroperitoneal White Adipose Tissue ◽  
17Β Estradiol

scholarly journals Endocrine and Metabolic Signaling in Retroperitoneal White Adipose Tissue Remodeling during Cold Acclimation

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Aleksandra Jankovic ◽  
Aleksandra Korac ◽  
Biljana Buzadzic ◽  
Vesna Otasevic ◽  
Ana Stancic ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Cold Acclimation ◽  
White Adipose Tissue ◽  
Protein Level ◽  
Metabolic Response ◽  
Expression Profiles ◽  
Hypoxia Inducible Factor ◽  
Metabolic Remodeling ◽  
Retroperitoneal White Adipose Tissue ◽  
Adipose Tissue Remodeling

The expression profiles of adiponectin, resistin, 5′-AMP-activated protein kinaseα(AMPKα), hypoxia-inducible factor-1α(HIF-1α), and key enzymes of glucose and fatty acid metabolism and oxidative phosphorylation in rat retroperitoneal white adipose tissue (RpWAT) during 45-day cold acclimation were examined. After transient suppression on day 1, adiponectin protein level increased following sustained cold exposure. In parallel, on day 1, the protein level of HIF-1αwas strongly induced and AMPKαsuppressed, while afterwards the reverse was seen. What is more, after an initial decrease on day 1, a sequential increase in pyruvate dehydrogenase, acyl-CoA dehydrogenase, cytochromecoxidase, and ATP synthase and a decrease in acetyl-CoA carboxylase (from day 3) were observed. Similar to adiponectin, protein level of resistin showed a biphasic profile: it increased after days 1, 3, and 7 and decreased below the control after 21 days of cold-acclimation. In summary, the data suggest that adiponectin and resistin are important integrators of RpWAT metabolic response and roles it plays during cold acclimation. It seems that AMPKαmediate adiponectin effects on metabolic remodeling RpWAT during cold acclimation.

Sex differences in the effect of high-fat diet feeding on rat white adipose tissue mitochondrial function and insulin sensitivity

Metabolism ◽  
2012 ◽  
Vol 61 (8) ◽  
pp. 1108-1117 ◽  
Author(s):  
Emilia Amengual-Cladera ◽  
Isabel Lladó ◽  
Magdalena Gianotti ◽  
Ana M. Proenza
Keyword(s):  
Sex Differences ◽  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
White Adipose Tissue ◽  
Mitochondrial Function ◽  
High Fat Diet ◽  
High Fat

Mitochondrial function/dysfunction in white adipose tissue

2014 ◽  
Vol 99 (9) ◽  
pp. 1168-1178 ◽  
Author(s):  
Sihem Boudina ◽  
Timothy E. Graham
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Mitochondrial Function

Melatonin improves mitochondrial function in inguinal white adipose tissue of Zücker diabetic fatty rats

2014 ◽  
Vol 57 (1) ◽  
pp. 103-109 ◽  
Author(s):  
Aroa Jimenéz-Aranda ◽  
Gumersindo Fernández-Vázquez ◽  
María Mohammad A-Serrano ◽  
Russel J. Reiter ◽  
Ahmad Agil
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Mitochondrial Function ◽  
Zucker Diabetic Fatty Rats

Differential regulation of glyceroneogenesis by glucocorticoids in epididymal and retroperitoneal white adipose tissue from rats

Endocrine ◽  
2017 ◽  
Vol 57 (2) ◽  
pp. 287-297 ◽  
Author(s):  
Graziella Nascimento Ferreira ◽  
Rafael Rossi-Valentim ◽  
Samyra Lopes Buzelle ◽  
Sílvia Paula-Gomes ◽  
Neusa Maria Zanon ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Differential Regulation ◽  
Retroperitoneal White Adipose Tissue

scholarly journals A soyabean diet does not modify the activity of brown adipose tissue but alters the rate of lipolysis in the retroperitoneal white adipose tissue of male rats recovering from early-life malnutrition

2011 ◽  
Vol 108 (6) ◽  
pp. 1042-1051 ◽  
Author(s):  
Adriene Alexandra Paiva ◽  
Jaline Zandonato Faiad ◽  
Marina Satie Taki ◽  
Silvia Regina de Lima Reis ◽  
Letícia Martins Ignácio de Souza ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
White Adipose Tissue ◽  
Early Life ◽  
Uncoupling Protein ◽  
Male Rats ◽  
Fat Deposits ◽  
Brown Adipose ◽  
Pregnancy And Lactation ◽  
Retroperitoneal White Adipose Tissue

Nutritional recovery with a soyabean diet decreases body and fat weights when compared with a casein diet. We investigated whether the reduced adiposity observed in rats recovering from early-life malnutrition with a soyabean diet results from alterations in lipid metabolism in white adipose tissue (WAT) and/or brown adipose tissue (BAT). Male rats from mothers fed either 17 or 6 % protein during pregnancy and lactation were maintained on 17 % casein (CC and LC groups), 17 % soyabean (CS and LS groups) or 6 % casein (LL group) diets over 60 d. The rats maintained on a soyabean diet had similar relative food intakes, but lower body and retroperitoneal WAT weights and a reduced lipid content in the retroperitoneal WAT. The insulin levels were lower in the recovered rats and were elevated in those fed a soyabean diet. Serum T3 concentration and uncoupling protein 1 content in the BAT were decreased in the recovered rats. The thermogenic capacity of the BAT was not affected by the soyabean diet. The lipogenesis rate in the retroperitoneal WAT was similar in all of the groups except for the LL group, which had exacerbated lipogenesis. The enhancement of the lipolysis rate by isoproterenol was decreased in white adipocytes from the soyabean-recovered rats and was elevated in adipocytes from the soyabean-control rats. Thus, in animals maintained on a soyabean diet, the proportions of fat deposits are determined by the lipolysis rate, which differs depending on the previous nutritional status.

Ameliorating effects of lifelong physical activity on healthy aging and mitochondrial function in human white adipose tissue

2021 ◽  
Author(s):  
Anders Gudiksen ◽  
Albina Qoqaj ◽  
Stine Ringholm ◽  
Jørgen Wojtaszewski ◽  
Peter Plomgaard ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Exercise Training ◽  
White Adipose Tissue ◽  
Mitochondrial Function ◽  
Mitochondrial Respiration ◽  
Healthy Aging ◽  
Venous Blood ◽  
Oxidative Capacity ◽  
Low Grade ◽  
Lifelong Exercise

Abstract Growing old is patently among the most prominent risk factors for lifestyle related diseases and deterioration in physical performance. Aging in particular affects mitochondrial homeostasis and maintaining a well-functioning mitochondrial pool is imperative in order to avoid age-associated metabolic decline. White adipose tissue (WAT) is a key organ in energy balance and impaired mitochondrial function in adipocytes has been associated with increased low-grade inflammation, altered metabolism, excessive ROS production and an accelerated aging phenotype. Exercise training improves mitochondrial health but whether lifelong exercise training can sufficiently maintain WAT mitochondrial function is currently unknown. Therefore, to dissect the role and dose-dependence of lifelong exercise training on aging WAT metabolic parameters and mitochondrial function, young and older untrained, as well as moderately and highly exercise trained older male subjects were recruited and abdominal subcutaneous (s)WAT biopsies and venous blood samples were obtained to measure mitochondrial function and key metabolic factors in WAT and plasma. Mitochondrial intrinsic respiratory capacity was lower in sWAT from older than in young subjects. In spite of this, maximal mitochondrial respiration per wet weight, markers of oxidative capacity, and mitophagic capacity were increased in sWAT from lifelong highly exercise trained than all other groups. Furthermore, ROS emission was generally lower in sWAT from lifelong highly exercise trained than older untrained subjects. Taken together, aging reduces intrinsic mitochondrial respiration in human sWAT, but lifelong high volume exercise training increases oxidative capacity by increasing mitochondrial volume likely contributing to healthy aging.

Sexual-Dimorphism in Exercise-Induced Beiging and Altered Mitochondrial Function in Inguinal White Adipose Tissue (iWAT) from the Mouse

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 758-P
Author(s):  
PASQUALE NIGRO ◽  
ROELAND MIDDELBEEK ◽  
CHRISTIANO R. ALVES ◽  
BRENT G. ALBERTSON ◽  
LESLIE A. ROWLAND ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Sexual Dimorphism ◽  
White Adipose Tissue ◽  
Mitochondrial Function ◽  
Exercise Induced

Role of sympathetic nerves in effects of estradiol on rat white adipose tissue

1991 ◽  
Vol 260 (1) ◽  
pp. R47-R51 ◽  
Author(s):  
S. J. Lazzarini ◽  
G. N. Wade
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Sympathetic Nerves ◽  
Estradiol Benzoate ◽  
Sesame Oil ◽  
Fat Pad ◽  
Weight Losses ◽  
Ovx Rats ◽  
Retroperitoneal White Adipose Tissue

Two experiments examined the role of the sympathetic nerves in estradiol-induced fat pad weight losses in ovariectomized (OVX) rats. Rats were OVX, and the retroperitoneal white adipose tissue (RWAT) was unilaterally denervated 4 wk later. After 14 days of treatment with estradiol benzoate (EB, 2 micrograms/day), the intact pads lost 23% more weight than the denervated pads. There was no effect of denervation on fat pad weight or on cytosol estrogen receptor concentration in RWAT in the animals treated with sesame oil vehicle. These data suggest that the sympathetic nerves play a role in estrogen-induced reductions in fat pad weight but not via changes in adipose tissue cytosol estrogen receptors. A second experiment examined whether estradiol-induced fat pad weight losses are accompanied by increased norepinephrine (NE) turnover, an index of sympathetic activity, in adipose tissue. Rats were OVX and treated with EB or sesame oil vehicle. NE turnover was assessed by measuring the decline of tissue NE over time after injection of alpha-methyl-p-tyrosine, an inhibitor of tyrosine hydroxylase activity and thus NE biosynthesis. NE turnover in RWAT, but not heart, was significantly greater in animals treated with EB, suggesting that estradiol decreases fat pad weight in part by increasing sympathetic nervous system activity. It is possible that estradiol acts in the brain to regulate the activity of the sympathetic nerves to white adipose tissue and peripherally to alter adipose tissue responsiveness to catecholamines.

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