scholarly journals Endocrine and Metabolic Signaling in Retroperitoneal White Adipose Tissue Remodeling during Cold Acclimation

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Aleksandra Jankovic ◽  
Aleksandra Korac ◽  
Biljana Buzadzic ◽  
Vesna Otasevic ◽  
Ana Stancic ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Cold Acclimation ◽  
White Adipose Tissue ◽  
Protein Level ◽  
Metabolic Response ◽  
Expression Profiles ◽  
Hypoxia Inducible Factor ◽  
Metabolic Remodeling ◽  
Retroperitoneal White Adipose Tissue ◽  
Adipose Tissue Remodeling

The expression profiles of adiponectin, resistin, 5′-AMP-activated protein kinaseα(AMPKα), hypoxia-inducible factor-1α(HIF-1α), and key enzymes of glucose and fatty acid metabolism and oxidative phosphorylation in rat retroperitoneal white adipose tissue (RpWAT) during 45-day cold acclimation were examined. After transient suppression on day 1, adiponectin protein level increased following sustained cold exposure. In parallel, on day 1, the protein level of HIF-1αwas strongly induced and AMPKαsuppressed, while afterwards the reverse was seen. What is more, after an initial decrease on day 1, a sequential increase in pyruvate dehydrogenase, acyl-CoA dehydrogenase, cytochromecoxidase, and ATP synthase and a decrease in acetyl-CoA carboxylase (from day 3) were observed. Similar to adiponectin, protein level of resistin showed a biphasic profile: it increased after days 1, 3, and 7 and decreased below the control after 21 days of cold-acclimation. In summary, the data suggest that adiponectin and resistin are important integrators of RpWAT metabolic response and roles it plays during cold acclimation. It seems that AMPKαmediate adiponectin effects on metabolic remodeling RpWAT during cold acclimation.

Redox-dependent metabolic remodeling of white adipose tissue during cold acclimation: The role of Nrf2

2021 ◽  
Vol 177 ◽  
pp. S105
Author(s):  
Tamara Zakic ◽  
Marta Budnar ◽  
Strahinja Djuric ◽  
Andjelika Kalezic ◽  
Aleksandra Korac ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Cold Acclimation ◽  
White Adipose Tissue ◽  
Metabolic Remodeling

scholarly journals Oral Ang-(1-7) treatment improves white adipose tissue remodeling and hypertension in rats with metabolic syndrome

Nutrition: X ◽  
2019 ◽  
Vol 1 ◽  
pp. 100004 ◽  
Author(s):  
Maria Andréa Barbosa ◽  
Graziele Galdino de Sousa ◽  
Uberdan Guilherme Mendes de Castro ◽  
Cláudia Martins Carneiro ◽  
Vivian Paulino Figueiredo ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Tissue Remodeling ◽  
Adipose Tissue Remodeling

scholarly journals Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction

Aging Cell ◽  
2017 ◽  
Vol 16 (3) ◽  
pp. 508-517 ◽  
Author(s):  
Namiki Fujii ◽  
Takumi Narita ◽  
Naoyuki Okita ◽  
Masaki Kobayashi ◽  
Yurika Furuta ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Caloric Restriction ◽  
White Adipose Tissue ◽  
Binding Protein ◽  
Regulatory Element ◽  
Metabolic Remodeling ◽  
Element Binding Protein ◽  
Sterol Regulatory Element

scholarly journals Exercise Training Promotes Sex-Specific Adaptations in Mouse Inguinal White Adipose Tissue

2021 ◽  
Author(s):  
Pasquale Nigro ◽  
Roeland J. W. Middelbeek ◽  
Christiano R. R. Alves ◽  
Susana Rovira–Llopis ◽  
Krithika Ramachandran ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Exercise Training ◽  
White Adipose Tissue ◽  
Metabolic Response ◽  
Wheel Running ◽  
Secretory Protein ◽  
Acid Uptake ◽  
Male Mice ◽  
Female Mice ◽  
Response To Exercise

Recent studies demonstrate that adaptations to white adipose tissue are important components of the beneficial effects of exercise training on metabolic health. Exercise training favorably alters the phenotype of subcutaneous inguinal white adipose tissue (iWAT) in male mice including decreasing fat mass, improving mitochondrial function, inducing beiging and stimulating the secretion of adipokines. Here, we find that despite performing more voluntary wheel running compared to males, these adaptations do not occur in the iWAT of female mice. Consistent with sex-specific adaptations, we report that mRNA expression of androgen receptor co-activators are upregulated in iWAT from trained male mice, and that testosterone treatment of primary adipocytes derived from the iWAT of male, but not female mice, phenocopies exercise-induced metabolic adaptations. Sex-specificity also occurs in the secretome profile, as we identify Cysteine Rich Secretory Protein 1(<i>Crisp1</i>) as a novel adipokine that is only secreted from male iWAT in response to exercise. <i>Crisp1</i> expression is upregulated by testosterone and functions to increase glucose and fatty acid uptake. Our finding that adaptations to iWAT with exercise training are dramatically greater in male mice has potential clinical implications for understanding the different metabolic response to exercise training in males and females, and demonstrates the importance of investigating both sexes in studies of adipose tissue biology.

Prep1 deficiency improves metabolic response in white adipose tissue

2018 ◽  
Vol 1863 (5) ◽  
pp. 515-525 ◽  
Author(s):  
Antonietta Liotti ◽  
Serena Cabaro ◽  
Ilaria Cimmino ◽  
Serena Ricci ◽  
Claudio Procaccini ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Metabolic Response

scholarly journals SREBP-1c-Dependent Metabolic Remodeling of White Adipose Tissue by Caloric Restriction

2018 ◽  
Vol 19 (11) ◽  
pp. 3335 ◽  
Author(s):  
Masaki Kobayashi ◽  
Namiki Fujii ◽  
Takumi Narita ◽  
Yoshikazu Higami
Keyword(s):  
Adipose Tissue ◽  
Caloric Restriction ◽  
White Adipose Tissue ◽  
Regulatory Element ◽  
Whole Body ◽  
Peroxisome Proliferator ◽  
Master Regulator ◽  
Beneficial Effects ◽  
Age Related ◽  
Metabolic Remodeling

Caloric restriction (CR) delays the onset of many age-related pathophysiological changes and extends lifespan. White adipose tissue (WAT) is not only a major tissue for energy storage, but also an endocrine tissue that secretes various adipokines. Recent reports have demonstrated that alterations in the characteristics of WAT can impact whole-body metabolism and lifespan. Hence, we hypothesized that functional alterations in WAT may play important roles in the beneficial effects of CR. Previously, using microarray analysis of WAT from CR rats, we found that CR enhances fatty acid (FA) biosynthesis, and identified sterol regulatory element-binding protein 1c (SREBP-1c), a master regulator of FA synthesis, as a mediator of CR. These findings were validated by showing that CR failed to upregulate factors involved in FA biosynthesis and to extend longevity in SREBP-1c knockout mice. Furthermore, we revealed that SREBP-1c is implicated in CR-associated mitochondrial activation through the upregulation of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), a master regulator of mitochondrial biogenesis. Notably, these CR-associated phenotypes were observed only in WAT. We conclude that CR induces SREBP-1c-dependent metabolic remodeling, including the enhancement of FA biosynthesis and mitochondrial activation, via PGC-1α in WAT, resulting in beneficial effects.

scholarly journals Protein kinase Cβ deficiency attenuates obesity syndrome ofob/obmice by promoting white adipose tissue remodeling

2011 ◽  
Vol 53 (3) ◽  
pp. 368-378 ◽  
Author(s):  
Wei Huang ◽  
Rishipal R. Bansode ◽  
Naresh C. Bal ◽  
Madhu Mehta ◽  
Kamal D. Mehta
Keyword(s):  
Adipose Tissue ◽  
Protein Kinase ◽  
White Adipose Tissue ◽  
Tissue Remodeling ◽  
Adipose Tissue Remodeling ◽  
Obesity Syndrome

scholarly journals Srebp-1c/Fgf21/Pgc-1α Axis Regulated by Leptin Signaling in Adipocytes—Possible Mechanism of Caloric Restriction-Associated Metabolic Remodeling of White Adipose Tissue

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2054
Author(s):  
Masaki Kobayashi ◽  
Seira Uta ◽  
Minami Otsubo ◽  
Yusuke Deguchi ◽  
Ryoma Tagawa ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Caloric Restriction ◽  
White Adipose Tissue ◽  
Mitochondrial Biogenesis ◽  
Molecular Mechanisms ◽  
Whole Body ◽  
Fibroblast Growth Factor 21 ◽  
Leptin Signaling ◽  
Age Related ◽  
Metabolic Remodeling

Caloric restriction (CR) improves whole body metabolism, suppresses age-related pathophysiology, and extends lifespan in rodents. Metabolic remodeling, including fatty acid (FA) biosynthesis and mitochondrial biogenesis, in white adipose tissue (WAT) plays an important role in the beneficial effects of CR. We have proposed that CR-induced mitochondrial biogenesis in WAT is mediated by peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), which is transcriptionally regulated by sterol regulatory element-binding protein 1c (SREBP-1c), a master regulator of FA biosynthesis. We have also proposed that the CR-associated upregulation of SREBP-1 and PGC-1α might result from the attenuation of leptin signaling and the upregulation of fibroblast growth factor 21 (FGF21) in WAT. However, the detailed molecular mechanisms remain unclear. Here, we interrogate the regulatory mechanisms involving leptin signaling, SREBP-1c, FGF21, and PGC-1α using Srebp-1c knockout (KO) mice, mouse embryonic fibroblasts, and 3T3-L1 adipocytes, by altering the expression of SREBP-1c or FGF21. We show that a reduction in leptin signaling induces the expression of proteins involved in FA biosynthesis and mitochondrial biogenesis via SREBP-1c in adipocytes. The upregulation of SREBP-1c activates PGC-1α transcription via FGF21, but it is unlikely that the FGF21-associated upregulation of PGC-1α expression is a predominant contributor to mitochondrial biogenesis in adipocytes.

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