An ESIPT-based fluorescent probe for sensitive and selective detection of Cys/Hcy over GSH with a red emission and a large Stokes shift

2017 ◽  
Vol 58 (33) ◽  
pp. 3209-3213 ◽  
Author(s):  
Xingjiang Liu ◽  
HuiHui Tian ◽  
Lei Yang ◽  
Yuanan Su ◽  
Man Guo ◽  
...  
2018 ◽  
Vol 16 (27) ◽  
pp. 5036-5042 ◽  
Author(s):  
Lei Yang ◽  
Yuanan Su ◽  
Yani Geng ◽  
Haiqing Xiong ◽  
Jinliang Han ◽  
...  

A vinethene-based fluorescent probe has been developed for the sensitive and selective detection of Hg2+ with a low detection limit, a red emission and a large Stokes shift. The probe has been successfully applied to detect Hg2+ in aqueous solutions, living cells and organisms.


2018 ◽  
Vol 16 (7) ◽  
pp. 1150-1156 ◽  
Author(s):  
Lei Yang ◽  
Yuanan Su ◽  
Zhankui Sha ◽  
Yani Geng ◽  
Fengpei Qi ◽  
...  

An azido-based fluorescent probe was developed for the sensitive and selective detection of H2S with a red emission and a large Stokes shift. The probe was successfully applied to detect H2S both in aqueous solution and in living cells.


Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2337
Author(s):  
Yan Zheng ◽  
Peng Hou ◽  
Yu Li ◽  
Jingwen Sun ◽  
Hongxia Cui ◽  
...  

Due to the redox properties closely related to numerous physiological and pathological processes, biothiols, including cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), have received considerable attention in biological science. On account of the important physiological roles of these biothiols, it is of profound significance to develop sensitive and selective detection of biothiols to understand their biological profiles. In this work, we reported an efficient fluorescent probe, PHPQ-SH, for detecting biothiols in vitro and vivo, based on the phenothiazine-HPQ skeleton, with DNBS (2,4-dinitrobenzenesulfonate) as the response unit. Probe PHPQ-SH exhibited brilliant sensing performances toward thiols, including a large Stokes shift (138 nm), excellent sensitivity (for GSH, LOD = 18.3 nM), remarkable fluorescence enhancement (163-fold), low cytotoxicity, rapid response (8 min), and extraordinary selectivity. Finally, the probe PHPQ-SH illustrated herein was capable of responding and visualizing biothiols in MCF-7 cells and zebrafish.


The Analyst ◽  
2018 ◽  
Vol 143 (23) ◽  
pp. 5779-5784 ◽  
Author(s):  
Dugang Chen ◽  
Zi Long ◽  
Yecheng Dang ◽  
Li Chen

A new probe ANT selectively mapped endogenous Cys in living cells with bright red-emission and a large Stokes shift.


2018 ◽  
Vol 10 (32) ◽  
pp. 3991-3999 ◽  
Author(s):  
Wang Zhang ◽  
Gu Weijing ◽  
Tian Cheng ◽  
Bingxiang Wang ◽  
Yuliang Jiang ◽  
...  

A novel turn-on fluorescent probe (DDND) for highly selective detection of biothiols over other amino acids was synthesized and investigated in this work, which used the 2,4-dinitrobenzenesulfonyl group as a fluorescent quencher.


2019 ◽  
Vol 43 (33) ◽  
pp. 13212-13216 ◽  
Author(s):  
Yifan Rong ◽  
Chen Wang ◽  
Panfeng Chuai ◽  
Yunfan Song ◽  
Shuang Zhou ◽  
...  

This probe exhibited red emission (λmax = 590 nm) and a large Stokes shift (143 nm) for the detection of biothiols.


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