scholarly journals Assessing Modes of Action, Measures of Tissue Dose and Human Relevance of Rodent Toxicity Endpoints with Octamethylcyclotetrasiloxane (D4)

2022 ◽  
Author(s):  
Melvin E. Andersen ◽  
Tracy Guerrero
Keyword(s):  
Tissue Dose ◽  
Modes Of Action ◽  
Action Measures

Therapeutic options in male osteoporosis

2013 ◽  
Vol 22 (04) ◽  
pp. 271-276 ◽  
Author(s):  
P. Farahmand ◽  
J. D. Ringe
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Public Health Problem ◽  
Male Osteoporosis ◽  
Individual Risk ◽  
Modes Of Action ◽  
Increased Risk ◽  
Study Results ◽  
Long Term Treatment ◽  
Male Patients

SummaryOsteoporosis in men is increasingly recognized as an important public health problem but affected patients are still under-diagnosed and -treated. As in women the diagnostic and therapeutic strategy has to be adapted to the individual case. In the practical management it is very important to detect possible causes of secondary osteoporosis, to explain the possibilities of basic therapy counteracting individual risk factors and communicate that osteoporosis is a chronic disease and adherence to a long-term treatment is crucial. In established severe osteoporosis a careful analgesic therapy is important to avoid further bone loss related to immobility. In elderly men with increased risk of falling insufficient Vitamin D supply or impaired activation of Vitamin D due to renal insufficiency must be taken into consideration. Specific medications available today for the treatment of male osteoporosis comprise among antiresorptive drugs the bis phosphonates alendronate, risedronate and zoledronic acid. Denosumab, the first biological therapy is approved for men with androgen deprivation therapy for prostate cancer. An important advantage of this potent antiresorptive drug is the increased adherence due to the comfortable application by sixmonthly subcutaneous injections. Study results from the 2-year multi-center randomized controlled ADAMO-Study will very soon allow the use of denosumab in all types of male osteoporosis. Teriparatide, the 34 N-terminal amino acid sequence of parathyroid hormone was approved for men with osteoporosis as an anabolic agent based on proven efficacy by different studies. Among drugs with other modes of action the D-hormone pro-drug alfacalcidol can be used in men alone or in combination with the advantage of pleiotropic effects on calcium absorption, parathyroids, bone and muscle. Recently also Strontium-ranelate was approved for male patients with the limitation to exclude men with clinical relevant cardiovascular risk factors. In general the possibilities to treat male osteoporosis have considerably improved during recent years. Today there is a choice of a spectrum of drugs from mild to strong potency with different modes of action on bone turnover to design strategies for individual male patients.

Pesticides Modes of Action and Resistance: A Perspective from the 2019 IUPAC Congress

2019 ◽  
Vol 30 (4) ◽  
pp. 157-163 ◽  
Author(s):  
Franck E. Dayan ◽  
Geert Haesaert ◽  
Thomas Van Leeuwen ◽  
Lindy Holden-Dye ◽  
Andrew Crossthwaite ◽  
...  
Keyword(s):  
Modes Of Action

Multi-chain action of exo-D-galacturonanase from carrot

1983 ◽  
Vol 48 (12) ◽  
pp. 3579-3588
Author(s):  
Kveta Heinrichová ◽  
Jana Perečková
Keyword(s):  
Optimal Condition ◽  
Degradation Products ◽  
Degradation Kinetics ◽  
Hydrolytic Cleavage ◽  
Chain Mechanism ◽  
Modes Of Action ◽  
Enzyme Degradation ◽  
Good Agreement

Two possible modes of action of exo-D-galacturonanase from carrot (E.C. 3.2.1.67) were investigated; this enzyme catalyses the sequential hydrolytic cleavage of pectants and oligogalacturonans by a terminal action from the nonreducing end of the molecule. The experiments indicate that the investigated exo-D-galacturonanase degrades these substrates by a predominantly multi-chain mechanism. Distribution of degradation products of oligomeric substrates (hexa- and pentagalacturonide) under an optimal condition for the action of the enzyme (pH and temperature) indicates that a multi-chain enzyme attack with a prevalent simple collision is involved. Results of the enzyme degradation kinetics are in a good agreement with the above-mentioned presumption.

The Myth of a Migration Crisis in France

2018 ◽  
pp. 126-144
Author(s):  
Isabelle Rigoni
Keyword(s):  
Civil Society ◽  
National Security ◽  
Ethnic Diversity ◽  
European Countries ◽  
Terrorist Attacks ◽  
Modes Of Action ◽  
Security Context ◽  
Migration Crisis ◽  
Institutional Actors

France is an old immigration country but has been slow to recognize itself as such. Since 2000, the Western security context has produced a new stage in migration and asylum policies. The tragic and traumatic nature of terrorist attacks in France and other European countries has legitimized the strengthening of national security laws, fueled more conservative attitudes regarding cultural and ethnic diversity, and fed into debates on communitarianism, multiculturalism, and universalism. This chapter analyzes how migratory dynamics have been constructed as a crisis in contemporary France and examines the initiatives of civil society towards what politics and media consider to be a migration crisis. Finally, it analyzes the modes of action used by various social and institutional actors in the context of an imagined migration crisis.

scholarly journals Extraneous E-Cadherin Engages the Deterministic Process of Somatic Reprogramming through Modulating STAT3 and Erk1/2 Activity

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 284
Author(s):  
Yu-Hao Liu ◽  
Chien-Chang Chen ◽  
Yi-Jen Hsueh ◽  
Li-Man Hung ◽  
David Hui-Kang Ma ◽  
...  
Keyword(s):  
Stochastic Process ◽  
Molecular Mechanism ◽  
Activity Ratio ◽  
Cell Types ◽  
Deterministic Process ◽  
Modes Of Action ◽  
Molecular Events ◽  
Different Cell Types ◽  
Selection Of ◽  
E Cadherin

Although several modes of reprogramming have been reported in different cell types during iPSC induction, the molecular mechanism regarding the selection of different modes of action is still mostly unknown. The present study examined the molecular events that participate in the selection of such processes at the onset of somatic reprogramming. The activity of STAT3 versus that of Erk1/2 reversibly determines the reprogramming mode entered; a lower activity ratio favors the deterministic process and vice versa. Additionally, extraneous E-cadherin facilitates the early events of somatic reprogramming, potentially by stabilizing the LIF/gp130 and EGFR/ErbB2 complexes to promote entry into the deterministic process. Our current findings demonstrated that manipulating the pSTAT3/pErk1/2 activity ratio in the surrounding milieu can drive different modes of action toward either the deterministic or the stochastic process in the context of OSKM-mediated somatic reprogramming.

Serotonin and Melatonin Show Different Modes of Action on Aβ42 Protofibril Destabilization

2021 ◽  
Vol 12 (4) ◽  
pp. 799-809
Author(s):  
Yehong Gong ◽  
Chendi Zhan ◽  
Yu Zou ◽  
Zhenyu Qian ◽  
Guanghong Wei ◽  
...  
Keyword(s):  
Modes Of Action
Sign in / Sign up

Export Citation Format

Share Document