Different cytotoxic and apoptotic responses of MCF-7 and HT1080 cells to MnO2 nanoparticles are based on similar mode of action

Toxicology ◽  
2019 ◽  
Vol 411 ◽  
pp. 71-80 ◽  
Author(s):  
Hisham A. Alhadlaq ◽  
Mohd Javed Akhtar ◽  
Maqusood Ahamed
Keyword(s):  
Mode Of Action ◽  
Mno2 Nanoparticles ◽  
Ht1080 Cells ◽  
Similar Mode ◽  
Mcf 7

Explanation of non-additive effects in mixtures of similar mode of action chemicals

Toxicology ◽  
2015 ◽  
Vol 335 ◽  
pp. 20-26 ◽  
Author(s):  
Masashi Kamo ◽  
Hiroyuki Yokomizo
Keyword(s):  
Mode Of Action ◽  
Additive Effects ◽  
Similar Mode

scholarly journals Bacteriocins In Poultry Nutrition – A Review / Bakteriocyny w żywieniu drobiu – artykuł przeglądowy

2013 ◽  
Vol 13 (3) ◽  
pp. 449-462 ◽  
Author(s):  
Damian Józefiak ◽  
Anna Sip
Keyword(s):  
Mode Of Action ◽  
Potential Role ◽  
Bacterial Species ◽  
Human Nutrition ◽  
Limited Information ◽  
Gastrointestinal Microbiota ◽  
Broiler Performance ◽  
Close Relationship ◽  
Similar Mode ◽  
Poultry Nutrition

Abstract In recent years, a number of studies have shown a close relationship between broiler performance, health and the gastrointestinal microbiota. However, taking the complexity and biodiversity of the micro-ecosystem into consideration, a manipulation of the microbiota in a way that is profitable both for the host bird and for the farmer seems a difficult goal to achieve. Bacteriocins are extracellular proteinaceous compounds, synthesized by many bacterial species. Due to their different bacteriostatic effects, they have been used in human nutrition for decades. However, limited information is available regarding their effects in poultry, even though that similar mode of action as in other animals is possible. Therefore, the aim of the present review is to discuss present bacteriocin classification, mode of action and their potential role in poultry nutrition.

scholarly journals New Synthetic Nitro-Pyrrolomycins as Promising Antibacterial and Anticancer Agents

Antibiotics ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 292 ◽  
Author(s):  
Maria Valeria Raimondi ◽  
Alessandro Presentato ◽  
Giovanna Li Petri ◽  
Miriam Buttacavoli ◽  
Agnese Ribaudo ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Biological Activity ◽  
Anticancer Agents ◽  
Mode Of Action ◽  
Biologically Active ◽  
Minimal Bactericidal Concentration ◽  
High Cytotoxicity ◽  
Pathogen Strains ◽  
Mcf 7

Pyrrolomycins (PMs) are polyhalogenated antibiotics known as powerful biologically active compounds, yet featuring high cytotoxicity. The present study reports the antibacterial and antitumoral properties of new chemically synthesized PMs, where the three positions of the pyrrolic nucleus were replaced by nitro groups, aiming to reduce their cytotoxicity while maintaining or even enhancing the biological activity. Indeed, the presence of the nitro substituent in diverse positions of the pyrrole determined an improvement of the minimal bactericidal concentration (MBC) against Gram-positive (i.e., Staphylococcus aureus) or -negative (i.e., Pseudomonas aeruginosa) pathogen strains as compared to the natural PM-C. Moreover, some new nitro-PMs were as active as or more than PM-C in inhibiting the proliferation of colon (HCT116) and breast (MCF 7) cancer cell lines and were less toxic towards normal epithelial (hTERT RPE-1) cells. Altogether, our findings contribute to increase the knowledge of the mode of action of these promising molecules and provide a basis for their rationale chemical or biological manipulation.

The Heparin-Glotar Surface; Mdde Of Action And Practical Application

1981 ◽  
Author(s):  
P Olsson ◽  
R Larsson ◽  
L-E Lins ◽  
E Nilsson
Keyword(s):  
Blood Vessels ◽  
Mode Of Action ◽  
Surface Coating ◽  
Anticoagulant Activity ◽  
Coagulation System ◽  
Practical Application ◽  
Plasma Coagulation ◽  
Similar Mode

A heparinized surface with non-thrombogenic characteristics was prepared by stabilization of an ionic heparinamine complex with glutardialdehyde. The process can be applied to a large variety of materials.The coating makes the surface platelet canpatible because np fibrinogen is adsorbed. The interaction of the surface with plasma coagulation system is based upon its ability to adsorb active coagulation enzymes (thrombin) and to promote inhibition of the adsorbed enzyme in the presence of circulating anti thrombin III. The sequence involving enzyme adsorbaticn and subsequent inhibition is regenerative. Investigations on blood vessels have revealed that the intact endotheliim exerts a similar mode of action with regard to inhibition of coagulation enzymes.When the heparin in the surface coating is substituted for glucosaminoglycans with less anticoagulant activity than heparin, the created surfaces is still platelet compatible and maintains the ability to adsorb enzyme, but loses the ability to generate inhibition of the adsorbed enzymes. Such surfaces are highly thrcmbogenic.The heparin surfaces have been tested experimentally for various applications. A heparin coated intravascular pO2 sensor was used for accurate measurements without recalibrations for several days. A non-heparinized electrode deteriorated within hours. Hemodialysis was performed on non-heparinized dogs using surface-heparinized hemodialysis set.

Similar mode of action of pyrethroids and DDT on sodium channel gating in myelinated nerves

Nature ◽  
1982 ◽  
Vol 295 (5850) ◽  
pp. 601-603 ◽  
Author(s):  
Henk P. M. Vijverberg ◽  
Johan M. van der Zalm ◽  
Joep van den Bercken
Keyword(s):  
Sodium Channel ◽  
Mode Of Action ◽  
Channel Gating ◽  
Similar Mode ◽  
Myelinated Nerves

Characterization of a norflurazon-resistant mutant of Chlamydomonas reinhardtii

Weed Science ◽  
1997 ◽  
Vol 45 (3) ◽  
pp. 374-377 ◽  
Author(s):  
Varsha Vartak ◽  
Sujata Bhargava
Keyword(s):  
Chlamydomonas Reinhardtii ◽  
Mode Of Action ◽  
Resistant Mutant ◽  
Phytoene Desaturase ◽  
Wild Type ◽  
Cross Tolerance ◽  
In The Wild ◽  
Similar Mode ◽  
Target Enzyme

A norflurazon-resistant mutant has been isolated from Chlamydomonas reinhardtii that showed a three-fold factor of resistance over wild type cultures. In comparison to wild type cultures, the mutant showed better retention of chlorophylls and carotenoids when grown in light in the presence of norflurazon. When grown in the dark, chlorophyll losses were similar, while carotenoid losses were lower than in the wild type cultures. Higher levels of phytoene accumulated in the wild type cultures in the presence of norflurazon than in the resistant cultures. The resistant cultures also showed cross tolerance to EMD-IT 5914, a herbicide with a similar mode of action. Norflurazon resistance in this alga appears to arise from alterations in the target enzyme phytoene desaturase.

A new cytotoxic sesquiterpene lactone from Euphorbia microsphaera Boiss against human breast cancer (MCF-7) and human fibrosarcoma (HT1080) cells

Toxicon ◽  
2021 ◽  
Vol 202 ◽  
pp. 60-66
Author(s):  
Kourosh Azizi ◽  
Azadeh Hamedi ◽  
Negar Azarpira ◽  
Azar Hamedi ◽  
Masoumeh Shahini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sesquiterpene Lactone ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Ht1080 Cells ◽  
Mcf 7

BACILLUS THURINGIENSIS δ-ENDOTOXEV: ON THE RELATIVE ROLES OF SPORES AND CRYSTALS IN TOXICITY TO SPRUCE BUDWORM (LEPIDOPTERA: TORTRICIDAE)

1977 ◽  
Vol 109 (11) ◽  
pp. 1515-1518 ◽  
Author(s):  
P. G. Fast
Keyword(s):  
Bacillus Thuringiensis ◽  
Mode Of Action ◽  
Choristoneura Fumiferana ◽  
Spruce Budworm ◽  
Regression Coefficients ◽  
Similar Mode

AbstractNewly moulted sixth instar larvae of spruce budworm, Choristoneura fumiferana, were force fed graded dosages of preparations containing (1) purified crystals, (2) purified spores, and (3) mg/mg mixtures of purified spores and purified crystals. The LD50 for purified crystals was 0.094 μg/larva and for the mixture 0.096 μg/larva but the latter preparation had an LD50 of 0.048 μg/larva based on crystals indicating that the presence of 2.4 × 105 spores enhanced the toxicity of crystals twofold. The LD50 spore crystal corresponded to LD60 for crystals alone. The LD50 for spores treated with proteinase to remove residual crystals was 20 μg/larva, or 1,0 × 108 spores. The regression coefficients were not significantly different from each other in all three preparations indicating a common or similar mode of action. It is concluded that spores play little or no role in mortality of spruce budworm induced by Bacillus thuringiensis insecticides.

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